Tom Earnest

Tom Earnest
Washington University in St. Louis | WUSTL , Wash U · Division of Computational & Data Sciences

Master of Science

About

13
Publications
1,389
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144
Citations
Citations since 2017
13 Research Items
144 Citations
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201720182019202020212022202301020304050

Publications

Publications (13)
Article
The cover image is based on the Original Article Oral oxycodone self‐administration leads to features of opioid misuse in male and female mice by Richard A. Slivicki et al., https://doi.org/10.1111/adb.13253.
Article
Full-text available
Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current opioid epidemic. There are several challenges with modelling oxycodone abuse. First, prescription opioids including oxycodone are orally self‐administered and have different pharmacokinetics and dynamics than morphine or fentanyl, which have been more c...
Preprint
Use of prescription opioids, particularly oxycodone is an initiating factor driving the current opioid epidemic. There are several challenges with modeling oxycodone abuse. First, prescription opioids including oxycodone are orally self-administered and have different pharmacokinetics and dynamics than morphine or fentanyl which have been more comm...
Article
Full-text available
The nucleus accumbens shell (NAcSh) and the ventral pallidum (VP) are critical for reward processing, although the question of how coordinated activity within these nuclei orchestrates reward valuation and consumption remains unclear. Inhibition of NAcSh firing is necessary for reward consumption, but the source of this inhibition remains unknown....
Preprint
Full-text available
Prescription opioid use is an initiating factor driving the current opioid epidemic. There are several challenges with modeling prescription opioid addiction. First, prescription opioids such as oxycodone are orally self-administered and have different pharmacokinetics and dynamics than morphine or fentanyl. This oral route of administration determ...
Article
Full-text available
Actigraphy, an objective measure of motor activity, reliably indexes increased movement levels in attention-deficit/hyperactivity disorder (ADHD) and may be useful for diagnosis and treatment-monitoring. However, actigraphy has not been examined in complex neurodevelopmental conditions. This study used actigraphy to objectively measure movement lev...
Preprint
Full-text available
A pause in firing of nucleus accumbens shell (NAcSh) neurons is critical for reward consumption; however, the substrate driving this pause is unknown. While ventral pallidal (VP) activity encodes reward value, the specific roles of VP subpopulations in computation and expression of this value are poorly understood. Here, we establish that inhibitor...
Article
There is a major clinical need for new therapies for the treatment of chronic itch. Many of the molecular components involved in itch neurotransmission are known, including the neuropeptide NPPB, a transmitter required for normal itch responses to multiple pruritogens in mice. Here, we investigated the potential for a novel strategy for the treatme...
Article
Full-text available
Itch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released by mast cells. The natriuretic polypeptide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching responses in mice, but it is unclear which itch-inducing agents stimulate these cells and the receptors involve...

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