How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
Citations since 2016
8 Research Items
Purpose: OCT can be used for glaucoma assessment, but its usefulness may depend on image quality, disease stage and segmentation algorithm. We aimed to determine how layer thicknesses as assessed with different algorithms depend on image quality and disease stage, how reproducible the algorithms are, and if the algorithms (dis)agree. Methods: Op...
Glaucomatous damage can be quantified by measuring the thickness of different retinal layers. However, poor image quality may hamper the accuracy of the layer thickness measurement. We determined the effect of poor image quality (low signal-to-noise ratio) on the different layer thicknesses and compared different segmentation algorithms regarding t...
We compared eleven OCT devices in their ability to quantify retinal layer thicknesses under different signal-strength conditions, using a commercially available phantom eye. We analyzed a medium-intensity 50 µm layer in an identical manner for all devices, using the provided log-scale images and a reconstructed linear-scale tissue reflectivity metr...
The aim of this paper was to investigate differences in brain structure volumes between schizophrenia and affective psychoses, and whether cumulative lifetime antipsychotic or benzodiazepine doses relate to brain morphology in these groups. We conducted two systematic reviews on the topic and investigated 44 schizophrenia cases and 19 with affectiv...
High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 c...
Background: High doses of antipsychotic medication have been associated with loss in cortical and total gray matter in schizophrenia, but the studies have not adjusted for benzodiazepine use. There are no modern imaging studies on the effects of benzodiazepine on brain structures in spite of evidence suggesting adverse effects such as cognitive imp...
Introduction The effects of long-term antipsychotic medication use on structural brain changes in psychoses are still unknown. Severity and duration of illness are key confounders when evaluating antipsychotic effects on brain morphology. Objectives Understanding the role of antipsychotic medication on brain morphology in psychoses. Aims To analy...
EGRET is the training environment for 15 highly talented Early Stage Researchers. The individual and collaborative outputs of their work contribute to the following aims: a) acquiring new, quantitative knowledge on glaucoma and the ageing visual system; and b) applying this new knowledge to boost innovation in glaucoma care in both the public and private sectors.