Ulrike Horn

University of Greifswald · Institute of Diagnostic Radiology and Neuroradiology

To investigate therapy associated changes in the cerebral representation of movement after stroke, we used functional magnetic resonance imaging (fMRI) during an active and a passive motor task for the affected and unaffected hand before and after a three week comprehensive hand motor training. Twelve patients in the subacute phase from 2 to 9 week...

Several biomarkers have been identified which enable a considerable prediction of hand-motor outcome after cerebral damage already in the subacute stage after stroke. We here review the value of MRI biomarkers in the evaluation of corticospinal integrity and functional recruitment of motor resources. Many of the functional imaging parameters are no...

Background: The particular function of the left anterior human insula on emotional arousal has been illustrated with several case studies. Only after left hemispheric insula lesions, patients lose their pleasure in habits such as listening to joyful music. In functional magnetic resonance imaging studies (fMRI) activation in the left anterior insul...

Background: The insula has important function in monitoring and integrating physiological responses to a personal experience of multimodal input. The experience of chills in response to auditory stimuli is an important example for a relevant arousing experience coupled with bodily response. A group study about altered chill experiences in patients...

The term 'chill' refers to a short-term bodily event of high arousal, which marks an emotional peak experience when occurring in response to music. Chill responses arise in a clearly circumscribed time frame and can also be reliably elicited by unpleasant sounds. Previous research, however, mostly focused on individually selected stimuli and positi...

Spatial integration of parts of the body is impaired in patients with complex regional pain syndrome (CRPS). Because the training of mental rotation (MR) has been shown to be among the effective therapy strategies for CRPS, impairment of MR is also important for the pathophysiological understanding of CRPS. The aim of this study was to evaluate whe...

Introduction: Previous work highlighted the importance of a network of affective, appraisal, motor and sensory interoceptive regions for chill response to pleasant music. However, no study has been performed yet about neural representation to unpleasant sounds associated with chill experience. We here developed a new fMRI-design for both pleasant (...

Spatial integration of the body matrix, especially representation of the affected side is reduced in patients suffering from complex regional pain syndrome (CRPS; Moseley et al., 2009). The parietal sulcus integrates multimodal sensory input to spatial aspects of the own body and is therefore essential for processing mental rotation (MR) (Lebon et...

Motor imagery (MI) is the mental simulation of action frequently used by professionals in different fields. However, with respect to performance, well-controlled functional imaging studies on MI training are sparse. We investigated changes in fMRI representation going along with performance changes of a finger sequence (error and velocity) after MI...

Objective Motor imagery (MI) is the mental simulation of action frequently used by professionals in different fields. The knowledge about changes in functional representation of motor patterns trained with mental imagery is sparse. In addition, we do not know how changes in functional representation during imagery training are associated with preci...

Objective Outcome prediction after motor stroke for the acute to subacute phase can be consulted for individual therapy modification. For the outcome of severely impaired patients the intactness of the pyramidal tract descending from the lesioned hemisphere (ipsilesional; i) has been described as an important parameter for upper limb strength as a...

Objective In order to investigate changes in functional representation of hand movement after stroke we used functional magnetic resonance imaging (fMRI) during an active motor task of the affected hand before and after a three week comprehensive motor training. Methods 12 patients in the subacute phase after mild to moderate motor stroke (4.8 ± 2....

Background: Connectivity-based predictions of hand motor outcome have been proposed to be useful in stroke patients. We intended to assess the prognostic value of different imaging methods on short-term (3 months) and long-term (6 months) motor outcome after stroke. Methods: We measured resting state functional connectivity (rsFC), diffusion weight...