Tzu-Sen Yang

Tzu-Sen Yang
Taipei Medical University | TMU · College of Biomedical Engineering

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52
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711
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Publications

Publications (52)
Article
Full-text available
Photobiomodulation (PBM) has recently emerged in cellular therapy as a potent alternative in promoting cell proliferation, migration, and differentiation during tissue regeneration. Herein, a single-cell near-infrared (NIR) laser irradiation system (830 nm) and the image-based approaches were proposed for the investigation of the modulatory effects...
Article
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There has been great interest in identifying the biological substrate for light-cell interaction and their relations to cancer treatment. In this study, a near-infrared (NIR) laser is focused into the nucleus (nNIR) or cytoplasm (cNIR) of a single living cell by a high numerical aperture condenser to dissect the novel role of cell nucleus in mediat...
Article
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Many revolutionary approaches are on the way pertaining to the high occurrence of tooth decay, which is an enduring challenge in the field of preventive dentistry. However, an ideal dental care material has yet to be fully developed. With this aim, this research reports a dramatic enhancement in the rehardening potential of surface-etched enamels t...
Article
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The present study aimed to synthesize biphasic calcium phosphate ceramics (CaPs) composed of β-tricalcium phosphate (β-TCP) and hydroxyapatite (HAp) from the propagated Scleractinian coral and dicalcium phosphate anhydrous using a solid-state reaction followed by heat treatment at a temperature of 1100 °C for 1 h to 7 days. The as-prepared coral an...
Article
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We presented an approach to address cancer cell chemotaxis and response to tyrosine kinase inhibitor PD153035 at the single-cell level. We applied an optical tweezer system together with the platform at the single-cell level to manipulate an epidermal growth factor (EGF)-coated bead positioned close to the filopodia to locally stimulate HT29 cells,...
Article
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This study evaluated color stability and staining susceptibility of five direct resin-based composites (RBCs) subjected to light-activated in-office bleaching with 40% hydrogen peroxide (HP). The test materials included 5 RBCs, which consisted of one nano-filled, one sub-micron, one bulk-filled, and two nano-hybrid RBC types. Ten disc-shaped specim...
Article
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The current work focuses on the development of a novel electrospun silk fibroin (SF) nonwoven mat as a GTR membrane with antibacterial, biomineralization and biocompatible properties. The γ-poly glutamic acid (γ-PGA)-capped nano silver fluoride (NSF) and silver diamine fluoride (SDF) were first synthesized, which were dip-coated onto electrospun si...
Article
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Mineral trioxide aggregate (MTA) is well known as an effective root canal filling material for endodontics therapy. Within MTA, bismuth oxide (Bi2O3) serving as the radiopacifier still has biocompatibility concerns due to its mild cytotoxicity. In the present study, we tried to modify the Bi2O3 radiopacifier by doping hafnium ions via the sol-gel p...
Article
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The effects of anodized titanium (Ti) with a potential hydrogen fluoride (HF) acid pretreatment through cathodization on the formation of nano-porous Ti dioxide (TiO2) layer were characterized using field-emission scanning electron microscopy, grazing incidence X-ray diffractometer, and contact angle goniometer. The biocompatibility was determined...
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This study aims to fabricate silk fibroin/calcium sulfate (SF/CS) composites by one-pot synthesis for bone regeneration applications. The SF was harvested from degummed silkworm cocoons, dissolved in a solvent system comprising of calcium chloride:ethanol:water (1:2:8), and then mixed with a stoichiometric amount of sodium sulfate to prepare variou...
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This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4⋅0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right ma...
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Previously, we successfully developed an extracorporeal endotoxin removal device (EERD) that is based on the novel next generation alternating microtube array membrane (MTAM-A) that was superior to the commercial equivalent. In this article, we demonstrated multiple different parameter modifications that led to multiple different types of novel new...
Article
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In this study, five urethane acrylates (UAs), namely aliphatic urethane hexa-acrylate (87A), aromatic urethane hexa-acrylate (88A), aliphatic UA (588), aliphatic urethane triacrylate diluted in 15% HDD (594), and high-functional aliphatic UA (5812), were selected to formulate five UA-based photopolymer resins for digital light processing (DLP)-base...
Article
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Selective laser melting (SLM) is extensively used for fabricating metallic biomedical products. After 3D printing, it is almost always advisable to apply a heat treatment to release the internal tensions or optimize the mechanical properties of the printed parts. The aim of this paper is to investigate the effects of heat treatment of SLM printed T...
Article
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This study aimed to investigate the free calcium released from different brands of toothpaste after incorporation with a beta-tricalcium phosphate (β-TCP)/amorphous calcium phosphate (ACP) mixed powder and with β-TCP powder alone. Four brands of toothpaste were used for the experiment: Nano-Bio Activation Toothpaste, Colgate Total Advanced Whitenin...
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The present study established a maximum standard for printing quality and developed a preliminary ideal index to print three-dimensional (3D) construct using the Gly-Arg-Gly-Asp (GRGD) peptide modified Pluronic-F127 hydrogel (hereafter defined as 3DG bioformer (3BE)) as bioink. In addition, the biocompatibility of 3BE for 3D printing applications w...
Presentation
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This Scientific Report 2020-2021 presents the main research activities carried out by the Professors and research teams of the College of Biomedical Engineering at Taipei Medical University, Taipei, Taiwan. The report highlights the main research focus of the College in the fields of (a) Biomedical Materials and Tissue Engineering, (b) Nanomedicine...
Article
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This study aimed to elucidate the local effect and micro-computed tomographic (μ-CT) assessment following bone implantation of an innovative bioceramic (α-calcium sulfate hemihydrate; α-CSH) on femur lateral condyle cortical bone of rabbit models. The innovative α-CSH bioceramic was synthesized through a green processing technology (microwave irrad...
Article
Objective: Spasmodic torticollis is a debilitating neurological movement disorder associated with somatization, obsessive-compulsive, interpersonal sensitivity, depression, and anxiety. Usually, clinician had difficulty to precisely and quantitatively describe clinical outcomes using measurements of patients’ facial and neck movements. Methods: Mot...
Presentation
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This document presents the Research fields and performance of the College of Biomedical Engineering of Taipei Medical University (TMU). After only three years of existence, our College of Biomedical Engineering (CBME) was already listed in the top 150 in Academic Ranking of World Universities (ARWU) in 2018. CBME has 26 full-time professors and clo...
Article
Objectives: The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant. Materials and methods: The surface characteristic, biomechanical behavior and hemocompati...
Article
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Purpose Electrochemical oxidation following sandblasting and acid-etching (SLA) treatment has received interest as a surface modification procedure for titanium (Ti) implants (denoted as an SLAffinity surface); however, little information is available on its impacts on the in vivo performance of SLAffinity-Ti implants. The present study evaluated t...
Article
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Being endowed with an ability of capturing and releasing oxygen, the ceria surface conventionally assumes the role of catalyzing redox reactions in chemistry. This catalytic effect also makes possible its cytotoxicity toward microorganisms at room temperature. To study this cytotoxicity, we synthesized the doped and undoped ceria particles of 8-9 n...
Article
Titanium dioxide (TiO2) layers were prepared on a Ti substrate by using oxygen plasma immersion ion implantation (oxygen PIII). The surface chemical states, structure, and morphology of the layers were studied using X-ray photoelectron spectroscopy, X-ray diffraction, Raman microscopy, atomic force microscopy and scanning electron microscope. The m...
Article
Purpose: The aim of the present study was to examine the osseointegration in low-density bone tissue for SLAffinity-treated implants with StemBios (SB) cell therapy. Materials and methods: The morphologies of SLAffinity-treated surfaces were characterized using scanning electron microscopy. In the animal model, implants were installed in the man...
Article
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Radiation therapy for cancer patients works by ionizing damage to nuclear DNA, primarily by creating double-strand breaks (DSB). A major shortcoming of traditional radiation therapy is the set of side effect associated with its long-range interaction with nearby tissues. Low-energy Auger electrons have the advantage of an extremely short effective...
Article
Chemotaxis of cancer cells is an essential component of tumor dissemination. The chemotactic response is comprised of three separate steps, including chemosensing, polarization and locomotion. We present an innovative approach on chemotaxis assay to address cancer cell chemotaxis. We applied a high-resolution optical tweezers system to manipulate e...
Article
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In the application of microarray data, how to select a small number of informative genes from thousands of genes that may contribute to the occurrence of cancers is an important issue. Many researchers use various computational intelligence methods to analyzed gene expression data. To achieve efficient gene selection from thousands of candidate gen...
Article
This study developed calcium phosphate bone substitutes and their microstucture and in vitro cell response were evaluated in comparison with commercial hydroxyapatite (HA). HA powder was ball-milled and then sintered to transfer into the calcium phosphate bulks (CPB). The density, hardness, and microstructure of the CPB were investigated. The viabi...
Article
In this study, the electrical discharge machining (EDM) was formed on the surface of the Ti-6Al-4V (Ti64) specimen. The properties of adhesion and proliferation of MG-63 cells were evaluated the interactions between the EDM-treated layer and cells. The incorporation of oxygen roughened the EDM-treated specimen surface on a microscale, where the nan...
Article
Background The surface properties of Ti–6Al–4V (Ti64) alloys extensively affect the biological responses in a physical environment. To enhance the surface biocompatibility of Ti64 specimens, in the present study, electrical discharge machining (EDM) was performed to produce the modified layer on the surface of the Ti64 specimen. Methods The EDM-fu...
Article
Recently, the structure-function relationships between amphotericin B (AmB) and ergosterol have been solved using synthetic techniques that require a mycosamine-mediated direct binding interaction between AmB and ergosterol to form AmB ion channels. However, studies to directly probe the AmB-induced membrane permeability changes have not been condu...
Article
Background/Purpose Restriction endonuclease is found in bacteria and can precisely cut off the DNA sequence specificity invaded from outside. Using the restriction endonuclease to cleave the double-stranded DNA at specific recognition nucleotide sequences is regarded as important biotechnology. However, traditional approaches cannot directly observ...
Article
An image-based approach to predict the fluid temperature in microfluidic flow cell is presented. We apply Fourier-based cross-correlation processing to determine the lateral displacement of the optically trapped bead; therefore, both the mean square displacement (MSD) and the diffusion coefficient (D) can be obtained. On the other hand, applying th...
Article
An image-based approach to predict the fluid temperature in microfluidic flow cell is presented. We apply Fourier-based cross-correlation processing to determine the lateral displacement of the optically trapped bead; therefore, both the mean square displacement (MSD) and the diffusion coefficient (D) can be obtained. On the other hand, applying th...
Article
Accurately predicting binding affinity constant (K(A)) is highly required to determine the binding energetics of the driving forces in drug-DNA interactions. Recently, PD153035, brominated anilinoquinazoline, has been reported to be not only a highly selective inhibitor of epidermal growth factor receptor but also a DNA intercalator. Here, we use a...
Article
Binding behavior of DNA: A wormlike chain model is applied to determine the zero-force binding energetics of an intercalated DNA complex. A mono-intercalating agent is synthesized which can be very easily inserted into the DNA bases (see figure). This approach is particularly important in nuclear medicine and new radiation therapies.
Article
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Recently, Shy and his co-workers developed a new turbulent flow system that used a pair of counter-rotating fans and perforated plates to generate stationary near-isotropic turbulence, as verified by LDV measurements, for the study of premixed turbulent combustion processes. This paper evaluates for the first time the correlations between spatial a...
Article
This paper describes experiments on small solid particle settling behaviour in stationary homogeneous isotropic air turbulence. We present here a new methodology using a recently developed cruciform apparatus: a large horizontal cylindrical vessel equipped with a pair of counter-rotating fans and perforated plates at each end is used to generate st...
Article
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This paper describes experimentally small solid particle settling behaviors in a stationary homogeneous isotropic air turbulence. The problem was investigated numerically by Wang & Maxey (1993), Yang & Lei (1998), among others, and a relevant experiment was recently conducted by Lasheras and his co-workers (2002) to study the effect of preferential...
Article
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This paper reports an experimental study on the preferential accumulation and the settling velocity of small solid particles in Taylor-Couette (TC) air flows that are generated by two concentric rotating cylinders. For particle preferential accumulation, we use a high-speed laser sheet imaging technique in T-C flow with only the inner cylinder rota...
Chapter
This note reports a particle image velocimetry technique for obtaining fully resolved measurements of the velocity field u(x,y,z,t) throughout a four- dimensional spatiotemporal region on the inner scale in a near-isotropic stationary turbulence generated by a pair of vibrating grids in a water tank. The method uses a high-speed successive sweeping...
Chapter
The correlations between spatial and temporal behaviours of both fine-scale intermittency and the scaling of n th-order velocity structure function in a near- isotropic turbulence are studied experimentally, without adopting Taylor's hypothesis, using a high-speed digital particle image velocimetry together with the wavelet transform analysis. In t...
Article
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The ensemble-average settling velocity, V s , of heavy tungsten and glass particles with different mean diameters in an aqueous near-isotropic turbulence that was generated by a pair of vertically oscillated grids in a water tank was measured using both particle tracking and particle image velocimetries. Emphasis is placed on the effect of the Stok...
Article
The temporal responses of solid particles in a near-homogeneous turbulent gas flow field are investigated experimentally using particle image velocimetry (PIV) and a wavelet transform analysis. The near-homogeneous turbulence is created in a large cruciform apparatus. The large horizontal vessel is equipped with a pair of counter-rotating fans and...
Article
The preferential concentration of heavy particles in turbulence is demonstrated experimentally in a well-known Taylor-Couette (TC) flow using a high-speed laser sheet imaging technique. Three different particles, lead, tungsten and copper particles with different mean diameters are used, such that the corresponding values of Stokes number (St) can...
Article
Flamelet models have been widely applied to predict premixed turbulent combustion, such as for instance, the Bray-Moss-Libby (BML) model in which spatial flamelet statistics and, thus, mean reaction rate were deduced from a mean reaction progress variable ( ) and a mean crossing frequency. Recently, Shy et al. introduced a methodology based upon a...
Article
In the flamelet framework for premixed turbulent combustion, a transport equation for the flame surface density, commonly known as the Σ-equation, can be formulated but requires closure assumptions. We have applied an aqueous autocatalytic reaction, which produces a self-propagating chemical surface (liquid flame) with characteristics closely match...

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