Tuhina Khan

Tuhina Khan
  • Postdoctoral Research Fellow
  • Medicinal Chemist at University of Antwerp

Drug Discovery, Medicinal Chemistry, Synthetic Chemistry, Anti-tumor Therapy, Metabolic Disorders.

About

9
Publications
2,075
Reads
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220
Citations
Introduction
Experienced & motivated medicinal chemist with interest in drug design, discovery and development. Solid background and extensive experience in Medicinal Chemistry research and modern Synthetic Organic Chemistry. In-depth knowledge of Hit-Lead optimization and structure-activity relationship studies along with design, synthesis, purification, and spectroscopic characterization of target compounds (small heterocycles and biologically active compounds).
Current institution
University of Antwerp
Current position
  • Medicinal Chemist
Additional affiliations
January 2016 - July 2016
National Institute Of Technology Silchar
Position
  • Msc thesis
May 2015 - July 2015
Indian Institute of Technology Guwahati
Position
  • Summer Intern
February 2019 - March 2019
Trinity College Dublin
Position
  • Visiting PhD Felow
Education
March 2017 - June 2020
University of Siena
Field of study
  • Medicinal Chemistry
June 2014 - July 2016
National Institute Of Technology Silchar
Field of study
  • Organic Chemistry
August 2010 - August 2013
University of Calcutta
Field of study
  • Chemistry

Publications

Publications (9)
Article
Full-text available
Endoplasmic reticulum aminopeptidases ERAP1 and 2 are intracellular aminopeptidases that trim antigenic precursors and generate antigens presented by major histocompatibility complex class I (MHC-I) molecules. They thus modulate the antigenic repertoire and drive the adaptive immune response. ERAPs are considered as emerging targets for precision i...
Article
Leishmania spp. are responsible for up to 1 million new cases each year. The current therapeutic arsenal against Leishmania is largely inadequate, and there is an urgent need for better drugs. Trypanothione reductase (TR) represents a druggable target since it is essential for the parasite and not shared by the human host. Here, we report the optim...
Article
The search of new therapeutic tools for the treatment of cancer is being a challenge for medicinal chemists. Due to their role in different pathological conditions, histone deacetylase (HDAC) enzymes are considered valuable therapeutic targets. HDAC6 is a well-investigated HDAC-class IIb enzyme mainly characterized by a cytoplasmic localization; HD...
Article
Autophagy is a lysosome dependent cell survival mechanism and is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Targeting autophagy in cancer therapy attracted considerable attention in the past as stress-induced autophagy has been demonstrated to contribute to both drug resistance and malign...
Article
Telomeres are protective chromosomal ends that shield the chromosomes from DNA damage, exonucleolytic degradation, recombination, and end-to-end fusion. Telomerase is a ribonucleoprotein that adds TTAGGG tandem repeats to the telomeric ends. It has been observed that 85 to 90% of human tumors express high levels of telomerase, playing a crucial rol...
Article
Oral squamous cell carcinomas (OSCC) and esophageal squamous cell carcinomas (ESCC) exhibit a survival rate of less than 60% and 40%, respectively. Late‐stage diagnosis and lack of effective treatment strategies make both OSCC and ESCC a significant health burden. Autophagy, a lysosome‐dependent catabolic process, involves the degradation of intrac...
Article
We developed a Jocic-type protocol for the construction of the pyrrolonaphthoxazepine (PNOX) core. After an initial investigation based on the isolation of a trichloromethyl carbinol derivative, we shifted our attention towards a multicomponent single-step protocol. Screening of a variety of bases and solvents led to the identification of the optim...
Article
Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. Benzoxazepines were recently identified as a novel class of MTAs. These anticancer agents were thoroughly characterized for th...
Article
Full-text available
Here, we have reported an efficient method for the synthesis of β-ketosulfides. A thermodynamically more stable enolate ion is generated from unsymmetrical ketones and reacts predominantly with in situ generated sulfenyl iodide, from various disulfides to give α­sulfenylation products. The base potassium tert-butoxide is used in a solvent mixture o...

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