
Tomas KollerComenius University Bratislava · 5th Department of Internal Medicine
Tomas Koller
associate professor, MD., PhD.
About
143
Publications
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Introduction
Tomas Koller currently works at the 5th Department of Internal Medicine, Comenius University in Bratislava. Tomas does research in Gastroenterology, Hepatology and Nutrition and Dietetics. Their current project is sarcopenia and frailty in liver disease.
Additional affiliations
May 2003 - April 2004
September 2011 - May 2020
February 2005 - present
Education
September 1992 - June 1998
Publications
Publications (143)
Background and aims
Alcohol-associated hepatitis (AH) frequently triggers acute decompensation (AD) in cirrhosis, with severe AH linked to high short-term mortality, especially in acute-on-chronic liver failure. Current corticosteroid treatments have limited efficacy, highlighting the need for new therapies. We hypothesized that severe AH outcomes...
Rationale
Severe alcohol-associated hepatitis (SAH) is the most critical, acute, inflammatory phenotype within the alcohol-associated liver disease (ALD) spectrum, characterized by high 30- and 90-day mortality. Since several decades, corticosteroids (CS) are the only approved pharmacotherapy offering highly limited survival benefits. Contextually,...
Background and aims
Intestinal inflammation assessed by fecal calprotectin (F‐CAL) in advanced chronic liver disease (ACLD) may represent an early sign of intestinal barrier dysfunction. We aimed to explore the usefulness of F‐CAL testing in ACLD in the prediction of adverse outcomes (AO, death, or LT) and refinement of prognostic stratification....
By analyzing 996 patients from the RH7 cirrhosis registry within the 4.5 years of inclusion interval, we mapped the path of patients to liver transplantation. We found that 283 patients (28.4%) opened a transplant protocol with a median of 4 days from registration, of which 117 (11.7%) were placed on a waiting list with a median of 91 days from the...
Background:
Severe alcohol-associated hepatitis (SAH) is the most serious phenotype of the alcohol-associated liver disease (ALD) spectrum, characterized by high short-term mortality. The only approved therapy with corticosteroids (CS) has modest and short-term survival benefits; moreover, new therapeutic alternatives are unmet need. Fecal microbio...
Background:
The high prevalence of liver cirrhosis in Slovakia leads to a great need for transplant treatment. The outcome of liver transplantation is influenced by several factors.
Aim:
The main objective of this study is to test the effectiveness of prehabilitation compared to standard of care.
Design:
Prospective, double-arm, randomized, op...
Introduction and objectives: Slovakia ranks among the leaders in preventable deaths, but a systematic analysis of the share of
digestive system cancers (DSCs) and their trends has been lacking. We analyzed data on mortality from DSCs in Slovakia in the years 2011–2020
with an emphasis on premature deaths, sex differences, and trends for individual...
Is the time ripe for microbiome to be levered in clinical hepatology? Is the preventive, predictive, and personalized medicine (3PM/PPPM) realm offering a framework for just an intellectual exercise in the world of natura cogitans, or can we already predict, personalize, and prevent liver diseases by targeting microbiome? Can the knowledge be extra...
Background:
Despite long-term use of infliximab (IFX) in IBD treatment, its optimized use is unclear due to its complicated pharmacokinetics/dynamics. Hence, the predictive value of IFX trough levels (TL) is important in treatment management.
Methods:
We performed a prospective, cross-sectional, observational study with 74 IBD patients treated w...
The number of liver transplants for the indication of hepatocellular carcinoma is increasing. We consider the so-called Milan criteria, based on the number and size of the tumour, to be the basic indication framework. However, the original criteria are too restrictive – they prevent access to transplantation for a number of patients who would other...
Background Lower back pain is a common issue, but little is known about the prevalence of pain in patients with
liver cirrhosis during hospitalisation. Therefore, the objective of this study was to determine lower back pain in
patients with liver cirrhosis.
Methods The sample consisted of patients with liver cirrhosis (n = 79; men n = 55; women n =...
Liver cirrhosis is associated with a poor quality of life (QOL). The COVID-19 pandemic has led to several restriction measures and psychosocial consequences whose impact on QOL has combined with that of cirrhosis in an unknown way. Therefore, we have used our cirrhosis registry to assess the quality of life before the pandemic (on the first admissi...
A series of two case reports discusses the differential diagnosis of painless jaundice in the elderly and points to autoimmune pancreatitis as one of its rarer causes. In search for the cause, the first step is to rule out the malignant origin of the obstruction using the clinical picture, imaging examinations, and EUS-guided biopsy. An imaging exa...
Background
Alcohol consumption is an important issue. Adverse childhood experiences (ACEs) can affect alcohol consumption later in life. Therefore, the main objective of this study was to test the association between ACE and the alcohol consumption in college students.
Materials and methods
A cross-sectional study on college students was conducted...
Introduction: Liver cirrhosis is associated with a poor quality of life (QOL). The SARS-CoV-2 coronavirus pandemic has led to several restriction measures and psychosocial consequences whose impact on QOL has combined with that of cirrhosis in an unknown way. Therefore, we have used our cirrhosis registry to assess quality of life before the pandem...
Introduction: Liver cirrhosis is associated with a poor quality of life (QOL). The SARS-CoV-2 coronavirus pandemic has led to several restriction measures and psychosocial consequences whose impact on QOL has combined with that of cirrhosis in an unknown way. Therefore, we have used our cirrhosis registry to assess quality of life before the pandem...
Background: Non-alcoholic fatty liver disease (NAFLD) is the fastest-growing cause of liver diseases; after liver transplantation (LT) for another indications bears the name de novo NAFLD. Aims: We set out to determine the incidence of de novo NAFLD and its associations with BMI and fibrosis in patients (pts) after LT at a single transplant centre....
Objectives: There is no consensus about specific serum 25(OH)D levels associated with higher risk of severe outcome in COVID-19 patients. According to the literature patients with serum 25(OH)D levels < 12 ng/ml are clearly deficient at all ages. Our aim was to assess COVID-19 mortality in the settings of severe 25(OH)D deficiency.
Methods: A coho...
Objectives: There is no consensus about specific serum 25(OH)D levels associated with higher risk of severe outcome in COVID-19 patients. According to the literature patients with serum 25(OH)D levels < 12 ng/ml are clearly deficient at all ages. Our aim was to assess COVID-19 mortality in the settings of severe 25(OH)D deficiency.
Methods: A coho...
Objectives:
Non-communicable diseases are estimated to account for 90 % of total deaths and 19 % of premature deaths in Slovakia. Major preventable risk factors of premature mortality are overweight, obesity and alcohol consumption.
Background:
Screening of risk factors related to alcoholic and nonalcoholic fatty liver diseases (AFLD and NAFLD,...
Non-traumatic spontaneous intramural duodenal hematoma is a rare cause of proximal gastrointestinal obstruction which may present with hemorrhage, jaundice and pancreatitis. In this case report we present a case of spontaneous duodenal hematoma in a 28-year-old female with a history of acute pancreatitis, admitted to hospital for convulsive upper a...
Sarcopenia is defined as an age-associated loss of skeletal muscle function and muscle mass and is common in older adults. Sarcopenia as a disease is currently of interest not only to orthopedists and surgeons but also to internists, endocrinologists, rheumatologists, cardiologists, diabetologists, gynaecologists, geriatricians and paediatricians....
According to several studies, women with Crohn's disease (CD) had reduced fertility, which is mostly due to voluntary decisions and reduced ovarian reserve. In our study, we aimed to compare reproductive health parameters (RHP), previous pregnancy complications and outcomes, and ovarian reserve (OR) assessed by the anti-Mullerian hormone (AMH) in C...
Hospitalized patients in internal medicine have an increased risk of low physical reserve which further declines during the hospital stay. The diagnosis requires bed-side testing of functional domains or more complex investigations of the muscle mass. Clinically useful biomarkers of functional status are needed, thus we aimed to explore the potenti...
Hospitalized patients in internal medicine have an increased risk of low physical reserve which further declines during the hospital stay. The diagnosis requires bed-side testing of functional domains or more complex investigations of the muscle mass. Clinically useful biomarkers of functional status are needed, thus we aimed to explore the potenti...
Sarcopenia is defined as an age-associated loss of skeletal muscle function and muscle mass and is common in older adults. Sarcopenia as a disease is currently of interest not only to orthopedists and surgeons but also to internists, endocrinologists, rheumatologists, cardiologists, diabetologists, gynaecologists, geriatricians and paediatricians....
According to several studies, women with Crohn's disease (CD) had reduced fertility, which is mostly due to voluntary decisions and reduced ovarian reserve. In our study, we aimed to compare reproductive health parameters (RHP), previous pregnancy complications and outcomes, and ovarian reserve (OR) assessed by the anti-Mullerian hormone (AMH) in C...
Background: Pancreatic cystic lesions (PCLs) are being more frequently diagnosed and some have the potential for malignant transformation. The decision for performing EUS-FNA and indicating surgery remains challenging. Aims: To evaluate the feasibility and diagnostic yield of EUS-FNA, and in patients undergoing surgery to compare results of EUS-F...
Súhrn: Bolesti brucha patria medzi pomerne časté symptómy u adolescentov. Príčiny, ktoré sa podieľajú na bolestiach brucha, sú pestré a tým aj diferenciálna diagnostika je pomerne rozsiahla a zložitá. To súvisí pravdepodobne s tým, že brucho zaberá pomerne veľkú oblasť, obsahuje množstvo orgánov, štruktúr, systémov vrátane lymfatických uzlín, ktor...
Background:
Ursodeoxycholic acid response score (URS) is a prognostic model that estimates the baseline probability of treatment response after 12 months of ursodeoxycholic acid (UDCA) therapy in patients with primary biliary cholangitis (PBC).
Aim:
To independently evaluate the predictive performance of the URS model.
Methods:
We used a cohor...
Background:
Muscle growth promoters are being developed for the treatment of disease-induced loss of muscle mass. Ligandrol and ostarine are selective androgen receptor modulators (SARMs) with a non-steroidal structure and a presumably more favorable side effect profile. In recent years, these substances with or without "post-cycle therapy" (PCT)...
Objective:
To identify pretreatment laboratory parameters associated with treatment response and to describe the relationship between treatment response and liver decompensation in patients with primary biliary cholangitis treated with ursodeoxycholic acid.
Methods:
We defined treatment response as both ALP ≤ 1.67 × ULN and total bilirubin ≤ 2 ×...
Background:
Physical frailty increases susceptibility to stressors and predicts adverse outcomes of cirrhosis. Data on disease course in different etiologies are scarce, so we aimed to compare the prevalence and risk factors of frailty and its impact on prognosis in nonalcoholic fatty liver (NAFLD) and alcoholic (ALD) cirrhosis. Patients and Metho...
Introduction: Anabolic agents are prohibited in professional sports, but their availability makes its use widespread among amateur athletes. Our goal was to report all cases of anabolic-induced liver injury. Patients and methods: We included all inpatients with acute liver injury and previous anabolic use over the last 4 years. We recorded history,...
At present, we have enough tools for quick and accurate assessment of the muscle strength and functional status of a patient with cirrhosis. In recent years, the diagnostic criteria for sarcopenia and frailty are gradually merging into one, primarily for practical reasons. Both of them are equally negative predictors of disease development in hospi...
Chronic liver disease management is a comprehensive approach requiring multi-professional expertise and well-orchestrated healthcare measures thoroughly organized by responsible medical units. Contextually, the corresponding multi-faceted chain of healthcare events is likely to be severely disturbed or even temporarily broken under the force majeur...
Aim:
To assess and compare the feasibility and prognostic value of various frailty assessment tools among decompensated cirrhosis inpatients.
Methods:
Our prospective observational registry included consecutive patients admitted for cirrhosis between June 2017 and July 2018. Exclusion criteria were intensive-care unit admission, hepatocellular c...
Purpose
Patients with advanced chronic liver disease (ACLD) often have a poor nutritional status. In the management, current guidelines recommend dietary counseling and oral nutritional supplements (ONS). Nutritional goals and adherence to ONS are difficult to achieve while studies addressing adherence are scarce. We aimed to evaluate adherence to...
Background:
Certain trials have demonstrated that surveillance of hepatocellular carcinoma (HCC) lowers mortality via earlier diagnosis and therapy. We aimed to analyse surveillance performance in order to define targets for improvement.
Methods:
We retrospectively analysed consecutive patients (pts) ELIGIBLE for surveillance between January 2001...
Background:
Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength, common among patients with decompensated advanced chronic liver disease (dACLD). Irisin is a recently identified myokine, which is mainly expressed and secreted by skeletal muscle. Pointing to the essenti...
Introduction: Advanced chronic liver disease (ACLD) is associated with immune deficiency, which increases the risk of bacterial infections and the consequences thereof, including mortality. Aim: We aimed to characterise infections by the frequency, aetiology, type and associated prognosis in patients (pts) with ACLD hospitalised at the Liver Unit....
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of and indications for chronic liver disease and liver transplant (LTx). NAFLD arising after LTx for another indication is called de novo NAFLD. Aim: To determine the incidence of de novo NAFLD as dia gnosed by magnetic resonance imaging (MRI) spectroscopy (MRS)....
PŮVODNÍ PRÁCE Prevalence and risk factors of T-cell mediated rejection in patients after liver transplantation from deceased donors: a retrospective study over 10 years E4 | VNITŘNÍ LÉKAŘSTVÍ / Vnitř Lék 2020; 66(E-1): e4-e10 / www.casopisvnitrnilekarstvi.cz Prevalence and risk factors of T-cell mediated rejection in patients after liver transplant...
It is well known that smoking is the risk factor in the development and clinical course of Crohn´'s disease (CD), but on the other hand, smoking is a protective factor against ulcerative colitis (UC). The pathways that are influenced by smoking in CD and UC are poorly understood. The aim of our study was to analyse the influence of smoking on the m...
Drug-induced liver injury (DILI) is a common event in patients with rheumatic diseases (RD) on biological therapy (BT). We aimed at evaluating the prevalence and pattern of DILI. Consecutive RD patients treated with BT were followed for 6 months. ALT and ALP >the upper limit normal (ULN) and<to 3xULN defined injury Grade 1 and >3xULN injury Grade 2...
Cholelithiasis is more common in patients with Crohn’s disease (CD) than in the healthy population. The aim here was to examine risk factors for cholelithiasis in a cohort of CD patients and to compare the prevalence of cholelithiasis in a cohort of CD patients with that in a control group. This was a single-center retrospective case-control study....
Cholelithiasis is more common in patients with Crohn's disease (CD) than in the healthy population. The aim here was to examine risk factors for cholelithiasis in a cohort of CD patients and to compare the prevalence of cholelithiasis in a cohort of CD patients with that in a control group. This was a single-center retrospective case-control study....
Background
Alcohol use disorders affect 10% of the European population. Alcohol-related liver disease (ALD) is the most common indication for liver transplantation in Slovakia. The aim of this study was to determine the proportion of patients with ALD who received a liver transplant who had alcohol relapsed, and the risk factors for alcohol relapse...
In hospitalized patients with advanced chronic liver disease (ACLD), we aimed to evaluate the association between myostatin and muscle mass, its relation to inflammation and to assess the added prognostic value of myostatin for survival. In a prospective single-center cohort study, inclusion criteria were: consecutive hospitalization for ACLD and C...
Background
In thus far published literature, the cholelithiasis in patients with Crohn’s disease (CD) is twice more frequent than in the general population. The reason for this difference has not been satisfactorily explained. The aim of our study was to determine the prevalence of cholelithiasis in CD patients, to compare prevalence with a control...
Introduction:
Sarcopenia is associated with a higher risk of adverse outcomes among hospitalized patients with chronic diseases. Currently, an unmet need lies in its low diagnostic yield. We conducted a pilot study with the aim to screen hospitalized patients for sarcopenia using the EWGSOP2 criteria.
Patients and methods:
A cross-sectional stud...
Background and Aims
Chronic hepatitis C is a systemic disease and type 2 diabetes mellitus (T2DM) belongs to more common extrahepatic. The aim of this study was to (i) explore the prevalence of impaired fasting glucose (IFG) and T2DM in patients with chronic hepatitis C, (ii) explore the effect of direct acting antivirals (DAA) treatment on the gly...
Objective:
The aim of the study was to identify factors influencing infliximab (IFX) trough levels (TL) in patients with inflammatory bowel disease (IBD).
Methods:
This was a multicentre cross-sectional study performed at 5 large IBD centres in Slovakia. The cohort consisted of IBD patients, treated either with original IFX or CT-P13 biosimilar,...
SERUM MYOSTATIN IN PREDICTING GENDER-SPECIFIC SARCOPENIA AND SURVIVAL IN PATIENTS HOSPITALIZED WITH DECOMPENSATED ADVANCED CHRONIC LIVER DISEASE
Lubomir Skladany, Tomas Koller, Janka Vnencakova, Svetlana Adamcova-Selcanova
Background
Sarcopenia (SP) in dACLD may predict mortality; its clinical use is hindered by the lack of unifying simple and v...
SERUM MYOSTATIN IN PREDICTING GENDER-SPECIFIC SARCOPENIA AND SURVIVAL IN PATIENTS HOSPITALIZED WITH DECOMPENSATED ADVANCED CHRONIC LIVER DISEASE
Lubomir Skladany, Tomas Koller, Janka Vnencakova, Svetlana Adamcova-Selcanova
Background
Sarcopenia (SP) in dACLD may predict mortality; its clinical use is hindered by the lack of unifying simple and v...
The aim of this study was to analyze the influence of 25(OH)VD serum concentration on the expression of mRNA cytokines (IL-6, IL-8, IL-12, IL-17, IL-23, TNFα, CCR1, CCR2, CCR5, CCR9, CCL5, TLR2, TLR4, TLR5, CD207 ,CD206, FoxP3) in mucosa of IBD patients. The cohort consisted of 86 IBD patients (48 CD and 38 UC) followed at the IBD center of Univers...
Objectives:
Osteoporosis and osteopaenia are known chronic complications of inflammatory bowel diseases. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of bone mineral density (BMD).
Patients and methods:
The study was designed as a case-control study with the aim to assess and compare bon...
Little is known about the clinical relevance of treating post-menopausal women with no prior history of fragility fracture and bone mineral densities (BMD) within the osteopenic range. In recent years, in addition to BMD and FRAX fracture probability assessments, a surrogate measure of bone micro-architecture quality, called the trabecular bone sco...
AIM
To analyze 1-year liver injury burden in inflammatory bowel disease (IBD) patients.
METHODS
During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase (AT) activities of ALT, AST, ALP and gamma-glutamyl tr...
Introduction and aims: Association between coronary artery disease (CAD) and male gonadal status has been previously suggested, but still remains inconclusive. The aims of our study in males with recent acute coronary syndrome (ACS) were to evaluate the prevalence of hypogonadism, to compare their gonadal status with non-ACS matched controls and to...