Tomer Jordi Chaffer

Tomer Jordi Chaffer
McGill University | McGill · Division of Experimental Medicine

Bachelor of Science

About

16
Publications
4,106
Reads
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23
Citations
Citations since 2016
16 Research Items
23 Citations
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20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
Introduction
Skills and Expertise
Additional affiliations
June 2018 - August 2018
McGill University
Position
  • Undergraduate Research Trainee

Publications

Publications (16)
Article
Full-text available
Introduction Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders that show delays and deficits in the development of multiple brain functions, which are characterized by social communication, poor language development, and restricted and stereotyped patterns of interests and behaviours. ASD affects about 1-2 % of the populat...
Article
Rationale: Loss of skeletal muscle mass and function is a common clinical feature and poor prognostic indicator in various diseases. A promising therapeutic approach of regenerative medicine for repair of skeletal muscle is through the delivery of cellular therapies targeting regulators of muscle regeneration (myogenesis). However, not all the pro...
Article
Rationale: The loss of skeletal muscle function can have dramatic health consequence. Skeletal muscle dysfunction are found in a wide range of clinical conditions, including cancer cachexia, starvation, sepsis, and aging. Autophagy is an essential catabolic process that remove damaged cytosolic components. Accumulating evidence indicates that insu...
Article
Full-text available
As Bitcoin continued to make headlines in 2021, additional digital assets such as non-fungible tokens brought more users into the blockchain ecosystem. As more individuals and entities took a closer look at the use cases for blockchain technology, the term metaverse began to emerge across news outlets and social media platforms. With Mark Zuckerber...
Preprint
Full-text available
Septic patients frequently develop skeletal muscle wasting and weakness, resulting in severe clinical consequences and adverse outcomes. Autophagy is a stress-induced degradative process essential to cell survival. Recent studies have demonstrated that sepsis triggers sustained induction of autophagy in skeletal muscles, although the impact of this...
Article
Constituting ~40% of human body mass, skeletal muscles are critical for general health. Indeed, they play key roles in posture, mobility, thermogenesis, glucose homeostasis, and metabolism. Skeletal muscles have a striking ability to adapt to various physiological and pathological conditions by changing their size, composition, and metabolic proper...
Article
Skeletal muscles account for 40-50% of the whole-body mass in healthy individuals, and they contribute to a multitude of vital functions, such as in movement, postural support, breathing, thermogenesis, and metabolism. The decline of skeletal muscle mass and function is a common feature observed in many pathological conditions, such as cancer, chro...
Article
Skeletal muscles play a fundamental role in maintaining homeostasis. Composing up to 40% of the body mass in healthy individuals, skeletal muscles contain several bundles of muscle fiber rich with vascularization and innervation. The malleable structural components of skeletal muscle contribute to the body’s overall integrity. In turn, skeletal mus...
Article
Full-text available
Sepsis elicits skeletal muscle weakness and fiber atrophy. The accumulation of injured mitochondria and depressed mitochondrial functions are considered as important triggers of sepsis-induced muscle atrophy. It is unclear whether mitochondrial dysfunctions in septic muscles are due to the inadequate activation of quality control processes. We hypo...
Article
Sepsis elicits skeletal muscle weakness and fiber atrophy. The accumulation of injured mitochondria and depressed mitochondrial functions are considered as important triggers of sepsis-induced muscle atrophy. It is unclear whether mitochondrial dysfunctions in septic muscles are due to the inadequate activation of quality control processes. We hypo...
Poster
The accumulation of mitochondrial dysfunction is believed to contribute to skeletal muscle weakness and loss in severe sepsis. Changes in mitochondrial mitophagy, dynamics and morphology can greatly impact mitochondrial function, and vice versa. However, whether mitochondrial mitophagy, dynamics and morphology in skeletal muscle are altered in seps...
Poster
Sepsis-induced skeletal muscle dysfunction contributes to physical disability, and increased mortality in intensive care unit patients. Autophagy is a catabolic process by which cells degrade their own components. Recent studies indicate that sepsis triggers sustained induction of autophagy in skeletal muscles; however, the impact of autophagy on s...

Questions

Questions (7)
Question
Has anyone used valinomycin or carbonyl cyanide m-chlorophenylhydrazone (CCCP) to study mitophagy in C2C12? If so, please advise on concentration and duration of treatment. Thanks.
Question
Does anyone have suggestions for linking a list of lncRNAs to their target mRNAs? I am looking to generate networks consisting of lncRNA-mRNAs that are activated or downregulated in response to a particular intervention (as identified by microarray analysis). Thanks.
Question
I used poly-d-lysine but it did not seem to work as the cells eventually detached after 3 days of differentiation. Is matrigel a better option? I am attempting to differentiate until day 7.
Thanks.
Question
I read that NH4CL and chloroquine treatments can be used to block autophagic flux. Are there any other acceptable treatments?
Question
Currently, I can only find case reports on the rare condition I am planning to conduct a meta-analysis on. I will be evaluating outcomes and efficacy of treatments. Are there any known guidelines or methodological assessments to consider when conducting a meta-analysis on case reports? Any resources or advice would be greatly appreciated.

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