Tsvetoslav Georgiev

Tsvetoslav Georgiev
Medical University of Varna · Department of Internal Medicine

MD, PhD
Associate Editor at Rheumatology International; RI and SoMe Editor of Rheumatology (BG); EMEUNET subcommittee member.

About

51
Publications
154,755
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354
Citations
Introduction
Rheumatologist with interests in osteoarthritis, biomarkers, imaging (ultrasound), SpA, COVID-19. Associate editor at Rheumatology International; secretary of Revmatologiia (Bulgaria); EB member of SN Comprehensive Clinical Medicine; proud EMEUNET member.
Additional affiliations
September 2019 - December 2021
Medical University of Varna
Position
  • Professor (Assistant)
July 2019 - present
University Hospital St. Marina Varna
Position
  • Rheumatologist
January 2019 - July 2019
Serdika Hospital
Position
  • Medical Doctor
Education
April 2013 - May 2018
Medical University of Sofia
Field of study
  • Rheumatology
September 2006 - December 2012
Medical University of Sofia
Field of study
  • Medicine

Publications

Publications (51)
Article
Full-text available
Optimal management of knee osteoarthritis (KOA) should include, where possible, modification of risk factors through targeted interventions. The objectives of the present narrative review were to identify, summarize, and cluster all the potentially modifiable risk factors that influence the course of KOA, and discuss their susceptibility to alterat...
Article
Full-text available
Our aim was to appraise publications from Bulgaria, to assess their global impact, and to describe features and challenges unique to the rheumatology practice in Bulgaria characterized by stringent cost constraints. The Scopus database was queried on 25th July 2018 and data on the number of published documents, their Hirsch-indices and citations nu...
Article
Full-text available
Psoriatic arthritis (PsA) is a pleiotropic inflammatory disease from the spectrum of spondyloarthritides which can potentially affect many organ systems. The chronic nature of the inflammatory milieu presented in rheumatic diseases, is similar to that of atherosclerosis, suggesting a common pathogenic basis. Effector cells of innate and adaptive im...
Conference Paper
Background: Since the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19) (1), our understanding of the underlying pathophysiology is constantly evolving in order to explain the wide range of heterogenic clinical manifestations (2). Nevertheless, limited data are avai...
Conference Paper
Full-text available
Background Bulgaria is among the countries with the lowest vaccination rate of adult population in Europe. The presence of autoimmune rheumatic disease could further contribute to vaccine hesitancy and skepticism and influence patients’ attitudes towards vaccination [1, 2]. However, little is still known about the willingness and particular causes...
Article
Full-text available
Objective: Our aim was to analyze levels of proinflammatory biomarker interleukin-18 (IL-18) in healthy controls and patients with polycystic ovary syndrome (PCOS) focusing on its association with obesity, clinical, hormonal, and metabolic characteristics. Methods: Fifty-eight patients with PCOS were enrolled in the study fulfilling the Rotterda...
Article
Introduction: Ovarian folliculogenesis requires a fine balance between extra- and intra-ovarian factors. Endocannabinoids are found in the female reproductive system and are essential for a normal follicular growing process and ovulation. First, our study aimed to analyze levels of the endocannabinoid-2-arachidonoylglycerol (2-AG)-in patients with...
Article
Background: The endocannabinoid system is involved in the regulation of energy balance and ovarian function and may be implicated in the pathogenesis of polycystic ovary syndrome (PCOS). The purpose of the present study is to determine anandamide (AEA) levels in PCOS patients and controls and to analyze its association with metabolic and hormonal...
Article
Full-text available
MY LIFE AS A CLINICIAN, RESEARCHER AND EDITOR
Article
Full-text available
Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and polymorphisms in the cytokine genes and their receptors are thought to influence its development. The aim of this case–control study was to investigate the association of the IL-17A rs2275913, IL-17RC rs708567 and TGFB1 rs1800469 polymorphisms with SLE, its clinical manif...
Article
Full-text available
Type 2 diabetes (T2D) is one of the most common chronic metabolic disorders in adulthood worldwide, whose pathophysiology includes an abnormal immune response accompanied by cytokine dysregulation and inflammation. As the T2D-related inflammation and its progression were associated with the balance between pro and anti-inflammatory cytokines, antic...
Article
Full-text available
Introduction: The study aimed to analyze clinical data for early-stage knee osteoarthritis, assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire among patients with polycystic ovary syndrome (PCOS) and healthy volunteers and to examine their relationship with hyperandrogenism in PCOS. Methods: The study included 54 pa...
Article
Full-text available
The close link between osteoarthritis (OA) and metabolic disorders on the one hand and hormonal disorders on the other suggests a possible association between OA and endocrine-metabolic disorders, such as PCOS. The aim of this review is to analyze the relationship between PCOS and OA, to consider the common pathogenetic mechanisms between the two c...
Article
Full-text available
Background Recently evolved from a monochromic flu-like disease to a polysyndromic “spectrum of disease”, our understanding of coronavirus disease 2019 (COVID-19) is still far from being complete [1]. Hyperinflammation involving not only the lungs but also the musculoskeletal system, skin, cardiovascular, genitourinary systems is immune-mediated re...
Article
Full-text available
Background Sustainability, the ability of drugs to maintain remission or low disease activity (LDA) in patients with rheumatoid arthritis (RA), plays a crucial role for the prevention of structural damage to joints and thus, preserving patients’ functional capacity, health-related quality of life and general sense of well-being. Therefore, studying...
Article
Full-text available
Background Osteoarthritis (OA) is a slowly progressive disease that probably begins in young adulthood when a timely treatment would present the possibility to reverse or slow down the disease process. Obesity and sex hormones play an essential role in the pathogenesis of OA in women and their influence on joint function persists throughout the who...
Article
Introduction: OBJECTIVES: Our aim was to analyze the link between hyperandrogenism and early clinical manifestations of osteoarthritis (OA), knee cartilage thickness, and serum cartilage oligomeric matrix protein (sCOMP) levels in patients with polycystic ovary syndrome (PCOS) and to compare them with healthy volunteers. Methods: Fifty-four PCOS...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) pandemic has become challenging even for the most durable healthcare systems. It seems that vaccination, one of the most effective public-health interventions, presents a ray of hope to end the pandemic by achieving herd immunity. In this review, we aimed to cover aspects of the current knowledge of severe acute...
Poster
Full-text available
Introduction: Two of the most studied members of the endocannabinoid system (ECS) are arachidonoyl ethanolamide (anandamide, AEA) and 2-arachidonoyl glycerol (2-AG). The ECS has been confirmed to have effects on metabolism, energy and appetite control, ovarian function, and woman reproduction. Its role in polycystic ovary syndrome (PCOS) pathogene...
Article
Full-text available
Introduction. Sarcopenia or muscle atrophy is a common feature of many chronic diseases of the musculoskeletal system including those accompanied by chronic low back pain (LBP). Purpose. The aim of the study was to evaluate the morphological changes of the muscles in the lumbosacral region in patients with axial spondyloarthritis (AxSpA) who underw...
Poster
Full-text available
Introduction: Polycystic ovary syndrome (PCOS) has been associated with a variety of proinflammatory conditions such as obesity, type 2 diabetes, dyslipidemia, hypertension, and metabolic syndrome. Interleukin-18 (IL-18) is a strong proinflammatory biomarker. Our goal was to analyze the IL-18 levels in PCOS patients and to determine which parameter...
Article
Full-text available
The expectations from any future disease-modifying treatment for knee osteoarthritis (KOA) are extremely high as it has to impact the joint as a whole leading to favorable alterations of diverse tissues and functions. In this light, targeting the knee only from the inside may not be biologically justified for the management of a whole joint disease...
Article
Full-text available
Objective: To evaluate serum matrix metalloproteinase (MMP)-3 levels as a prognostic marker for the progression of cartilage damage in patients with knee osteoarthritis (KOA). Methods: Fifty-six patients who met the ACR criteria for KOA, were included in a one-year observational prospective clinical study. Complete baseline and follow-up data were...
Article
Full-text available
Recent advances in our understanding of coronavirus disease 2019 (COVID-19) and the associated acute respiratory distress syndrome might approximate the cytokine release syndrome of severe immune-mediated disease. Importantly, this presumption provides the rationale for utilization of therapy, until recently reserved mostly for autoimmune diseases...
Conference Paper
Full-text available
Background: Osteoarthritis (OA) is a leading cause of disability worldwide and pain is its cardinal symptom. Ranging from structural injuries to central sensitization, multifactorial mechanisms play an important role in pain perception in patients with knee OA (KOA) defining a discrepancy between pain and structural damage. Imaging modalities such...
Article
Full-text available
Purpose: Our study aims at assessing the clinical effectiveness and comparing treatment response in patients injected with intra-articular high-molecular-weight cross-linked hyaluronic acid (HMWHA) or platelet-rich plasma (PRP) in the routine clinical practice. Methods: Fifty-one consecutive patients aged 40 to 80 years were included in this open-l...
Article
A significant place in the treatment of osteoarthritis (OA) is taken by physical therapy. Its modalities may be grouped into the following three categories, which could be used alone or in combination: 1) physiotherapeutic (preformed); 2) kinesitherapeutic; 3) resort-climatic (natural) means. The purpose of this review is to outline the place of ph...
Conference Paper
Full-text available
Background Hyaluronic acid (HA) is a natural polysaccharide, which is an important structural component of synovial fluid and cartilage. There are different injectable forms of HA used for clinical application. Highly cross-linked/high-molecular-weight hyaluronans (HMWHA) provide additional stability and improve functionality [1], resulting in long...
Article
Full-text available
Objectives Although knee osteoarthritis (KOA) is a leading cause of impaired functioning among older adults globally, little is still known about the complex mechanisms of disability accumulation in these patients. The aim of the study was to analyze the clinical parameters of patients with KOA in a Bulgarian population and to determine which of th...
Article
Full-text available
The aim of the present study was to investigate the relationship between CRP and clinical parameters of the disease, including quality of life of patients with knee osteoarthritis (KOA) in Bulgarian population. 132 patients (81% female) with symptomatic KOA (mean age of 63.45 years) and 31 healthy volunteers were included in the study. Their clinic...
Conference Paper
Full-text available
Background Extrusion of the medial meniscus is a consequence of the complex interactions among joint structures and altered tissue mechanics involved in the osteoarthritis (OA) process.[1] Potential contributing factors are cartilage loss, meniscal tears, obesity and knee malalignment [2–4] – features strongly associated with knee OA. Ultrasound (U...
Article
Full-text available
Biochemical markers reflecting joint remodeling in osteoarthritis (OA) are a promising diagnostic tool. The aim of this study was to investigate serum levels of candidate biomarkers in subjects with and without knee OA and assess their correlation with clinical parameters and knee structural damage. 56 patients with primary knee OA and 31 healthy c...
Article
Cartilage oligomeric matrix protein (COMP) is an oligomeric tissue-specific glycoprotein synthesized by chondrocytes. It represents structural damage in knee OA observed by imaging modalities such as radiography and MRI. The purpose of this study was to correlate serum COMP levels with MRI-detected structural damage of different joint elements in p...
Article
There is a wide variety of tools to measure different aspects of health in patients with knee osteoarthritis (KOA). These include the visual analogue scale for determining pain intensity, disease-specific self-reported questionnaires or interviews, and generic questionnaires for overall health assessment, which evaluate quality of life and the degr...
Article
Full-text available
Introduction. Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disorder characterized by axial and peripheral joint involvement as well as extra-articular manifestations such as skin and nail disease, enthesitis, dactylitis, uveitis, etc. Given the broad clinical spectrum, the assessment of the natural course, activity, therapeut...
Data
The article analyzes the opportunities of combining homogeneous data derived from diversified sources of information. The emphasis in the analysis is placed on the possibility of applying parametric empirical Bayesian methods for the purposes of medical diagnostic tests for purposes of medical analysis of various diseases or in studies on the impac...
Article
Full-text available
The article analyzes the opportunities of combining homogeneous data derived from diversified sources of information. The emphasis in the analysis is placed on the possibility of applying parametric empirical Bayesian methods for the purposes of medical diagnostic tests for purposes of medical analysis of various diseases or in studies on the impac...
Article
Osteoarthritis is a degenerative joint disease characterized by loss of joint cartilage, projections along the bone edges (osteophytes) and changes in the underlying bone (subchondral osteosclerosis), and a number of biochemical and morphological changes, involving both the synovial membrane and joint capsule and periarticular structures. It is the...
Conference Paper
Full-text available
This paper concerns the reliability assessment of sensors networks, shaped in line with hierarchic structures. Proper reliability indices for this purpose are suggested and mathematically expressed. An approach to reliability assessment of sensor networks is also suggested and applied to two case studies concerning medical purpose implementation an...
Conference Paper
Full-text available
This paper concerns the reliability assessment of sensors networks, shaped in line with hierarchic structures. Proper reliability indices for this purpose are suggested and mathematically expressed. An approach to reliability assessment of sensor networks is also suggested and applied to two case studies concerning medical purpose implementation an...
Article
Остеоартрозата (OA) е най-честото заболяване, водещо до ставна болка, придружена в различна степен от функционален дефицит и намалено качество на живот. ОА е бавен, прогресиращ и инвалидизиращ процес с висока честота в човешката популация. Според статистически данни тя засяга 12-15% от възрастното население, а във възрастта над 75 години от ОА стра...
Article
Full-text available
Summary. Plain film radiography still remains the “gold” standard in the assessment of knee osteoarthritis. It is a two-dimensional projection of three-dimensional joint structures. Radiographic changes include joint space narrowing, formation of osteophytes, subchondral osteosclerosis and cysts, deformity of the bone contour to complete ankylosis....
Article
Full-text available
In this article is looking for adequate solution of the task to the unification of uniform information from diverse sources for purposes of medical analysis of the research of various diseases or the impact of new drugs on the state of patients.
Article
During the last few years, the expenses for therapy number with biological agents of patients with RA are progressively increasing due to the increased of cases undergoing biological treatment. This pattern is one of the main causes for increased expenditure on the part of the National Health Insurance Fund. There are several problems that make the...
Article
Intraarticular application of hyaluronans improves the biomechanical properties of the osteoarthritis synovial fluid restoring its viscosity and elasticity. Over the past years attention has also been paid to antiinflammatory and anti-nociceptive properties of the hyaluronic acid which are not quite fully understood yet. The total clinical effect i...
Article
The main feature of osteoarthritis is the disruption of the articular cartilage induced by complex interaction of genetic, metabolic, biochemical and biomechanical factors followed by secondary inflammation. The process includes increased levels of catabolic processes of the cartilage and suboptimal reparative response to its destruction. Although...
Article
The contemporary concept of osteoarthritis (OA) considers the disease a pathological process which involves whole joint structure - cartilage, synovium, subchondral bone, ligaments and periarticular muscles. Changes in these tissues are an essential part of the pathogenic mechanisms of the disease and present an interesting target for research of p...
Article
Vitamin D3 is part of the group of fat-soluble vitamins and controls the calcium concentration in the blood and in the bones. Researchers present more and more data concerning its effects that reach far beyond what is known by now. Before the era of antibiotics sunbathing was part of the treatment against infections such as tuberculosis. Today it i...

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Projects (3)
Project
To study COVID-19 and its complex interactions with rheumatic diseases