Trinh Phan-CanhMax Perutz Labs | MFPL · Department of Medical Biochemistry
Trinh Phan-Canh
PhD Student in Medicine
Molecular pathogenesis and drug resistance mechanisms of Candida auris
About
11
Publications
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Introduction
TRINH Phan-Canh is currently a PhD Student at Max Perutz Labs Vienna, Medical University of Vienna. Trinh does research in host-pathogen interactions and molecular mechanisms of antifungal resistance. You can find his portfolio at phancanhtrinh.com
Additional affiliations
March 2016 - July 2020
Education
August 2015 - January 2018
September 2010 - September 2015
Publications
Publications (11)
Repression of retrotransposition is crucial for the successful fitness of a mammalian organism. The domesticated transposon protein L1TD1, derived from LINE-1 (L1) ORF1p, is an RNA-binding protein that is expressed only in some cancers and early embryogenesis. In human embryonic stem cells, it is found to be essential for maintaining pluripotency....
Polymicrobial co- and superinfections involving bacterial and fungal pathogens pose serious challenges for diagnosis and therapy, and are associated with elevated morbidity and mortality. However, the metabolic dynamics of bacterial–fungal interactions (BFI) and the resulting impact on disease outcome remain largely unknown. The fungus Aspergillus...
Intraspecies variations that affect pathogenicity and antifungal resistance traits pose a serious obstacle to efficient therapy of Candida auris infections. Recent reports indicate that mutations determine drug susceptibility and virulence. However, mutations alone cannot fully explain a bewildering variety of phenotypes in clinical isolates from k...
Repression of retrotransposition is crucial for the successful fitness of a mammalian organism. The domesticated transposon protein L1TD1, derived from LINE-1 ORF1p, is an RNA-binding protein that is expressed only in some cancers and early embryogenesis. In human embryonic stem cells it is found to be essential for maintaining pluripotency. In can...
Repression of retrotransposition is crucial for the successful fitness of a mammalian organism. The domesticated transposon protein L1TD1, derived from LINE-1 ORF1p, is an RNA-binding protein that is expressed only in some cancers and early embryogenesis. In human embryonic stem cells it is found to be essential for maintaining pluripotency. In can...
The pronounced skin tropism and pan-antifungal resistance traits of the fungal pathogen Candida auris stand out as a serious health threat. Here, we show that a carbonic sensing pathway (CSP) promotes development of resistance to amphotericin B through a reactive oxygen species (ROS) response, as well as ectopic cell wall and membrane lipid homeost...
The surge in antimicrobial drug resistance in some bacterial and fungal pathogens constitutes a significant challenge to health care facilities. The emerging human fungal pathogen Candida auris has been particularly concerning, as isolates can display pan-antifungal resistance traits against all drugs, including echinocandins.
Candida albicans is a normal component of the human microflora that colonizes mucosal/epithelial surfaces and the gastrointestinal tract as a commensal organism. However, in an immunocompromised host, it can cause life-threatening infections of high mortality and morbidity. Virulence as well as antifungal drug resistance of C. albicans is often reg...
Asteraceae species were widely applied in traditional medicines in Asian countries as sources of natural antioxidants and antimicrobial agents. This study aimed to evaluate DPPH-scavenging capacities and antimicrobial activities of nine Asteraceae species collected from Southern Vietnam. Antioxidant and antimicrobial activities were determined by s...
Questions
Questions (5)
Hi everyone,
I am working with gene deletion on Candida auris. I transformed my cassette constructed by Fushion PCR into C. auris. I got a lot of clones comparing negative control plates.
Now I am screening by colony PCR. My problem is the target deletion clone is so rare, it took me a lot of time.
Do you know how to improve the efficiency of homologous recombination in Candida?
Thank you very much!
I install autodock vina plus in Pymol - Mac OS 10.12.6, but I can't load it. Please support me a solution!
Thanks so much!
I read a paper from PNAS (http://www.pnas.org/content/101/46/16222). They used a lysis buffer with high amount of PVP (6,3g/5mL). It is very viscous, I can't take it by pipet!!!
To each gram of separated cells or whole-sponge tissue ground in liquid nitrogen was added 5 ml of lysis buffer containing 100 mM Tris·HCl (pH 8), 1.4 M NaCl, 20 mM EDTA, 2 ml of CTAB solution at 55°C, 100 μl of 10% SDS, 350 μl of 100 mM diethyldithiocarbamate (DETC), 100 μl of mercaptoethanol, 6.3 g of polyvinylpyrrolidone, 10 mg of lysozyme, and 500 μg of proteinase K.
Please support me in the case. I have read a Rhizopus clinical case.
Generally, I think Rhizopus spp., Mucor spp. is Zygomycetes species, which haven't septa. However, in this picture, Rhizopus sp. have many septa.
I am testing urease activity to identify Trichophyton? The result shows in below picture (4 days culture). Which tubes are negative and positive?
