Touhami Lanez

• Professor
• Lab Supervisor at University of Eloued

The aim of the present study was to evaluate the antioxidant capacity and the total phenolic content of propolis extract, obtained from colonies of honeybees located in El-Oued (south of Algeria). The total phenolic content was evaluated using the Folin-Ciocalteu method and the antioxidant capacity was measured using the following methods: 2, 2-dip...

Cyclic voltammetry was used to explore the interaction of (ferrocenylmethylamino) benzonitrile (FMAB) with superoxide anion radical (\({\text{O}}_{2}^{. - }\)), electrochemically generated by the reduction in commercial molecular oxygen in acetonitrile. The difference in the electrochemical behavior of \({\text{O}}_{2}^{. - }\) in the absence and p...

Starting from a readily available building block, two straightforward diastereoselective approaches to functionalized 3¢- methyl-branched carbocyclic nucleoside analogues of neplanocin F and abacavir bearing different purine bases are described. The key steps are a regioselective allylic hydroxylation in the first approach and a ring opening of a c...

The present study examined the antioxidant activity of methanolic extracts of propolis samples from different regions of Algeria. Total phenol content (TPC) was determined by using Folin-Ciocalteau Reagent. Total flavonoid content (TFC) was determined by using aluminum chloride method. Resulting ranged between (210.884±0.754-19.626±0.301 mg/100g) a...

In the title compound, [Fe(C5H5)(C15H16NO)], the two cyclo­penta­dienyl (Cp) rings are nearly parallel to each other, forming a dihedral angle of 3.7 (1)°, and adopt a staggered conformation. The amide group is almost perpendicular to the plane of the substituted Cp ring, with a C—N—C—C torsion angle of 101.3 (2)°, and the N and O atoms in the etha...

This study investigates the binding of ferrocenylmethyl nucleobase derivatives to DNA through electrostatic interactions, employing a combination of experimental and theoretical approaches to elucidate binding mechanisms and explore their potential for DNA targeting. UV–Vis spectroscopy and cyclic voltammetry (CV) were used to evaluate binding affi...

The rise of antimicrobial resistance poses a major public health threat by reducing the efficacy of treatments against infections in humans, animals, and plants. This study evaluates the antibacterial potential of three ferrocenylmethylaniline derivatives: Ferrocenylmethylaniline (FMA), N-Ferrocenylmethyl-N-acetylaniline (FMAA), and N-Ferrocenylmet...

The present study has investigated the binding interactions of four N‐ferrocenylmethyl‐nucleobase derivatives: N1‐ferrocenylmethyladenine (FcMeAd), N1‐ferrocenylmethyl‐cytosine (FcMeCy), N1‐ferrocenylmethylthymine (FcMeTh), and N6,9‐bis(ferrocenyl‐methyl)adenine ((FcMe)2Ad), with human hemoglobin (HHb) and bovine serum albumin (BSA). A combination...

This study presents the synthesis and characterization of a novel series of ferrocenylmethylnucleobase compounds, namely, FcMeAd, FcMeCy, FcMeTh, and (FcMe)₂Ad with promising antioxidant and antidiabetic properties. Spectroscopic techniques confirmed their sandwich‐like geometry, with the nucleobase moiety coordinated to the ferrocene unit. Density...

This study presents the synthesis, computational analysis, and bioevaluation of a new series of ferrocenylmethylnucleobase complexes (FcMeAd, FcMeCy, FcMeTh, and (FcMe)2Ad) designed for potential antioxidant and antidiabetic applications. The synthesized complexes were characterized using a range of spectroscopic and electrochemical techniques, inc...

Background The study focuses on evaluating the parasitic potential of novel metronidazole analogs using computational methods. Specifically, it aims to target key enzymes of oral anaerobes, including UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) of Fusobacterium nucleatum and DNA topoisomerase (Topo) of Prevotella intermedia. Objective...

The utilization of medicinal plants for therapeutic purposes has been deeply rooted in traditional medicine practices. In this study, we focus on the extraction, Gas Chromatography-Mass Spectrometry (GC/MS) analysis, and evaluation of antidiabetic activity of essential oils derived from two indigenous medicinal plants native to the southern region...

The present study aims to evaluate the pesticidal potential of a series of novel silichristin analogues isolated from silybum marianum using in silico approaches, focusing on their effects on the 4-hydroxyphenylpyruvate dioxygenase (HPPD) and acetylcholinesterase (AChE) receptors. A combinatorial library of 729 silichristin derivatives was construc...

Nickel tetraphenyl‐porphyrin (NiTPPH₂) and zinc tetra(4‐methophenyl)‐porphyrin (ZnTPPH₂(p‐methyl)) were successfully synthesized and characterized using ¹ H NMR spectroscopy. Their antioxidant activities and interactions with the superoxide anion radical () were evaluated using cyclic voltammetry. Remarkably, NiTPPH₂ displayed superior antioxidant...

Objective An investigation on the antioxidant activity and ADME properties of some N-phenylalkanehydrazides (NPhs) in comparison with ascorbic acid was carried out. Materials and Methods The power of the compounds to scavenge the superoxide anion radical was examined using cyclic voltammetry. Furthermore, molecular docking was used to examine how...

This study presents an in silico investigation into the potential DNA binding properties of novel derivatives of N-(Acetylphenyl)-N-Ferrocenylmethylnitroaniline using different computational techniques, including molecular docking and ADME/Toxicity assessment, we explored the interaction between these derivatives and DNA. The results reveal promisi...

The superoxide anion radical scavenging activities of a series of twenty-eight ferrocenylmethylaniline derivatives were measured in an in vitro study followed by in silico studies which included quantitative structure-activity relationship (QSAR), toxicity prediction, molecular docking studies, and molecular dynamics simulations. Multilinear regres...

Gadolinium aluminium garnet (Gd 3 Al 5 O 12) nanopowders, with 30 at% lutetium substitution have been successfully synthesized using the co-precipitation method. Several sources, such as aluminium nitrate or sulphate, have been used to develop the (Gd 0.7 Lu 0.3) 3 Al 5 O 12 (GdLuAG) compound via normal and reverse add titration using ammonium hydr...

The investigation employed cyclic voltammetry (CV) assays to assess the scavenging efficacy of two recently developed compounds, namely meso-tetramethophenyl-porphyrin TPPH2(o-methyl) and mesotetrabiphenyl- porphyrin (TbiPPH2), against the superoxide anion radical ( �� ._). The IC50 values derived from the CV assays indicated significant scavenging...

Afzelin has been designed and tested for its in silico antibacterial activity against DNA gyrase complex of Staphylococcus aureus. The results of the toxicity study indicate that afzelin displayed moderate antibacterial potential against staphylococcus aureus with LD50 = 5000 mg/Kg, which is almost four times and a half weaker than that obtained fo...

The present study investigates the electrostatic binding interactions between ferrocenylmethylnitroaniline derivatives and DNA using a combination of experimental and theoretical approaches. The objective is to elucidate the binding mechanisms and evaluate the potential of these derivatives as DNA-targeting agents. Experimental techniques, includ...

Overactivation of the NOX results in an excess production of ROS, which is linked to oxidative stress and deoxyribonucleic acid (DNA) damage. Free radical formation is a physiological event mainly coming from cellular respiration. Inflammatory diseases, cardiovascular diseases, and cancer are only some illnesses that this could trigger. Therefore,...

N-ferrocenylmethylaniline (FA) and its N-acetylated derivative (NFA) have been synthesized and fully characterized by various physicochemical techniques such as 1H and 13C NMR spectroscopy, their interactions with chicken blood DNA (CB-DNA) were studied by cyclic voltammetry (CV) and molecular docking (MD). The obtained results suggested that both...

This manuscript reports the binding of N’-ferrocenylmethyl-N’-phenylbenzohydrazide (FhD) with deoxyribonucleic acid (DNA) studied by absorption spectroscopy and cyclic voltammetry. DFT calculations were also performed and revealed important physical characteristics of the FhD compound. Subsequently, the system was explored by computational molecula...

Obtaining hybrid materials, such as composite materials, represents a contemporary research challenge as researchers strive to create new materials with advanced structural, optical, and thermal properties. Algeria is blessed with abundant date palms, which generate substantial cellulosic residues, contributing to environmental pollution when left...

Supporting information

The antioxidant and the DPPH free radical scavenging activity of 4-phenyl-3H-1,2-dithiole-3-thione (DT1), 5-(4-fluorophenyl)−3H-1,2-dithiole-3-thione (DT2), 5-(4-phenyl-3-thioxo-3H-1,2dithiol-5-yl)-benzo[d]oxazole-2(3H)thione (DT3) and 4-methyl-5-((phenylamino)methyl)−3H-1,2-dithiole-3-thione (DT4) was investigated using cyclic voltammetry (CV) and...

In this study, two solvents with different polarity were used in the extraction of the dried powdered roots of the plant Juncus rigidus; ethanol, acetone, during two different growth stages : ripening period (November) and flowering period (April). Total phenolics, total flavonoids, and total flavanols contents were evaluated using the colorimetric...

One of the major challenges in type 2 diabetes is the inhibition of the enzyme alpha‐amylase, since many molecules targeting this enzyme based on or derived from medicinal plants have been synthesized to counteract the α‐amylase action. The present study investigated the in‐vitro and in‐silico antidiabetic capacities of three flavonol glucosides ob...

The interaction of the protein structure of α‑amylase and α‑glucosidase extracted from the protein data bank (PDB Code: 3BC9; 3W37) with ligands N-Ferrocenyl-methylaniline (FMA), N-Ferrocenylmethyl-N-4-nitrobenzoyl-aniline (4FMNBA) and N-Ferrocenylmethyl-N-acetylaniline (FMAA) were investigated by performing docking studies using AutoDock Tools 4.2...

The objective of the current work is to extract a new mucilage fraction from Astragalus gyzensis Bunge. seeds, which are collected from the El-Oued province (septentrional Algerian Sahara) and evaluated for their antidiabetic potential. The mucilage fraction is obtained using hot water extraction followed by alcoholic precipitation of polysaccharid...

Afzelin has been designed and tested for its in silico antibacterial activity against DNA gyrase complex of Staphylococcus aureus. The results of the toxicity study indicate that afzelin displayed moderate antibacterial potential against staphylococcus aureus with LD50 = 5000 mg/Kg, which is almost four times and a half weaker than that obtained fo...

In the current study, molecular geometry, electronic structure, effect of the substitution, and structure physical-chemistry relationship for Quercetin derivatives have been studied by DFT (B3LYP) theory and Hartree-Fock (HF). The calculated values, net charges, MESP contours/surfaces have also been drawn to explain the electronic reactivity of Que...

Marine macroalgae biomass is a valuable renewable resource that can be used for the development of bioeconomy through the valorisation of valuable compounds. The aim of the current study is separate macroalgal polysaccharides with bioactive properties from brown macroalgae Fucus spiralis based on a designed biocascading biorefinery approach. Thus,...

The inhibition effect of meso-tetraphenyl-porphyrin (TPPH2), meso-tetra4-methophenyl-porphyrin TPPH2(p-Me), and meso-tetra4-actophenyl-porphyrin (TAcPPH2) on the corrosion of XC52 mild steel in aerated 0.5 M aqueous sulfuric acid solution was studied by potentiodynamic polarization experiments and quantum chemical calculations. Results from potenti...

Date palm ( Phoenix dactylefera L. ) fibers, which are natural wastes, have been recovered and exploited in the synthesis of composite materials by mixing them with two different polymers: polyvinyl chloride (PVC) and polystyrene (PS). The four samples were characterized using infrared spectroscopy (FTIR), water absorption rate (W) measurements, th...

This paper explores the synthesis, characterization and electrocatalytic behavior of a new ferrocenyl-substituted tetradentate Nickel Schiff base complex. The complex, N,N-Bis[5-(N,N-ferrocenmethylaminophenyl)methylsalicylidyne]-1,2-diaminoethane of nickel(II) ((Fc-Me-Ani)2-LNiII), was prepared by heating the tetradentate Schiff base ligand ((Fc-Me...

The antioxidant activity of 3-nitrophenylferrocene (3NPF) and 3,3'-nitrophenylferrocene (3,3'NPF) and their reduced amines was measured using superoxide anion radical (2O −. ). Binding parameters such as binding free energies and binding constants were also calculated. delta G sign and values suggest respectively the spontaneity and a strong intera...

Breast cancer is the most common cancer in women in front of colorectal cancer and lung cancer. Ferrocene derivatives have proved their efficiency against breast cancer cells. In this thesis we aimed to find new ferrocene derivatives having pharmacochemistry properties as potential drugs against human breast cancer cells. A series of 29 N-ferroceny...

The main goal of this work is the preparation of potentially biologically active compounds and evaluating their antioxidant and anticancer activities. In this context, a series of 2, 3, and 4-benzonitrilferrocene were prepared by the coupling reaction between ferrocene and the diazonium salts of the corresponding cyanoaniline. Cyclic voltammetry a...

Cyclic voltammetry (CV) assays were performed to measure superoxide anion radical (O2•-) scavenging activities of six novel N-ferrocenylmethyl-N-(nitrophenyl)-acetamides and N-fer-rocenylmethyl-N-(cyanophenyl)acetamides (FMA1-FMA6), followed by molecular docking simulations and in silico toxicity prediction. The obtained values of IC50 from CV assa...

Pour sa (leur) participation au SÉMINAIRE INTERNATIONAL SUR LES SCIENCES DE LA MATIERE (PHYSIQUE ET CHIMIE) en ligne (webinaire), organisé par Algerian Journal of Engineering, Architecture and Urbanism le 17 et 18 Septembre 2021, avec un poster intitulé: Electrochemical, spectroscopic and molecular docking studies of Nferrocenylmethyl-4-nitroanilin...

Electronic structures, the effect of the substitution, structure physicochemical property/activity relationships and drug-likeness applied in pyrazine derivatives, have been studied at ab initio (HF, MP2) and B3LYP/DFT (density functional theory) levels. In the paper, the calculated values, i.e., NBO (natural bond orbitals) charges, bond lengths, d...

Main protease (Mpro) of SARS-CoV-2 is a key CoV enzyme that plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for SARS-CoV-2 the new strain of coronavirus. In this study, we evaluated biologically active compounds present in medicinal plants as potential SARS-CoV-2 Mpro inhibitors, using a mo...

Background Since the binding of estradiol to its receptor promotes breast cancer cell proliferation (in the ER+ tumours), many molecules targeting this protein have been synthesized to counteract the estradiol action. Ferrocene derivatives have proved their efficiency against hormone-dependent breast cancer cells (MCF-7). Objective In this study,...

Synthèse et étude de l'activité antioxydante et antimutagène de quelques porphyrines H2TPP(o,p-methoxy) et H2TPP(p-acetyl)

This work include several advanced molecular docking tools to study the interactions of our newly synthesized 1,3,4-thiadiazole derivatives in the active site of penicillin binding protein and DNA gyrase against Staphylococcus aureus, the enzymes targeted for antimicrobial agents. Results such as MolDock scores, binding energies, residue binding di...

This work aims to determine structural, crystal properties and molecular spectroscopy of three N-ferrocenylmethyl-N-phenylamide using DFT method. The computed bond lengths, bond angles and dihedral angles of the titled molecules were calculated and compared with the experimental geometrical parameters, the amount of positive and negative charges us...

Optimization of experimental conditions of formic acid recovery from its aqueous solution by a liquid-liquid extraction, with alcohols, was carried out in this study. The effect of each parameter governing the process such as: pH of aqueous solution, partition coefficient and initial concentration on acid, volume ratio between phases and temperatur...

The enzyme Leucine-rich repeat kinase 2 (LRRK2) has become a target of therapeutic interest in Parkinson research.Athree-dimensional quantitative structure-activity relationships(3D-QSAR) study was performed on twenty six azaindazole derivatives as LRRK2 inhibitorsobtained using rigid body alignment (Distill). CoMFA and CoMSIA model shave achieved...

We have studied the binding interaction of N-ferrocenylmethyl-2-nitroaniline (2FMNA), N-ferrocenylmethyl-3-nitroaniline (3FMNA), and N-ferrocenylmethyl-4-nitroaniline (4FMNA) with bovine serum albumin (BSA) by absorption spectroscopy, cyclic voltammetry, and molecular docking techniques. The results indicated that these derivatives could bind to BS...

The binding affinity of 2-ferrocenylbenzonitrile (2FBN) and 4-ferrocenylbenzonitrile (4FBN) with bovine serum albumin (BSA) has been investigated by cyclic voltammetry, absorption spectroscopy and molecular modelling techniques. The results indicated that both of the two derivatives could bind to BSA and cause conformational changes with the order...

Three ferrocenylmethylnucleobases (FcMeNb) were synthesized and characterized by cyclic voltammetry, electronic absorption, FT-IR and NMR spectroscopy. The energy of frontier molecular orbitals was determined using DFT/B3LYP method combined with 6-311++G(d,p) basis set in acetonitrile. The lower standard rate constant values of the FcMeNb compounds...

Licence: CC BY-NC-ND 4.0 Citation information: ZEGHEB, NADJIBA; Elhafnaoui, LANEZ; Lanez, Touhami (2020): N-ferrocenylmethyl-Derivatives As Spike Glycoprotein Inhibitors Of SARS-CoV-2 Using In Silico Approaches. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.12278078.v1 Background and Objectives: By the end of 2019, a novel human coronaviru...

p> Background and Objectives: By the end of 2019, a novel human coronavirus outbreak started in Wuhan and spread to the world becoming a global pandemic, patients were diagnosed with severe respiratory syndrome. Studies have shown that SARS-CoV2 interact with angiotensin-converting enzyme 2 (ACE2), its host cell receptor, by its Spike Glycoprotein....

Macrolide antibiotics have been the focus of widespread research due to increasing bacterial resistance. Structure elucidation of a large number of macrolides, shows the existence of two parts. The first one is a macrocyclic system from 12 to 40 links with a lactone function; the second part is a sugar. Conformational analysis indicates that each s...

This formation certificate Has been successfully attended at the IPPM'20 in the workshop on Synthesis, characterization, applications, and challenges of new materials

Binding parameters of the interaction of 3-Nitrophenylferrocene (3FcNO2) with DNA, has been measured by cyclic voltametry (CV) and electronic spectroscopy (Uv-Vis). The obtained results were validated by molecular docking (MD) using AutoDock Tools software. CV results further indicated that 3FcNO2 interact to DNA by hydrogen bonding with binding co...

Ferrocene derivatives families have attracted the scientists‘ attention based on all chemical and physical characterizations that have it. In addition, these compounds widely used in different fields in particular biomedical applications. in this investigation have been studied the binding affinity of title compound with DNA using electrochemical a...

In the title compound, [Fe(C5H5)(C12H11N2O2)], the two cyclopentadienyl (Cp) rings are nearly eclipsed and parallel to each other, the dihedral angle between their mean planes being 2.54 (1) . One of the Cp rings is substituted by a nitrobenzenamine group, which is essentially perpendicular to the substituted cyclopentadienyl ring, with an N—C(H2)—...

Background An electrochemical method based on cyclic voltametry techniques was used to measure the antioxidant activity of two ferrocene-nucleobases. Objective The present study aims to measure the antioxidant activity of two ferrocene derivatives bearing nucleobases; the technique is based on the reaction of the in-situ electrochemical generated...

Dear colleagues, By releasing the volume 11, Issue 3 on the 1st of September 2019, we mark the 10th anniversary of the Journal of Fundamental and applied sciences (JFAS); we want to share with you this very special celebration. On behalf of JFAS’s Editors, Editorial Board, and on my own, we thank you heartly for your continuous support. Without the...

The first part of this work is an overlook on ferrocene derivatives-DNA and BSA interactions. The binding free energies of ferrocene derivatives with double-stranded DNA and BSA were determined using cyclic voltammetry and electronic spectroscopy techniques under similar conditions. Binding free energy values obtained from cyclic voltammetry were v...

Background Meso-tetra-4-actophenyl-porphyrin (TAcPPH2) was synthesized by reacting 4- acetyl-benzaldehyde with pyrrole in propionic acid, and used as a ligand for the synthesis of palladium (II) complex (PdTAcPP). The structure of the ligand and the complex were characterized by NMR and electronic spectroscopy. Methods he antioxidant activity and...

In this work, we present a docking study of new ferrocene derivatives (3CPF) with DNA using AutoDock 4.2 software. In addition, this work has been performed by following three steps 1) molecular optimization 2) target preparation 3) visualizing the nature of interactions.

The antioxidant activity of N’-méthylferrocéyl-N'-phénylaceto-hydrazide was surveyed utilizing spectrophotometrical and electrochemical technics. We used 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) for the Spectrophotometrical measures and the cyclic voltammetry assays were supported activity by measuring the reaction peak current of comparatively...

In this paper we present the synthesis and the evaluation of the antioxidant activity of meso-tetra-p-tolylporphyrin (TPPH 2 (p-methyl)) using superoxide anion radical. 2 (O)  in DMF as a solvant. The binding parameters of the interaction between the synthesised compound and the radical. 2 O  were also measured using cyclic voltammetry techniques...

The aim of this stydy was to examine the interaction of DNA with the ligand N,N-dimethylaminomethylferrocene (NDF) in buffer phosphate solution (pH = 7.2) by electronic spectroscopy, electrochemical and molecular docking technics. The electrochemical results showed that the binding constant and free binding energy of the addauct DNA-NDF is equal to...

The aim of this stydy was to examine the interaction of DNA with the ligand N,N-dimethylaminomethylferrocene (NDF) in buffer phosphate solution (pH = 7.2) by electronic spectroscopy, electrochemical and molecular docking technics. The electrochemical results showed that the binding constant and free binding energy of the addauct DNA-NDF is equal to...

Herein we describe the determination of binding parameters of the interaction of N'-ferrocenylmethyl-N'-phenylacetohydrazide (FcA) and N'-ferrocenylmethyl-N'-phenyl-propionohydrazide (FcP) derivatives with chicken blood double-stranded DNA (cb-ds DNA) in phosphate buffer (PB) solution at physiological pH 7.2 by electronic spectroscopy and molecular...

This study aims to establish a group of heterogeneous organic compounds of porphyrin and derived compounds. This is useful for many medical fields such as phototherapy or industrial therapy, namely dyes and OLED screens. On this basis, we assembled a group of six compounds and a group of their compounds with different metals (Zn, Co, Cu, Fe and Pd)...

Molecular docking calculations were used to evaluate the antitumor activities of N-ferrocenylmethyl-N-phenylpropanamide (FP) and N-ferrocenylmethyl-N-pheylbenzohydrazide (FH) against the enzymes of breast cancer 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) and human steroidogenic cytochrome P450 17A1 prostate cancer mutant A105L (CYP17A1)...

Qualitative and Quantitative structure-activity relationship (QSAR) studies have been performed on twenty-three molecules of 1,3,4-Thiadiazole derivatives. The compounds used are among the most tubulin inhibitors. A multiple linear regression (MLR) procedure was used to design the relationships between molecular descriptor and tubulin inhibition of...

L'objectif de notre étude est de synthétiser le dérivé N-ferrocénylméthylaniline résulte de l’incorporation d’un motif ferrocénique dans le squelette de base de l’aniline et d’évaluation in silico, in vitro et in vivo de leur activité biologique. L’étude in silico et in vitro de l’interaction ADN-FMA montre qu’il y a une interaction spontanée entre...

Octanol/water partition coefficients P of several substituted ferrocene were calculated on the basis of the adaptation of the existing XlogPv2.0 approach. The predict of calculated partition coefficients values for selected ferrocenes derivatives were compared with known experimental values taken from literature .the shown results confirmed that th...

Pesticides are among the most potentially hazardous compounds to human, animals, and the environment, they can damage the environment and accumulate in ecosystems and cause serious disturbances. Although they have highly specific actions, some pesticides are capable of interacting with cellular structures directly or after processing by metabolic e...

The current work aims in its first part to synthesize 3-nitrophenylferrocene after diazotizing nitroaniline in the meta position by the sodium nitrite and the formation of the corresponding diazonium salt: 3-nitrobenzendiazonium sulfate, then the salt in solution was added to the ferrocene for the purpose of introducing the nitrophenyl moiety there...

This work aimed to evaluate the antioxidant capacity (AC), total phenolic (TPC) and flavonoids content (TFC) of the ethanolic extracts four vraities of Solanum tuberosum L (potato), TPC of whole roots shows values ranged from 19.21 to 08.88 mg AG/g of extract and TFC varied from 25.03 to 10.91 mg rutin/g of extract. However, this phytochemical cont...

In the present study, the interaction of the optimised structure of ligand N-ferrocenylmethyl-N-phenylacetamide (FPA) with double-stranded DNA (PDB ID: 1BNA) extracted from protein data bank (http://www.rcsb.org./pdb) was investigated by performing docking studies using AutoDock 4.2 docking software. The binding energy of the docked structure of th...

Cyclic voltammetry (CV) and UV–Visible spectroscopy (UV–Vis) techniques were used to calculate binding parameters of 4-methyl-5-((phenylimino)methyl)-3H-1,2-dithiole-3-thione (MPDT) and 5-(4-fluorophenyl)-3H-1,2-dithiole-3-thione (FPDT) with DNA. The results obtained from both techniques were confirmed by computational molecular docking using AutoD...

This paper reports the synthesis, spectroscopic characterizations and electrochemical behavior of the obtained tetradentate copper(II)-Schiff base complex with its two wings as ferrocenylaniline moieties. This new ferrocenic derivative with two ferrocenylaniline entities surrounding the copper(II)-Salen complex (5) was synthesized by reacting N-fer...

L’approche thérapeutique du cancer constitué trois axes principaux, la chirurgie, la radio-oncologie et la chimiothérapie, ce dernier repose sur l'utilisation de substances pharmacologiques pour tuer les cellules tumorales où la principale cible de ces substances est l’ADN. Parmi les composés organométalliques qui ont de capacité d’interagit avec l...

The ligand oxime, C7H9N5O2, was Synthesis and characterises with different characterization methods such as 1H NMR and FTIR spectroscopy. The complexation of this ligand with manganese (II) perchlorate yielded pink crystals of formula [Mn (C7H9N5O2)2]2+ , 2[ClO4] -, which crystallized in the monoclinic space group P21/n with a = 12.824(3), b=13.799...

The pyridine-2,6-dicarboxamide oxime, C7H9N5O2, was Synthesis and characterises with 1H NMR and FTIR spectroscopy . The reaction of this ligand with nickel (II) perchlorate yielded green crystals of formula [Ni(C₇H₉N₅O₂)₂]²⁺,2[ClO₄]-, which crystallized in the monoclinic s...

The present work aimed to study the effect of two different commonly applied extraction techniques for the evaluation of total phenolic contents (TPC), total flavonoid contents (TFC) and total antioxidant capacity (TAC) of fresh south Algerian red potatoes cultivars (Solanum tuberosum L). These techniques are namely Soxhlet extraction (SE) and ultr...