Tomas Leon

Tomas Leon
University of California, Berkeley | UCB · Department of Environmental Health Sciences

About

15
Publications
864
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
53
Citations

Publications

Publications (15)
Poster
Full-text available
MGDrivE (Mosquito Gene Drive Explorer) is an open-source modeling framework to simulate and evaluate novel genetic control tools in spatial mosquito populations. The software has four modules: A) a genetic inheritance module accommodates the dynamics of gene drive systems, B) a population dynamic module accounts for mosquito life history, D) a land...
Article
Full-text available
Background: Vector-borne diseases are a major cause of disease burden in Guayaquil, Ecuador, especially arboviruses spread by Aedes aegypti mosquitoes. Understanding which household characteristics and risk factors lead to higher Ae. aegypti densities and consequent disease risk can help inform and optimize vector control programs. Methods: Cros...
Preprint
Full-text available
A rare example of a successful long-term elimination of the mosquito Aedes aegypti is in Brisbane, Queensland, where the legislatively-enforced removal of rainwater tanks drove its disappearance by the mid-1950s. However, a decade-long drought led to the mass installation of rainwater tanks throughout the region, re-introducing critical breeding si...
Poster
Full-text available
MGDrivE (Mosquito Gene Drive Explorer) is an open-source modeling framework to simulate and evaluate novel genetic control tools in spatial mosquito populations. The software has four modules (right): i) a genetic inheritance module accommodates the dynamics of gene drive systems, ii) a population dynamic module accounts for mosquito life history,...
Article
Full-text available
Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials. The prospect of field trials requires models that incorporate a significant degree of ecological detail, including parameters that change over time in response to environ...
Preprint
Full-text available
Background Vector-borne diseases are a major cause of disease burden in Guayaquil, Ecuador, especially arboviruses spread by Aedes aegypti mosquitoes. Understanding which household characteristics and risk factors lead to higher Ae. aegypti densities and consequent disease risk can help inform and optimize vector control programs. Methods Cross-se...
Poster
Full-text available
Models that simulate the effects of interventions on malaria vectors and transmission make assumptions about how mosquitoes move in the environment, such as isotropic behavior and no sex-related differences. These are applied to dispersal between households and villages and processes such as host-seeking and oviposition. Most models use mathematica...
Poster
Full-text available
CRISPR/Cas9-based technologies have revitalized interest in gene-editing technologies as means to control mosquito-borne diseases. Amongst candidate disease-control mechanisms, gene- replacement strategies are considered some of the most promising due to their resilience to generation of resistant alleles (caused by errors in homology-directed repa...
Preprint
Full-text available
Interest in gene drive technology has continued to grow as promising new drive systems have been developed in the lab and discussions are moving towards implementing field trials. The prospect of field trials requires models that incorporate a significant degree of ecological detail, including parameters that change over time in response to environ...
Presentation
Full-text available
In this work, we present our framework with applications to various novel gene-drive systems such as: reciprocal chromosomal translocations, toxin-antidote-based underdominant systems. In doing so, we show how our model can be used to answer relevant questions in the field of mosquito-borne diseases elimination, such as: how to make fair comparison...
Poster
Full-text available
Malaria, dengue, Zika, and other mosquito-borne diseases continue to pose a major global health burden through much of the world. The advent of CRISPR/Cas9-based gene editing and its demonstrated ability to streamline the development of gene drive systems has reignited interest in the application of this technology to the control of mosquitoes and...
Article
It is pressing to investigate the influence factors of eutrophication in Dongting Lake, which is the second largest freshwater lake in China and is faced with more and more serious eutrophication problems by natural and man-made factors in recent years. In this study, a new multivariate analysis approach integrating the maximum likelihood estimatio...
Article
Land use regression (LUR) models have proven to be a robust technique for predicting spatial distribution of pollutants with high resolution. Wind direction is an important factor affecting atmospheric environment quality. However, conventional LUR models have difficulties taking wind direction into consideration. This study put forward a semicircu...

Network

Cited By