Trudy Voortman

Trudy Voortman
Erasmus MC and Wageningen University

Nutritional Epidemiology

About

233
Publications
30,313
Reads
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Citations
Introduction
In my research group, we study the role of nutrition and lifestyle in health throughout the life-course, i.e. from pregnancy and infancy to old age, with a particular focus on cardiometabolic health and on pathways underlying effects of nutrition on disease risk. Projects include systematic reviews and studies using data from population-based prospective cohort studies, including the Generation R Study and the Rotterdam Study. // See for further information: https://www.trudyvoortman.com/
Additional affiliations
June 2015 - December 2015
Harvard University
Position
  • PostDoc Position
January 2014 - present
University of Cambridge, UK / Leiden University College, the Netherlands / International Conference on Biomedical Sciences, Albania
Position
  • Guest lecturer
Description
  • University of Cambridge: lectures on maternal & child health - Leiden University College: lectures on childhood obesity - ICBMS Albania: Teacher and course coordinator Understanding Medical Research for Health Professionals
May 2012 - present
Erasmus MC
Position
  • PhD Student
Description
  • In my research I focus on nutrition and cardiometabolic health. Projects include both systematic reviews and studies using data from Generation R, a birth cohort study in Rotterdam. In addition, I supervise the thesis work of BSc, MSc and DSc students.
Education
August 2012 - August 2014
Netherlands Institute for Health Sciences (NIHES)
Field of study
  • Epidemiology
September 2009 - August 2011
Wageningen University & Research
Field of study
  • Nutrition & Health
September 2006 - August 2009
Wageningen University & Research
Field of study
  • Nutrition & Health

Publications

Publications (233)
Article
Background: There is concern about a reemergence of vitamin D deficiency in children in developed countries. Objectives: The aims of this study were to describe vitamin D status in the Generation R study, a large multiethnic cohort of 6-y-old children in The Netherlands, and to examine sociodemographic, lifestyle, and dietary determinants of vitami...
Article
Early life factors may influence kidney growth and function throughout the life course. We examined the associations of breastfeeding duration and exclusivity and age at introduction of solid foods with kidney outcomes at school age. Prospective cohort study from fetal life onward. 5,043 children in the Netherlands. Infant feeding was assessed pros...
Article
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Obesity is highly heritable. Genetic variants showing robust associations with obesity traits have been identified through genome-wide association studies. We investigated whether a composite score representing healthy diet modifies associations of these variants with obesity traits. 32 BMI- and 14 waist-hip ratio (WHR)-associated SNPs were genotyp...
Article
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Background: Previous studies suggest that high protein intake in infancy leads to a higher body mass index (BMI) in later childhood. We examined the associations of total, animal and vegetable protein intake in early childhood with detailed measures of body composition at the age of 6 years. Methods: This study was performed in 2911 children par...
Article
Background & aims: High protein intake has been linked to increased type 2 diabetes (T2D) risk. However, if this association differs by protein from specific food sources, and if a habitual high protein intake affects insulin resistance and prediabetes risk are largely unknown. We aimed to investigate associations between protein intake from diffe...
Article
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Purpose To assess the association between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet and the incidence of open-angle glaucoma (iOAG), as well as the association between iOAG and two other well-established diets in the Netherlands, i.e., the Mediterranean diet and Dutch dietary guidelines. Methods In the Rotterdam S...
Article
Background: MicroRNAs (miRNAs) represent a class of non-coding RNAs that regulate gene expression and are implicated in the pathogenesis of different diseases. Alcohol consumption might affect the expression of miRNAs, which in turn could play a role in risk of diseases. Objective: We investigated whether plasma concentrations of miRNAs are alte...
Article
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Background Multimorbidity poses a major challenge for care coordination. However, data on what non-communicable diseases lead to multimorbidity, and whether the lifetime risk differs between men and women are lacking. We determined sex-specific differences in multimorbidity patterns and estimated sex-specific lifetime risk of multimorbidity in the...
Preprint
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Trimethylamine N-oxide (TMAO) is a circulating microbiome-derived metabolite implicated in the development of atherosclerosis and cardiovascular disease (CVD). We investigated whether plasma levels of TMAO, its precursors (betaine, carnitine, deoxycarnitine, choline) and TMAO-to-precursor ratios associate with clinical outcomes, including CVD and m...
Article
Studies on mice have shown a relationship between dietary intake of advanced glycation end-products (dAGEs) and deterioration of musculoskeletal health, but human studies are absent. We investigated the relationship between dietary intake of carboxymethyllysine (dCML) – an AGE prototype – and risk of sarcopenia at baseline and after 5 years of foll...
Article
Context Predicting the onset of menopause is important for family planning and to ensure prompt intervention in women at risk of developing menopause-related diseases. Objective To summarize risk prediction models of natural menopause onset and their performance. Data Sources and Study Selection Five bibliographic databases were searched up to Ma...
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Previous studies suggest that nitric oxide is involved in the regulation of the intraocular pressure (IOP) and in the pathophysiology of open-angle glaucoma (OAG). However, prospective studies investigating the association between dietary nitrate intake, a source of nitric oxide, and incident (i)OAG risk are limited. We aimed to determine the assoc...
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Objectives Evidence regarding dietary phytoestrogens in relation to mortality remains limited and mixed. We aimed to examine associations of dietary intake of total and subclasses of phytoestrogens, specifically: isoflavones, lignans, and coumarins, with total and cause-specific mortality in US men and women. Methods We prospectively followed 75,9...
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Purpose Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms. Methods We included randomized...
Article
Maternal pregnancy fatty acid status is associated with child health. Epigenetic gestational age acceleration, referring to a discrepancy between chronological and epigenetic gestational age, may underlie these associations. Previous research suggests that analysing fatty acid patterns rather than individual fatty acids may overcome the caveat of m...
Preprint
Dietary patterns in childhood have been associated with child neurodevelopment and cognitive performance, while the underlying neurobiological pathway is unclear. We aimed to examine associations of dietary patterns in infancy and mid-childhood with pre-adolescent brain morphology. We included 1888 and 2326 children with dietary data at age one or...
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Full-text available
DNA methylation (DNAm) has been reported to be associated with many diseases and with mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction. We performed an epigenome-wide association study of whole blood DNAm in relation to mortality in 15 cohorts (n = 15,013). During a mean follow-up...
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Food-approach eating behaviors are associated with an increased risk of developing overweight/obesity and binge-eating disorder, while obesity and binge-eating disorder have also been linked with altered brain morphology in adults. To understand these associations, we examined the association of food-approach eating behaviors during childhood with...
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Purpose Diet is an important determinant of cardiometabolic disease risk in adults. We aimed to study associations of diet quality with cardiometabolic health in school-age children. Methods This study was embedded in the Generation R Study a prospective population-based cohort in Rotterdam, the Netherlands and included 3991 children. Food intake...
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Educational inequalities in all-cause mortality have been observed for decades. However, the underlying biological mechanisms are not well known. We aimed to assess the role of DNA methylation changes in blood captured by epigenetic clocks in explaining these inequalities. Data were from eight prospective population-based cohort studies, representi...
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Several lifestyle factors have been linked to risk for heart failure (HF) and premature mortality. The aim of this study was to estimate the impact of a healthy lifestyle on life expectancy with and without HF among men and women from a general population. This study was performed among 6113 participants (mean age 65.8 ± 9.7 years; 58.9% women) fro...
Article
Background Accumulation of advanced glycation end products (AGEs) in tissues has been linked to various age-related disease phenotypes. Therefore, we investigated the potential relationship between skin AGEs accumulation and frailty. Methods A cross-sectional analysis was performed on 2521 participants from Rotterdam study. Skin AGEs were assessed...
Preprint
DNA methylation (DNAm) has been reported to be associated with many diseases and mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction.We performed an epigenome-wide association study of whole blood DNAm in relation to mortality in 15 cohorts (n=15,013). During a mean follow-up of 10 y...
Article
Full-text available
Urinary metabolic profiling is a promising powerful tool to reflect dietary intake and can help understand metabolic alterations in response to diet quality. Here, we used 1H NMR spectroscopy in a multicountry study in European children (1147 children from 6 different cohorts) and identified a common panel of 4 urinary metabolites (hippurate, N-met...
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Evidence suggests neutral or moderately beneficial effects of dairy intake on type 2 diabetes mellitus risk. Nevertheless, evidence on associations with early phases of type 2 diabetes remains inconsistent. We aimed to examine associations between dairy-type intake with prediabetes risk and longitudinal insulin resistance. The analytic sample consi...
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Background Adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has been linked to a decreased risk of dementia, but reverse causality and residual confounding by lifestyle may partly account for this link. We aimed to address these issues by studying the associations over cumulative time periods, which may provi...
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The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our “modern” postwar societies globally characterized by rural-to-urban migration, modernization of agricultural practices, and transportation, climate chan...
Article
Introduction: The disease burden of nonalcoholic fatty liver disease (NAFLD) increases rapidly, in line with the obesity pandemic. Physical activity has been linked to a lower risk of NAFLD. However, the impact of different intensities of activity and sedentary behavior and whether their effects on NAFLD are explained by metabolic health remain un...
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Background Children with Autism Spectrum Disorders (ASD) tend to be selective in their food intake which may compromise their diet quality. While ASD diagnoses capture severe levels of impairment, autistic traits vary on a continuum throughout the population. Yet, little is known about how autistic traits relate to diet quality at the population le...
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Background Type 2 diabetes (T2D) is a heterogeneous disease with well-known genetic and environmental risk factors contributing to its prevalence. Epigenetic mechanisms related to changes in DNA methylation (DNAm), may also contribute to T2D risk, but larger studies are required to discover novel markers, and to confirm existing ones. Results We p...
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Background Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas. Recently, DNA methylation-based inference of alcohol consumption from blood was reported with high accuracy, but these results were based on employing the same dataset for model training and testing, which ca...
Article
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Background Diet has been suggested to play a role in determining the age at natural menopause; however, the evidence is inconsistent. Objective We systematically reviewed and evaluated published research about associations between diet and onset of natural menopause (ONM). Methods We searched 6 databases (Medline, Embase, Cochrane, PubMed, Web of...
Article
Nutritional approaches are considered a promising strategy for dementia prevention, but the composition of an optimal neuroprotective diet remains undetermined. The Mediterranean‐ DASH Intervention for Neurodegenerative Delay (MIND) diet has been developed which contains food components that are thought to be specifically neuroprotective. However,...
Preprint
Full-text available
Even though physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Here, we combine data for up to 674,980 individuals from 51 studies in a trans-ancestry meta-analysis of genome-wide association studies for self-reported moderate-to-vigorous intensity physical activity d...
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Physical inactivity is a major public health problem, and there are concerns this might have increased during the COVID-19 pandemic. We aimed to identify distinct trajectories of physical activity over a 6-week period after the first restrictive measures and to explore determinants of these trajectories in a population-based cohort of middle-aged a...
Article
Introduction Blood pressure has been suggested as potential factor contributing to the increased risk of cardiovascular disease observed in women experiencing early menopause (<45 years). However, whether the association between early menopause and hypertension is causal remains unclear (1,2). Purpose To evaluate the observational and causal assoc...
Poster
Background Obesity is a well-established risk factor for incident atrial fibrillation (AF). Whether different body fat depots differentially associate with AF development remains largely unknown. Purpose We aimed to investigate the associations between various body fat depots and the risk of new-onset AF among middle-aged and elderly individuals f...
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Background Observational studies have reported associations between serum phosphate and body mass index (BMI) in specific clinical settings but the nature of this relation in the general population is unclear. Objective The aim of this study was twofold: to investigate the association between serum phosphate and BMI and body composition, and to ex...
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Objectives Menopause is accompanied by huge metabolic changes, increasing the risk of cardiometabolic diseases. The impact of diet, as a modifiable lifestyle factor, on cardiovascular health in general populations has been well established. The purpose of this systematic review is to summarize the evidence on the effects of whole diet on lipid prof...
Article
Aims Data on the lifetime risk of type 2 diabetes (T2D) incidence across different cardiovascular health (CVH) categories are scarce. Moreover, it remains unclear whether a genetic predisposition modifies this association. Methods and results Using data from the prospective population-based Rotterdam Study, a CVH score (body mass index, blood pres...
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Full-text available
Observational studies suggest that early onset of menopause is associated with increased risk of hypertension. Whether this association is causal or due to residual confounding and/or reverse causation remains undetermined. We aimed to evaluate the observational and causal association between age at natural menopause (ANM) and blood pressure traits...
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Background Emerging evidence suggests beneficial impacts of plant-based diets on glucose metabolism among generally healthy individuals. Whether adherence to these diets is related to risk of gestational diabetes mellitus (GDM) is unknown. Objectives We aimed to examine associations between plant-based diets and GDM in a large prospective study....
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Population-based studies suggest a role for dairy, especially yogurt, in the prevention of type 2 diabetes (T2D). Whether dairy affects T2D risk after myocardial infarction (MI) is unknown. We examined associations of (types of) dairy with T2D incidence in drug-treated, post-MI patients from the Alpha Omega Cohort. The analysis included 3401 patien...
Article
Background & aims Dietary intake of several specific macronutrients have been linked to risk of coronary heart disease (CHD). However, this association may depend on overall macronutrient composition rather than one single macronutrient. Therefore, we aimed to investigate the associations of macronutrient intake and CHD and its related risk factors...
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Full-text available
Aims Lifestyle changes, such as increasing physical activity (PA), are a cornerstone of treatment of patients with chronic heart failure (HF). However, improving PA in HF patients is challenging, and low participation rates for cardiac rehabilitation (CR) as well as relapse to low PA levels after CR are major issues. We designed a randomized contro...
Article
Background - Carbohydrate responsive element binding protein (ChREBP) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus have separately been linked to high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations. We hypothesized SSB...
Preprint
Full-text available
Educational inequalities in mortality have been observed for decades, however the underlying biological mechanisms are not well known. We assessed the mediating role of altered aging of immune cells functioning captured by DNA methylation changes in blood (known as epigenetic clocks) in educational associated all-cause mortality. Data were from eig...
Article
Full-text available
Importance: Previous studies have indicated that gut microbiome may be associated with development of type 2 diabetes. However, these studies are limited by small sample size and insufficient for confounding. Furthermore, which specific taxa play a role in the development of type 2 diabetes remains unclear. Objective: To examine associations of...
Article
Context Adult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent at young age. Objective To study associations between child’s adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8,...
Article
Objectives Dietary patterns (DPs) in childhood have been associated with neurodevelopmental disorders and cognitive performance in children. However, little is known about the underlying neurobiological mechanisms. We aimed to examine associations of DPs in early and mid-childhood with pre-adolescent brain morphology in a large population-based coh...
Article
Full-text available
Objectives Previous studies suggest a positive association between coffee consumption and liver health, yet the evidence available is not unequivocal. Given the burden of liver disease, we studied the relationship of habitual coffee consumption with serum biomarkers of liver health and non-alcoholic fatty liver disease (NAFLD) incidence. Methods W...
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Objectives Given its popularity, there is an increasing interest in the study of coffee intake and its effect on health. Previous studies linked coffee consumption to lower type 2 diabetes (T2D) risk. However, potential underlying mechanisms remain unclear. We hypothesized that coffee's effects on systemic inflammation may play a role. We studied c...
Article
Objectives Children with Autism Spectrum Disorders (ASD) tend to have sensory disturbances and behavioral rigidity which may predispose them to be selective in their food intake, potentially compromising their nutritional status. While ASD captures severe levels of impairment, autistic traits vary on a continuum throughout the general population. Y...
Article
Full-text available
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 ×...
Article
Introduction: Dairy consumption, especially yogurt, and circulating biomarkers of dairy fat (odd chain fatty acids, OCFAs), have been associated with a lower risk of type 2 diabetes (T2D) in population-based studies. Whether these associations are also present in post-myocardial infarction (MI) patients is unknown. Hypothesis: We hypothesized that...
Article
Background: Coffee intake has been linked to lower type 2 diabetes (T2D) risk. We hypothesized this may be mediated by coffee’s effects on inflammation. Methods: Using participants from the UK Biobank (UKB n=145370) and Rotterdam Study (RS n=7172) cohorts, we studied associations of coffee intake with incident T2D; longitudinally measured insulin r...
Article
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Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of di...
Article
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Background Previous studies have suggested that insufficient concentrations of vitamin D are associated with dental caries in primary teeth, but evidence remains inconclusive. Objectives We assessed the longitudinal associations between prenatal, perinatal, and early childhood serum 25-hydroxyvitamin D concentrations [25(OH)D] and the risk of dent...
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Full-text available
The aging population faces two conditions that threaten healthy aging: high fat mass (obesity) and low muscle mass and function (sarcopenia). The combination of both—referred to as sarcopenic obesity—synergistically increases the risk of adverse health outcomes. The two conditions often co-occur because they reinforce each other and share common et...
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Previous studies showed that prolonged breastfeeding increases the risk of caries. However, the observed associations were mainly based on non-European populations, and important confounding and mediating factors like socioeconomic position (SEP) and diet were often neglected. The aim of this study was to investigate the role of breastfeeding and b...
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Background Chronic axonal polyneuropathy is a common, usually multifactorial disease and there is no treatment available yet. We investigated the association between cardiovascular health, defined by the health score of the American Heart Association, and chronic axonal polyneuropathy. Methods Between June 2013 and January 2017, we investigated pa...