Tomoei Takahashi

Tomoei Takahashi
Nagoya University | Meidai · Department of Complex Systems Science

About

3
Publications
95
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
0
Citations

Publications

Publications (3)
Preprint
Full-text available
In this study, we propose an analytic statistical mechanics approach to solve a fundamental problem in biological physics called protein design. Protein design is an inverse problem of protein structure prediction, and its solution is the amino acid sequence that best stabilizes a given conformation. Contrary to previous computational physics studi...
Article
Full-text available
Protein design is the inverse approach of the three-dimensional (3D) structure prediction for elucidating the relationship between the 3D structures and amino acid sequences. In general, the computation of the protein design involves a double loop: A loop for amino acid sequence changes and a loop for an exhaustive conformational search for each am...
Preprint
Full-text available
A novel protein design method using Bayesian learning is proposed in this work. We consider a posterior probability of amino acid sequences by taking into account water and assuming a prior of sequences. For some instances of a target conformation of a two-dimensional (2D) lattice Hydrophobic-Polar (HP) model, our method successfully finds an amino...

Network