Tuhina Khan

Tuhina Khan
Institut Pasteur de Lille · U1177 - Drugs & Molecules for Living Systems

Postdoctoral Research Fellow
Drug Discovery, Medicinal Chemistry, Synthetic Chemistry, Anti-tumor Therapy, Metabolic Disorders.

About

8
Publications
1,797
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
145
Citations
Citations since 2017
8 Research Items
145 Citations
2017201820192020202120222023010203040
2017201820192020202120222023010203040
2017201820192020202120222023010203040
2017201820192020202120222023010203040
Introduction
Experienced & motivated medicinal chemist with interest in drug design, discovery and development. Solid background and extensive experience in Medicinal Chemistry research and modern Synthetic Organic Chemistry. In-depth knowledge of Hit-Lead optimization and structure-activity relationship studies along with design, synthesis, purification, and spectroscopic characterization of target compounds (small heterocycles and biologically active compounds).
Additional affiliations
April 2021 - present
Institut Pasteur de Lille
Position
  • Postdoctoral Research Fellow
Description
  • Development of bioactive compounds for application in metabolic diseases and their co-morbidities
February 2019 - March 2019
Trinity College Dublin
Position
  • Visiting PhD Felow
March 2017 - June 2020
Università degli Studi di Siena
Position
  • PhD Student
Description
  • Development of Novel Heterocyclic Compounds as Anti-cancer Agents
Education
March 2017 - June 2020
Università degli Studi di Siena
Field of study
  • Medicinal Chemistry
June 2014 - July 2016
National Institute of Technology, Silchar
Field of study
  • Organic Chemistry
August 2010 - August 2013
University of Calcutta
Field of study
  • Chemistry

Publications

Publications (8)
Article
Leishmania spp. are responsible for up to 1 million new cases each year. The current therapeutic arsenal against Leishmania is largely inadequate, and there is an urgent need for better drugs. Trypanothione reductase (TR) represents a druggable target since it is essential for the parasite and not shared by the human host. Here, we report the optim...
Article
The search of new therapeutic tools for the treatment of cancer is being a challenge for medicinal chemists. Due to their role in different pathological conditions, histone deacetylase (HDAC) enzymes are considered valuable therapeutic targets. HDAC6 is a well-investigated HDAC-class IIb enzyme mainly characterized by a cytoplasmic localization; HD...
Article
Autophagy is a lysosome dependent cell survival mechanism and is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Targeting autophagy in cancer therapy attracted considerable attention in the past as stress-induced autophagy has been demonstrated to contribute to both drug resistance and malign...
Article
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolytic degradation, recombination, and end-to-end fusion. Telomerase is a ribonucleoprotein that adds TTAGGG tandem repeats to the telomeric ends. It has been observed that 85 to 90% of human tumors express high levels of telomerase, playing a crucial rol...
Article
Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas (ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis and lack of effective treatment strategies make both OSCC and ESCC a significant health burden. Autophagy, a lysosome‐dependent catabolic process, involves the degradation of intrac...
Article
We developed a Jocic-type protocol for the construction of the pyrrolonaphthoxazepine (PNOX) core. After an initial investigation based on the isolation of a trichloromethyl carbinol derivative, we shifted our attention towards a multicomponent single-step protocol. Screening of a variety of bases and solvents led to the identification of the optim...
Article
Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. Benzoxazepines were recently identified as a novel class of MTAs. These anticancer agents were thoroughly characterized for th...
Article
Full-text available
Here, we have reported an efficient method for the synthesis of β-ketosulfides. A thermodynamically more stable enolate ion is generated from unsymmetrical ketones and reacts predominantly with in situ generated sulfenyl iodide, from various disulfides to give α­sulfenylation products. The base potassium tert-butoxide is used in a solvent mixture o...

Network

Cited By