Togas Tulandi

• Professor at McGill University

Objective: Our study focused on evaluating a possible relationship between endometriosis, Raynaud’s syndrome or migraine among women. Design: This was a cross-sectional population-based study. Participants/Materials, Setting, Methods: We used 12,684,067 hospitalized patient records in the Healthcare Cost and Utilization Project (HCUP) database betw...

Background: There is a paucity of studies on the association between polycystic ovary syndrome (PCOS) and endometriosis and the occurrence of venous thromboembolism (VTE). Objective: Our study aimed to evaluate the association between PCOS, endometriosis, deep vein thrombosis (DVT) and pulmonary embolism (PE). Methods: This was a retrospective stud...

Objectives To evaluate factors associated with malignancy in patients with endometrial polyps. Materials and Methods We conducted electronic database research on PubMed, MEDLINE, EMBASE, COCHRANE, and Google Scholar from inception for all studies on endometrial polyp. After removing duplicates, and title and abstract screening, we had a total of 1...

Objective: In recent years, several studies have proposed an association between endometriosis and various cardiovascular diseases. Our study evaluated the association between endometriosis and atherosclerosis in patients under 35 years of age using a large population database. Design: This was a retrospective population-based study. Participan...

Objectives Endometriosis is a common gynecological disease with a significant economic burden. Growing evidence has suggested the role of aberrant gene expression and epigenetic mechanisms in the pathogenesis of endometriosis. This study aims to identify potential key genes, epigenetic features, and regulatory networks in endometriosis using an int...

Objectives: Endometriosis is a common gynecological disease with a significant economic burden. Growing evidence has suggested the role of aberrant gene expression and epigenetic mechanisms in the pathogenesis of endometriosis. This study aims to identify potential key genes, epigenetic features, and regulatory networks in endometriosis using an in...

Objective: Endometriosis diagnostic delays are still encountered due to the lack of a reliable, noninvasive diagnostic test. Besides, menstrual blood is a relatively untapped field for diagnostics, yet it provides a readily accessible source for investigating common gynecological conditions. In the present study, we aim to evaluate the expression l...

Free full access until Jan 5th, 2024 https://authors.elsevier.com/a/1i5tjbXYirE6B Background: There is a lack of information regarding the impact of the physical symptoms associated with endometriosis and chronic pain on the mental health and well-being of affected women. Thus, our study aimed to evaluate the relationship between endometriosis, ch...

Study objective To characterize the incidence, clinical features, and demographic characteristics of women with catamenial pneumothorax with the use of a large national database in the United States. Design Retrospective case control study of the Healthcare Cost and Utilization Project, Nationwide Inpatient Sample (HCUP-NIS) database between 2004...

Background While hypertensive disorders of pregnancy (HDP) coexist with maternal anxiety and depression, it is unclear how these conditions affect neonatal outcomes. We evaluated the prevalence as well as associations and potential mechanisms between HDP, maternal anxiety and depression, preterm birth (PTB), and small for gestational age (SGA). Me...

Cervical cerclages are associated with improved live birth rates and have low short- and long-term risks. However, there have been reports of fistula formation or erosion of cerclage into the surrounding tissue. Those complications are uncommon and yet are serious. The risk factors associated with its development are still unclear. The purpose of o...

Background: While hypertensive disorders of pregnancy (HDP) coexist with maternal anxiety and depression, it is unclear how these conditions affect neonatal outcomes. We evaluated the prevalence as well as associations and potential mechanisms between HDP, maternal anxiety and depression, preterm birth (PTB), and small for gestational age (SGA)....

Objective To evaluate the combined effects of age and endometriosis on ovarian reserve in women with infertility. Methods We conducted a cross‐sectional study using an institutional database. Women with sonographic, laparoscopic, or histologic evidence of endometriosis were defined as the study group and the remaining women served as a control gro...

In brief Immune dysfunction may contribute to or cause recurrent implantation failure. This article summarizes normal and pathologic immune responses at implantation and critically appraises currently used immunomodulatory therapies. Abstract Recurrent implantation failure (RIF) may be defined as the absence of pregnancy despite the transfer of ≥3...

Objective : To evaluate the association between endometriosis and the risk of preeclampsia and other maternal outcomes in spontaneously conceived women. Data Sources : PubMed, MEDLINE, EMBASE, Scopus, Cochrane Library, Web of Science, and Google Scholar were systemically searched for studies published from inception until November 2021 (CRD4202019...

Objectives: The objective of this study was to evaluate the extent, type, and severity of spin in randomized controlled trials (RCTs) in obstetrics and gynecology. Data Sources: The top five highest impact journals in obstetrics and gynecology were systematically searched for RCTs with non-significant primary outcomes published between January 1, 2...

Objective: To evaluate whether the increased risk of breast cancer is dependent on the formulation of menopausal hormone therapy (HT) used. Methods: We performed a population-based case-control study of women aged 50 years or older using data from the U.K. Clinical Practice Research Datalink. Women with incident cases of breast cancer were age-m...

Objective The number of couples experiencing infertility treatment has increased, as has the number of women and men experiencing infertility treatment-related stress and anxiety. Therefore, there is a need to provide information and support to both men and women facing fertility concerns. To achieve this goal, we designed a mhealth app, Infotility...

Propose To investigate embryo retention (ER) rate in embryo transfer (ET) cycles and its effects on reproductive outcomes in a large database. Methods A matched retrospective cohort study in a tertiary academic hospital-based reproductive center. A total of 15,321 ET cycles were performed from January 2008 to December 2018. Each woman was matched...

Purpose To determine the frequency of hereditary breast cancer associated with different mutated genes and to evaluate fertility preservation (FP) outcomes among young women with hereditary breast cancer when compared to non-hereditary breast cancer. Material and methods A retrospective cohort study of women with breast cancer who underwent fertil...

Objective To perform a systematic review on consumption, leftover, and disposal of prescribed opioids after surgery in obstetrics and gynecology (PROSPERO ID 249856). Data sources Electronic database searches on PubMed, EMBASE, Cochrane library, and MEDLINE as well as other search methods, including all studies published between the years 2000 and...

Objective To evaluate whether sexual orientation affects sperm parameters. Methods This was a cross-sectional study using existing data from an academic reproductive centre for the period of April 01, 2009, to March 31, 2021. We compared the results of sperm analysis from male patients who were in same-sex relationships (study group) with those of...

Granulosa cells of growing ovarian follicles elaborate filopodia-like structures termed transzonal projections (TZPs) that supply the enclosed oocyte with factors essential for its development. Little is known, however, of the mechanisms underlying the generation of TZPs. We show in mouse and human that filopodia, defined by an actin backbone, emer...

Background Endometriosis is a condition associated with pelvic pain, infertility, and possibly with decreased quality of life as well as psychiatric disorder. The purpose of our study was to evaluate the association between pain characteristic, psychiatric disorder, and quality of life in women with endometriosis. Methods A cross-sectional study w...

Recurrent pregnancy loss (RPL) is frequently encountered in the outpatient setting. Despite extensive investigation, up to 50% of patients will be diagnosed with idiopathic RPL, for which no effective treatment exists. While the immune system is intricately involved in the initiation and maintenance of pregnancy, there are no validated diagnostic t...

Objectives Spin occurs when specific reporting strategies are used to distort the findings featuring the benefits of treatment. The objective of this study was to evaluate the nature and frequency of spin in randomized controlled trials (RCTs) in obstetrics and gynecology. Methods The top five journals in obstetrics and gynecology with thehighest...

A retrospective observational study was conducted to evaluate open-access journals in obstetrics and gynaecology, published between 2011 and 2019. Journals were classified based on their registration in open-access journal directories. Of 176 journals, 47 were not registered. Journals registered in the Directory of Open Access Journals (DOAJ) demon...

This new edition provides a much-needed reference book to accommodate emerging and expanding knowledge in fertility preservation, the rapidly growing field of reproductive medicine associated with advances in oncology. Written by a team of world-leading experts in the field and comprehensive in its scope, the book covers the full range of technique...

Background Abdominal cerclage is indicated for some women with cervical insufficiency. Long-term complications from cerclage are rare. Case Here we report the case of a patient who presented with recurrent urinary tract infection and hematuria 5 years after laparoscopic abdominal cerclage. Cystoscopy revealed bladder stones surrounding a foreign b...

Objective To evaluate associations between endometriosis and tubal and ovarian cancers in a large population-based study. Methods The Health Care Cost and Utilization Project – National Inpatient Sample databases from 2005 to 2014 were used in this study. Data on patients with a diagnosis of tubal or ovarian cancer and endometriosis (overall and s...

Study Objective The objective of our study is to provide a contemporary description of hysterectomy practice and temporal trends in Canada. Design A national whole population retrospective analysis of data from the Canadian Institute for Health Information Setting Canada Patients All women who underwent hysterectomy for benign indication from 01...

Objective To provide an evidence-based algorithm to guide the diagnosis and management of pregnancy of unknown location and tubal and nontubal ectopic pregnancy. Target Population All patients of reproductive age. Benefits, Harms, and Costs The implementation of this guideline aims to benefit patients with positive β-human chorionic gonadotropin...

Objective: To evaluate the association between endometriosis and bowel obstruction or intussusception using a large population database. Methods: This was a population-based study using data from the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) from 2005 to 2014. We studied women aged 18 to 55 years without infl...

Background Evidence on whether anxiety or mood disorders increases the risk of hypertensive disorders of pregnancy (HDP) has been conflicting. We aimed to evaluate the prevalence of maternal mental disorders over time and their associations with HDP. Methods This was a population-based retrospective study involving 9,097,355 pregnant women using H...

PurposeTo evaluate the effect of non-cavity-distorting intramural leiomyomas on the placental histopathology pattern and perinatal outcome in singleton live births resulting from in vitro fertilization treatment.Methods The study population included all singleton live births following in vitro fertilization treatment with autologous oocytes during...

Objective To conduct a systematic review and meta-analysis evaluating the effect of hydrosalpinx on pregnancy outcomes, to compare different types of management of hydrosalpinx and their impact on pregnancy rates as well as on the ovarian reserve. Data sources Electronic based search using Pubmed, EMBASE, Ovid MEDLINE, Google Scholar, ClinicalTria...

Reflecting the current trends, the utilization of frozen-thawed transfer cycles has been steadily increasing worldwide; outcome predictors of these cycles are therefore a major research goal. Our aim was to investigate whether the outcome of a fresh single blastocyst transfer (SBT) can serve as a prognostic factor for the subsequent vitrified–warme...

To assess the added value of maturing immature oocytes collected during fertility preservation treatments in women with malignancy. A retrospective case-control study analyzing the results of 327 cancer patients undergoing fertility preservation treatments. Oocyte maturation rates and cycle parameters were compared between 3 types of fertility pres...

Study Objective Evaluate the shift in surgical trends for myomectomy and subsequent changes in the number of uterine ruptures over the years. Methods Retrospective analysis utilizing the HCUP-NIS database. Evaluating women, aged 18 – 40 years, who underwent myomectomy by laparoscopy or laparotomy, and who subsequently had uterine rupture between 2...

INTRODUCTION Uterine rupture is an uncommon typically occurring during pregnancy or labor. One of the risk factors in uterine rupture is previous myomectomy either by laparoscopy or laparotomy. Due to regulation of FDA on myoma morcellation, many gynecologists have returned to myomectomy by laparotomy. The purpose of the study was to evaluate this...

INTRODUCTION One of the complications of endometriosis rarely described is bowel obstruction (BO). The purpose of our study was to evaluate the incidence of BO among women with endometriosis, the trend and the demographic characteristics. METHODS We used the data from the Healthcare Cost and Utilization Project—Nationwide Inpatient Sample (HCUP-NI...

Objectives To investigate the association between celiac disease and pregnancy, delivery, and neonatal outcomes, using a population database cohort. Methods We conducted a retrospective cohort study utilizing the Health Care Cost and Utilization Project-Nationwide Inpatient Sample database over 11 years from 2004 to 2014. A delivery cohort was cre...

Purpose To evaluate and better characterize the incidence, clinical presentations and risk factors of TOA in postmenopausal women and to evaluate the incidence of underlying malignancy in postmenopausal women with TOA. Methods Electronic based search using Pubmed, EMBASE, Ovid MEDLINE, Google Scholar, and Cochrane Central Register of Controlled Tr...

PurposeTo evaluate fertility preservation outcomes in breast cancer women with different hormonal receptor profiles before oncological treatment.Methods The study population included women with a diagnosis of breast cancer who underwent fertility preservation from 2009 until 2018 at a university-affiliated tertiary hospital. Stimulation parameters...

Objective To examine if and how factors associated with infertility-related concerns and opportunity to discuss concerns differ between male and female fertility patients. Methods A cross-sectional survey of 313 female and 254 male patients recruited from Canadian fertility clinics. An online survey asked about sociodemographic characteristics, ps...

Objective: To evaluate the impact of lymphoma aggressiveness on ovarian response during fertility preservation treatment. Design: Retrospective cohort study. Setting: University-affiliated tertiary hospital. Patient(s): Women with lymphoma who underwent ovarian stimulation for fertility preservation in the period from 2009 to 2018. Interven...

Intrauterine adhesions (IUAs) are a result of trauma to the basalis layer of the endometrium and may lead to clinical sequelae such as miscarriage, infertility, and menstrual irregularities. Hysteroscopy is recognized as the gold standard in diagnosis and management, although the optimal treatment after surgical intervention remains unclear. This r...

Objective: With the rising trend of postponing motherhood, there has been an increasing rate of infertility. Social fertility preservation offers the potential to overcome this age-related infertility, and many women are turning to the Internet to seek medical information. The aim of this study was to evaluate online information on social fertilit...

Study Objective The aim of our study is to test a combination of biological markers differentially expressed in samples from women with or without endometriosis. Methods Design ENDOSEARCH is a prospective multicentric international clinical trial registered with Clinical Trial.gov. Setting 20 renowned specialized centers in Europe, USA, Canada, a...

Study Objective Hysterectomies are the most commonly performed gynecologic procedure and are associated with faster recovery and decreased complications when performed minimally invasively compared with abdominally. The objectives were to measure temporal trends in minimally invasive hysterectomy for Canada and each province/territory and to determ...

Research question: Does breast cancer spread and aggressiveness affect fertility-preservation results? Design: Retrospective cohort study of women with breast cancer undergoing fertility-preservation treatment. Inclusion criteria: age 18-38 years and use of gonadotrophin releasing hormone antagonist protocol; exclusion criteria: recurrent canc...

This investigation sought systematically to review and meta-analyze evidence on reproductive outcomes following uterine artery occlusion (UAO) at myomectomy. Databases searched included PubMed, EMBASE, Ovid MEDLINE, Web of Science, and ClinicalTrials.gov. Eligible studies included observational and randomized controlled trials in which patients und...

https://preprints.jmir.org/preprint/15132/submitted . Background: Given the complexity of infertility diagnoses and treatments and the convenience of the Internet for finding health-related information, people undergoing fertility treatments often use online resources to obtain fertility information and support. However, little is known about wh...