Uchenna Nwagha

Uchenna Nwagha
University of Nigeria | UNN · Department of Obstetrics and Gynecology

MBBS. MSc. PhD. MPA.FWACS.FMCOG.cert ART.Cert Cosmetic Gynaecology

About

107
Publications
30,234
Reads
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1,151
Citations
Additional affiliations
October 2010 - present
University of Nigeria,College of Medicine
Position
  • Professor
January 2008 - December 2011
University of Nigeria
April 2002 - present
University of Nigeria-Teaching Hospital
Position
  • Consultant
Education
September 1983 - June 1989
University of Nigeria/West African Post Graduate Medical College
Field of study
  • Medicine (Physiology and OBGY)

Publications

Publications (107)
Article
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Infertility is a subject of worldwide concern as it affects approximately 15% of couples. Among the prime contributors of infertility, urogenital bacterial infections have lately gained much clinical importance. Staphylococcal species are commensal bacteria and major human pathogens mediating an array of reproductive tract infections. Emerging evid...
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Background: Pre-eclampsia is a common obstetric complication of pregnancy in Nigeria, and oxidative stress has been implicated in its aetiopathogenesis. Despite this fact, there is a paucity of information regarding the serum antioxidant micronutrient status of pre-eclamptic Nigerian women. The objective of the was to determine the mean serum leve...
Article
Background: Short inter-pregnancy interval (IPI) is a potential risk factor for adverse pregnancy outcomes. Previous reports from sub-Sahara Africa documented increasing incidence of short IPI but evidence is lacking in its effect on pregnancy outcome. Aim: The study aimed to determine the effect of short IPI on pregnancy outcome in Nigeria. Su...
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Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of tenofovir-based antiviral combination regimens for hepatitis B virus (HBV) for the prevention of mother-to-child transmission of HBV, in HIV-positive pregnant women co-infected with HBV. Copyright © 2020 The Cochr...
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Male infertility is a multifactorial condition which in some cases are presented with unidentifiable underlying causes. Men with idiopathic or non-curable oligoasthenoteratozoospermia as well as with unexplained infertility may be provided with non-hormonal medical treatment which includes the use of anti-inflammatory, antioxidants, fibrinolytic co...
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Ghrelin is a multifunctional peptide hormone, conventionally known to be secreted by the stomach. The synthesis of ghrelin by the reproductive organs signifies its autocrine and/or paracrine actions upon the gonads. Expression of the functional ghrelin receptor is observed in different levels of the hypothalamic-pituitary-gonadal axis, suggesting i...
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Gynecological bacterial infections (GBIs) are prevalent in our environment and as a result pose a number of physical, social and psychological consequences. These infections are acquired through several ways. Treating GBIs is a daunting task making its control the most important strategy to alleviating its physical and psychosocial consequences. To...
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Objective: Wide range antioxidant micronutrients deficiencies during pregnancy have been reported in rural areas. This study was undertaken to determine if parity influences the serum levels of antioxidant micronutrients during subsequent pregnancy. Method: This is a cross-sectional study where pregnant women with varying number of previous pregnan...
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Background: Human Immunodeficiency Virus sero-discordance is high among heterosexual couples in Africa. However, only few studies have explored the factors that are associated with the prevalence in sub-Saharan Africa. The aim of this study was to determine the prevalence of female sero-discordance among HIV positive pregnant women in Owerri and to...
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Introduction: Pregnancy has been associated with changes in the eye which could be physiological, pathological, or exacerbation of pre‑existing ocular conditions. Visual acuity (VA) and refractive error (RE) changes are part of the physiological changes that may occur during pregnancy. Objective: The objective of the present study was to investigat...
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Objective: In Nigeria, many pregnant women as well as health-care providers are unaware of the effect of pregnancy on the eye. The present study investigated the changes in central corneal thickness (CCT), corneal sensitivity (CS), and intraocular pressure (IOP) among pregnant women in a tertiary hospital in Nigeria and the relationship between th...
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Oxidative stress in pregnancy reduces immunity and predisposes pregnant women to many diseases, prompting the need for antioxidants' supplementations. This cross-sectional study was undertaken to make more comprehensive evaluation of levels of antioxidant micronutrients in different trimesters in uncomplicated pregnancy in rural setting and establi...
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Purpose: This meta-analysis, following our previous reports those documented an overall 57% diminution in mean sperm concentration around the globe over past 35 years and 32.5% decline in past 50 years in European population, attempts to report the declining trend of sperm concentrations in African population between 1965 and 2015. Methods: In the...
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Background: Preoperative fasting of patients aims to reduce the residual gastric volume (RGV). The magnitude of this reduction is yet to be ascertained in the Nigerian population. Aim: To compare the RGV and pH of patients fasted for 6-12 h with those allowed oral intake of fluid up to 2 h preoperatively. Subjects and methods: This randomized...
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Key words: Some biochemical and haematological changes have been reported in malaria parasitemic pregnant women in urban and rural malaria-endemic areas, indicating different oxidative status of symptomatic and asymptomatic patients. The aim of this study was to assess the levels of some antioxidant vitamins in symptomatic malaria parasitemic pregn...
Article
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Background: Immune response to malaria parasitemia results from several biochemical and haematological changes that occur in this condition. Some of these changes earlier reported in parasitemic pregnant women in urban and rural malaria-endemic areas indicated different oxidative status of symptomatic and asymptomatic patients. Aim: This study was...
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Background: Immune response to malaria parasitemia results from several biochemical and haematological changes that occur in this condition. Some of these changes earlier reported in parasitemic pregnant women in urban and rural malaria-endemic areas indicated different oxidative status of symptomatic and asymptomatic patients. Aim: This study was...
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Background: Early amniotomy is common in obstetric practice but, its effectiveness has not been proven. Objectives: To determine the effects of early amniotomy on the duration of labour, and other maternal / neonatal outcomes of uncomplicated pregnancies in Enugu, South-east Nigeria. Methods: A randomized controlled study of 214 consenting ter...
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Hibiscus sabdariffa (HS) is widely consumed in Nigeria as a refreshing beverage and also as an antihypertensive agent. Since three decades ago when its antihypertensive activities were reported in several animal experiments, its consumption has greatly increased. The aim of this study is to investigate the effect of HS consumption on blood pressure...
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Background: Female sexual dysfunction is a common, condition that significantly reduces the quality-of-life of the affected persons. Unfortunately, because of the veil of secrecy that shrouds discussions on human sexuality, there has been limited research on this topic in some sociocultural settings. Aim: The aim was to determine the prevalence...
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Background: Students' poor performance in physiology examinations has been worrisome to the university community. Reported preference of peer-tutoring to didactic lectures at the University of Nigeria Medical School has not been investigated. Aim: The aim of this work is to design/implement low-cost interventions to improve teaching and learning...
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Introduction: Metabolic abnormalities are often common among human immunodeficiency virus (HIV) patients. The atherogenic index of plasma (AIP) is increasingly being used as a screening tool for dyslipidemia as it predicts the presence of small, dense, and highly atherogenic low density lipoprotein (LDL) and high density lipoprotein (HDL) particles...
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Background: Forced expiratory volume in 6 s (FEV6) and FEV1/FEV6 ratio have traditionally been used as a surrogate for forced vital capacity (FVC) and FEV1/FVC in the assessment of spirometric lung function in nonpregnant subjects. However, the existence of this relationship during pregnancy is yet to be ascertained. Aim: The aim of this study w...
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Background: Maternal micronutrient and antioxidant status is critical to fetal growth and survival. Poor socioeconomic conditions in the rural areas portend undernutrition with inevitable micronutrients deficiencies. Presently, there are conflicting reports on the serum levels of some mineral antioxidants during pregnancy. Aim: To determine the ser...
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Background: Malaria is a leading cause of mortality as well as a barrier to economic and social development in developing countries. The use of insecticide-treated nets (ITNs) for malaria vector control is effective in controlling malaria attacks in pregnant women and under-5 children. The Nigerian government, in its bid to achieve the Millennium...
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In other to provide some insight into the issue of male fertility with aging, several experimental, clinical and cross‑sectional epidemiological studies have been undertaken to characterize the relationship between paternal ages as a marker of the semen quality and male fertility status. The present review summarizes, comprehensively, the mechanism...
Article
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In normal pregnancy, free radicals are still generated. These free radicals are beneficial to the body at physiological levels, but when their production rates overwhelm the synergistic actions of available antioxidants, several deleterious or harmful conditions may ensue, including adverse pregnancy outcomes. These outcomes have been variously des...
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Background: Obesity in pregnancy is a global health problem which is associated with poor pregnancy outcomes. The use of weight and height, measured at about ten weeks of gestation, to produce pre-gestational body mass index is recommended for the diagnoses of the condition but limitations abound in under resourced settings. Objectives: To measu...
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Background: Micronutrient replacement is done indiscriminately, without recourse to peculiar socioeconomic and sociodemographic variables. Particularly, the relationship between parity, body weight, and some micronutrients has received minimal attention in Nigeria. Aim: To determine the relationship between parity, body weight, and some micronutrie...
Article
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Background: Micronutrient replacement is done indiscriminately, without recourse to peculiar socioeconomic and sociodemographic variables. Particularly, the relationship between parity, body weight, and some micronutrients has received minimal attention in Nigeria. Aim: To determine the relationship between parity, body weight, and some micronutrie...
Article
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There is need for periodic evaluation of medical students’ performance in professional medical examinations. This helps to identify possible gaps in teaching and may offer solutions that could redress such situations. This study is an audit of medical students’ performance in 2nd MBBS professional examinations in physiology at the University of Nig...
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Deficiencies in micronutrients are common in our environment, leading to indiscriminate replacement strategies. Selenium is an antioxidant micronutrient that may undergo depletion during pregnancy and lactation. Regrettably, information in this matter is scanty in Nigeria. To determine maternal selenium concentration during pregnancy and lactation....
Article
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Background: Pregnancy is characterized by generation of reactive species and reduction in immune functions of the woman, exposing her to oxidative stress and infections/infestations. In developing countries, pregnant women seldomly seek antenatal care early in their pregnancies, exposing them to pregnancy complications. Aim: The aim of this study i...
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Background : Acquired resistance to protein C in pregnancy has been established as one of the factors associated with thromboembolic phenomenon, an important cause of maternal mortality and morbidity. Objectives: To establish the mean levels of PCA ratio (measure of protein C resistance) of among our pregnant women since maternal mortality rate of...
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In malaria endemic areas, maternal mortality as high as 0.7% and above of live births have been reported, and these have correlated positively with low haemoglobin levels during pregnancy. Anaemia is the most common consequences of malaria infection in both immune and non-immune individuals, contributing significantly to both maternal and infant mo...
Article
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In malaria endemic areas, maternal mortality as high as 0.7% and above of live births have been reported, and these have correlated positively with low haemoglobin levels during pregnancy. Anaemia is the most common consequences of malaria infection in both immune and non-immune individuals, contributing significantly to both maternal and infant mo...
Article
Full-text available
In malaria endemic areas, maternal mortality as high as 0.7% and above of live births have been reported, and these have correlated positively with low haemoglobin levels during pregnancy. Anaemia is the most common consequences of malaria infection in both immune and non-immune individuals, contributing significantly to both maternal and infant mo...
Article
Full-text available
Background: The delivery of many children at short interval is associated with micronutrient depletion and weight gain. However, the relationship between the levels of the micronutrients and the body weight is yet to be ascertained. Objectives: To determine the relationship between parity, body weight and some antioxidant vitamins in non-pregnan...
Article
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Background: Hemolytic disease of the newborn, secondary to rhesus D (Rh D) iso-immunization, contributes significantly to perinatal morbidity and mortality. Prevalence data in Nigeria, and Southeast Nigeria in particular, is very scanty. This study was carried out to provide our experience in this preventable clinical condition in Enugu, Southeast...
Article
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Anthropometry in pregnancy is a comparative measure of size, proportion and composition of the body in relation to pregnancy. Anthropometric indices are useful in the assessment of nutritional status of pregnant women and predicting pregnancy outcome. To determine the effect of gravidity on anthropometric indices of pregnant women in Enugu, South E...
Article
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In developing countries, under nutrition is common, and this plays a crucial role in the pathogenesis of malaria and anemia. Indeed it has been associated with adverse pregnancy outcomes. Unfortunately, published evidence concerning the situation is lacking. To evaluate some nutritional function indices of pregnant women in a rural Nigerian communi...
Article
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Background: The delivery of many children at short interval is associated with micronutrient depletion and weight gain. However, the relationship between the levels of the micronutrients and the body weight is yet to be ascertained. Objectives: To determine the relationship between parity, body weight and some antioxidant vitamins in non-pregnant N...
Article
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HIV infection is a risk factor for cervical cancer and both diseases are prevalent in Nigeria. The study determined the prevalence of cervical squamous intraepithelial lesion (SIL) among HIV-positive women in Enugu state, which has the highest HIV burden in South-eastern Nigeria. Pap smear was carried out on 150 HIV-positive (HIV+ve) women and 150...
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Copper and selenium are important trace elements in man. They function as antioxidants and play roles in oxido-reductase reactions. Several imported multivitamin preparations are given to our women during pregnancy and lactation to correct possible deficiencies. The aim of the study is to determine the serum level of these micronutrients (selenium...
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The expansion of biomedical knowledge and the pursuit of more meaningful learning have led to world-wide evidence-based innovative changes in medical education and curricula. The recent emphasis on problem-based learning (PBL) and student-centred learning environments are, however, not being implemented in Nigerian medical schools. Traditional dida...
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It is commonly assumed that preterm babies are malnourished and this has led to all forms of micronutrient supplementation including iron. The aim of the study is to compare the iron content in breast milk of mothers who had preterm and term babies. Ninety six (96) lactating mothers who delivered their babies at term and 68 lactating mothers who ha...
Article
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There is no doubt that micronutrient deficiency is common in our environment. Replacements have thus been instituted without adequate information on specific and peculiar micronutrient needs of our people. Zinc is an essential micronutrient which is prone to maternal depletion during pregnancy and lactation. Unfortunately, studies in that regard in...
Article
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The current call for continuous support by women for women during labor takes for granted that women prefer to be supported by other women rather than their husbands. This study aimed at identifying the experiences and preferences of parturients as regards support in labor. Questionnaires were administered to 395 parturients at the University of Ni...