Ulrich Hohenleutner

• Prof. Dr.
• Deputy Head of Department at University Hospital Regensburg

Fractional CO2 -laser resurfacing is increasingly used for treating rhytides and photoaged skin because of its favorable benefit-risk ratio. A key outcome measure and treatment goal in aesthetic laser therapy is patient satisfaction. However, few data are available on patient-reported outcomes after fractional ablative skin-resurfacing. To compare...

Kapilläre Malformationen (Naevi flammei) werden bei unter 1 % der Neugeborenen beobachtet und können mit anderen vaskulären und nichtvaskulären Fehlbildungen vergesellschaftet sein. Sie treten überwiegend (etwa 2/3) im Kopf-Hals-Bereich auf und können sehr stigmatisierend für die Betroffenen sein. Blitzlampengepumpte gepulste Farbstofflaser stellen...

Results of profilometric skin analyses after fractional ablative skin resurfacing are not only important for evaluating the efficacy of this therapy but are also relevant for physicians practicing laser and aesthetic skin therapy. So far, objective measurements of wrinkle reduction after fractional CO2 -laser resurfacing are scarce, and it remains...

Capillary malformations (port-wine stains) are observed in less than 1 % of neonates and may occur coincidentally with other vascular and nonvascular malformations. Two thirds of lesions occur in the head and neck area and may have important cosmetic and psychological implications for the patients. Treatment with flashlamp-pumped pulsed dye lasers...

Complete clearance of port-wine stains (PWS) is difficult to achieve, mainly because of the resistance of small blood vessels to laser irradiation. Indocyanine green (ICG)-augmented diode laser treatment (ICG+DL) may overcome this problem. To evaluate the feasibility of ICG+DL therapy of PWS and to compare the safety and efficacy of ICG+DL with the...

Complete clearance of port wine stains (PWS) is difficult to achieve, mainly because of the resistance of small blood vessels to laser irradiation. Indocyanine green (ICG)-augmented diode laser treatment (ICG+DL) may overcome this problem. This pilot study evaluates the feasibility of ICG-augmented diode laser therapy of PWS and compares safety an...

In the literature, non-ablative fractionated photothermolysis (nFP) is accredited with improvement of wrinkles and scars combined with a reduced downtime. The purpose of this work was to evaluate the impact of a combination laser (1,320/1,440 nm) for nFP on hypertrophic scars, acne scars, and facial wrinkles. Thirty-six patients suffering from hype...

So far, pulsed dye lasers have been regarded as the gold standard in the treatment of port-wine stains (PWS). Recently, intense pulsed light (IPL) has been reported to achieve more pronounced fading in some patients. To evaluate the efficacy and the side effects of IPL treatment of PWS in a direct comparison to the short-pulsed dye laser (SPDL) and...

Dermatologic laser therapy is a rapidly-changing field with many new innovations. One of the most important is the introduction of fractional photothermolysis. This method is established for skin rejuvenation and acne scars; both the original non-ablative devices and newer ablative ones are available. While its side effects and the patient’s downti...

Dermatologic laser therapy is a rapidly-changing field with many new innovations. One of the most important is the introduction of fractional photothermolysis. This method is established for skin rejuvenation and acne scars; both the original non-ablative devices and newer ablative ones are available. While its side effects and the patient's downti...

To confirm a local R0 resection of tumors with infiltrative growth at problem sites and for sparing of tissue, microscopically controlled surgery represents a safe and proven method, particularly when there are no gaps between the tissue taken at the incision margins.

Micrographic surgery is mainly used for excising basal cell carcinomas in high-risk body sites. The time-consuming process of frozen histopathology could be potentially accelerated by the application of ex vivo confocal laser scanning microscopy (CM). We examined the margins of 52 excised basal cell carcinomas by means of CM, and compared the resul...

Treatment of progressive disseminated essential telangiectasia and erythrosis interfollicularis colli by flashlamp pulsed dye laser frequently results in a mottled appearance and often leads to hypo- or hyperpigmentation after treatment. Furthermore, treatment is time-consuming due to the small spot size. To report the successful removal of thin ve...

The presented guidelines on the use of laser and intense pulsed light (IPL) systems in treating skin conditions and imperfections reflect the state of laser technology and medical knowledge of its use as of 2006. The recommendations contained herein are based on average requirements for diagnosis and treatment, which in actual practice may vary in...

The Q-switched Ruby laser (QSRL) is used for the treatment of pigmented lesions. The influence of QSRL treatment on gene expression of nontransformed primary melanocytes has not been addressed in vitro. We investigated the gene expression profile of melanocytes following QSRL irradiation. Primary melanocytes were irradiated with the QSRL (694 nm)....

Venous malformations are common vascular anomalies which only occur sporadically. We present a series of 25 patients with extratruncular venous malformations of the skin or the neighboring mucosa that are arranged in a segmental pattern. All lesions were sporadic and mostly unilateral. According to the extent of the vascular malformation, two subgr...

Hereditary haemorrhagic telangiectasia (HHT) is a familial, autosomal, dominant, multi-system, vascular, dysplasia. Besides repetitive epistaxis, cutaneous eruptive macules and nodules lead to recurring bleeding and cosmetic problems. We report on a pilot study of four cases of HHT in which cutaneous lesions were treated with a pulsed neodymium:ytt...

Ainhum (dactylolysis spontanea) is a distinct clinical and radiological disorder of dark-skinned people characterized by a progressive development of a constricting band encircling the toe which usually results in spontaneous amputation. Ainhum mainly occurs in African natives, but in times of global migration and tourism, Ainhum is likely to be mo...

Intense pulsed light sources are not lasers. They produce high-energy flashes of light of several milliseconds’ duration with a broad wavelength spectrum, ranging from visible light to well into the infrared spectrum. Filters are used to cover the light source, eliminating certain wavelengths in order to optimize treatment of different conditions....

The authors have indicated no significant interest with commercial supporters.

Since the first construction of a laser by Maiman in 1960 and the first clinical application of a laser in the therapy of skin lesions by Leon Goldman, laser therapy has become an important therapeutic modality in dermatology. Various lasers can be used for the treatment of different vascular and non-vascular lesions. According to our results, vasc...

Over the last 10 years (1993-2003), 1931 childhood hemangiomas in children under 3 years were treated with the Flashlamp-pumped-pulsed dye laser (FPDL) in the department of dermatology/University of Regensburg. The treatment results were evaluated after the first treatment. After one single treatment, in 7.1% (n: 92) a complete regression could be...

We report a 73-year-old woman with the typical findings of "Rosai-Dorfman disease" (RDD) including massive, painless lymphadenopathy, fever and multiple, asymptomatic cutaneous lesions on her face, collum and neck. Histologically, the lesions were marked by characteristic large macrophages exhibiting emperipolesis.

Cutaneous plasmacytosis is a rare disease predominantly found in Japanese patients. We describe the case of a 75-year-old white female with cutaneous plasmacytosis of the face and involvement of the bone marrow. In contrast to other cases of cutaneous plasmacytosis, the patient revealed hypogammaglobulinemia and elevated levels of free light chains...

A 64-year-old woman with a clinically diagnosed 'lentigo simplex' on her right cheek was dermatologically treated several times with a CO2 laser. Three years later she showed a metastasis of a malignant melanoma in her right parotid gland. Considering this case, as well as other published cases reporting malignant melanomas occurring after laser tr...

Grundsätzlich zu unterscheiden ist hier zwischen atrophischer, also mit Substanzverlust einhergehender Narbenbildung (z. B. Akne- oder Windpockennarben), narbenbedingten Störungen des Oberflächenreliefs (Stufenbildung nach Operations- oder Unfallnarben, retikuläre Narben nach bakteriellen Infektionen), hypertrophen Narben (überschießende, jedoch ni...

Der Lichen sclerosus et atrophicus ist eine chronisch-entzündliche Erkrankung unklarer Ätiologie, die häufig die Genitalregion von Männern und Frauen befällt. Klinisch typisch sind porzellanweiße, atrophische Veränderungen mit follikulären Keratosen. Neben disseminierten, kleinfleckigen Formen finden sich am Stamm auch häufiger größere, plaqueartig...

Bei epidermalen Nävi handelt es sich um kongenitale, umschriebene oder systematisierte, hamartomatöse Fehlbildungen. Entsprechend den verschiedenen Zelltypen, die von der pluripotenten Stammzelle des Ektoderms ausgehen können, unterscheidet man keratinozytäre Nävi (verruköse, epidermale Nävi mit und ohne Akantholyse, lineäre Porokeratose, inflammat...

Schmucktätowierungen sind definiert als das beabsichtigte Einbringen von Pigmentpartikeln in die Haut mit der Konsequenz einer meist permanenten, umschriebenen Farbänderung. Zu unterscheiden ist zwischen Laien- und professionellen Tätowierungen.

Naevi flammei sind die häufigste und für den Dermatologen wichtigste extratrunkuläre kapilläre Fehlbildung [92]. Nach Schnyder [138,139] müssen die medianen oder symmetrischen Naevi flammei von den lateralen, asymmetrischen unterschieden werden. Die medianen, welche v. a. Nacken, Stirn und Augenlider befallen, werden bei bis zu 30% der Neugeborenen...

Bei pigmentierten Hautveränderungen stellt sich meist aus psychologischen und ästhetischen Gründen, gelegentlich auch aus Gründen der Melanomprophylaxe, v. a. bei kongenitalen Nävuszellnävi, die Frage nach einer Entfernung mit möglichst geringer Narbenbildung. Hierzu zählen die Lentigines, die Café-au-lait-Flecken und die Naevi spili, die erworbene...

Derzeit werden über 80 verschiedene humanpathogene, zu unterschiedlichen Erkrankungen führende Papillomviren unterschieden.

De frequentie van voorkomen van benigne ovariumcysten is niet precies bekend. De meest voorkomende benigne tumoren zijn: epitheliale tumoren (sereus of mucineus cyste-adenoom), dermoï dcysten (benigne teratoom) en endometriosecysten. De kans op een maligniteit neemt toe met de leeftijd. Premenopauzaal is het risico op een maligniteit 13% en postmen...

Therapy of eruptive vellus hair cysts (EVHCs) often leads to unsatisfying results or recurrences. Recently, erbium:yttrium-aluminum-garnet (Er:YAG) laser therapy has been recommended in this condition. To report the results of Er:YAG laser treatment and discuss the treatment options in EVHC, presenting a review of the literature. Full-face Er:YAG l...

Background: Therapy of eruptive vellus hair cysts (EVHCs) often leads to unsatisfying results or recurrences. Recently, erbium:yttrium-aluminum-garnet (Er:YAG) laser therapy has been recommended in this condition. Objective: To report the results of Er:YAG laser treatment and discuss the treatment options in EVHC, presenting a review of the literat...

Over the last 10 years (1993-2003), 1931 childhood hemangiomas in children under 3 years were treated with the Flashlamp-pumped-pulsed dye laser (FPDL) in the department of dermatology/University of Regensburg. The treatment results were evaluated after the first treatment. After one single treatment, in 7.1% (n: 92) a complete regression could be...

Congenital cartilaginous rests of the neck (wattles) are very rare, probably branchiogenic malformations. To discuss the clinical and histologic features and the therapy of wattles. We report a 4-year-old patient with symmetric exophytic nodules of the neck that had been present since birth. The two lesions, 0.5 3 0.5 cm, were removed. The histopat...

BACKGROUND. Ectopic, axillary breast tissue can develop any disease that affects the normal breast, including fibroadenoma. OBJECTIVE. To report and discuss a case of fibroadenoma of the axilla in a 23-year-old woman. METHODS. Case report and discussion of the rare entity of fibroadenoma of the axilla. RESULTS. The histology was identical to the fi...

A 2-year-old girl with Moya Moya disease who had relapsing cerebrovascular strokes presented with loose skin folds, 'chicken' skin appearance and perforating elastosis serpiginosa-like lesions in the genitocrural region. Histologically, calcified material perforating the epidermis and adjacent short curled and mineralized elastic fibres suggested a...

Nonablative resurfacing has proven its efficacy in vascular and pigmented lesions, while its capacity of substantial wrinkle reduction is still discussed controversially. We present the treatment results of a 1,450 nm diode laser for facial rhytides. Thirty facial regions were treated with a 1,450 nm diode laser. Pre- and post treatment pictures we...

Hemangiomas and vascular malformations are the most common vascular lesions of infancy. Different lasers can be used for treatment. Nd:YAG laser photocoagulation is particularly effective because of its deep penetration into tissue. Thirty-one patients, aged from three months to 18 years, with voluminous hemangiomas and venous malformations were tr...

Two absorbable polydioxanone threads are compared regarding intraoperative handling qualities, scar dehiscence, and possible side effects. In 30 excisions, half of each suture was performed with PDS II (Ethicon GmbH, Norderstedt, Germany), whereas the other half was closed with Serasynth (Serag-Wiessner, Naila, Germany). Clinical evaluation for sca...

Background: Psoriasis is a chronic, genetically determined inflammatory disease, characterized by an immunomediated pathogenesis, which affects approximately 1-3% of the population. Various modalities have been used for psoriasis treatment, including ultraviolet (UV) radiation. Narrowband UVB (311 nm) phototherapy is a well-established, widely use...

Kaposi sarcoma (KS) in patients who are seronegative and seropositive for human immunodeficiency virus is currently the most common malignant tumor in central Africa. It accounts for 50% of all tumors reported in central African countries. Owing to the rising number of patients and the limitations of current therapies, there is an urgent demand for...

The two major variants of amelanotic malignant melanoma are the verrucous and the polypoid forms. A further--albeit rare--red eczematous variety has also been described. We report two female patients with reddish, non-pigmented, scaly lesions on the upper arm and the shoulder that had developed 2 to 3 years previously. One biopsy showed the diagnos...

Patients with end-stage renal disease often suffer from different dermatologic conditions. Reports indicate that 50-100% of patients with end-stage renal disease have at least one cutaneous disorder. The persisting chronic uremia is responsible for a variety of structural and functional skin changes. Dialysis or even renal transplantation leads to...

Patienten mit schwerer Beeintrchtigung der Nierenfunktion leiden hufig unter einer Reihe von dermatologischen Begleiterkrankungen. So weisen 50–100% aller Patienten mit terminaler Niereninsuffizienz wenigstens eine Hautvernderung auf. Die chronisch bestehende Urmie fhrt an Haut und Hautanhangsgebilden zu einer Vielzahl von strukturellen und funktio...

The aim of this study was to find the recurrence rates of basal cell carcinomas treated with micrographic surgery in the Department of Dermatology, University of Regensburg. From 1992 to 1997, 261 basal cell carcinomas (178 primary and 83 recurrent) have been treated. The mean duration of follow-up was 5 years (range 1-9). Data were analysed by lif...

Laser therapy has become an integral part of therapeutic alternatives in dermatology. Nevertheless, there are only few statistical data on the role of lasers in everyday practice of dermatological clinics. Analysis of laser patients, indications and lasers used. We analysed 10244 patients treated with laser therapy in the Department of Dermatology...

Our aim was to determine the most effective treatment parameters for laser-assisted hair removal using long-pulsed Nd:YAG-lasers. 42 volunteers were treated with 1064 nm long-pulsed Nd:YAG-lasers. We used two different laser systems (Lyra XP, Wavelight and Smartepil II Deka-LMS) with various pulse lengths, fluences, and spot sizes. For each paramet...

The porokeratotic eccrine ostial and dermal duct naevus or PEODDN represents a very rare hamartoma of the eccrine sweat glands. A 16-year old boy had developed subtle hyperkeratotic skin lesions on his right hallux at six months of age. When he was eight years old, he developed similar lesions on his right palm. Clinically the lesions were coniform...

The porokeratotic eccrine ostial and dermal duct naevus or PEODDN represents a very rare hamartoma of the eccrine sweat glands. A 16-year old boy had developed subtle hyperkeratotic skin lesions on his right hallux at six months of age. When he was eight years old, he developed similar lesions on his right palm. Clinically the lesions were coniform...

Background. Spindle cell hemangioma (SCH) is an uncommon benign vascular tumor. Objective. To report and discuss a case of SCH in an 11-year-old boy. Methods. A case report and discussion of the rare entity of SCH are given. Results. The excision of a vascular tumor showed a vascular connection to the great saphenous vein. Histologic examination wa...

Discoid lupus erythematosus (DLE) is a rare disorder in childhood, with 22 cases reported in the English-language literature. Less than 2% of patients with DLE have an onset before 10 years of age. We describe two children with DLE and lupus profundus with an onset of the disease at the ages of 11 and 15 years and focus on likely histopathologic di...

A port-wine stain is a congenital vascular malformation characterized by a dilatation of superficial dermal capillaries. We report on 4 patients with port-wine stains and eczema. In two patients, the port-wine stain was on the neck, in one case on the back, in one case on the left cheek. These patients were treated with the flashlamp-pumped pulsed...

The flashlamp-pumped pulsed dye laser (FPDL) is regarded as the gold standard in the treatment of port wine stains. The purpose of this prospective, intra-individual, comparative clinical study was to investigate whether a frequency-doubled variable pulsed Nd:YAG laser (frequency-doubled Nd:YAG) is equally as safe and effective as established laser...

A 66-year-old woman presented to our outpatient clinic with a 3 x 2.5-cm tense, hemorrhagic-appearing bulla on her forefoot. Histopathology and immunohistochemistry confirmed a transtumoral-transepidermal blister formation within an advanced acrolentiginous malignant melanoma (MM). To study bullous malignant melanoma. Blistering in MMs represents a...

Oral lichen planus (OLP) is a chronic disease of uncertain origin. Many patients with OLP are refractory to all available therapies. The 308-nm excimer laser was used as a possible additional method in the treatment of OLP. Eight patients with OLP were treated using the 308-nm UVB excimer laser. Clinical improvement was achieved in six patients. Tw...

BACKGROUND: A 66-year-old woman presented to our outpatient clinic with a 3×2.5-cm tense, hemorrhagic-appearing bulla on her forefoot. Histopathology and immunohistochemistry confirmed a transtumoral–transepidermal blister formation within an advanced acrolentiginous malignant melanoma (MM). OBJECTIVE: To study bullous malignant melanoma. METHODS:...

Zusammenfassung Ein Naevus flammeus ist eine kongenitale Fehlbildung bestehend aus multiplen dilatierten Gefäßen des oberflächlichen Gefäßplexus in der Dermis. Es wird über vier Patienten mit Ekzemen im Bereich eines Naevus flammeus berichtet. Bei zwei von ihnen war das Feuermal am Hals lokalisiert, bei einem Patienten am Rücken und beim vierten an...