Tobias Hedtke

Tobias Hedtke
Fraunhofer Institute for Microstructure of Materials and Systems IMWS | IWM · Business Unit Biological and Macromolecular Materials

Master of Science


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Research activities: Molecular structure and cross-linking of elastin - - - Elastin degradation - - - Development and characterization of biomimetic materials - - - Microstructural and molecular characterization of biological materials and biomaterials
Additional affiliations
June 2017 - present
Martin Luther University Halle-Wittenberg
  • PhD Student
January 2017 - present
Fraunhofer Institute for Microstructure of Materials and Systems IMWS
  • Research Associate
  • Development and characterization of biofunctional materials for medical and environmental applications; transfer of basic extracellular matrix research to application in biomaterial design with special focus on Elastin (PhD Thesis)
October 2014 - December 2016
October 2011 - September 2014


Publications (6)
Objective: TSP-1 (thrombospondin 1) is one of the most expressed proteins in platelet α-granules and plays an important role in the regulation of hemostasis and thrombosis. Interaction of released TSP-1 with CD47 membrane receptor has been shown to regulate major events leading to thrombus formation, for example, platelet adhesion to vascular endot...
Electrospinning is a well-established and widely used method for the production of protein-based fibrous biomaterials. The visualization of the morphology and the characterization of sample features related to the three-dimensional (3D) structure, like the porosity and fibers thickness, is crucial for the design and fabrication of tailor-made and a...
Background Skin ageing is associated with structure-functional changes in the extracellular matrix, which is in part caused by proteolytic degradation. Since cysteine cathepsins are major matrix protein-degrading proteases, we investigated the age-dependent expression of elastolytic cathepsins K, S, and V in human skin, their in vitro impact on th...
Full-text available
Elastic fibers are essential assemblies of vertebrates and confer elasticity and resilience to various organs including blood vessels, lungs, skin, and ligaments. Mature fibers, which comprise a dense and insoluble elastin core and a microfibrillar mantle, are extremely resistant toward intrinsic and extrinsic influences and maintain elastic functi...
Elastin is an essential structural protein in the extracellular matrix of vertebrates. It is the core component of elastic fibers, which enable connective tissues such as those of the skin, lungs or blood vessels to stretch and recoil. This function is provided by elastin's exceptional properties, which mainly derive from a unique covalent cross‐li...
Lysyl oxidases (LOXs) play a central role in extracellular matrix remodeling during development and tumor growth and fibrosis through cross-linking of collagens and elastin. We have limited knowledge of the structure and substrate specificity of these secreted enzymes. LOXs share a conserved C-terminal catalytic domain but differ in their N-termina...


Question (1)
Hi everyone,
We purchased MMP-2/MMP-9 Inhibitor II ((2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, CAS 193807-60-2). Unfortunately, it was stored for 12 days at ambient temperature and not at -20C as recommended by the supplier. Is it still usable? Does anyone have experience with this? Or would you recommend to buy it new?
This is the link to the purchased product:
Thank you!
Regards, Tobias


Cited By


Projects (4)
Optimized protective equipment, in particular respiratory protection masks, are required for the protection of medical personnel and people with weakened health in times of the SARS-CoV-2 pandemic. Our goal is to develop improved, high-quality protective textiles and masks, which provide a high protection through antiviral properties and additional design features. Aims are furthermore to maintain a high level of wearing comfort even during extended periods of wear, but also to improve speech intelligibility.
Design and development of innovative materials for dermal applications.
matriheal is a spin-off concept of the Fraunhofer Institute for Microstructure of Materials and Systems IMWS and focusses on the development and production of fully degradable elastin-based wound dressings. For more information visit (available in German, English webpage under construction).