Tuyen Van Nguyen

• PhD
• Managing Director at Institute of Chemistry, Vietnam Academy of Science and Technology

Circular agriculture is an advanced agricultural model that combines circular economy principles with ecological agriculture, aimed at promoting sustainable agriculture and reducing environmental impact. This review delves into the theoretical and practical foundations of circular agriculture by analyzing scientific literature from both domestic an...

Simple and efficient strategies have been developed for the synthesis of three structurally diverse dipyrrolo[1,2‐a : 2′,1′‐c][1,4]benzodiazepine (DPBD) derivatives. Firstly, two‐component reaction between 4‐aroylpyrrolo[1,2‐a][1,4]benzodiazepines and electron‐deficient internal alkynes in different conditions was applied to obtain isomeric geminal...

Podophyllotoxin, along with its numerous derivatives and related compounds, is well known for its broad-spectrum pharmacological activity, especially for anticancer potential. In this study, several isatin–podophyllotoxin hybrid compounds were successfully synthesized with good yields through microwave-prompted three-component reactions of 2-amino-...

Background: Pittosporum (the family Pittosporaceae) contains flowering plants, which was used as folk medicines in some countries of Asia, Europe, and Africa. Traditional use and pharmacological values of plants in this genus were deduced from a great role of their secondary metabolites. Objective: The ultimate goal of the review fully provides sig...

Background and purpose Ischemic stroke (IS) is classified into clinical subtypes and likely influenced by various lipid components. Nevertheless, the roles of apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), and apoB/apoA-I ratio in different IS subtypes remain underexplored. This study aimed to investigate the differential distribution of pla...

Phytochemical study of the leaves of Styrax annamensis Guillaumin resulted in the isolation of a new natural product egonol-3’’-sulphate (1), and two new derivatives egonol-3-methyl-D-galactopyranoside (2) and 7-methoxy-2-(3’,4’-methylenedioxyphenyl)-benzofuran-5-carboxamide (3). Their chemical structures were ­elucidated by spectroscopic data. Com...

In recent years, organophosphate esters (OPEs) have become one of the most common additives in various consumer products worldwide, therefore the exposure and impact of OPEs on human health are drawing a lot of attention. In this study, three metabolites of OPEs including bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), diphenyl phosphate (DPhP) and...

Azomethine and thiourea groups possess potential bioactive functions in pharmacological substances so organic ligands containing both imine and thiourea groups and their metal complexes will be expected to have remarkable bioactivities. In this study, some iron(III) and copper(II) complexes containing Schiff base thiourea ligands derived from 1‐(2‐...

A series of new fluorinated dihydrofurano-napthoquinone compounds were sucessfully synthesized in good yields using microwave-assisted multi-component reactions of 2-hydroxy-1,4-naphthoquinone, fluorinated aromatic aldehydes, and pyridinium bromide. The products were fully characterized using spectroscopic techniques and evaluated for their anti-in...

Purpose: Summary of tumor-produced circulating proteins as biomarkers in breast cancer (BC) detection. Subjects and method: A meta-analysis of 50 researches on protein biomarkers in BC diagnosis. Results: Many studies have shown that tumors continuously release components such as protein, RNA, and DNA into the bloodstream during apotosis. There are...

In this study, a novel superabsorbent polymer tapioca starch-g-poly(acrylic acid-2-acrylamido-2-methylpropane sulfonic acid)/ammonium polyphosphate (TS-g-AA-AMPS/APP) was synthesized based on the graft copolymerization of tapioca starch (TS) with acrylic acid (AA) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) via free radical polymerizati...

A phytochemical study of the methanolic extract of Syzygium cerasiforme leaves led to the isolation of seven compounds ( 1 – 7 ). Their chemical structures were identified as benzyl‐6ʹ‐ O ‐galloyl‐β‐ d ‐glucopyranoside ( 1 ), 3‐methoxy‐4‐hydroxyphenol 1‐ O ‐β‐D‐(6ʹ‐ O ‐galloyl)‐glucopyranoside ( 2 ), betulonic acid ( 3 ), 3‐ epi ‐betulinic acid ( 4...

Epoxy resin has been extensively used in many industrial and daily applications due to its unique properties. However, the high flammability of epoxy has limited its further development. DOPO derivatives, which are organophosphorus compounds, are highly effective components of flame retardant epoxy composites due to their good compatibility with th...

Two different synthetic approaches to novel heterocyclic hybrid compounds of 4-azapodophyllotoxin were investigated. The obtained products were characterized by infrared spectroscopy, nuclear magnetic resonance spectroscopy, and high-resolution mass spectrometry. MTT protocol was then performed to examine the cytotoxic activity of these products ag...

This study aims to develop an identification and quantification method for 13 Polybrominated diphenyl ethers (PBDEs) (BDE-28, 47, 99, 100, 153, 154, 183, 196, 197, 203, 206, 207, and 209) in indoor dust utilizing a GC/MS instrument. Different GC/MS conditions were investigated to find out the most optimize GC/MS condition for PBDEs measurement. Cal...

Objective: Alpinia is a big genus of flowering plants in the family Zingiberaceae. The plants of this genus are generally aromatic due to their essential oils. The current study aims to identify chemical compositions in the rhizome and leaf oils of Alpinia vietnamica H.Đ. Trâǹ, Luu & Škorničk. Methods: Essential oils of A vietnamica rhizomes and le...

Objective: The study was conducted to evaluate the in vitro acetylcholinesterase (AchE) inhibition activity of novel pyrano[2,3- d]pyrimidine derivatives. Methods: A series of new pyrano[2,3- d]pyrimidine derivatives were synthesized in moderate to good yields (63%-81%) by using microwave-prompted “one-pot” two-step multicomponent reactions of cycl...

High fire‐resistance polypropylene (PP) composites were prepared by using environment‐friendly flame retardants including expandable graphite (EG), red phosphorus (RP), and magnesium hydroxide (MH). Synergism between EG, RP, and MH on the thermo‐oxidation behavior and flame resistance of PP was found. The incorporation of MH and RP formed highly th...

Four undescribed phenolic glycosides including three stilbene derivatives (1 and 3) and sodium salt of 3 (2), and a chalcone glycoside (4), together with thirteen known compounds (5-17) were isolated from the leaves of Syzygium attopeuense (Gagnep.) Merr. & L.M.Perry. Their chemical structures were elucidated to be (Z)-gaylussacin (1), 6''-O-galloy...

Three undescribed triterpene glycosides syzybullosides A-C (1-3) along with fourteen known compounds were isolated from the leaves of Syzygium bullockii (Hance) Merr.& L.M. Perry, including six triterpene glycosides (1-6), four phenolics (7-9, 17), four megastigmanes (10-13), and three flavonoids (14-16). The structures of 1-17 were elucidated by e...

In this research, microwave‐assisted “one‐pot” multicomponent reactions have been employed for the synthesis of new chromeno[2,3‐d]pyrimidines containing fluorine atoms. The biological significance of the obtained compounds was highlighted by evaluating in vitro for cytotoxic activity against four human cancer cell lines (HepG2, hepatoma carcinoma;...

In this study, an investigation on the pollution status, distribution, and ecological risk to the aquatic organisms of six organophosphate tri-esters (tri-OPEs) and two organophosphate tri-esters (di-OPEs) in surface water in urban Hanoi, Vietnam were conducted. In 37 surveyed water samples (6 rivers and 17 lakes), all eight targeted OPEs were disc...

A new isopropyl chromone (1) and a new flavanone glucoside (2) together with eleven known compounds (3–13) were isolated from the leaves of Syzygium cerasiforme (Blume) Merr. & L.M.Perry. Their structures were elucidated as 5,7‐dihydroxy‐2‐isopropyl‐6,8‐dimethyl‐4H‐chromen‐4‐one (1), 5,7‐dihydroxyflavanone 7‐O‐β‐D‐(6′′‐O‐galloylglucopyranoside) (2)...

Objective: To investigate the relation of surgical treatment with patient’s 180-day outcome. Subject and method: Thirty-six patients who suffered a first spontaneous cerebellar hemorrhage (SCH) were treated with operation from January 2017 to March 2022. This study aimed to identify potential clinical and computed tomography (CT) features influenci...

Intraventricular hemorrhage (IVH), accounting for about 45% of acute spontaneous intracranial hemorrhage (ICH), is often associated with obstructive hydrocephalus and poor functional outcomes [1] [2]. Obstructive hydrocephalus and increased intracranial pressure are common after IVH because of an obstruction of normal cerebrospinal fluid (CSF) flow...

Objective: To evaluate the safety and the efficacy of internal carotid artery (ICA) infusion of autologous bone marrow-derived stem cells (BMSC) in subacute middle cerebral artery (MCA) infarct. Subject and method: A prospective, open-label, non-randomized was conducted in patients with MCA infarct, within 7-40 days from onset. Sixty-two patients s...

Background: Osmotic demyelination syndrome (ODS) is characterized by widespread degeneration of myelin within the central nervous system (CNS) and has no established treatment. A limited number of cases have reported positive outcomes with corticosteroid in the treatment of ODS. We report the case of complete recovery of ODS with corticosteroid. Ca...

Objective: To assess the safety and the efficacy of intravenous infusion of autologous bone marrow-derived stem cells (BMSC) in subacute middle cerebral artery (MCA) infarct. Subject and method: A prospective, open-label, non-randomized was performed in patients with MCA infarct, within 7-40 days from onset. Sixty-three patients, satisfying the inc...

The current report describes the chemical investigation and biological activity of extracts produced by three fungal strains Fusarium oxysporum, Penicillium simplicissimum, and Fusarium proliferatum isolated from the roots of Piper nigrum L. growing in Vietnam. These fungi were namely determined by morphological and DNA analyses. GC-MS identificati...

An unsymmetrical salen-type Schiff base ligand, (Z)-1-(((2-((E)-(2-hydroxy-6-methoxybenzylidene)amino)phenyl)amino)methylene)naphthalen-2(1H)-one, and its Zn(II), Cu(II), Co(II), Mn(II), and Fe(III) complexes were synthesized and characterized by mass (MS), nuclear magnetic resonance (NMR), infrared (IR), ultraviolet-visible (UV-Vis) spectra, and e...

The efficient synthesis of 12‐substituted‐3,4,4a,5,12,12a‐hexahydrobenzo[ b ]acridine‐1,6,11(2 H )‐triones starting from 2‐amino‐1,4‐naphthoquinone, 1,3‐cyclohexanedione, and different (hetero)aromatic aldehydes was developed. These reactions were carried out in acetic acid under microwave irradiation in the presence of p ‐toluenesulfonic acid as c...

749 γ-Butyrolactone, an ester functionality containing five-membered heterocycle, is one of the privileged structures of diverse natural products, such as sesquiterpene lactones and lignan lactones. 1,2 They have attracted considerable attention because of their in vitro cytotoxic, 3-5 anti-malarial, 6 antiH1N1, 7 antimicrobial, 7-9 anti-inflammato...

Chemical research of the ethyl acetate extract from rhizomes of Alocasia odora (Roxb.) K.Koch, Araceae, led to the isolation and NMR determination of alocasin A, hyrtiosin B, hyrtiosulawesine, β-sitosterol, and daucosterol. The first three compounds showed moderate xanthine oxidase inhibitory activity. All five isolates compounds are promising agen...

High-performance flexible multilayer transparent conducting electrodes (TCE) based on silver nanowires (AgNWs), graphene oxide (GO), and poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) materials on the flexible polyethylene terephthalate (PET) substrate were successfully fabricated by spin-coating technique. The multilayer elect...

Phytochemical investigation of the ethyl acetate extract of Styrax annamensis leaves has led to the isolation and determination of a new lignan, 7R,8S,7′S,8′R-3,4,3′-trimethoxy-9,4′,7′-trihydroxy-8.8′,7.O.9′-lignan (1), together with a known compound, 4-ketopinoresinol (2). Compound 2 was isolated from the genus Styrax for the first time, and showe...

In this study, g-C3N4/UU-200 heterojunction photocatalysts displaying superior photocatalytic activity for organic pollutant elimination under white LED light irradiation were fabricated via an in situ solvothermal method. The successful construction of a heterojunction between g-C3N4 and UU-200 was evidenced by X-ray diffraction, Fourier transform...

Trong bài báo này, chúng tôi trình bày một số kết quả mới về công thức tính nón tiếp tuyến bậc nhất và tập tiếp xúc bậc hai của các hệ ràng buộc dưới giả thiết về tính calm của ánh xạ tập ràng buộc với nhiễu chính tắc. Các kết quả nhận được mở rộng và cải tiến kết quả tương ứng trong [3], [11] và [12]

A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using microwave-assisted three-component reactions is reported in this study. Novel podophyllotoxin-naphthoquinone derivatives with modification on ring E were synthesized. All the synthetic compounds were assessed in terms of their cytotoxicity profile against four cancer...

A convenient three‐component synthetic approach was developed en route to new and significative N‐arylated‐dihydrobenzo[g]quinoline‐5,10‐diones using 2‐hydroxy‐1,4‐naphthoquinone, a variety of aromatic aldehydes, and 4‐(arylamino)furan‐2(5H)‐ones. A sequence of steps including Knoevenagel condensation, Michael addition, [1,3]‐hydrogen shift, intram...

Five copper(II) complexes bearing aroylhydrazone Schiff base ligands were prepared and studied by spectroscopies which indicated that the ligands can act as dianionic tridentate chelates in enol forms. The obtained mass spectra data induced the hydrazone Schiff base copper(II) complexes as binuclear copper(II) complexes probably. The effective magn...

The green and efficient approach for synthesis of 2-hydroxy-3-(arylmethyl)(4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl)-1,4-naphthoquinones starting from 2-hydroxy-1,4-naphthoquinone, tetronic acid, and aromatic aldehydes was developed. These reactions were carried out in ethanol under microwave irradiation in the presence of ammonium acetate as catalyst...

A new approach for fabricating high-performance electrochemical sensors for lead ion detection using the square-wave anodic stripping voltammetry method was developed. The sensor consisted of a working electrode fabricated from silver nanowires (AgNWs) and graphene oxide (GO) on polyethylene terephthalate substrates. The morphological, electrochemi...

Mục tiêu: đánh giá nồng độ apolipoprotein A-I, apolipoprotein B huyết tương, tỷ số apolipoprotein B/A-I bệnh nhân nhồi máu não do xơ vữa động mạch lớn. Xác định giá trị tiên lượng xơ vữa động mạch lớn bệnh nhân nhồi máu não của tỷ số apoB/apoA-I. Đối tượng và phương pháp: gồm 40 người nhóm chứng và 248 bệnh nhân nhồi máu não điều trị nội trú tại Tr...

Mục tiêu: Đánh giá sự thay đổi nồng độ alkaline phosphatase (ALP) huyết tương bệnh nhân nhồi máu não (NMN) tại Bệnh viện Trung ương Quân đôi 108. Bước đầu khảo sát giá trị tiên lượng nhồi máu não của chỉ số ALP huyết tương. Đối tượng và phương pháp: 70 người khỏe mạnh và 120 bệnh nhân nhồi máu não được điều trị tại Trung tâm Đột quỵ não - Bệnh viện...

Mục tiêu: Đánh giá nồng độ apolipoprotein A-I, apolipoprotein B huyết tương, tỷ số apolipoprotein B/A-I theo tình trạng xơ vữa động mạch não. Xác định giá trị tiên lượng xơ vữa hẹp, tắc động mạch trong sọ bệnh nhân nhồi máu não của tỷ số apoB/apoA-I. Đối tượng và phương pháp: Gồm 248 bệnh nhân nhồi máu não điều trị nội trú tại Trung tâm Đột quỵ não...

New propene derivative 1-(3’,4’-methylenedioxyphenyl)-2-(2’’- hydroxy-5-(3’’’-hydroxypropyl)-3’’-methoxyphenyl)prop-2-en-1-one (1), along with three known triterpenoids ursolic acid (2), pomolic acid (3), and maslinic acid (4) were isolated from the leaves of Styrax annamensis species. All structures were assigned by spectroscopic analysis. Compoun...

Searching for bioactive agents from medicinal plants, eleven constituents were isolated from Polyscias guilfoylei stem for the first time, including a nucleoside uracil (1), two sterols β-sitosterol (2) and daucosterol (3), a saponin androseptoside A (4), two lignans (+)-pinoresinol (5) and (+)-syringaresinol (6), four phenolic acids protocatechuic...

Herbaceous annual plants of the genus Xanthium are widely distributed throughout the world and have been employed medicinally for millennia. This contribution aims to provide a systematic overview of the diverse structural classes of Xanthium secondary metabolites, as well as their pharmacological potential. On searching in various reference databa...

Cộng hưởng từ 3.0 tesla sọ não có khả năng phát hiện những bất thường trong nhu mô cũng như mạch máu não như: u não, teo não, thoái hóa chất trắng, nhồi máu não, phình động mạch não, dị dạng động tĩnh mạch não, hẹp, tắc mạn tính mạch máu não... ngay từ khi chưa có triệu chứng lâm sàng. Chính vì vậy, rất có ý nghĩa trong điều trị dự phòng đột quỵ. C...

Nghiên cứu của chúng tôi đánh giá kết quả điều trị của nhóm bệnh nhân ung thư cổ tử cung giai đoạn FIGO IB1-IIA1 được phẫu thuật triệt căn ngay từ đầu tại bệnh viện K. Đối tượng và phương pháp nghiên cứu: Chúng tôi tiến hành nghiên cứu hồi cứu trên 158 bệnh nhân ung thư cổ tử cung giai đoạn FIGO IB1-IIA1, được phẫu thuật cắt tử cung triệt căn ngay...

A herbal remedy formulation including Stixis suaveolens and Pandanus tonkinensis has been established to treat liver diseases in the North‐West region of Vietnam. This study aimed to provide in vitro as well as in vivo scientific evidences which illustrate the hepatoprotective effect of water extract of the above formulation. As a result, the highe...

A new racemic xanthone, garmckeanin A ( 1 ), and eight known analogues 2 –9 were isolated from the ethyl acetate (EtOAc) extract of the Vietnamese Garcinia mckeaniana leaves. Their structures were determined by MS and NMR spectral analyses and compared with the literature. The EtOAC extract showed good cytotoxicity against cancer cell lines KB, Lu,...

Background: Patients with spontaneous supratentorial intracerebral hemorrhage who had large hematomas, seriously edema and high intracerebral pressure showing a poor prognosis, with mortality rate is very high. Surgical decompressive craniectomy evacuation hematoma treatment (DCEH) effectively reduce high intracranial pressure. However, some studie...

The anti-cancer activity of bannaxanthone E isolated from Garcinia mckeaniana leaves was assessed through a flow cytometric method on human lung SK-LU-1 cancer cells, including cell cycle changes and induction of cell apoptosis. Treatment with bannaxanthone E led to the suppression of cell cycle progression at the G2/M phase to 19.6% at 4 µM, and i...

Novel 1,4-pyranonaphthoquinone derivatives were successfully synthesized via the microwave-assisted three-component reaction of 1,4-naphthoquinone, malononitrile, and various arylaldehydes in ethanol in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst, and subsequently evaluated in terms of their antimicrobial and antifungal activitie...

For the first time the 4-dimethylaminopyridine (DMAP) catalyzed straightforward and efficient procedure has been developed for the synthesis of 3,3′-(arylmethylene) bis(2-hydroxynaphthalene-1,4-dione) derivatives starting from lawsone (2-hydroxy-1,4-naphthoquinone) and a variety of (hetero)aromatic aldehydes in ethanol under microwave irradiation....

A new muurolane-type sesquiterpene, a new flavone arabinofuranoside derivative, and other five known flavone arabinofuranoside derivatives were isolated from the leaves of Fissistigma bicolor (Annonaceae family). Their chemical structures were determined to be (1S,6R,7S)-muurola-4,10(14)-diene-15-ol (1), quercetin 3-O-β-D-apiofuranosyl-(1→2)-α-L-ar...

Mục tiêu: Khảo sát chỉ số tim – chân (CAVI) và mối liên quan với một số đặc điểm lâm sàng, cận lâm sàng bệnh nhân thận nhân tạo chu kỳ. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang 111 bệnh nhân thận nhân tạo chu kỳ và 88 người bình thường có cùng độ tuổi, giới. Tất cả các đối tượng đều được đo chỉ số CAVI. Kết quả: Chỉ số CAVI trung bình ở...

Three new xanthones, garcimckeans A-C (1-3) were isolated from the methanol extract of the stems of Garcinia mckeaniana (Clusiaceae). Their structures were established by extensive spec�troscopic analysis (HR-ESI-MS and 1 D and 2 D NMR) and by com�parison of the spectral data with those reported in the literature. Compounds 1-3 displayed weak cytot...

This study investigated the occurrence, distribution of several additive brominated flame retardants (BFRs) such as polybrominated diphenyl ethers (PBDEs) and some novel brominated flame retardants (NBFRs) in urban indoor dust collected from ten inner districts of Hanoi, Vietnam to assess the contamination status, emission sources, as well as their...

A facile and efficient synthesis of novel naphthoquinone-based chalcone hybrids (7 and 24) via the microwave-assisted one-pot three-component reactions of 2-substituted-1,4-naphthoquinones, N,N-dimethylformamide dimethyl acetal (DMF-DMA), and acetophenone derivatives has been reported. Whereas the synthesis of hybrids 7 proceeded via a condensation...

Mục tiêu: Tìm hiểu mối liên quan giữa nồng độ gamma-glutamyl transferase (GGT) huyết tương với hội chứng chuyển hóa (Metabolic syndrome - MS) tại Bệnh viện Trung ương Quân đội 108. Đối tượng và phương pháp: Nghiên cứu tiến cứu, mô tả cắt ngang trên 104 bệnh nhân có MS và 108 bệnh nhân không có MS đến khám và điều trị ngoại trú tại Khoa Khám bệnh -...

Six Fe(III) complexes bearing unsymmetrical salen-type ligands derived from 2-hydroxynaphthaldehyde and substituted salicylaldehydes were synthesized by coordinating the unsymmetrical salen-type ligands with FeCl3.6H2O. The synthetic complexes were characterized by electrospray ionization mass spectra (ESI-MS), effective magnetic moments (μeff), an...

Unsymmetrical tetradentate Schiff base Fe(III) and Cu(II) complexes were prepared by the coordination of some unsymmetrical tetradentate Schiff base ligands with CuCl2·2H2O or FeCl3·6H2O. The obtained complexes were characterized by ESI-MS, IR, and UV-Vis. The spectroscopic data with typical signals are in agreement with the suggested molecular for...

Lycopene and resveratrol are well-known for their high bioactivity, anti-inflammatory effects, and strong antioxidant properties. The combination of lycopene and resveratrol was synergistic in the potentializing immunity of the mammal body. In this study, the scalable co-encapsulation of lycopene and resveratrol into polymeric nanoparticles was per...

An efficient method was developed to prepare a series of novel 3-benzoyl-4H-benzo[g]chromene-5,10-dione derivatives from 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes and arylenaminones in glacial acetic acid under microwave irradiation. This transformation presumably occurs via a Knoevenagel condensation – dehydration – Michael addition – O-cyc...

A convenient microwave-assisted one-pot four-component synthetic approach was developed en route to novel functionalized benzo[a]pyridazino[3,4-c]phenazine derivatives starting from 2-hydroxy-1,4-naphthoquinone, aromatic aldehydes, methyl hydrazine and o-phenylenediamine. Nine new derivatives were successfully synthesized and subsequently evaluated...

Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds (Z)−3-((6,8-dimethyl-4-oxo-1,4-d...

Genus Styrax belongs to the family Styracaceae, which is widely distributed in tropical and subtropical regions and has been applied in pharmacological uses and food chemical products. Original research articles related to Styrax plants are now abundant, but there has not been an overview account to demonstrate the highlights in phytochemical and p...

Pt(II) complexes bearing one N-salicylidene-(S)-1-phenylethylamine [HL(S)] or N-salicylidene-(R)-1-phenylethylamine [HL(R)] were synthesized and characterized by electrospray ionization mass spectroscopy (ESI-MS), Fourier-transform infrared (FT-IR), nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopies. The results of the micr...

Mục tiêu: Đánh giá kết quả và các biến chứng của phương pháp lấy huyết khối bằng dụng cụ cơ học ở bệnh nhân rung nhĩ đột quỵ thiếu máu não cấp do tắc nhánh lớn động mạch sọ. Đối tượng và phương pháp: Can thiệp lâm sàng, tự chứng. Tiến hành trên 121 bệnh nhân thiếu máu não cấp do tắc nhánh lớn động mạch sọ được can thiệp lấy huyết khối bằng dụng cụ...

Mục tiêu: Đánh giá vai trò của chụp cắt lớp vi tính 320 dãy đầu thu trong đánh giá sự xâm lấn mạch máu của u vùng đầu tụy. Đối tượng và phương pháp: Hồi cứu kết hợp tiến cứu, mô tả cắt ngang được tiến hành trên 85 bệnh nhân nghi ngờ u vùng đầu tụy trên lâm sàng, được chụp cắt lớp vi tính 320 dãy, điều trị phẫu thuật và có kết quả mô bệnh học tại Bệ...

Mục tiêu: Đánh giá sự thay đổi một số chỉ số tế bào máu ngoại vi của bệnh nhân đột quỵ nhồi máu não trước và ngay sau khi lấy dịch tuỷ xương tạo khối tế bào gốc để điều trị phục hồi các tổn thương não. Đối tượng và phương pháp: 57 bệnh nhân (40 nam, 17 nữ) sau đột quỵ nhồi máu não từ 7 - 30 ngày, được lấy 240ml dịch tuỷ xương từ gai chậu sau trên 2...

Objective: To implement the process and to evaluate the effectiveness of extracting necessary stem cell components and removing unnecessary cell components. Subject and method: 57 patients (40 male and 17 female patients) with subacute ischemic stroke (7th day - 30th day) including 40 male and 17 female patients. 240ml of bone marrow taken from ili...

Two efficient and practical approaches are reported for the synthesis of β- and δ-carbolines from 3,4-dibromopyridine. The synthesis is based on site-selective Cu-catalyzed double C–N coupling reactions and subsequent annulations by twofold Pd-catalyzed C–N coupling with amines.

Giá trị của cộng hưởng từ tưới máu trong bệnh lý nhồi máu não cấp, minh họa bằng một trường hợp đột quỵ nhồi máu cấp tính được chụp cộng hưởng từ tưới máu ở Khoa Chẩn đoán hình ảnh - Bệnh viện Trung ương Quân đội 108. Chúng tôi báo cáo một trường hợp nhồi máu cấp tính về đặc điểm lâm sàng, cận lâm sàng, đặc điểm tổn thương trên cộng hưởng từ tưới m...

Mục tiêu: Đánh giá đặc điểm tế bào máu ngoại vi và tuỷ xương của bệnh nhân đột quỵ nhồi máu não trước khi lấy dịch tuỷ xương số lượng lớn. Đối tượng và phương pháp: 57 bệnh nhân đột quỵ nhồi máu não từ 7 - 30 ngày sau đột quỵ (40 nam, 17 nữ), mỗi bệnh nhân được lấy khoảng 2ml máu ngoại vi và chọc hút khoảng 1 - 1,5ml dịch tủy xương từ mào chậu. Số...

Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component reaction starting from 2-hydroxy-1,4-naphthoquinone, tetronic acid, and various aromatic aldehydes has been described. This multicomponent domino reaction proceeded through the Knoevenagel condensation, Michael addition, deprotonation, and...

A series of new plinabulin-quinoline derivatives and their simplified analogues was obtained from N,N′-diacetyl-2,5- diketopiperazines utilizing its aldol condensation with benzaldehydes. One compound showed strong activity related to three (KB, HepG2 and Lu) cancer cell lines while two other compounds demonstrated high potencies against breast car...

Background: Centipeda minima (the family Asteraceae) is an annual herbaceous plant native to the tropical regions, especially in eastern tropical Asia. C. minima is well-known in the list of medicinal plants with capacities in treatment of whooping cough, nasal allergy, malaria, and asthma. More than sixty reports on phytochemical and pharmacologi...

Searching for bioactive agents from Vietnamese plants, nine compounds, including five nor-lignan-type benzo-furans 1-5, two lignans 6 and 7, one sterol 8 and one triterpenoid 9 were separated from Styrax argentifolius for the first time. 5-((E)-2-Carboxyvinyl)-7-methoxy-2-(3 ′ ,4 ′-methylenedioxyphenyl)benzofuran (1) and 5-carboxy-7-methoxy-2-(3 ′...

A series of novel podophyllotoxin-naphthoquinone compounds 5a-p were synthesized in good yields using microwave-assisted four-component reactions of 2-hydroxy-1,4-naphthoquinone, aromatic benzaldehydes, tetronic acid and ammonium acetate. All the synthezied compounds were fully characterized by spectral data and evaluated for their cytotoxicity act...

Zinc oxide nanoflakes were synthesized using the wet precipitation method from aqueous solutions of zinc nitrate and sodium hydroxide. The obtained materials were characterized by means of X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and nitrogen adsorption–desorption methods. The presence of sodium laur...

In this work, we treated chitin with 2-(azidomethyl)oxirane and successfully involved the resultant azido chitin derivatives in the ultrasound-assisted Cu(I)-catalyzed azido-alkyne click (CuAAC) reaction with propargylic ester of N,N,N-trimethyl glycine. Thus, we obtained novel water-soluble triazole chitin derivatives. The triazole chitin derivati...

Acute obstructive hydrocephalus is a complication of intraventricular hemorrhage, which requires a combination of medical and surgical treatments. We report a clinical case of intraventricular hemorrhage extension secondary to a ruptured arteriovenous malformation, successfully treated with a combination of methods: endovascular embolization of art...

The flame‐retardant low‐density polyethylene (LDPE) composites loading aluminum hydroxide (ATH), red phosphorus (RP), and expandable graphite (EG) were successfully prepared. The flame retardancy, the thermo‐oxidative stability, and the mechanical property of the composites were investigated. The synergistic effect of ATH, RP, and EG on the flame‐r...

The title compound, C21H23NO4S, obtained by alkaline treatment of 1,5-bis­(1-phen­oxy)-3-aza­pentane at moderate heating, is a N-tosyl­ated secondary vinyl­amine. An intra­molecular S=O⋯H—C hydrogen bond generates a 13-membered ring. The benzalacetone moiety adopts a trans conformation with respect to the C=C double bond, which is slightly longer t...

We used nanoparticles which possess simultaneously active (antimicrobial, UV-protective and antioxidant) and smart (temperature sensing) properties. The nanoparticles (2Rh = 450 nm, PDI = 0.118 ± 0.014, ζ-potential = 21 mV and Tg = 8 ± 1 °C) are based on polyethylene glycol (PEG)/methyl cellulose (MC) core with anthocyanidin and sodium acetate, and...

This study aims to synthesize and evaluate the photocatalytic activity of bismuth terephthalate material (Bi-BDC) synthesized by solvothermal (ST) and microwave-assisted solvothermal (MW) methods. Differences in the crystal structure and crystal shape were assessed by analytical methods such as X-ray diffraction (XRD), scanning electron microscope...

An effective approach to the synthesis of thieno[2,3‐g]indolizine derivatives has been developed. A wide variety of reagents such as unsaturated aldehydes, methylvinylketone, esters of acrylic acid, maleic anhydride, methyl propiolate, dimethyl and diethyl acetylenedicarboxylates in the construction of functionally diverse rarely encountered tricyc...

One new oleanane-type triterpene glycoside, oleanolic acid-[28 -O-β-d-glucopyranosyl]-3 -O-[ β-d-glucopyranosyl(1→6)- β-d-glucopyranosyl](1→3)[ α-l-arabinofuranosyl(1→4)]- β-d-glucuronopyranoside (1), and 3 known ones {oleanolic acid-[28 -O-β-d-glucopyranosyl]-3 -O-[ β-d-galactopyranosyl(1→3)]-[ β-d-glucopyranosyl(1→2)]- β-d-glucuronopyranoside (2)...

From the leaves of Aralia chinensis, 3 oleanane-type triterpene glycosides have been isolated, including 1 new glycoside, 3β,23 -dihydroxyolean-12-ene-28-oic acid 3 -O-β-d-glucopyranosyl-(1→3)- α-l-arabinopyranosyl-(1→3)-β-d-glucuronopyranoside 28 -O-β-d-glucopyranosyl ester (named as araliachinoside A, 1), and 2 known ones, 3β,23 -dihydroxyolean-1...

Synthesis of novel indeno[1,2-c]isoquinoline derivatives, functionalized at the D ring and bearing 1,2,3-triazole unit, has been reported. These hybrid compounds display cytotoxic activity against two human cancer cell lines – KB and HepG2 with half maximal inhibitory concentration (IC50) values in a range of 20–40 μM.

Five 2-aroyl-5-bromo­benzo[b]furan-3-ol compounds (two of which are new) and four new 2-aroyl-5-iodo­benzo[b]furan-3-ol compounds were synthesized starting from salicylic acid. The compounds were characterized by mass spectrometry and ¹H NMR and ¹³C NMR spectroscopy. Single-crystal X-ray diffraction studies of four com­pounds, namely, (5-bromo-3-hy...