Uliana Mamokhina

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• Researcher at Moscow State University of Psychology & Education

Low-level auditory processing difficulties have been previously reported in children with Autism Spectrum Disorder (ASD), and some studies showed the relationship between these difficulties in the primary auditory cortex and language impairment in ASD. However, there is still a limited number of studies that comprehensively assess (i) amplitudes, l...

Background: Thalamocortical functional and structural connectivity alterations may contribute to clinical phenotype of Autism Spectrum Disorder (ASD). As previous studies focused mainly on thalamofrontal connections in ASD, we comprehensively investigated the thalamic functional networks and white matter pathways projecting also to temporal, pariet...

p style="text-align: justify;"> Objectives. To individualize interventions during tutoring support for children with autism spectrum disorders (ASD), an assessment of the skills necessary for group learning is conducted. In Russia, there are no diagnostic tools specifically developed for tutors that consider the unique nature of their tasks. The pr...

p style="text-align: justify;"> Objectives . Children with Autism Spectrum Disorder (ASD) often face difficulties in speech perception, particularly in noisy environments. These problems are associated with central auditory processing disorders. FM systems, which improve the signal-to-noise ratio, can be used to enhance speech perception. The aim o...

Abstract. The article presents the second part of the comprehensive study of speech understanding and comprehension in children with autism spectrum disorders. We present results of evaluation of expressive speech at the level of phonology, lexicon, morphosyntax and discourse in primary schoolchildren with ASD. The study revealed correlations betwe...

Objective: Some studies have hypothesized that atypical neural synchronization at the delta frequency band in the auditory cortex is associated with phonological and language skills in children with Autism Spectrum Disorder (ASD), but it is still poorly understood. This study investigated this neural activity and addressed the relationships between...

The neurobiology of Autism Spectrum Disorder (ASD) is hypothetically related to the imbalance between neural excitation (E) and inhibition (I). Different studies have revealed that alpha-band (8–12 Hz) activity in magneto- and electroencephalography (MEG and EEG) may reflect E and I processes and, thus, can be of particular interest in ASD research...

Objective Delayed speech and language development is one of the main diagnostic criteria for autism spectrum disorders (ASD) and is found almost in all children with ASD. Language development in children with ASD may differ from the norm both quantitatively (delayed speech development, reduced vocabulary, scarcity of speech and limitation in its us...

Alpha-band (8-12 Hz) event-related desynchronization (ERD) or a decrease in alpha power in electro-and magnetoencephalography (EEG and MEG) reflects the involvement of a neural tissue in information processing. It is known that most children with autism spectrum disorder (ASD) have difficulties in information processing, and, thus, investigation of...

The core symptoms of Autism Spectrum Disorder (ASD) are impairments in social interaction/communication and the presence of stereotyped and repetitive behaviour. The amygdala and hippocampus are involved in core functions in the "social brain" and, thus, may be of particular interest in ASD. Previous studies demonstrated inconsistent results, revea...

The article discussed ASD heterogeneity in terms of the severity of autistic manifestations, cognitive and speech abilities in children with different levels of functioning. We present results of a study of speech understanding at the level of phonology, vocabulary, morphosyntax and discourse in primary schoolchildren with ASD. The study revealed c...

Increased oxidative/genotoxic stress is known to impact the pathophysiology of ASD (autism spectrum disorder). Clinical studies, however, reported limited, heterogeneous but promising responses to treatment with antioxidant remedies. We determined whether the functional polymorphism of the Nrf2 gene, master regulator of anti-oxidant adaptive reacti...

Autism Spectrum Disorder (ASD) is characterized by social interaction and communication deficits, repetitive behavior and often by co-occurring conditions such as language and non-verbal IQ development delays. Previous studies reported that those behavioral abnormalities can be associated with corpus callosum organization. However, little is known...

Language impairment is comorbid in most children with Autism Spectrum Disorder (ASD), but its neural mechanisms are still poorly understood. Some studies hypothesize that the atypical low-level sensory perception in the auditory cortex accounts for the abnormal language development in these children. One of the potential non-invasive measures of su...

Language impairment is comorbid in most children with Autism Spectrum Disorder (ASD) but its neural basis is poorly understood. Using structural magnetic resonance imaging (MRI), the present study provides the whole-brain comparison of both volume- and surface-based characteristics between groups of children with and without ASD and investigates th...

The article presents an overview of studies on the problem of speech evaluation in childhood. We analyzed the material based on the model that describes 4 levels of language: phonetics and phonology, morphosyntax, semantics and pragmatics. The article contains the analysis of studies describing each level of language as well as existing approaches...

Background: Autism Spectrum Disorder (ASD) is characterized by social interaction and communication deficits, repetitive behavior and often by co-occurring conditions such as language and non-verbal IQ development delays. Previous studies reported that those behavioral abnormalities can be associated with corpus callosum organization. However, litt...

The article deals with the problem of organizing and implementing a system of comprehensive support for children with autism spectrum disorders in the Russian Federation. The purpose of the work is to identify features, trends, directions, risks and benefits of implementing successful regional practices of comprehensive support for children with AS...

The purpose of the present research was to comprehensively assess the language abilities of Russian primary-school-aged children with Autism Spectrum Disorder (ASD), varying in non-verbal IQ, at all linguistic levels (phonology, lexicon, morphosyntax, and discourse) in production and comprehension. Yet, the influence of such non-language factors as...

The article presents the analysis of support services provided in RRCs (Regional Resource Centers for Supporting Individuals with Autism Spectrum Disorders). The authors provide 4 main principles of supporting services organization for individuals for autism spectrum disorders (ASD): integrative and multi-disciplinary approach, the use of the evide...

The objective of the present study is to investigate the relationship between the receptive language, and the index of non-verbal intelligence and the level of severity of autistic disorders in primary-school-aged children with Autism spectrum disorder. One of the main areas influenced by autistic disorders is communication. Therefore, the study of...

Background: Abnormal language development in both expressive and receptive domains occurs in most children with Autism Spectrum Disorder (ASD), although the language deficit is not a core symptom of ASD. However, previous studies disagree on the difference in the degree of impairment between expressive and receptive language in ASD. Existing resear...

Sensory impairments in children with ASD can be one of the main issues that affect social adaptation and integration into society. In present pilot study, the sensory profile of primary school children with ASD investigated using the Sensory Experience Questionnaire SEQ 3.0, which is being validated on a large group of children with developmental d...

International Society for Autism Research Abstract Book

Currently, more than 1000 genes described in which mutations are observed in autism spectrum disorders. Neurobiological predictors have been found to presume these abnormalities in early postnatal ontogenesis. However, the mechanisms of the occurrence of these genetic abnormalities remain unclear. This is connected to the particular interest in the...

The objective of this study is to provide a detailed description of clinical characteristics of disorders associated with FMR1 gene, which is located on the long arm of chromosome X. The most frequent FMR1 mutations are related to CGG-repeat expansion in the promoter region: premutation (from 55 to 199), full mutation (more than 200 repeats). The f...

The importance of developing a model of initial support for a child with suspicion of an autism spectrum disorder is underlined. The main principles of the diagnostic examination, which are based on the interaction between specialists of various profiles, are listed. The primary importance of strict compliance with the diagnostic protocol, which al...

The article describes the features of speech development and functioning of people with autism spectrum disorders on the basis of foreign and Russian research in this field. The characteristic features of expressive speech in autism, uniqueness of communicative use and speech perception in connection with the peculiarities of perception of sensory...