Tsubasa Matsuoka

Hakubaku Co., Ltd. · Research and Development Department

Objective Barley, abundant in β-glucan, a soluble dietary fiber, holds promise in obesity prevention. Given the microbial metabolism of dietary fiber in the gastrointestinal tract, we investigated the role of gut microbiota in non-obese individuals consuming high levels of barley. Methods Our study enrolled 185 participants from “The cohort study...

Barley is rich in β-glucan, which can alter gut microbiota and metabolome profiles, potentially affecting host metabolism. However, the microbiota and metabolites increased by barley β-glucan remain unclear. In this study, we focused on the gut-microbiota-derived metabolite succinate and investigated the microbiome and metabolome profiles altered b...

Background: Barley, a grain rich in soluble dietary fiber β-glucan, is expected to lower blood pressure. Conversely, individual differences in its effects on the host might be an issue, and gut bacterial composition may be a determinant. Methods: Using data from a cross-sectional study, we examined whether the gut bacterial composition could exp...

Background and objectives: Barley mixed rice, "Mugi gohan," is traditionally eaten with yam paste in Japan. Both ingredients contain dietary fiber and reportedly reduce postprandial hyperglycemia. However, evidence supporting the benefits of combining barley mixed rice with yam paste is limited. In this study, we evaluated whether ingesting a comb...

(1) Background: Consumption of barley has been known to exert beneficial effects on glucose tolerance; however, it has also been reported that there are inter-individual differences in these responses. Recent evidence has suggested that these individual differences are mediated by the gut microbiota. (2) Methods: In the present study, we aimed to u...

Background Barley reportedly reduces postprandial hyperglycemia in healthy individuals. However, its effects in patients with type 2 diabetes mellitus (T2DM) undergoing antidiabetic therapy remains unclear. This study aimed to clarify the effects of barley intake on postprandial hyperglycemia in T2DM patients who use metformin or acarbose.MethodsT2...

Barley is a grain rich in β-glucan, a soluble dietary fiber, and its consumption can help maintain good health and reduce the risk of metabolic disorders, such as dyslipidemia. However, the effect of barley intake on the risk of dyslipidemia has been found to vary among individuals. Differences in gut bacteria among individuals may be a determining...

Background Barley contains abundant soluble beta-glucan fibers, which have established health benefits. In addition, the health benefits conferred by the gut bacteria have attracted considerable interest. However, few studies have focused on the barley consumption and gut bacteria of the Japanese population. In this study, we aimed to identify the...

Objective: Barley contains abundant soluble β –glucan fibres, which have established health benefits. In addition, the health benefits conferred by the gut microbiota have attracted considerable interest. However, few studies have focused on the barley intake and microbiota of the Japanese population. In this study, we aimed to identify the relatio...

Consumption of barley has been known to exert beneficial effects on metabolic disorders; however, it has also been reported that there are inter-individual differences in these responses. Recent evidence has suggested that these individual differences are mediated by the gut microbiota. Therefore, in the present study, we aimed to understand the re...

The prebiotic effect of high β-glucan barley (HGB) flour on the innate immune system of high-fat model mice was investigated. C57BL/6J male mice were fed a high-fat diet supplemented with HGB flour for 90 days. Secretory immunoglobulin A (sIgA) in the cecum and serum were analyzed by enzyme-linked immunosorbent assays (ELISA). Real-time PCR was use...

We evaluated whether intake of β-glucan-rich barley flour affects expression levels of genes related to glucose and lipid metabolism in the ileum, liver, and adipose tissues of mice fed a high-fat diet. C57BL/6J male mice were fed a high-fat diet supplemented with high β-glucan barley, for 92 days. We measured the expression levels of genes involve...

Objective: Foods reducing postprandial hyperglycemia could suppress the postprandial blood glucose response after the next meal (a "second-meal" effect). However, the second-meal effect of refined barley flour bread has not been evaluated. The aim of this study is to determine whether consumption of refined barley flour bread reduces postprandial...

Recently, the flavor wheels of many beverages like coffee and tea have been developed to express their characteristic taste and flavor. However, barley tea has not yet been characterized. In this study, we aimed to identify the flavor and taste characteristics of barley tea by analytical sensory evaluation and gas chromatography-olfactometry (GC-O)...

Background: Several health foods are available in the market for their ability to mitigate modern high-calorie diets. Coffee and many kinds of teas are expected to reduce calories and help control body weight because these beverages contain rich polyphenols (tannins, flavonoids and catechins). Sorghum tea is available in the market as such a bevera...

Background: Overeating is a common problem for humans in modern life. One option to decrease food intake is to consume plant-derived polyphenols during meals. Because studies have observed impaired digestion and absorption in farm animals fed sorghum, sorghum tea, containing rich polyphenols, may be suitable for this purpose at meals. We performed...

The present study investigated the effect of β-glucan-rich barley on metabolic syndrome related indicators in Japanese men and women. Fifty Japanese men and women whose BMI was 27.8 ± 3.1 were selected. This study was carried out according to randomized, single-blind, and placebo-controlled procedures. Subjects were randomly assigned to either 30%...

The objective of this study was to examine the effect of ingestion of Japanese noodles containing barley flour on blood sugar levels. Ten patients with mild type 2 diabetes were selected to eat Japanase noodles (the placebo meal) and Japanese noodles containing barley flour (the test meal) which had a high beta glucan concentration. Blood sugar and...

山梨県における水稲有色素米の安定生産技術を確立するために, 施肥体系, 収穫時期, 粒厚について検討した. 赤米 「西南赤精 137 号」, 緑米 「緑万葉」 ともに施肥体系は収量性, 耐倒伏性などから窒素基肥量を 5 kg/10a, 減数分裂期の追肥を 2~ 4 kg/10a が適していた. 収穫適期は, 収量性, 玄米外観品質, 機能性成分含量から 「西南赤橋 137 号」 は出穂期からの積算気温 900 C 程度,「緑万葉」 は 800~ 900 C であることを明らかにした. 粒厚選別は 1.7 mm 以上において, 玄米外観品質などを低下させることなく, 玄米収量を増やすことができた.

小麦フスマ高含有のビスケットの排便改善効果を検討した。小麦フスマ高含有ビスケットを20歳前後の女子学生38名に1日当たり42 g（食物繊維量で7.5 g）摂食させ，排便状況に及ぼす影響について検討した。試験方法は摂食期間前の1週間から排便状況に関するアンケートを毎日記入させ，被験食は2週間摂取させた。小麦フスマ高含有ビスケットの小麦フスマ配合量は47%，食物繊維含量17.8%であった。その結果，排便日数，排便量共に摂食1週目から有意に上昇し（P < 0.05），2週目には排便量が摂食期間前1週間の2倍以上になった（P < 0.01）。層別解析を行った結果，排便日数は摂食1週目から有意に上昇し（P < 0.01），排便量も摂食2週目には事前と比べて有意差を認めた（P < 0.01）。

We conducted studies to select barley cultivars potentially useful for roasted barley tea. First, we analyzed the properties of barley grain; and then we roasted the grains of each barley cultivar to a similar level of darkness. The properties of the barley grain were then statistically compared with those of roasted barley. We found a high negativ...

Plant regeneration using the genetic transformation method often induces somatic mutation as well as epigenetic alteration. In addition, methods commonly used for grapevine (Vitis vinifera L) transformations are time-consuming due to the long reproductive cycle of the grapevine. Therefore, an improved method is needed for more efficient grapevine t...