Umit Sayin

Umit Sayin
Istanbul University · Institute of Forensic Sciences

27.13
 · 
Associate Professor-MD, PhD, www.humitsayin.com

About

92
Publications
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Introduction
Umit Sayin currently works at the Institute of Forensic Sciences, Istanbul University. H. Ümit Sayin, who is particularly specialized on neuro -psycho pharmacology and neuroscience, received his M.D. degree from İstanbul Medical Faculty in 1987, Pharmacology degree from Cerrahpaşa Medical Faculty in 1993, and did his postdoctoral work on Neuroscience at the Neurology Department, University of Wisconsin, Madison, USA (1994-1996). He has worked on cellular electrophysiology, electrophysiology of learning and LTP, experimental models of epilepsy, kindling and animal behavior, voltage and current clamp techniques, microdialysis and psychopharmacology, experimental psychology, human sexuality at various Universities, such as University of Newfoundland (Canada, 1989-1990), Oxford University (U
Research Experience
June 2004 - April 2016
Istanbul University
Position
  • Professor (Associate)
June 1994 - June 2002
University of Wisconsin–Madison
Position
  • scientist

Publications

Publications (92)
Book
Full-text available
Psychopharmacology of Altered States of Consciousness (ASC)● Ancient Cultures and Shamanic Psychoactive Practices ● Entoptic Images and Phosphenes during Psychedelic States ● Secret Archaic Language of Neurons● Religions, Common Symbols and Archetypes● Pagan Cults, Sexuality and Psychoactive Plants● Shamanic Practices of Psychoactive Substances and...
Article
Full-text available
Resumen (SPANISH TRANSLATION) Este artículo explica algunos de los nuevos hallazgos sobre la sexualidad femenina, la Respuesta Sexual Expandida (RSE) y los orgasmos prolongados–ampliados en comparación con las descripciones de las antiguas filosofías tántricas y taoístas. El orgasmo femenino y las «experiencias pico» femeninas tienen su adecuado re...
Article
Full-text available
Abstract Female orgasm is one of the unsolved phenomena in female physiology and psychology. Most of the women do not actually know their natural capacity in attaining powerful orgasms; male biases have, most of the time, shaped the norms of the sexual behavior of women in many cultures. 50 to 65 % of women can attain multiple orgasms. In some of t...
Article
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CORRECTED PROOF: In sexuality research and sex therapy, it is generally very difficult to define “the normal” and to differentiate variations, mild and harmless fantasies, sexual games and fantasy role play from paraphilia. In DSM classifications, there are still dilemmas, misinterpretations, contradictions and controversies to define paraphilias...
Article
Full-text available
Hedonism and pleasure are one of the main goals of human life. Pleasure can be accepted as a reward for the brain, while the major reward neurotransmitters are dopamine, norepinephrine, oxytocin and gluta-mate. Boost of dopamine in the "hedonic hot spots" creates euphoria, delight, pleasure, contentment and is associated with happiness. The reward...
Article
Full-text available
A Multidisciplinary Academic Journal Published Quarterly by CİSEATED-ASEHERT • www.ciseated.org • www.sexusjournal.com • Abstract: American Psychiatric Association (APA) revised and updated the DSM-IV into DSM-5 in 2013; DSM-6 is said to be on the way. DSM Manual is globally used for the diagnosis of psychiatric disorders. In 2013 APA was about to...
Article
Full-text available
A Multidisciplinary Academic Journal Published Quarterly by CİSEATED-ASEHERT • www.ciseated.org • www.sexusjournal.com • Abstract: American Psychiatric Association (APA) revised and updated the DSM-IV into DSM-5 in 2013; DSM-6 is said to be on the way. DSM Manual is globally used for the diagnosis of psychiatric disorders. In 2013 APA was about to...
Article
Full-text available
Pleasure is a mental and emotional state that humans and other animals experience as positive, enjoyable, satisfying, giving joy and happiness or worth seeking. It may include other mind states such as happiness, entertainment, enjoyment, ecstasy, and euphoria, with peak experiences. According to the "incentive salience model" pleasure has three co...
Article
Full-text available
Pleasure principal" is one of the most important driving forces of the human psyche. Kinds of pleasure in human beings include various satisfactions, such as food intake for the survival, satisfaction of the ego and higher cortical cognitive functions, sexual satisfaction and orgasm, satisfaction of basic physiological needs and peak experiences, s...
Article
Full-text available
Abuse of methamphetamine, cocaine and morphine is an increasing global problem. According to 2018 UNODOC report between 2012 and 2016, 151 millions of people used cannabis; 146 millions of people consumed cocaine; 275 millions of people used opioids and opiates; 131 millions of people consumed amphetamines. According to another Global Drug Survey-2...
Article
Full-text available
Id, ego and superego are three abstract compartments of the human psyche according to the schools of psychoanalysis, established by Freud. Although these are abstract notions, today we have the neuroscientific basis of knowledge for defining them in terms of neuroanatomy and psychopharmacology. Hedonic hot spots or pleasure centers in the limbic sy...
Book
Full-text available
İçindekiler Önsöz 1-Cinsellik Nedir? 2-Cinsel Beyin-Cinsel Zihin 3-Cinsel Zihinde Beynin Nöroanatomisi, Nörofizyolojisi, Psiko-Farmakolojisi, Nöro-Kimyası 4-Cinsel Beynin, Hazzın ve Orgazmın Nörobilimi 5-Duygusal Zeka (EQ) ve Cinsel Zeka (SQ) 6-Cinsel Nesneler; Cinsel Haz Nesneleri: Normal Nedir? Anormal Nedir? 7-Kendi Cinsel Beyninizi Keşfedin! Ci...
Article
Full-text available
Pleasure principal" is one of the most important driving forces of the human psyche. Pleasures in human beings include various satisfactions, such as food intake for the survival, satisfaction of the ego and higher cortical cognitive functions, sexual satisfaction and orgasm, satisfaction of basic physiological needs. Female orgasm, which does not...
Article
Full-text available
A Multidisciplinary Academic Journal Published Quarterly by CİSEATED-ASEHERT • www.ciseated.org • www.sexusjournal.com • Abstract: Constructing a System Theory (ST) is a method to establish a logical, mathematical, self-consistent, self-existing, coherent model to explain the interactions of the elements, functions and development of a closed o...
Article
Full-text available
A Multidisciplinary Academic Journal Published Quarterly by CİSEATED-ASEHERT • www.ciseated.org • www.sexusjournal.com • Abstract: A short overview and summary of sexual behavior of Turkish women in Turkey is briefly given with some survey statistics, which were realized in 1993, 2003, and 2013. Also a short view of women rights problems is summa...
Article
Full-text available
Abstract: In DSM-V (2013), a new sexual disorder will be defined as “Hypersexual Disorder” in the human female, described by Martin P. Kafka and APA , according a new scale called HDSI (Hypersexual Disorder Screening Inventory). However, lately there have been very fierce debates about the validity of HDSI in the academic circles . Recent publicat...
Article
Full-text available
A Multidisciplinary Journal Published Quarterly by CİSEATED-ASEHERT • www.ciseated.org • www.sexusjournal.com • 413 ISSN 2536-5185 (web) Abstract: Altered states of consciousness induced by hallucinogens (H-ASC) is still a vaguely understood phenomenon. Taken the diverse psychological effects they exert, the main mechanism of action of hallucinog...
Book
Full-text available
içindekiler 1. Giriş ve Önsöz 2. Cinsel Araştırmaların Kısa Tarihçesi ve ESR 3. Kadınlarda Eski ve Yeni Cinsel Anatomi-Fizyoloji, Yeni Erojen Bölgeler 4. Kadınlarda Uyarılmanın ve Orgazmın Nörolojik Kontrolü ve ESR 5. Kadınlarda Cinsel Uyarılmanın, Orgazmın ve ESR’nin Nörokimyası 6. Kadınlarda Artırılmış Cinsel Doyum (ESR) ve PC-Kas Ağı 7. Artırılm...
Book
Full-text available
Giriş ve Önsöz Kadın Orgazmının Tarihçesi Kadınlarda Orgazm Araştırmaları Kadınlarda Orgazmın Temel Fizyolojisi Kadınlarda Orgazmı Güçlendiren ve Bloke Eden Faktörler Kadınlarda Orgazm Çeşitleri Kadın Orgazmının ve Aşkın Nörobiyolojisi Kadın Cinselliği ve Hormonlar Bazı Kadınlarda Ultra Orgazm: ESR Kadınların Orgazmlarında Ekstremler: Yaşanmış Dene...
Article
Full-text available
Psychoactive plants have been consumed by many cultures, cults and groups during religious rituals and ceremonies for centuries and they have been influential on the eruption of many images, secret and religious symbols, esoteric geometrical shapes, archetypes, religious figures, and philosophy of religions since the dawn of Homo sapiens. Some of t...
Article
Full-text available
Abstract: Psychoactive plants which contain hallucinogenic molecules that induce a form of altered states of consciousness (H-ASC) have been widely used during the religious rituals of many cultures throughout the centuries, while the consumption of these plants for spiritual and religious purposes is as old as human history. Some of those culture...
Article
Full-text available
Abstract: Although there are many forms of female orgasms described in the literature, there are still debates about the female orgasmic response and no unified theory to explain those orgasmic reflexes and sexual responses have been proposed. Also, there are inconsistent reports and comments about the ‘vaginal versus clitoral orgasm controversy’....
Article
Full-text available
Female orgasm and female 'peak experiences' are well recognized in the ancient historical literature of the India, China and Far East. Eastern cultures tried to discover the limits and extents of female orgasmic response for centuries unlike the Western cultures, where, for centuries, pleasure and orgasm of females were accepted as a sin and were n...
Article
Full-text available
This review summarizes the structural and electrophysiological changes in the epileptic hippocampus in various animal models of epilepsy. Tornado hypothesis of epileptic hippocampus, states that there are many progressive detrimental changes in the hippocampus of the epileptic rats. PTZ, PTZ kindling, pilocarpine, electrical kindling, kainic acid,...
Book
Full-text available
Sanat insanlık tarihi boyunca her zaman matematik, bilim, tıp, temel bilimler, anatomi, fizik ve teknolojideki gelişmeler ile beraber büyümüş ve gelişmiştir. Sanat bilimi etkilemiş, bilim de sanatı etkilemiştir. Bilim, matematik ve analitik düşünce beynin sol yarımküresinin bir ürünüyse; Sanat da beynin sağ yarım küresinin bir ürünüdür. İki dal da...
Article
Full-text available
El orgasmo femenino y las “experiencias pico” femeninas tienen su adecuado reconocimiento en la antigua literatura histórica de la India, China y Extremo Oriente. Por siglos, las culturas orientales trataron de descubrir los límites y alcances de la respuesta orgásmica femenina, a diferencia de las culturas occidentales, donde, por siglos, el place...
Article
Full-text available
Female orgasm and female “peak experiences” are well recognized in the ancient historical literature of the India, China and Far East. Eastern cultures tried to discover the limits and extents of female orgasmic response for centuries unlike the Western cultures, where, for centuries, pleasure and orgasm of females were accepted as a sin and were n...
Chapter
Full-text available
Psychoactive plants that induce a form of altered states of consciousness (hallucinogen-induced ASC (H-ASC)) have been widely used during the religious rituals of many cultures throughout the centuries. Some of the psychoactive ingredients of the plants that were used during these religious rituals were opium, cannabis (tetrahydrocannabinol), psilo...
Book
Full-text available
Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common...
Article
Full-text available
Constructing a System Theory (ST) is a method to establish a logical, mathematical, self-consistent, self-existing, coherent model to explain the interactions of the elements, functions and development of a closed or open system. System Theory (ST) is very important to define, organize, evaluate, control, regulate the systems and form mathematical...
Article
Full-text available
ESSM-Copenhagen-2015-February http://www.essm.org/congress.html Effects of Low Frequency Bullet Vibrators on the Clitoral Orgasm and Sexual Lives of Turkish Women Ümit Sayın1, 2, Taner Arısal1, Asiye Kocatürk1,3 and Müge Arısal1 1: ASEHERT-CİSEATED; 2: İstanbul University; 3:Medipol University-İstanbul Introduction: Vibrator use in Turkey is very...
Poster
Full-text available
Introduction: Vaginismus is an increasing sexual function disorder (SFD) in the Turkish female population, as well as anorgasmia. Since there is a chaos about the treatment of vaginismus and anorgasmia among the Turkish Sex Therapists and health professionals, most of the classical behavioral and cognitive therapy models are not used. For the behav...
Poster
Full-text available
Rationale (Optional): Nicole Daedone, the author of the bestselling book “SLOW SEX” has developed a technique of clitoral stimulation, coined as “OMING Meditation-Orgasm Technique” (Daedone, 2011). There have been claims that this method induced altered states of consciousness (ASC) in some women after a certain period of time, we have performed a...
Poster
Full-text available
Introduction: The hormone and neurotransmitter OXYTOCIN (OXY) has been proposed to take part in many behavioral patterns of female behavior, including sexual arousal, orgasm, LOVE, attachment to the partner, birth and motherhood. It is hypothesized to be used in sex therapy to treat vaginismus, anorgasmia, arousal problems and others in future. We...
Poster
Full-text available
Introduction: It is reported that perfumes and fragrances have effects on mood, consciousness, childhood memories, recent or distant memories, anxiety, sexual arousal, and libido. It is also hypothesized that fragrances and perfumes have direct effect on the limbic system, temporal lobe and also sub-consciousness & collective unconsciousness, assoc...
Poster
Full-text available
Introduction: There has long been a furious debate on the “Vaginal vs. Clitoral Orgasm” since the times of Freud. Some feminists opposed vaginal orgasm declaring and supporting the hypothesis that “there is only clitoral orgasm, but no phenomenon called vaginal orgasm and women do not need men and sexual intercourse to attain an orgasm”. Hite Repor...
Poster
Full-text available
Background and Introduction: The use of vibrators (VBs) is not very widespread among women in Turkey. A survey was made after the use of VBs (bullet vibes) among Turkish women to understand the reactions against VBs and the effects of VBs in female sexual response. Methods: We have recently made a survey on 32 women, part of which has been realized...
Poster
Full-text available
Introduction: Most of the psychiatric drugs used in the treatment of depression, anxiety and bipolar disorder, mania and psychosis influence sexual behavior, libido and the potency to get pleasure and to attain orgasm. Because of lack of proper control in Turkey, many anti-depressive SSRI’s and agents impairing dopaminergic system, dopamine recepto...
Poster
Full-text available
Introduction: In Turkey there is no sex education at the levels of high schools and universities. Maybe that is why sexual problems and sexual function disorders (SFD) are increasing day by day. For healthy sexuality and sexual behavior, structured and healthy education on human sexuality is essential. During the last decades, some SFD’s such as va...
Poster
Full-text available
Introduction: Sex Toys (STs) and vibrators (VBs) have been used in Europe and Americas successfully in sex therapy. The frequency of using VBs by women in Turkey is less than 1 % (Kadınca Report-KR, 1993 and Hülya Report-HR, 2003) compared to the frequency of 52,5 % in USA (Reference: Articles of Herbenick and Rosenberger). There is strong resistan...
Poster
Full-text available
Introduction: Sex Toys (STs) and vibrators (VBs) have been used in Europe and Americas successfully in sex therapy, since the dawn of direct-current electric motor, around 1880s. The famous comedy-history film “HISTERIA” summarizes how the VBs were started to be used by physicians and sex therapist by the end of 19th Century in USA. However, althou...
Poster
Full-text available
ESSM-Copenhagen-2015-February http://www.essm.org/congress.html Correlation of Good Sexual Relationships & Satisfaction in Marriage with the Domestic Violence in 398 Postpartum Women in İstanbul Asiye Kocatürk1,3 and Ümit Sayın1, 2 1: ASEHERT-CİSEATED; 2: İstanbul University; 3:Medipol University-İstanbul Introduction: The authors started a series...
Poster
Full-text available
ESSM-Copenhagen-2015-February http://www.essm.org/congress.html Orgasmic Behavior and the Frequencies of Sexual Function Disorders in 398 Postpartum Women in İstanbul Ümit Sayın1, 2 and Asiye Kocatürk1,3 1: ASEHERT-CİSEATED; 2: İstanbul University; 3:Medipol University-İstanbul Introduction: Very few studies are realized on the orgasmic behavior an...
Book
Kitap Adı: Kadınlarda Orgazmın Psikolojisi Yazar: Doç. Dr. H. Ümit Sayın humitsayin@yahoo.com 1. Basım, Kasım 2014 © Copyright, Doç. Dr. Ümit Sayın, 2014-İstanbul Bu kitap sadece 18 yaşından büyüklere satılır! Editör: Onur Şenyurt Kapak Tasarımı: Dr. Ümit Sayın Mijampaj ve Sayfa Düzeni: Dr. Ümit Sayın Resim, Şekil ve Şemalar: Dr. Ümit Sayın Basım...
Article
Full-text available
Neural activity promotes circuit formation in developing systems and during critical periods permanently modifies circuit organization and functional properties. These observations suggest that excessive neural activity, as occurs during seizures, might influence developing neural circuitry with long-term outcomes that depend on age at the time of...
Article
Full-text available
Introduction History The Turkish Republic, established on the remains of Ottoman Empire in 1923, is one of the few secular Islamic countries in the world. Ninety-nine percent of the population is said to be Muslim — although the definition of "being Muslim" in Turkey makes it unlikely that all of these Muslims practice orthodox Islam, Islamic rules...
Article
Full-text available
Psychoactive plants which contain hallucinogenic molecules that induce a form of altered states of consciousness (HASC) have been widely used during the religious rituals of many cultures throughout the centuries, while the consumption of these plants for spiritual and religious purposes is as old as human history. Some of those cultures were shama...
Article
Full-text available
Psychoactive plants have been consumed by many cultures, cults and groups during religious rituals and ceremonies for centuries and they have been influential on the eruption of many images, secret and religious symbols, esoteric geometrical shapes, archetypes, religious figures, and philosophy of religions since the dawn of Homo sapiens. Some of t...
Article
Full-text available
Although there are many forms of female orgasms described in the literature, there are still debates about the female orgasmic response and no unified theory to explain those orgasmic reflexes and sexual responses have been proposed. Also, there are inconsistent reports and comments about the 'vaginal versus clitoral orgasm controversy'. Recently,...
Poster
Full-text available
Introduction: Grafenberg’s Spot (G-Spot) was hypothesized to take part in the development of female orgasm in many debates since 1950’s. Lately, it has been proposed that not only G-Spot exists, but there are also other deep vaginal erogenous zones (DVZ) which can trigger orgasm in some women. Methods: During our various ongoing surveys on female s...
Poster
Full-text available
Introduction: It is well known and estimated that childbirth affects the sexual response of women. We investigated the influence of childbirth on sexual response of women in Turkey. Methods: 11 women were questioned about their sexual activities before pregnancy, during first trimester, second trimester, third trimester and 3 months after childbirt...
Poster
Full-text available
Rationale and Introduction: Pelvic Floor Muscles (PFM) are important muscle network between pubis and coccyx, that take part crucial roles in many sexual functions. We have shown that PFM strength is directly correlated with the intensity and quality of orgasms, the possibility of attaining vaginal orgasms and the development of Expanded Sexual Res...
Poster
Full-text available
Introduction: In Eastern literature centuries ago and in Western literature during the last decades, there were descriptions of different and intense female orgasm patterns. It is hypothesized that in a minority of women, orgasmic response can be enhanced and expanded, as coined with the term Expanded Sexual Response (ESR). The neurological and neu...
Poster
Full-text available
Altered States of Consciousness (ASC) During Female Orgasms and Expanded Sexual Response (ESR): Don’t Use Drugs, Use Expanded Orgasms! Rationale and Introduction: Expanded Sexual Response (ESR) is defined as “being able to attain long lasting and/or prolonged and/or multiple and/or sustained orgasms and/or status orgasmus that lasted longer and mor...
Chapter
Full-text available
Contents Preface 3 Woet Gianotten: Cancer and Sexuality 7 Introduction 7 Facts & Figures 7 The Damage Done 8 Sexual Consequences of specific cancers 10 The Average Cource of Sexuality in Cancer 14 Minority Groups 15 Dealing With Sexuality & Intimacy in Case of cancer 15 Patrick Jern & Juhana Piha: Towards Improved Diagnostic Criteria and Treatment...
Poster
Full-text available
Authors: Nurcan Armagan1, Ümit Sayin2 and Asiye Kocatürk3 Institution: 1 Dept. of Obstetrics and Gynecology, Anatolian and Zeynep Kamil Hospitals, Üsküdar, İstanbul-Turkey 2 Institute of Forensic Sciences, İstanbul University, Cerrahpaşa, İstanbul-Turkey 3 Dept. of Midwife and Nursery, Health Sciences Institute, Marmara University, İstanbul-Turkey...
Poster
Full-text available
Authors: Asiye Kocatürk1 and Ümit Sayin2 Institution: 1 Dept. of Midwife and Nursery, Health Sciences Institute, Marmara University, İstanbul-Turkey 2 Institute of Forensic Sciences, İstanbul University, Cerrahpaşa, İstanbul, Turkey Corresponding E-mail: humitsayin@gmail.com Abstract Title: A Comparison of Hyper-active Sexual Tendencies between Tur...
Poster
Full-text available
Authors: Asiye Kocatürk1, Ümit Sayın2, Gizem Y. Baş3, Cevdet Kocatürk1 Institution: 1 Dept. of Midwife and Nursery, Health Sciences Institute, Marmara University, İstanbul-Turkey 2Institute of Forensic Sciences, İstanbul University, Cerrahpaşa, İstanbul-Turkey 3 Bogazici University Corresponding E-mail: humitsayin@gmail.com Abstract Title: Comparis...
Article
Full-text available
Altered states of consciousness induced by hallucinogens (H-ASC) is still a vaguely understood phenomenon. Taken the diverse psychological effects they exert, the main mechanism of action of hallucinogens; LSD, ibogaine, THC, PCP, MDMA, methamphetamine, mescaline, psilocybin and DMT, of which psychological effects are discussed in the article, are...
Article
Full-text available
Expanded Sexual Response (ESR) is a recently defined phenomenon. It is defined as "being able to attain long lasting and/or prolonged and/or multiple and/or sustained orgasms and/or status orgasmus that lasted longer and more intense than the classical orgasm patterns defined in the literature". During our detailed preliminary survey to investigate...
Poster
Full-text available
PELVIC FLOOR MUSCLE STRENGHT IS CORRELATED WITH ATTAINING VAGINAL ORGASMS IN HUMAN FEMALE AS MEASURED BY KEGEL PERINEOMETER (Poster Presentation) Ümit Sayın, M.D., Ph.D. (Institute of Forensic Sciences, Istanbul University, Cerrahpaşa-İstanbul) E-mail: humitsayin@gmail.com Asiye Kocatürk, Ph.D. (Midwife Training Department, Health Sciences Institut...
Poster
Full-text available
THE MAIN PARAMETERS AND NEW DEFINITIONS OF ENHANCED AND EXPANDED SEXUAL RESPONSE (ESR) (Poster Presentation) Ümit Sayın, M.D., Ph.D. (Institute of Forensic Sciences, Istanbul University, Cerrahpaşa-İstanbul) E-mail: humitsayin@gmail.com Marjo Ramstadius (Jokioinen, Finland) E-mail: marjo.ramstadius@nic.fi Rationale: In medical literature, there are...
Book
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DÖRDÜNCÜ BASKIYA (EDİSYONA) ÖNSÖZ “Derin Seks” evrimleşmiş ve gelişmiş bir kitap dizisidir. 2010 yılında Klan yayınları tarafından yayınlanan kitap, 2014 ve 2015 yıllarında 2. ve 3. bas-kıyı yapmış; piyasaya çıkar çıkmaz da bu baskılar tükenmiştir. Türkiye’de kitap çıkarmak çok zahmetli ve para harcamayı gerektiren; karşılığını da hemen ala-madığı...
Book
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Sorularla, Resimlerle DÜNYAYI YÖNETEN GİZLİ GÜÇLER Doç. Dr. Ümit Sayın ARKA KAPAĞIN SPOTLARI: • Dünyayı yönetmekte olan gizli güçler nelerdir? • Küresel Elit’in ve Küresel Sermayenin gizli yöntemleri ve örgütleri nelerdir? • Masonik gizli örgütler nedir? • Bu örgütlerin gizli yöntemleri nelerdir? • Masonluk nedir? • Masonluktaki, Örgütlerdeki gi...
Book
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Doğan Öz’e, Çetin Emeç’e, Abdi İpekçi’ye, Turan Dursun’a, Muammer Aksoy’a, Bahriye Üçok’a, Uğur Mumcu’ya, A. Taner Kışlalı’ya, Em. Binb. İhsan Güven’e, Necip Hablemitoğlu’na, Danıştay Hakimi Mustafa Yücel Özbilgin’e, şehit edilen tüm komutanlarımıza, subaylarımıza ve erlerimize, Atatürkçü, laik ve demokratik Cumhuriyeti korumak mücadele veren Musta...
Poster
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Salvinorin A, the first known naturally occurring non-nitrogenous full agonist at j-opioid receptors, is the psychoactive component of the hallucinogenic mint Salvia divinorum (1). Salvia divinorum, or any of its active ingredients are not specifically listed in the Controlled Substances Act and it is currently used as a legal alternative to controll...
Book
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İçindekiler Önsöz…………………………………………………………. Genişletilmiş dördüncü baskıya önsöz............................. Bir zaman Yolculuğu: 2028 Yılındayız, Yer Büyük Ortadoğu ........................................... 11 Eylül Olayı İlgili İlk Yazılar………………………………. Dünyayı Yöneten Gizli Örgütler........................................ Gizli Örgütler ve...
Article
HuR is a ubiquitously expressed AU-rich element (ARE)-binding protein that interacts with and stabilizes selective early response gene (ERG) mRNAs after cell activation or stress. To date, approximately 20 mRNAs have been unambiguously defined as HuR ligands. Given the discordance between the large number of ERG mRNAs and those few defined as ligan...
Article
Full-text available
Seizures in the developing brain cause less macroscopic structural damage than do seizures in adulthood, but accumulating evidence shows that seizures early in life can be associated with persistent behavioral and cognitive impairments. We previously showed that long-term spatial memory in the eight-arm radial-arm maze was impaired in rats that exp...
Article
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Repeated brief seizures evoked by kindling progressively increase seizure susceptibility and eventually induce spontaneous seizures. Previous studies have demonstrated that the initial seizures evoked by kindling increase paired-pulse inhibition at 15-25 msec interpulse intervals in the dentate gyrus and also induce apoptosis, progressive neuronal...
Article
Glutamate activates a class of receptors coupled to G-proteins that initiate second messenger cascades, change ion channel function, cause release of calcium from intracellular stores, and produce long-term changes in synaptic strength. We used the CA3 region of the adult rat hippocampal slice to evaluate group I metabotropic glutamate receptor (mG...
Book
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Atalarımız Atabaşkan dilini konuşan ve Ön-Türklerin bir kolu olduğu düşünülen Amerika kıtasının gerçek sahibi tüm Kızılderili Kardeşlerimize ! ÖNSÖZ VE GİRİŞ: ıl 1995, İlkbahar. Yer Wisconsin’ın başkenti, Madison. Ana cadde State Street’de Dev Senato binasını karşıma alarak yürüyorum. Defalarca girdiğim Kızılderili hediyelik eşyaları satan dükkana...
Article
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Activation of muscarinic cholinergic receptors produces oscillations in the hippocampal slice that resemble the theta rhythm, but also may produce abnormal synchronous activity that is more characteristic of epileptiform activity. We used pilocarpine, a muscarinic agonist and convulsant, and an elevation in extracellular potassium (5-7.5 mM) to pro...
Article
Purpose: The transition from an interictal to an ictal pattern of epileptiform activity is a strategic target for antiepileptic drug (AED) action. Both the muscarinic agonist pilocarpine and the selective group I metabotropic glutamate receptor (mGluR) agonist (RS)-3,5-dihydroxyphenylglycine (DHPG) produce prolonged synchronous activity in the hip...
Article
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Gamma vinyl GABA (GVG), an irreversible GABA transaminase inhibitor, has anticonvulsant effects. GVG increases GABA levels in the brain by blocking its degradation, and is presumed to enhance GABAergic inhibition, however, in some cases it exacerbates seizures. We investigated the effects of GVG in vivo and in vitro on paired pulse inhibition (PPI)...
Article
Full-text available
Neural activity influences the patterning of synaptic connections and functional organization of developing sensory and motor systems, but the long-term consequences of intense neural activity such as seizures in the developing hippocampus are not adequately understood. To evaluate the possibility that abnormal neural activity during early developm...
Article
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Single-electrode voltage-clamp techniques and bath application of the N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovaleric acid (APV) were used to study the time course of seizure-induced alterations in NMDA-dependent synaptic currents in granule cells of the dentate gyrus in hippocampal slices from kindled and normal rats. In...
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The effects on rodent anxiety of corticotrophin releasing factor (CRF), common experimental stressors and the CRF receptor blocker, α-helical CRF, were measured using the hole board and elevated plus-maze tests. Centrally administered (intracerebroventricular, i.c.v.) CRF increased anxiety in an anxioselective manner. α-Helical CRF (i.c.v) antagoni...

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La Revista Científica Arbitrada de la Fundación MenteClara incluye artículos y documentos en español e inglés sobre una amplia gama de temas y enfoques. Por su relevancia se destacan, aunque sin limitarse a, los artículos acerca de historia de las ideas y las religiones, de filosofía y espiritualidad, de crítica literaria, y de antropología, psicología, sociología, biotecnología y ciencias médicas -desde la visión del hombre como un sistema funcional interrelacionado de combinaciones psicobiológicas-. La Revista incluye tanto artículos teóricos y de reflexión como producto de investigaciones empíricas atravesados por (o cuestionando) la idea del sujeto -y su género- como una construcción de la cultura, independiente de la deidad e iguales entre si. Esta Revista Científica Arbitrada provee acceso libre, gratuito e inmediato a su contenido (sin necesidad de que el lector se registre) bajo el principio de que hacer disponible la investigación al público fomenta un mayor intercambio del conocimiento global y por lo tanto un mayor desarrollo del hombre. Esta revista tampoco cobra ningún tipo de arancel a los investigadores que deseen publicar sus trabajos. No tiene cargos para los autores por el envío ni por el procesamiento del artículo bajo el mismo principio del párrafo anterior. Para que su artículo sea incluido en la publicación, es necesario que los trabajos se encuentren libres de compromisos editoriales con cualquier otra revista u órgano editorial. Cada contribución será sometida primero a una evaluación de relevancia temática por el Comité Editorial y luego a una evaluación tipo doble ciego con evaluadores internos y externos. Los envíos deberán hacerse llegar por correo electrónico a la Revista Científica Arbitrada de la FMC. Esta revista se indexa automáticamente en CrossRef, PubMed, Google Sholar, Latindex, Redib, Caicyt y los principales Index y Bibliotecas. Utiliza además el sistema LOCKSS(Lots of Copies Keep Stuff Safe) para crear un archivo seguro y permanente de la revista. Licencia de Creative Commons Este obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 3.0 Unported. http://fundacionmenteclara.org.ar/revista