Tony D James

Tony D James
University of Bath | UB · Department of Chemistry

PhD University of Victoria, BSc University of East Anglia

About

451
Publications
48,620
Reads
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22,869
Citations
Additional affiliations
December 2020 - present
Henan Normal University
Position
  • Professor
January 2020 - present
Ewha Womans University
Position
  • Professor (Associate)
January 2019 - present
Qufu Normal University
Position
  • Professor
Education
September 1986 - December 1991
University of Victoria
Field of study
  • Chemistry
September 1983 - June 1986
University of East Anglia
Field of study
  • Chemistry

Publications

Publications (451)
Article
The occurrence of endoplasmic reticulum (ER) stress is the main cause of a variety of biological process that are closely related with numerous diseases. The homeostasis of the ER microenvironment...
Article
Lipase found in the gut microbiota participates in the digestion and absorption of dietary fats. As such, the gut microbiota is involved in the regulation of the host metabolism, affecting the levels of lipids and free fatty acids, ultimately resulting in obesity. In this study, an enzymatic activatable near-infrared fluorescent probe, DDAO-C6, was...
Article
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), which is a major threat to global public health. Currently, β-lactam antibiotics are rarely used in the treatment of TB, since Mtb naturally expresses β-lactamase (Blac) which renders Mtb resistant to such antibiotics due to β-lactam cleavage. Fortunately, antibi...
Article
Heavy metal pollution has resulted in numerous environmental challenges. However, classic approaches, involving the use of solid adsorbents are subject to limitations, including the high energy consumption required for processing before and after use. Accordingly, strategies that facilitate the use of metal capture media that extends beyond waste r...
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The construction of biocompatible and trackable‐imaging single‐atom nanozymes (SAzymes) with efficient catalytic activities is particularly desirable. Here, cobalt/titanium oxide (Co/TiO2) SAzymes are presented with cobalt atomically dispersed on nanoporous hollow TiO2 using a cation‐exchange strategy. Significantly, by varying the calcination cond...
Article
Multifunctional nanoplatforms for the early diagnosis and treatment of deep-seated tumors with high specificity are particularly desirable but face many challenges. Herein, nanoplatforms containing copper/manganese chalcogenide nanoflowers (CMC NFs) and ¹⁹F probes have been developed, which exhibit enhanced therapeutic efficiency and activatable ¹⁹...
Article
Hepatic ischemia-reperfusion injury (HIRI) is responsible for postoperative liver dysfunction and liver failure. Precise and rapid navigation of HIRI lesions is critical for early warning and timely development of pretreatment plans. Available methods for assaying liver injury fail to provide the exact location of lesions in real time intraoperativ...
Article
Due to their simplicity in preparation, sensitivity and selectivity, fluorescent probes have become the analytical tool of choice in a wide range of research and industrial fields, facilitating the rapid detection of chemical substances of interest as well as the study of important physiological and pathological processes at the cellular level. In...
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Full-text available
Over recent years, fluorescent probes exhibiting simultaneous responses to multiple targets have been developed for in situ, real-time monitoring of cellular metabolism using two photon fluorescence sensing techniques due to numerous advantages including ease of operation, rapid reporting, high resolution, long visualization time and being non-inva...
Article
Sustainable afterglow room‐temperature phosphorescence (RTP) from natural phenolics with long lifetime is a particularly attractive phenomenon but remains difficult to achieve. Here, we have prepared sustainable afterglow RTP materials (GA@SA) with a lifetime of up to ~934.7 ms by embedding gallic acid (GA) within a Ca2+‐crosslinked sodium alginate...
Article
Sustainable afterglow room‐temperature phosphorescence (RTP) from natural phenolics with long lifetime is a particularly attractive phenomenon but remains difficult to achieve. Here, we have prepared sustainable afterglow RTP materials (GA@SA) with a lifetime of up to ~934.7 ms by embedding gallic acid (GA) within a Ca2+‐crosslinked sodium alginate...
Article
A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates,...
Article
Lignin is a significant byproduct from the pulp and paper industry. However, the conversion of lignin to a resource with added value is plagued by expensive processing. Here we report that the syringyl units (S) of sodium lignosulfonate (LS) exhibit phosphorescence in water with a lifetime of ∼2 ms and the lifetime can be prolonged up to ∼618 ms by...
Article
Full-text available
Chemical warfare agents (CWAs) such as phosgene and nerve agents pose serious threats to our lives and public security, but no tools can simultaneously screen multiple CWAs in seconds. Here, we rationally designed a robust sensing platform based on 8-cyclohexanyldiamino-BODIPY (BODIPY-DCH) to monitor diverse CWAs in different emission channels. Tra...
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Ferroptosis is closely associated with cancer, neurodegenerative diseases and ischemia-reperfusion injury and the detection of its pathological process is very important for early disease diagnosis. Fluorescence based sensing technologies have become excellent tools due to the real-time detection of cellular physiological or pathological processes....
Article
The concept of a reversible polymer displacement sensor mechanism for electrochemical glucose monitoring is demonstrated. A pyrene-derivatised boronic acid chemo-receptor for glucose is adsorbed onto a graphene foam electrode. Spontaneous oxidative polymerisation of nordihydroguaiaretic acid (NHG) onto the graphene foam electrode leads to a redox a...
Article
The shortage of freshwater resources caused by heavy metal pollution is an acute global issue. Herein, a novel nanoplatform was fabricated by hydrothermal deposition of 3D-MoS2 nanospheres onto biocompatible wood...
Article
Luminogens characteristic of aggregation-induced emission (AIEgens) have been engineered for the development of imaging-guided photodynamic therapeutic (PDT) agents.
Article
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Changes in adenosine triphosphate (ATP) and peroxynitrite (ONOO–) concentrations have been correlated in a number of diseases including ischemia-reperfusion injury and drug-induced liver injury. Herein, we report the development of a fluorescent probe ATP-LW, which enables the simultaneous detection of ONOO– and ATP. ONOO– selectively oxidizes the...
Article
Employing fluorescent hydrogels for hazardous Hg(II) detection and removal is an efficient method for water purification. However, it remains challenging to establish a fluorescent system with low detection limit and high adsorption capacity that can readily be upcycled into a valuable material resource. Herein, we report on a fluorescent hydrogel...
Article
Full-text available
Glycated haemoglobin (HbA1c) is a diagnostic biomarker for type 2 diabetes. Traditional analytical methods for haemoglobin (Hb) detection rely on chromatography, which requires significant instrumentation and is labour-intensive; consequently, miniaturized devices that can rapidly sense HbA1c are urgently required. With this research, we report on...
Article
In vivo fluorescence imaging provides vital information required for biomedical research in living animals, and as such plays an essential role in disease assessment. Unfortunately, due to the lack of coherent approaches, in vivo fluorescence visualization is challenging, wasting not only time but the animals used. In recent years, cyanine-based sy...
Article
Biomacromolecular drugs have become an important class of therapeutic agents for the treatment of human diseases. Considering their high propensity for being degraded in the human body, the choice of an appropriate delivery system is key to ensure the therapeutic efficacy of biomacromolecular drugs in vivo. As an emerging class of supramolecular "h...
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Full-text available
Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanow...
Article
AzuFluor® 435-DPA-Zn, an azulene fluorophore bearing two zinc( ii )-dipicolylamine receptor motifs, exhibits fluorescence enhancement in the presence of adenosine diphosphate.
Article
Excited-state intramolecular proton transfer (ESIPT)-based fluorophores with two-photon excitation fluorescence (TPEF) are rare. Our aim with this research was to develop ESIPT-based fluorophores exhibiting TPEF. Herein, we used 4-hydroxyisoindoline-1,3-dione as a scaffold to develop a two-photon fluorescent probe BHID-Bpin, for the detection of pe...
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Full-text available
Over the past 30 years fluorescent chemosensors have evolved to incorporate many optical-based modalities and strategies. In this perspective we seek to highlight the current state of the art as well as provide our viewpoint on the most significant future challenges remaining in the area. To underscore current trends in the field and to facilitate...
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The microenvironment (local environment), including viscosity, temperature, polarity, hypoxia, and acidic-basic status (pH), plays indispensable roles in cellular processes. Significantly, organelles require an appropriate microenvironment to perform their specific physiological functions, and disruption of the microenvironmental homeostasis could...
Article
Amphiphilic carbon nitride (g-C3N4) was decorated onto reduced graphene oxide (rGO) to obtain rGO-g-C3N4 composites as excellent adsorbents for the removal of aromatic organic compounds from industrial wastewater. The as obtained rGO-g-C3N4 composites are effective adsorbents for organic compounds due to the amphiphilic g-C3N4. We propose a new ads...
Article
Sustainable organic afterglow room-temperature phosphorescence (RTP) is a particularly attractive phenomenon but remains difficult to achieve. Herein, inspired by the afterglow RTP of natural basswood, we prepare a series of sustainable afterglow RTP materials by confining lignin within a 3D poly(acrylic acid) network that mimics the wood matrix. T...
Article
Full-text available
Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man...
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Full-text available
Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have...
Article
Mercury ions are one of the most toxic heavy metals and as such they can cause serious risk to the human body and environment ecosystem. To effectively detect and remove Hg²⁺ from contaminated water, a new cellulose-based fluorescent hydrogel has been fabricated using a ratiometric probe with carbon dots as energy donor and rhodamine moiety as ener...
Article
Alkaline phosphatase (ALP) is an important enzyme-based biomarker present in several bacterial species; however, it is currently undervalued as a strategy to detect pathogenic bacteria. Here, we explore our ALP-responsive colorimetric and fluorescent probe (TCF-ALP) for such applications. TCF-ALP displayed a colorimetric and fluorescence response t...
Article
Racemases and epimerases catalyse changes in the stereochemical configurations of chiral centres and are of interest as model enzymes and as biotechnological tools. They also occupy pivotal positions within metabolic pathways and, hence, many of them are important drug targets. This review summarises the catalytic mechanisms of PLP-dependent, enola...
Article
The excessive use of antibiotics has led to a rise in drug-resistant bacteria. These "superbugs" are continuously emerging and becoming increasingly harder to treat. As a result, new and effective treatment protocols that have minimal risks of generating drug-resistant bacteria are urgently required. Advanced nanomaterials are particularly promisin...
Article
Optical imaging probes allow us to detect and uncover the physiological and pathological functions of an analyte of interest at the molecular level in a non-invasive, longitudinal manner. By virtue of simplicity, low cost, high sensitivity, adaptation to automated analysis, capacity for spatially resolved imaging and diverse signal output modes, op...
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Full-text available
Guaiazulene is an alkyl-substituted azulene available from natural sources and is a much lower cost starting material for the synthesis of azulene derivatives than azulene itself. Here we report an approach for the selective functionalisation of guaiazulene which takes advantage of the acidity of the protons on the guaiazulene C4 methyl group. The...
Article
Full-text available
The ester functionality is commonly seen in the areas of chemical biology and medicinal chemistry for the design of cell‐permeable active molecules. Ester‐based pro‐drug/pro‐sensor strategies are employed to mask polar functional groups (i. e. carboxylic acids) and improve the overall cell permeability of these functional molecules. However, their...
Article
Since the first demonstration of synthetic host/guest chemistry, the area of supramolecular chemistry has rapidly expanded and become highly influential in the areas of biomedicine, energy materials, catalysis and sensing. In recent years, the use of host/guest chemistry in combination with functional inorganic nanoparticles has resulted in many ne...
Article
Chiral molecules are widely used in many fields of research and so practically simple, accurate methods to measure their enantiopurities are required. This review’s initial focus is on one such method, the Bull-James assembly, which employs a three-component protocol combining 2-formylphenyl boronic acid, an amine, and a diol to self-assemble diast...
Article
Excess formaldehyde (FA) provides a significant threat that caused irreversible damage to both the environment and human health, and the issue of long-term FA emission exists in commercial products of leather. Therefore, to help control its FA content, we propose a fluorescence-based method to detect FA selectively using a reaction-based probe FAP-...
Article
In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes. The advantages of TPEF-based probes include deep tissue penetration and minimal photo-damage. We discuss the underlying two-photon (TP) fluorophores including hemicyanine and de...
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Full-text available
Small-molecule based fluorescent probes are increasingly important for the detection and imaging of biological signaling molecules due to their simplicity, high selectivity and sensitivity, whilst being non-invasive, and suitable for real-time analysis of living systems. With this perspective we highlight sensing mechanisms including Förster resona...
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Full-text available
Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease. Herein, we report the development of a molecular probe (LW−OTf) for the detection and imaging of two radical biomarkers involved in DILI. Initially, primary reactive oxygen species (ROS) superoxide (O2•−) selectively activates a near-infrared fluorescence (NI...
Article
Viscosity is a pivotal factor for indicating the dysfunction of the mitochondria. To date, most of the fluorescent probes developed for mitochondrial viscosity have been designed using BODIPY, hemicyanine, or pyridine-based molecular rotors as part of the core structure. Our aim with this research was to extend the range of suitable fluorophores av...
Article
With this research we set out to develop a coumarin-based novel fluorescent sensor NTR-AHC for the detection of biological thiols and nitroreductase (NTR). Probe NTR-AHC was constructed by attaching the NTR trigger moiety (p-nitrobenzyl) and biothiol acceptor (maleic acid monoamide), to the core fluorophore AHC. In the presence of both glutathione...
Article
In this study, “core–shell” gold nanoparticles (AuNPs) have been functionalised using a simple one-pot approach to form fucose-based glycoconjugate AuNPs (Fuc-AuNPs) and galactose-based glycoconjugate AuNPs (Gal-AuNPs), respectively. Owing to the selective carbohydrate-based recognition of the key virulence factors of P. aeruginosa, LecB (fucose-sp...
Article
Indicator displacement assays (IDAs) offer a unique and innovative approach to molecular sensing. IDAs can facilitate the detection of a range of biologically/environmentally important species, provide a method for the detection of complex analytes or for the determination and discrimination of unknown sample mixtures. These attributes often cannot...
Article
Lipid droplets (LDs) are cellular organelles that are essential for maintaining lipid and energy homeostasis. Once regarded as merely inert fat particles, they are now recognized as highly dynamic, mobile organelles required for preventing lipotoxicity and for interacting and cooperating with various organelles. Despite the progress made in underst...
Article
Here, we report a β-galactosidase (β-Gal) responsive photochromic fluorescent probe NpG that was designed to pre-bind to human serum albumin (HSA) to form a probe/ protein hybrid NpG@HSA. The formation of NpG@HSA led to an increase in fluorescence emission (525 nm) corresponding to the binding of the fluorescent naphthalimide unit with HSA. In addi...
Article
Full-text available
Azulene is a bicyclic aromatic chromophore that absorbs in the visible region. Its absorption maximum undergoes a hypsochromic shift if a conjugated electron-withdrawing group is introduced at the C1 position. This fact can be exploited in the design of a colorimetric chemodosimeter that functions by the transformation of a dithioacetal to the corr...
Article
Highly efficient luminescent materials have garnered considerable interest due to their special photophysical properties and potential applications. Aggregation-induced emission (AIE) is a photophysical phenomenon, in which concentrated or aggregated molecules produce enhanced light emission. In this review, we will introduce recent articles from t...
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Full-text available
Reaction-based fluorescent-probes have proven successful for the visualisation of biological species in various cellular processes. Unfortunately, in order to tailor the design of a fluorescent probe to a specific application (i.e. organelle targeting, material and theranostic applications) often requires extensive synthetic efforts and the synthet...
Article
In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte responsive systems. We discuss the underlying ener...
Article
Full-text available
In this work, we have developed an ESIPT benzimidazole-based platform (MO-E1 and MO-E2) for the two-photon cell imaging of ONOO- and a potential ONOO- -activated theranostic scaffold (MO-E3). Each benzimidazole platform, MO-E1-3, were shown to rapidly detect ONOO- at micromolar concentrations (LoD = 0.28 µM, 6.53 µM and 0.81 µM respectively). Thera...
Article
Herein, we demonstrate a combined fluorescent probe/shape encoded hydrogel strategy for the fast, sensitive and selective detection of bacterial species via their characteristic enzymes. A polyvinyl alcohol (PVA) hydrogel loaded with the fluorescent probe N,N'-(3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl)bis(2,2,3,3,3-pentafluoropropanam...
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Full-text available
Here, we report a new pentafluoropropanamido rhodamine fluorescent probe (ACS-HNE) that allows for the selective detection of neutrophil elastase (NE). ACS-HNE displayed high sensitivity, with a low limit of detection (<5.3 nM), and excellent selectivity toward elastase over other relevant biological analytes and enzymes. The comparatively poor sol...
Article
Fluoride anion pollution is one of the main problems that needs to be addressed in contaminated water. Herein, we have developed a novel sensing platform using a pyrene boronic acid and carbon dots (CDs) for the selective detection and removal of fluoride (F⁻) ion at environmentally relevant levels. The probe consists of pyrene-boronic acid (PyB) m...
Article
Determining enantiomeric excess (e.e.) in chiral compounds is key to development of chiral catalyst auxiliaries and chiral drugs. Here we describe a sensitive and robust fluorescence-based assay for determining e.e. in mixtures of enantiomers of 1,2- and 1,3-diols, chiral amines, amino alcohols, and amino-acid esters. The method is based on dynamic...
Article
In this article, a new hierarchical porous zirconia material with adjustable pore size is fabricated by using biomass materials of acacia mangium tannin extract (AMTE) and amphiphilic triblock copolymer poly(ethylene glycol)-blockpoly(propylene glycol)-block-poly(ethylene glycol) (P123) as a dual-template for the first time. All the raw materials w...
Article
Full-text available
We report on a supramolecular sensor array using fluorogenic peptide probes and graphene oxide that can target glycoproteins on a viral caspid, facilitating the differentiation of Ebola virus from Marburg...
Article
A new set of PVA hydrogels were formed using the boronate ester fluorescent probe, PF1 and the novel boronate fluorescent probe PT1 as the covalent crosslinkers. Treatment with aqueous H2O2...