Toke S Barfod

Toke S Barfod
Zealand University Hospital · Infectious Diseases and Internal Medicine

MD, PhD, Assoc. Prof.

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34
Publications
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212
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Introduction
Skills and Expertise

Publications

Publications (34)
Article
The study aimed to determine adjusted all‐cause mortality and cause of death in persons with chronic hepatitis B virus (HBV) infection compared with age – and sex‐matched persons from the general population. We used nationwide registers to identify persons aged ≥ 18 years with chronic HBV infection in 2002‐2017 in Denmark and included 10 age‐ and s...
Data
Inclusion and exclusion of patients with CHC and cirrhosis. Abbreviations: PIN, personal identification number; HCV, hepatitis C virus; CHC, chronic hepatitis C; CHB, chronic hepatitis B; TE, transient elastography; SVR, sustained virologic response; HCC, hepatocellular carcinoma.
Article
Full-text available
Background Chronic hepatitis C (CHC) causes liver cirrhosis in 5%–20% of patients, leading to increased morbidity and mortality. This study aimed to estimate liver-related morbidity and mortality among patients with CHC and cirrhosis in Denmark with and without antiviral treatment and sustained virologic response (SVR). Furthermore we aimed to esti...
Article
Objective: In Denmark, pregnant women have been screened for hepatitis B virus (HBV) since 2005, and children born to HBV-infected mothers offered hepatitis B immunoglobulin at birth, vaccination against HBV at birth and after 1, 2 and 12 months. The purpose of this study was to determine the risk of vertical HBV transmission in children born to m...
Article
Det er nu tyve år siden, jeg startede med at interessere mig for placebobegrebet og placeboeffekten. Siden har jeg primært arbejdet som hospitalslæge, og i årenes løb er betydningen af de aspekter af det lægelige arbejde, som placebobegrebet dækker over, vokset og vokset for mig. Samtidigt har placebobegrebet fået mindre og mindre relevans. Jeg tro...
Article
Background: In myelodysplastic syndrome (MDS), anemia often leads to red blood cell transfusion dependency and iron overload (IOL). Serum ferritin (SF) is used as a surrogate marker for IOL. IOL can lead to liver failure. Transient elastography (TE) also known as fibroscan is an easy and noninvasive procedure for liver stiffness measurements (LSM)....
Article
Full-text available
A high degree of adherence to antiretroviral therapy (ART) in patients infected with human immunodeficiency virus (HIV) is necessary for long term treatment effects. This study explores the role of timing of ART intake, the information patients received from health workers, local adherence patterns, barriers to and facilitators of ART among 28 HIV-...
Article
Full-text available
The first standard of care in treatment of chronic HCV genotype 1 infection involving directly acting antivirals was protease inhibitors telaprevir or boceprevir combined with pegylated-interferon and ribavirin (triple therapy). Phase III studies include highly selected patients. Thus, treatment response and development of viral resistance during t...
Article
Whipple's disease (WD) is a rare, chronic, systemic infection caused by the bacterium Tropheryma whipplei. New molecular techniques and epidemiological data over the latest decade have contributed to better understanding of this infection. The classical form of WD is characterized by arthritis followed years after by diarrhoea, weight loss and mala...
Article
In chronic viral hepatitis the liver biopsy helps the clinician to decide when to start treatment and plan follow-up. However, the execution of a liver biopsy is associated with discomfort, and sampling error can lead to misinterpretation. Serum markers and transient elastography (TE) are being considered as surrogates to the liver biopsy. The noni...
Article
This pilot study investigates the feasibility and effect of an intervention based on coaching and directly observed therapy (DOT), aimed at patients who are HIV-positive and have massive adherence problems and treatment failure. Participants were followed six months with coaching, homework and DOT. Eleven were enrolled and seven completed at least...
Article
Full-text available
Adherence is a decisive factor in achieving a successful response to antiretroviral therapy (ART) for HIV infection. No previous studies have been conducted regarding HIV treatment adherence in Guinea-Bissau. In this study we assessed barriers and facilitators to patient ART adherence. Semi-structured interviews were conducted with 20 adult, HIV in...
Article
Full-text available
We present the first case of intracerebral abscess after blood-borne infection with non-toxigenic Vibrio cholerae (non-01). The patient was a 66 year-old woman who was infected after swimming in Danish seawater during an unusually hot summer. She had predisposing haemochromatosis and a skin lesion on the ankle. We treated the patient with meropenem...
Article
Hvordan bør man evaluere komplekse behandlinger og behandlinger, der i en vis forstand primært virker gennem placeboeffekten? I denne artikel argumenteres for, at placebobegrebets flertydighed kan vanskeliggøre forskning i alternative behandlinger, og kan være forstyrrende for tolkningen af forskningens resultater. Der argumenteres for, at alternat...
Article
The case of a 66-year-old male with heart failure and cardiorenal syndrome is presented. The patient had normal renal function before intensive treatment with diuretics and ACE inhibitor. Shortly after the ACE inhibitor was stopped and diuretics were either stopped or reduced in dosage, his renal function normalized. Suggestions are presented for f...
Article
Previous studies have reported that forgetfulness is the most frequently mentioned reason for missed doses among patients on highly active antiretroviral therapy (HAART). However, no previous study has compared the reasons given by highly nonadherent patients with the reasons given by patients with better adherence. The objective of this study was...
Article
Full-text available
Editor—In their paper on the use of placebos in clinical practice, Nitzan and Lichtenberg say that they were unable to find more than one other study on the use of placebos in a clinical context.1,2 Eight similar studies are indexed in PubMed (see bmj.com). In the accompanying editorial, Spiegel points out that the Cochrane review on the placebo e...
Article
Grounded theory (GT) is a popular research method for exploring human behavior. GT was developed by the medical sociologists Glaser and Strauss while they studied dying in hospitals in the 1960s resulting in the book "Awareness of dying". The goal of a GT is to generate conceptual theories by using all types of data but without applying existing th...
Article
To investigate the interplay between resistance and adherence in the virological failure of three fundamentally different highly active antiretroviral therapy (HAART) regimens. We retrospectively identified 56 verified primary virological failures (viral load >400 HIV-1 RNA copies/mL) among 293 patients randomized to two nucleoside reverse transcri...
Article
We report a urinary tract infection (UTI) with erythrovirus B19 in an HIV-1-positive homosexual man persisting for more than 7 months after the decline of viremia after a primary infection. During the course of the UTI, the patient complained of soreness in the kidney region and suffered from transient episodes of edema and hematuria. Proteinuria a...
Article
There is a therapeutic potential in the doctor-patient relationship, in the diagnostic process, and in the symbolic elements of medical therapy. This unspecific effect seems, however, to be mainly caused by the doctor-patient relationship and the diagnostic process, and superfluous investigations and treatments should therefore not be initiated due...
Article
Strict compliance is required for a sustained response to antiretroviral therapy for HIV. Several studies from the US have found that African-Americans are less compliant and are more liable to treatment failure than caucasians. We describe a young, male refugee from Africa with treatment failure after non-compliance. A qualitative interview shows...
Article
Mycoplasma pneumoniae infection is sometimes followed by systemic reactions such as erythema multiforme major/Stevens-Johnsons syndrome. In the described case, a 30 year-old man developed severe inflammation of the oral mucous membranes following respiratory infection with Mycoplasma pneumoniae. There was also conjunctivitis and diarrhoea, and a ta...

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