Tym Sokolskyi

Tym Sokolskyi
University of Wisconsin–Madison | UW · Wisconsin Institutes for Discovery

Bachelor of Science

About

11
Publications
1,365
Reads
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6
Citations
Citations since 2016
10 Research Items
6 Citations
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201620172018201920202021202201234
201620172018201920202021202201234
Additional affiliations
August 2017 - present
Duke University
Position
  • Student
Education
August 2017 - May 2021
Duke University
Field of study
  • Evolutionary biology & Philosophy
August 2016 - May 2020

Publications

Publications (11)
Preprint
Full-text available
The origin of carbon fixation is a fundamental question in astrobiology. While the Calvin cycle is the most active on the modern Earth, the reductive TCA cycle (rTCA) pathway for carbon fixation has been proposed to have played an important role in early evolution. In this study, we examined the evolution of key enzymes in the rTCA, which are rare...
Article
Full-text available
Mitochondrial DNA (mtDNA) is prone to mutation in aging and over evolutionary time, yet the processes that regulate the accumulation of de novo mtDNA mutations and modulate mtDNA heteroplasmy are not fully elucidated. Mitochondria lack certain DNA repair processes, which could contribute to polymerase error-induced mutations and increase susceptibi...
Conference Paper
Full-text available
Fundamental to astrobiology is origin of autotrophy with reductive TCA cycle (rTCA) being often proposed as a primordial carbon fixation pathway. In this study we examined evolution of citrate cleavage reaction in rTCA done either by citryl-CoA synthase (CCS) and citryl-CoA ligase (CCL) with the release of citryl-CoA intermediate or by ATP citrate...
Preprint
Mitochondrial DNA (mtDNA) is prone to mutation in aging and over evolutionary time, yet the processes that regulate the accumulation of de novo mtDNA mutations and modulate mtDNA heteroplasmy are not fully elucidated. Mitochondria lack certain DNA repair processes, which could contribute to polymerase error-induced mutations and increase susceptibi...
Article
Sampling of six horizons of quartz-glauconite sands in Kaniv dislocations in Ukraine yielded more than three thousand vertebrate specimens, including elasmobranch teeth, chimaera dental plates, actinopterygian and sauropsid teeth and bones. Our study represents the first illustrated and detailed description of elasmobranch teeth from Ukrainian Albi...
Conference Paper
Full-text available
Nematodes are common detritophagous organisms exposed to a wide variety of microbiotas. Interestingly, different species of nematodes are known to acquire different species of bacteria from their habitats. Microbiomes can have a diverse set of functions, including protection against pathogens, metabolic alteration and xenobiotic detoxification. How...
Preprint
Full-text available
Vaults are large cone-shaped and highly conservative ribonucleoprotein complexes present in the cells of most major eukaryote clades. However, despite their wide distribution, their functions and evolutionary dynamics still remain enigmatic. Several minor functions in modulating signaling cascades and multidrug resistance phenotypes were previously...
Conference Paper
Full-text available
A partial skeleton including both dentaries and multiple isolated teeth of an early diverging iguanodontian (NCSM 29373) was excavated from the Cenomanian-aged Mussentuchit Member of the Cedar Mountain Formation in Emery County, Utah during the 2014-2016 field seasons. Due to the presence of jaw sections with unerupted teeth, we were able to calcul...
Conference Paper
Vaults are large cone-shaped and highly conservative ribonucleoprotein complexes present in the cells of most major eukaryote clades. However, despite their wide distribution, their functions and evolutionary dynamics still remain enigmatic. Several minor functions in modulating signaling cascades and multidrug resistance phenotypes were previously...
Conference Paper
During Albian stage of Early Cretaceous cartilaginous fish experienced a rapid diversification event that lead to the exploitation of ecological niches previously unoccupied by them. There are few locations in the world where marine vertebrate complexes of this age can be studied. Sampling from six thin layers of quartz-glauconite sands in Kanev di...
Article
Full-text available
FOSSIL ELASMOBRANCHII AND STRATIGRAPHY OF THE CREATEOUS DEPOSITS OF KANIV AREA Sections of the Createous deposits of the Southern part of Kaniv dislocation were studied and teeth of fossil Elasmobranchii were obtained from thin gravel sand interlayers. The species composition of the fauna allows us to establish the geological age of the taphocoeno...

Questions

Question (1)
Question
Dear researchers,
I am comparing proteins with sequence identity >30%, however most identical regions are concentrated in the coiled coil domains and surrounding regions. Structural allignments show RMSD of 1,6-3 and e-5 - e-8 (alligned regions are ~150 amino acids long). Is this data enough to infer homology between proteins or it falls in range of coiled coil conservativity?
Regards, Tim

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