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Molecular and cellular biophysicist working on the development of advanced optical imaging techniques to study dynamic structures and their interactions in the cell. In particular I am interested in using single-molecule super-resolution and functional read-out microscopy (such as FRET/FLIM) to uncover the machinery of the cellular leading edge and how this regulates actin-driven cell motility.
January 2020 - April 2020
- Undergraduate Tutor
- Undergraduate tutor, teaching molecular genetics. I teach both seminar-style tutorial classes as well as assist a senior lecturer in larger workshop-style classes.
Cell migration is important for development and its aberrant regulation contributes to many diseases. The Scar/WAVE complex is essential for Arp2/3 mediated lamellipodia formation during mesenchymal cell migration and several coinciding signals activate it. However, so far, no direct negative regulators are known. Here we identify Nance-Horan Syndr...
Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight ‘drug-like’ structure which is bioavailable and c...
To further elucidate global actin dynamics, branching, and the function and dynamics of the Arp2/3 branching mediator. To determine the role of newly discovered proteins which localise to the lamellipodia of migrating cells, and how they interact with other lamellipodial elements. To achieve this we will employ advanced optical and quantitative imaging, including new imaging and analysis techniques in super-resolution microscopy.