Tülay Bakırel

• Professor
• Professor at Istanbul University

Purpose: Prunus laurocerasus, is a plant species that grows widely in many regions of our country, especially in the Black Sea Region. The leaves of this plant are frequently used in the treatment of many diseases such as eczema, sore throat, asthma, cough and diabetes in traditional treatment. In the present study, it was aimed to the antioxidant...

Breast cancer resistance protein/ATP-binding cassette subfamily G2 (BCRP/ABCG2) is an ATP-binding cassette efflux (ABC) transporter expressed in the apical membrane of cells in tissues, such as the liver, intestine, kidney, testis, brain, and mammary gland. It is involved in xenobiotic pharmacokinetics, potentially affecting the efficacy and toxici...

Objectives: In this study, the role of ABCG2 in the milk levels of anthelmintic monepantel (MNP) and its main metabolite monepantel sulfone (MNPSO2) was determined using lactating wild-type and Abcg2−/− knockout female mice. Materials-Methods: Lactating mice were injected subcutaneously with 200 mL of oxytocin (1 IU/mL) 10 min prior to sample coll...

In this study, nanoparticles of amoxicillin (AMX) were prepared using chitosan (CHI) and polyethylene glycol (PEG). The physicochemical properties of the particles were investigated by FT-IR, DSC, SEM, and zeta potential analyses. The nanoparticles showed a spherical shape, and the average size of formulations was within the range of 696.20 ± 24.86...

Plant-based compounds have been used for medicinal purposes since ancient times, as easily accessible and low-cost treatment options. Despite the widespread belief that plants are quite safe and devoid of side effects, scientific studies have revealed the toxicity potential of active components of plants on healthy cells. The present study was desi...

This study was designed to investigate in vitro biological activities and phytochemical composition of aqueous and ethanolic extracts from Achillea sintenisii Hub- Mor. (AS). To determine the chemical composition of AS extracts, phytochemical analyses were performed by using HPLC–ESI-Q-TOF-MS-MS. Afterwards, both extracts were investigated in terms...

Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in layer chickens. Fluralaner is frequently used in layers infected with D. gallinae. However, no study to date has investigated the effects o...

This study aimed to evaluate the hyaluronidase and gelatinase inhibitory activities and toxicity potentials of Persea americana Mill. extract and its synthesized hybrid nanoflowers. In the first part of the study, characterization of the nanoflower structures was carried out and then, enzyme inhibitory activities of the methanol extract and hybrid...

Introduction Masitinib mesylate, a selective tyrosine kinase inhibitor of the c-KIT receptor, is used for the treatment of mast cell tumours in dogs. Masitinib has previously been investigated in various cancers; however, its potential anticancer effect in canine mammary tumours (CMTs) is unknown. In the present paper, we investigated the antiproli...

Nanotechnology-based drugs show superiority over conventional medicines because of increased bioavailability, lower accumulation in non-target tissues, and improved therapeutic index with increased accumulation at target sites. However, it is important to be aware of possible problems related to the toxicity of these products, which have therapeuti...

To date, no effective treatment has been found against coronaviruses (CoVs), which have re-emerged with severe acute respiratory syndrome CoV-2 (SARS-CoV-2) and have a high potential for disease in humans as well as domestic and wild animal species. The investigation of treatment options to combat this virus, which has a pandemic character with its...

Tıbbi Ürünlerin içermiş oldukları arzu edilmeyen bileşenlerin belirlenmesi, farmasötik kalitenin teminatı açısından bir ön koşuldur. Tıbbi ürünlerde etkin madde ve yardımcı maddeler dışında kalan herhangi bir bileşen olan safsızlıkların kontrolü ise bu güvencenin en kritik ve kompleks parametrelerinden birisidir. Farklı başlangıç materyalleri kulla...

The present study was designed to evaluate the wound healing activity of the extracts from Quercus coccifera L. Q. coccifera L. is used in the treatment of burns and wounds in traditional medicine. Although the wound healing activities of various Quercus species have been demonstrated previously, no scientific report has been published on the wound...

This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin. Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effec...

Thymus sipyleus Boiss. subsp. rosulans (Borbas) Jalas (TS) is a commonly used plant in the treatment of various complaints, including skin wounds in Turkish folk medicine. Despite the widespread traditional use of TS, there is not any scientific report confirming the effectiveness of this plant on the healing process. This research aimed to investi...

In this study, amoxicillin (AMO)-loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) nanoparticles were prepared as a polymer-based controlled release system. The physicochemical properties of the obtained nanoparticles were investigated by XRD, DSC/TGA, particle size analyses and zeta potential measurements. The average particle sizes were in t...

Amoxicillin is used in the treatment and prevention of a wide range of diseases in poultry breeding. However, its short half‐life and low bioavailability restrict its clinical application in these species. Entrapment of drugs into polymeric nanoparticles (nps) presents a means to improve gastrointestinal absorption and oral bioavailability of drugs...

Currently, there is a growing interest in combining anticancer drugs with the aim to improve outcome in patients suffering from tumours and reduce the long-term toxicity associated with the current standard of treatment. In this study, we evaluated the possible role of deracoxib against the toxicity of doxorubicin on normal canine mammary epithelia...

This study was conducted to compare the pharmacokinetic profiles of conventional (Fungizone®) and liposomal amphotericin B (AmBisome®) formulations in order to predict their therapeutic properties, and evaluate their potential differences in veterinary treatment. For this purpose, twelve healthy mixed breed dogs received both drugs at a dose of 0.6...

The present study was designed for the comparison of the antioxidant activities and total phenolic contents of different extracts obtained from Achillea nobilis subsp. sipylea and Alcea apterocarpa (FENZL) BOISS, which are two endemic species for the flora of Turkey. Plants were extracted using various solvents with different polarities by four ext...

Kanser tedavisinde kemoterapötik ve kemopreventif amaçla kullanılan bileşiklerin hedef hücrelerin yanı sıra sağlıklı hücreler üzerinde de sitotoksik etkilere sebep olduklarının belirlenmesi, araştırmacıları tedaviye bağlı toksisitenin azaltılmasına yönelik çalışmalara yönlendirmiş ve bu doğrultuda kanser sağaltımında bitkisel kaynakların etkinliğin...

Cyclooxygenase (COX) inhibitors have been shown to exert anti-angiogenic and anti-tumor activities on many types of malignant tumors. These anticancer properties make it worthwhile to examine the possible benefit of combining COX inhibitors with other anti-cancer agents. In the present study, we evaluated the potential of deracoxib (DER) in potenti...

İn this Project; Neonicotinoid group pesticides will be examined the effects of on honeybee health and be able to determine whether cause any toxicity. Investigate of these group pesticides levels on sunflower and cotton plants and can be determined how they affect the process by which the honey bees. The field study will be examined the effects of...

In recent years, significant emphasis has been placed on combination chemotherapy in cancer using cytotoxic agents and plant derived-bioactive substances that are capable of selectively arresting cell growth and inducing apoptosis in tumour cells. The present study was undertaken to evaluate the possibility that the combination of curcumin and cycl...

The present study evaluated the effects of doxorubicin (DOX) and deracoxib (DER), as single agents and in combination treatments, on antioxidant parameters in the canine mammary carcinoma cell line CMT-U27. The cells were exposed to DOX and DER for 24, 48 and 72 h. The viability and malondialdehyde (MDA), nitric oxide (NO), catalase (CAT), superoxi...

The aim of the present study is to evaluate the antioxidant and proliferative effects of aqueous and ethanolic extracts of Symphytum officinale. Antioxidant activities of extracts were determined by 2,2- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, superoxide radical scavenging and Folin-Ciocalteu assays. Proliferative effects of the extrac...

Cyclooxygenase (COX) inhibitors, already widely used for the treatment of pain and inflammation, are considered as promising compounds for the prevention and treatment of neoplasia. The aim of our study was to determine the direct antiproliferative effects of nonsteroidal anti-inflammatory drugs (NSAIDs), piroxicam and deracoxib, at a variety of co...

The aim of this study was to evaluate the plasma levels of endotoxin in bitches with pyometra and to investigate the effects of preoperative supportive therapy on plasma endotoxin levels (LPS), the complete blood count, serum biochemistry parameters (alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein, albumin, urea, and crea...

The present study evaluated the effects of doxorubicin (DOX) and deracoxib (DER), as single agents and in combination treatments, on antioxidant parameters in the canine mammary carcinoma cell line CMT-U27. The cells were exposed to DOX and DER for 24, 48 and 72 h. The viability and malondialdehyde (MDA), nitric oxide (NO), catalase (CAT), superoxi...

Rosemary (Rosmarinus officinalis), used in traditional Turkish folk medicine for the treatment of hyperglycaemia, is widely accepted as one of the medicinal herb with the highest antioxidant activity. Accordingly, the present study was designed to investigate the possible actions of ethanolic extract of the leaves of Rosmarinus officinalis on gluco...

The effects of the angiotensin converting enzyme inhibitors benazepril (B), enalapril (E), and ramipril (R) on the function, geometry, and dimensions of the left ventricle (LV) in the dogs with naturally acquired severe mitral regurgitation (MR) were evaluated by echocardiography. Thirty-two dogs, aged 8-16 years and weighing 10-12 kg, with fractio...

The purpose of this study was to evaluate the effect of a combined treatment with carprofen and enalapril on ductus construction in the medical treatment of Golden retriever dogs with PDA which are unable to undergo surgical treatment and have delayed diagnosis. PDA was diagnosed by using Doppler, echocardiography, electrocardiography, X-ray, and b...

The aim of this study was to investigate the presumptive effect of Bromocriptin, which causes antiprolactinemia in mammals, on the broodiness in deeply brooding turkey hens. The effect of Bromocriptin was estimated by considering such broody symptoms as hissing, nesting, cessation of laying, distance between the pelvic bones and blood prolactin val...

Linear alkylbenzene sulphonate (LAS) is among the most widely disseminated xenobiotics to enter waste streams and the aquatic environment. In the present investigation, we present a novel approach to evaluate in toxicity of LAS. The effects of sublethal levels (0.2 and 0.4 mg/l) of LAS on non-specific immune system, phagocytosis, respiratory burst...

This study reports haematological parameters and biochemical changes in liver, kidney, and gill after exposing rainbow trout (Oncorhynchus mykiss) to linear alkylbenzene sulfonate (LAS). Rainbow trout were exposed to LAS for a 54-day period. The three treatments included a control (unexposed), a treatment group I (0.2 mg/L LAS) and treatment group...

The possible pharmacological and toxicological effects of Pistada terebinthus L. in experimentally hypercholesterolemic rabbits were investigated in this study. A total of 28 rabbits were divided into four groups, and these groups were fed diets containing standard pellets (Group 1), cholesterol (2%) (Group II), P. terebinthus L. (1 g/kg body weigh...

Considering the relation between the endocrine and immune systems, the effects of zeranol, a synthetic oestrogen compound, on the growth rate and nonspecific immune system in rainbow trout (Oncorhynchus mykiss, Walbaum) were investigated. For this reason, fish were fed a diet containing 0, 2.5, 5, 10 and 20 ppm zeranol for 21 days. When the data wa...

Trifolium pratense contains phytoestrogens and thus it has estrogenic activity. Estrogen has an important role in the development of the reproductive system and the maintanence of its function, and for this reason the effect of Trifolium pratense on sperm parameters and spermatogenesis was examined. Furthermore, its acute toxicity was established....

Emboli of central nervous tissue were detected in the jugular venous blood of two of 15 sheep stunned with a conventional cartridge-operated captive bolt gun and in two of 15 sheep stunned with a pneumatically activated gun. No emboli were detected in arterial blood from these sheep or in venous blood from sheep stunned electrically. Emboli from an...

Tilmicosin is a long-acting macrolide antibiotic used in the treatment of respiratory disease. It was administered once (50 mg/kg b.wt) to fowls via the oral route for determination of kinetic properties and tissue levels. After oral administration, tilmicosin's pharmacokinetics conformed to a two compartment open model. Tilmicosin was slowly elimi...

The antimicrobial activities of cefquinome and tilmicosin were determined in vitro against P. multocida and O. rhinotracheale of poultry origin by serial broth macrodilution. Both antibiotics exhibited good in vitro antibacterial activity against the strains tested. The minimum inhibitory concentration (MIC) for cefquinome was 1.562 μg/ml and for t...

Some 14 ethanol extracts from 13 plant species collected from various regions of Turkey were assayed for in vitro antibacterial activity against two Gram positive and 5 Gram negative bacteria, using the disc-diffusion and dilution methods. The diameter of the inhibition zone in the disc-diffusion method shows that 12 extracts from the 14 plants stu...

This study was conducted to evaluate the pharmacologic effects of Polygonum lapathifolium L. (Polygonaceae), growing naturally in Turkey. The antiinflammatory activity of the ethanol extract of the root and rhizome of P. lapathifolium was evaluated using carrageenan-induced paw edema in rats. Intraperitoneal pretreatment with extract at doses rangi...

Etkileri Özet Bu araştırma, methimazol'ün ötroid köpeklerin kardiak fonksiyonlarının invaziv parametreleri üzerine olası etkilerinin saptanması amacıyla yapıldı. Çalışmada on adet ötroid köpek kullanıldı. Methimazol (30 mg/kg) uygulanmasından önce ve sekiz hafta sonra serum T 4 , T 3 ve TSH konsantrasyonları ve sol ventrikülün sistolik (LVSP) ve di...