Ulla Feldt-Rasmussen

Ulla Feldt-Rasmussen
Rigshospitalet | rigshospitalet · Medical Endocrinology and Metabolism

Professor, MD, DMSc

About

613
Publications
80,535
Reads
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19,570
Citations
Citations since 2016
137 Research Items
9247 Citations
201620172018201920202021202202004006008001,0001,2001,400
201620172018201920202021202202004006008001,0001,2001,400
201620172018201920202021202202004006008001,0001,2001,400
201620172018201920202021202202004006008001,0001,2001,400
Additional affiliations
October 1990 - present
Copenhagen University Hospital
Position
  • Professor (Full)
October 1990 - present
Rigshospitalet
Position
  • Professor (Full)

Publications

Publications (613)
Article
Full-text available
Background Cushing’s syndrome (CS) is associated with an hypercoagulable state and an increased risk of venous thromboembolism (VTE). Evidence-based guidelines on thromboprophylaxis strategies in patients with CS are currently lacking. We aimed to map the current clinical practice for thromboprophylaxis management in patients with CS across referen...
Article
Clinical manifestations of classic Fabry disease (α-galactosidase A deficiency) usually occur in childhood, while complications involving major organs typically develop in adulthood. Outcomes of Fabry-specific treatment among young patients have not been extensively reported. Our aim was to analyze clinical outcomes among patients aged 5–30 years a...
Article
Background Recent years have witnessed a considerable increase in clinical trials of new investigational agents for Fabry disease (FD). Several trials investigating different agents are currently in progress; however, lack of standardisation results in challenges to interpretation and comparison. To facilitate the standardisation of investigational...
Article
Objective Clinical practice guidelines recommend questionnaires with short recall. We compare responsiveness of ecological momentary assessments (EMA) and retrospective assessments of thyroid-related quality of life. Study Design and Setting Patients with newly diagnosed thyrotoxicosis completed retrospective Thyroid-related Patient-Reported Outco...
Article
Objective: Clinical observations over time of adults with growth hormone (GH) deficiency (GHD) have indicated a shift in patient characteristics at diagnosis. The objective was to compare baseline characteristics of patients diagnosed with adult onset GHD naive to GH replacement during three study periods [1994-1999 (P1), 2000-2004 (P2), and 2005-...
Article
Background: Maintenance immunosuppressive regimens after renal transplantation (RTx) most often include prednisolone, which may induce secondary adrenal insufficiency, a potentially life-threatening side effect to glucocorticoid (GC) treatment due to the risk of acute adrenal crisis. We investigated the prevalence of prednisolone-induced adrenal i...
Article
Full-text available
Importance Maternal hypothyroidism and hyperthyroidism are risk factors for preterm birth. Milder thyroid function test abnormalities and thyroid autoimmunity are more prevalent, but it remains controversial if these are associated with preterm birth. Objective To study if maternal thyroid function test abnormalities and thyroid autoimmunity are r...
Article
Context: Cushing's syndrome (CS) is associated with hippocampal atrophy and psychopathology. Objective: The primary objective of this systematic review was to assess hippocampal volume in CS patients. The secondary objectives were to assess cognitive functioning, depressive-, and anxiety symptoms, and quality of life (QoL) in CS patients. Data so...
Article
Fabry disease (FD) is a progressive X-linked disorder from deficiency of α-galactosidase and lysosomal accumulation of glycolipids. This Fabry Registry (NCT00196742) analysis assessed renal and cardiac outcomes of agalsidase beta treatment (1 mg/kg 2-weekly) for ≥2 years in male patients with age at first treatment (AFT) of 5-30 years. GLA variants...
Article
Fabry disease (FD) is a progressive X-linked disorder from deficiency of α-galactosidase. Gastrointestinal symptoms, neuropathic pain, and attacks of excruciating pain are among the earliest symptoms. This Fabry Registry (NCT00196742) analysis assessed changes in symptom reports from male and female patients on agalsidase beta with age at first tre...
Article
Full-text available
Background The purpose of this study was to examine the occurrence of cerebral infarction (ischemic stroke), in a large combined cohort of patients with anterior skull base meningiomas, pituitary adenomas and craniopharyngiomas, after fractionated stereotactic radiation therapy (FSRT). Material and Methods All patients, 18 years and older, with an...
Article
Full-text available
Background: Fabry disease is frequently characterized by gastrointestinal symptoms, including diarrhea. Migalastat is an orally-administered small molecule approved to treat the symptoms of Fabry disease in patients with amenable mutations. Methods: We evaluated minimal clinically important differences (MCID) in diarrhea based on the correspondi...
Article
Full-text available
Background: Heterozygous females with Fabry disease have a wide range of clinical phenotypes depending on the nature of their mutation and their X-chromosome inactivation pattern; it is therefore important to examine outcomes of enzyme replacement therapy (ERT) in the female patient population specifically. This paper presents the findings of a sy...
Article
In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The present study was performed to investigate the associations between placental levels of various POPs and thyroid hormones (THs). In a prospective Danish study initially esta...
Article
Objectives: Central hypothyroidism (CeH) is a rare form of hypothyroidism characterized by insufficient thyroid stimulation due to disturbed pituitary and/or hypothalamic functioning. Due to its origin and the whole clinical context, CeH represents a challenging condition in clinical practice as it is characterized by suboptimal accuracy of clinic...
Article
Introduction Cerebral palsy is the most common severe motor disability in childhood, but its etiology is incompletely understood. Studies have suggested that prenatal thyroid hormone disturbances affect child neurodevelopment and may alter motor function. Objective To investigate the association between maternal thyroid disorder in pregnancy and r...
Article
Objectives: Possible effects of HIV on thyroid function in the modern combination antiretroviral therapy (cART) era are largely unknown. We aimed to investigate the prevalence and associated risk factors of thyroid dysfunction in well treated people living with HIV (PLWH) and matched uninfected controls and to examine whether HIV is independently...
Article
Background: Fabry disease, an inherited lysosomal storage disorder, causes multi-organ pathology resulting in substantial morbidity and a reduced life expectancy. Although Fabry disease is an X-linked disorder, both genders may be affected, but generally to a lesser extent in females. The disease spectrum ranges from classic early-onset disease to...
Article
Full-text available
Background: Pheochromocytoma and catecholamine-secreting paraganglioma (PPGL) are rare but potentially life-threatening tumors. We aimed to validate diagnosis codes for PPGL in the Danish National Patient Registry, the Danish National Pathology Registry, and the Danish Registry of Causes of Death and to create a national cohort of incident PPGL pa...
Article
Full-text available
Background Cerebral palsy is the most frequent motor disability in childhood, but little is known about its etiology. It has been suggested that cerebral palsy risk may be increased by prenatal thyroid hormone disturbances. The objective of this study was to investigate whether maternal thyroid disorder is associated with increased risk of cerebral...
Article
Full-text available
Recent studies have shown a significant increase in the temporal trend of medullary thyroid carcinoma (MTC) incidence. However, it remains unknown to which extent sporadic medullary thyroid carcinoma (SMTC) and hereditary MTC (HMTC) affects the MTC incidence over time. We conducted a nationwide retrospective study using previously described RET and...
Conference Paper
Introduction: The thyroid-related quality-of-life patient-reported outcome ThyPRO questionnaire is the most widely used tool for measuring health-related quality of life (QoL) in patients with benign thyroid diseases. The aim of this study was to adapt and validate a Spanish version of the ThyPRO. Methods: The ThyPRO consists of 85 items, grouped...
Article
Fabry disease is a rare progressive X-linked lysosomal storage disorder which leads to neuropathic pain, organ dysfunction and cerebral pathology. Few studies have investigated cognitive impairment in Fabry disease and these previous studies are difficult to compare due to heterogeneous methodological designs and small cohorts. The objective was to...
Article
Full-text available
PurposeThe purpose of this study was to adapt different domains of an existing retrospective questionnaire to momentary versions, to use and assess cognitive interviewing for evaluating the new versions, and to compare momentary compatibility (i.e. an item’s potential to be validly converted to a momentary version) across different scales. Methods...
Article
The thyroid-related patient-reported outcome measure ThyPRO is currently the most reliable and valid instrument for the measurement of thyroid-related quality of life. The objective of the current study was to translate the original (85 items) and short (39 items) versions of ThyPRO into the Greek language as well as to validate and culturally adap...
Article
Full-text available
Context Acromegaly has been associated with increased risk of cancer morbidity and mortality, but research findings remain conflicting and population-based data are scarce. We therefore examined whether patients with acromegaly are at higher risk of cancer. Design A nationwide cohort study (1978-2010) including 529 acromegaly cases was performed....
Article
Full-text available
Objective: Gonadotropins (luteinizing hormone (LH) and follicle stimulating hormone (FSH)) are released from the pituitary gland and stimulate Leydig cells to produce testosterone and initiates spermatogenesis. Little is known about how and when the deterioration of semen quality occurs in patients with adult onset gonadotropin insufficiency Desig...
Article
Full-text available
Objective: Somapacitan is a reversible albumin-binding growth hormone (GH) derivative, developed for once-weekly administration. This study aimed to evaluate the safety of once-weekly somapacitan vs once-daily Norditropin®Local tolerability and treatment satisfaction were also assessed. Design: 26-week randomized, controlled phase 3 safety and t...
Article
Full-text available
Background: Several chemical UV filters/absorbers (in the following called UV filters) have endocrine disrupting properties in vitro and in vivo. Exposure to these chemicals, especially during prenatal development, is of concern. Objectives: To examine maternal exposure to UV filters and associations to maternal thyroid hormone and growth factor...
Article
Full-text available
INTRODUCTION: Patients with adrenal insufficiency have impaired health-related quality of life (QoL). The dual-release hydrocortisone preparation, Plenadren, has been developed to mimic the physiological cortisol release more closely than conventional hydrocortisone treatment. Plenadren has been shown to improve QoL, in particular fatigue, in patie...
Article
Context Data on the association between growth hormone (GH) replacement in patients with GH deficiency (GHD) after malignancies and new neoplasms show conflicting results. Objective To clarify the incidence of new malignant neoplasm in childhood (CO) and adult-onset (AO) adult cancer survivors (CS). Design Retrospective comparison of CO-CS and AO...
Article
Full-text available
PurposeThe purpose of this study is to evaluate whether damage to the hypothalamus due to craniopharyngioma or consequent surgery may involve the sleep-wake regulatory system, resulting in sleep disturbances and sleepiness. Methods Seven craniopharyngioma patients and 10 healthy controls were evaluated with sleep questionnaires including the Epwort...
Article
Full-text available
Motor activity in healthy young humans displays intrinsic fluctuations that are scale-invariant over a wide range of time scales (from minutes to hours). Human postmortem and animal lesion studies showed that the intact function of the suprachiasmatic nucleus (SCN) is required to maintain such scale-invariant patterns. We therefore hypothesized tha...
Article
Full-text available
IntroductionAutoimmune hypophysitis is a rare disease of the pituitary, which may affect vision by inflammation and compression of the optic chiasm. However, intrachiasmatic abscess formation has not been previously reported. Methods In this study, we report a case of a 29-year-old female with bitemporal hemianopia due to a cystic intrasellar tumor...
Article
Fabry disease is an X- linked inherited lysosomal storage disease caused by mutations in the GLA gene encoding the lysosomal enzyme alpha-galactosidase A (α-Gal A). The possible pathological significance of the D313Y variant in the GLA gene has not been verified and it may be a Fabry variant. Our aim was to elucidate whether the presence of the D31...
Article
Background: Multiple endocrine neoplasia (MEN) 2A and 2B are caused by REarranged during Transfection (RET) germline mutations. In a recent nationwide study we reported of an unusually high prevalence (33%) of families with the C611Y mutation and hypothesized that this might be due to a founder effect. We conducted the first nationwide study of ha...
Article
Context: Discordant GH and IGF-I values are frequent in acromegaly. The clinical significance and its dependence on treatment modality and of glucose-suppressed GH (GHnadir) measurements remain uncertain. Objective: To evaluate the effects of targeting either IGF-I or GH during somatostatin analog (SA) treatment. Patients and methods: 84 patie...
Article
Objective: Patients receiving long-term glucocorticoid treatment are at risk of developing adrenal insufficiency during treatment. We investigated the prevalence of prednisolone-induced adrenal insufficiency in the particular clinical situation where patients receive ongoing low-dose (5 mg/day) prednisolone treatment, a dose by itself too low to c...
Article
Full-text available
Autoimmune thyroid disease (AITD) is often observed together with other autoimmune diseases. The coexistence of two or more autoimmune diseases in the same patient is referred to as polyautoimmunity, and AITD is the autoimmune disease most frequently involved. The occurrence of polyautoimmunity has led to the hypothesis that the affected patients s...
Article
Full-text available
Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on...
Data
The influence of ghrelin on the thyroid-stimulating hormone (TSH)-induced increase in thyroglobulin (Tg) and cAMP production for each patient. The influence of ghrelin on the TSH-induced increase in thyroglobulin Tg and cAMP production at three different concentrations of TSH (0.1 IU/L, 0.5 IU/L and 1 IU/L). The basal levels, i.e. the values in the...
Data
The influence of ghrelin on the level of thyroglobulin (Tg) and cAMP in the absence of TSH. Grey = vehicle (without ghrelin), pattern = ghrelin (100 nM). Means (+SEM). *P < 0.05 compared to the control (vehicle). n = 8 in triplets. A) Ghrelin did not influence the basal level of Tg (μg/L) in the absence of TSH measured by enzyme-linked immunosorben...
Article
Traumatic brain injury (TBI) is a major public health problem with potentially debilitating consequences for the individual. Hypopituitarism after TBI has received increasing attention over the past decade; development of the condition as a consequence of TBI was previously hardly mentioned in textbooks on the subject. Hypopituitarism has been repo...
Article
Thyroid diseases are very common disorders in women, and thyroid hormones are crucial players in many aspects of fetal growth and neurodevelopment, both of which are dependent on an adequate supply of maternal thyroid hormones from early gestation onwards. It is therefore very important to keep women euthyroid during gestation. Globally, hypothyroi...