Tsung Ming Chen

Tsung Ming Chen
Taipei Medical University | TMU · Department of Otolaryngology

About

40
Publications
10,124
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
689
Citations

Publications

Publications (40)
Article
Background We sought to compare the clinical outcomes of Taiwanese patients with resected oral cavity squamous cell carcinoma (OCSCC) who underwent reconstruction with free versus local flaps.Methods From 2011 to 2017, we examined 8646 patients with first primary OCSCC who received surgery either with or without adjuvant therapy. Of these patients,...
Article
Importance There is currently no system to predict 90-day morality among patients with locally advanced head and neck squamous cell carcinoma (HNSCC) after the completion of concurrent chemoradiotherapy (CCRT). Objective To validate the accuracy of a predictive scoring system for 90-day mortality among patients with locally advanced HNSCC who have...
Article
Full-text available
Rationale: Human papillomavirus (HPV)-related oropharyngeal cancer is becoming more common, the primary cancer AQ4 usually occult and appearing only as cystic cervical lymph node (LN) metastasis. Distinguishing between a benign cystic lesion and cystic LN metastasis is challenging given their similar radiologic and histologic appearances. Patient...
Article
Full-text available
Purpose: To propose a risk classification scheme for locoregionally advanced (Stages III and IV) head and neck squamous cell carcinoma (LA-HNSCC) by using the Wu comorbidity score (WCS) to quantify the risk of curative surgeries, including tumor resection and radical neck dissection. Methods: This study included 55,080 patients with LA-HNSCC receiv...
Article
Full-text available
Background Few studies have evaluated the risk of oral cavity cancer (OC) in patients with recurrent oral aphthae (ROA) and dry eye syndrome (DES). This study assessed the risk of OC in patients who had received diagnoses of ROA and DES in Taiwan. Methods A population-based frequency-matched case–control study was conducted in which data were anal...
Article
Full-text available
Background Recurrent aphthous stomatitis (RAS) is considered a prophase symptom in patients with specific cancers. This study assessed the association between RAS and subsequent onset of cancer based on a nationwide population‐based database in Taiwan. Materials and Methods We selected study participants from the National Health Insurance Research...
Article
Background: Treatment for metastatic nasopharyngeal carcinoma (NPC) is challenging. Till now, a truly effective chemotherapy regimen for NPC has not yet been identified. These clinical observations prompted us to investigate a potential drug as alternative option for treating. Purpose: This study evaluated the inhibitory effects of Ovatodiolide...
Article
Background: No large-scale, head-to-head, phase III, randomized, controlled trial with an adequate sample size has investigated the effect of concurrent low-dose (LD) or high-dose (HD) cisplatin with radiotherapy on nasopharyngeal cancer (NPC). Thus, we conducted a propensity-score-matched, nationwide, population-based cohort study in Taiwan to in...
Article
Objectives Although patients with buccal squamous cell carcinoma (SCC) usually show acceptable outcomes, local control and survival rates are generally lower than those observed for tongue SCC. This study was designed to compare the clinical outcomes of Taiwanese patients with these two common oral cavity malignancies. Methods Patients with first...
Article
Full-text available
We examined the overall survival rates of a national cohort to determine optimal treatments and prognostic factors for patients with metachronous second primary head and neck squamous cell carcinomas (mspHNSCCs) at different stages and sites. We analyzed data of mspHNSCC patients collected from the Taiwan Cancer Registry database. The patients were...
Article
Full-text available
Background The National Comprehensive Cancer Network guidelines recommend that patients with oral cavity squamous cell carcinoma (OSCC) and cT4b disease should be either included in clinical trials or treated with a nonsurgical approach. However, surgery may be feasible in selected patients with adequate safety margins. Using the nationwide Taiwane...
Article
Full-text available
For locally advanced head and neck squamous cell carcinoma (HNSCC), therapeutic decisions depend on comorbidity or age. We estimated the treatment outcomes of patients with different Charlson comorbidity index (CCI) scores and ages to determine whether aggressive treatment improves survival.Data from the Taiwan National Health Insurance and cancer...
Article
Full-text available
The use of induction chemotherapy (CT) is controversial. We compared the survival of head and neck cancer patients receiving docetaxel- or platinum-based induction CT before concomitant chemoradiotherapy (CCRT) with the survival of those receiving upfront CCRT alone. Data from the National Health Insurance and cancer registry databases in Taiwan we...
Article
Full-text available
Patients with head and neck cancer are treated through surgery, radiotherapy (RT), and chemotherapy (CT). Carotid artery damage and neurotoxicity were previously observed in these patients. This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with long-term follow-up. Taiwan's Na...
Article
Full-text available
Globus pharyngeus and dysphagia are common complaints of patients referred to ear, nose, and throat (ENT) clinics. We aimed to establish an efficient method to rule out the presence of malignancy in patients with globus pharyngeus and dysphagia. The use of flexible transnasal esophagoscopy (TNE) was evaluated in 30 patients with globus pharyngeus a...
Article
Myeloid sarcoma in a patient with myelodysplastic syndrome (MDS) manifesting as a non-healing tonsillar ulcer is an extremely rare occurrence. We report the case of a 57-year-old male smoker with a non-healing tonsillar ulcer who underwent tonsillectomy to rule out tonsillar carcinoma after failed antibiotic therapy. On postoperative day 2, he pres...
Article
Full-text available
The objective was to demonstrate the aerobic and anaerobic microbiology of deep neck space abscess and to analyze the coverage rate of different empiric antimicrobial agents. A retrospective review of hospitalized patients with deep neck abscess diagnosed at a tertiary-care, general hospital between April 2001 and October 2006. The study enrolled 1...
Article
A case of sarcomatoid carcinoma of the parotid gland is described in a 47-year-old male. Despite radical surgery and postoperative chemoradiation therapy, a distant metastasis occurred 1 month after treatment. The primary site was composed of well-differentiated squamous cell carcinoma intermingled with spindle-shaped malignant mesenchymal cells. I...
Article
Full-text available
Oncocytic schneiderian papilloma (OSP), also known as cylindrical cell papilloma, is a rare benign sinonasal neoplasm. Due to its rare incidence, this disease is not well-understood by clinicians. The probability of malignancies arising in OSP is not low but they are rarely encountered in clinical practice. To the best of our knowledge, there is no...
Article
Full-text available
Renal cell carcinoma (RCC) is the most common malignant neoplasm of the kidney,and metastasis in head and neck areas are rarely described. We describe four cases ofmetastatic RCC in the head and neck areas treated between January 1995 and December2004. The metastatic sites included the basal region of the tongue, parenchyma of the bilateralparotid...
Article
Deep neck infections are not uncommon; however, a migrating fish bone is seldom a cause of a deep neck abscess. Fish bones are a sharp foreign body and can penetrate the oropharynx or esophagus. However, this rarely occurs. We report a case of deep neck abscess resulting from the intracorporeal migration of a fish bone. Initial radiography and esop...
Article
To evaluate various prognostic factors and the impact of imaging modalities on tumor control in patients with nasopharyngeal cancer (NPC) with cranial nerve (CN) palsy. Between September 1979 and December 2000, 330 NPC patients with CN palsy received radical radiotherapy (RT) by the conventional opposing technique at Chang Gung Memorial Hospital-Li...
Article
We report a case of extrathyroid carcinoma showing thymus-like differentiation (CASTLE) tumor. A 47-year-old man had a left neck mass that gradually enlarged over approximately 3 months. Sonography and CT scans showed a soft tissue mass located at the left parapharyngeal space with displacement of left carotid artery and submandibular gland. After...
Article
Nasopharyngeal carcinoma (NPC) has a high rate of neck lymph node and/or distant metastasis. We evaluated the value of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in staging NPC, especially in the detection of distant metastasis. A total of 95 patients, including 85 with primary and 10 with recurrent, NPC were enrolled. Dual-pha...
Article
Full-text available
This prospective, nonrandomized, case-control study evaluated the impact of (18)F-FDG PET in staging untreated squamous cell carcinoma of the buccal mucosa (BSCC) and compared the results with CT/MRI and histopathology. Between January 2002 and April 2004, 102 untreated BSCC patients with cM0 (no evidence of distant metastatic focus on chest radiog...
Article
This prospective, nonrandomized, case-control study evaluated the impact of F-18-FDG PET in staging untreated squamous cell carcinoma of the buccal mucosa (BSCC) and compared the results with CT/MRI and histopathology. Methods: Between January 2002 and April 2004, 102 untreated BSCC patients with cM0 (no evidence of distant metastatic focus on ches...
Article
F-18 fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scanning has been used to evaluate nasopharyngeal carcinoma (NPC). However, with positive FDG uptake in the contiguous paranasal sinus, it may be difficult to differentiate tumor invasion from an inflammatory process. We describe such a patient with NPC in whom an FDG PET scan r...
Article
Deep neck infections are not uncommon; however, a migrating fish bone is seldom acause of a deep neck abscess. Fish bones are a sharp foreign body and can penetrate theoropharynx or esophagus. However, this rarely occurs. We report a case of deep neckabscess resulting from the intracorporeal migration of a fish bone. Initial radiography andesophago...
Article
Telomerase activity has been found to be associated with many cancers, including head and neck squamous cell carcinoma (HNSCC). We examined the association of telomerase activity with the clinical outcome of patients with HNSCC. A PCR-based enzyme immunoassay method was used to measure telomerase activity in 217 matched (grossly normal and cancerou...
Article
The aim of this study was to evaluate the outcome of patients with Verrucous carcinoma (VC) of oral cavity treated at the Chung Gung Memory Hospital with respect to the tumor control rates after surgery, the risk of lymph node metastasis and the role of radiation therapy. Thirty-eight patients underwent primary treatment for VC of the oral cavity f...

Network

Cited By