Ting Luo

• PhD
• PostDoc Position at University of Texas Southwestern Medical Center

Hyperlipidemia has been suggested to be associated with dysregulation of lipid metabolism and gut microbiota. The present study prepared microencapsulated rice bran (MRB) with high stability based on in situ rice bran oil embedding and investigated the effects of MRB on lipid metabolism and gut microbiota in hyperlipidemic mice induced by high‐fat...

BACKGROUND Due to the high level of organic acids – primarily citric acid – black, red, and white currants have an excessively sour taste, making taste adjustment during processing challenging. This study investigated and evaluated the effects of an inoculation dose of the acid‐reducing yeast Issatchenkia terricola WJL‐G4 on several aspect such as...

This study aimed to elucidate the effect of tyrosol (TYR) on the amelioration of nonalcoholic fatty liver disease (NAFLD). Male C57BL/6J mice were fed a low-fat diet (LFD), a high-fat diet (HFD), or a HFD supplemented with 0.025% (w/w) TYR (TYR) for 16 weeks. Following a 16-week intervention, the TYR cohort exhibited diminished final body weight an...

Aims This study aimed to investigate the changes of cell membrane structure and function of Issatchenkia terricola under citric acid by performing physiological analysis. Methods and results The membrane integrity, surface hydrophobicity, structure, fluidity, apoptosis and fatty acid methyl esters composition of I. terricola WJL-G4 cells were dete...

Lotus root (LR) is prone to browning after harvest due to the oxidation of phenolic compounds by polyphenol oxidase (PPO). This study compared the effects of LR extract and BLR extract on cholesterol metabolism in high-fat diet (HFD) mice. Our findings highlighted the innovative potentiality of BLR extract in effectively regulating cholesterol meta...

Rice bran residue possessed a steady lipase activity ((26.68 ± 3.69)%) after its endogenous lipase was extracted continuously by phosphate buffer solution (PBS) for 24 h. Therefore, the aim of this research was to explore whether there exist any bound lipases in rice bran (Oryza sativa). Three physical treatments (grinding, homogenizing and ultraso...

The effect of diet-induced obesity on bone in rodents is variable, with bone mass increases, decreases, and no impact reported. The goal of this study was to evaluate whether the composition of obesogenic diet may influence bone independent of its effect on body weight. As proof-of-principle, we used a mouse model to compare the skeletal effects of...

Panax ginseng Meyer is a traditional Chinese medicine that is widely used as tonic in Asia. The main pharmacologically active components of ginseng are the dammarane-type ginsenosides, which have been shown to have anti-cancer, anti-inflammatory, immunoregulatory, neuroprotective, and metabolic regulatory activities. Moreover, some of ginsenosides...

BACKGROUND In recent years, there has been an increasing demand for plant‐based cheese analogues, however, the protein content of plant‐based cheeses currently on the market is generally low and cannot meet the nutritional needs of consumers. RESULTS Based on the ideal value similarity method (TOPSIS) analysis the best recipe for plant‐based chees...

Nonalcoholic fatty liver disease (NAFLD), which leads to insulin resistance, steatosis, and even hepatocellular carcinoma, is the most common chronic liver disease worldwide, however, effective treatment is still lacking. This study determined the role of liver FGF21 and the mechanisms underlying the protective effects of time‐restricted feeding (T...

Background: More than 30% of reproductive-age women are obese or overweight. Obesity and exposure to a high-fat diet (HFD) detrimentally affect endometrial development and embryo implantation. We previously reported that time-restricted feeding (TRF) improved ovarian follicular development, but whether and how TRF modulates embryo implantation are...

The aim of this meta-analysis was to systematically review the relationships between lactation diet and the composition of mature breast milk through screening multiple databases and gray literatures, with priority given to quantitative articles published in Chinese and English. We identified 27 cross-sectional studies that included 4355 lactating...

Background This study aimed to uncover the potential effects of zingerone (ZIN), one of the bioactive compounds in ginger, on the development of obesity as well as the mechanisms responsible for these effects in C57BL/6J mice fed with a high‐fat diet (HFD). Results Supplementation with 0.2% (wt/wt) zingerone for 16 weeks significantly reduced the...

As aromatic compounds found within red fruits and berries, raspberry ketones (RK) have the potential for nonalcoholic fatty liver disease (NAFLD) amelioration. However, the mechanism of RK on NAFLD is unclear, and their bioactive metabolite is unknown. As the major metabolites of RK that are mainly distributed in the liver, rhododendrol (RHO) is us...

Oxidative rancidity is a major issue limiting the utilization of flaxseed oil (FSO). Peptides possess an antioxidant effect; however, the flax cyclic peptide, a unique ingredient in FSO, has an obscure influence on the oxidation of FSO. Therefore, this study is aimed to investigate the effects of [1-9-NαC]-linusorb B3 (CLA) on the accelerated oxida...

Red raspberry is a kind of fruit with high nutritional values. To evaluate the comprehensive quality of 24 red raspberry varieties in Northeast China, physicochemical properties, bioactive compounds and sensory characteristics were measured, followed by principal component analysis (PCA) and cluster analysis (CA). Altogether, eight important proper...

Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Pana...

Hydrolysable tannins, mainly gallotannins and ellagitannins, either extracted directly from oak or as a part of lyophilized extracts from finished wine, have been associated with antioxidant and anti-inflammatory properties that may benefit human health. In this work we hypothesized that a commercially available oak tannin powder provided to C57BL/...

The present study investigated the mechanism underlying the impact of hesperidin (HES) on nonalcoholic fatty liver (NAFLD). C57BL/6J male mice were administered a low-fat diet, high-fat diet (HFD), or HFD plus 0.2% (wt/wt) HES (HFD + HES) diet. After 16 weeks of intervention, the mice in the HFD+HES group showed a lower final body weight and liver...

Headspace solid-phase microextraction (HS-SPME)–gas chromatography–mass spectrometry (GC–MS) was used for the determination of volatile compounds in infant formulas from different brands, stages, and countries of origin. Furthermore, the compositions in infant formula were compared with that in breast milk. Fifty-seven kinds of volatile compounds w...

Peptides derived from egg protein hydrolysate have potential hypoglycemic benefits by inhibiting α‐glucosidase. Herein, fluorescence spectroscopy and molecular docking were performed to investigate the α‐glucosidase inhibitory mechanism of the oligopeptides ARDASVLK and HNKPEVEVR from soft‐shelled turtle eggs. Gastrointestinal digestion characteris...

High content of citric acid in red raspberry juice leads to poor sensory experience. This study developed a feasible method to degrade citric acid in red raspberry juice using a novel characterized Issatchenkia terricola WJL-G4 isolated from red raspberry fruits. I. terricola WJL-G4 exhibited a potent capability of reducing the citric acid contents...

The consumption of phytochemicals, bioactive compounds in fruits and vegetables, has been demonstrated to ameliorate obesity and related metabolic symptoms by regulating specific metabolic pathways. This review summarizes the progress made in our understanding of the potential of phytochemicals as metabolic signals: we discuss herein selected molec...

Soluble polysaccharides derived from microbial fermentation of agricultural by-products were considered as potential functional ingredients, primarily having probiotic properties. Herein, soluble polysaccharides (FSRP) were isolated from soybean residue fermented by Neurospora crassa, and FSRP mainly contained rhamnose, arabinose, fucose, mannose,...

This study aimed to elucidate the responses of a novel characterized Issatchenkia terricola WJL-G4 against citric acid stress by performing physiological analysis, morphology observation, and structural and membrane fatty acid composition analysis. The results showed that under citric acid stress, the cell vitality of I. terricola WJL-G4 was reduce...

Rice grains were obtained from two Chinese provinces (Hubei and Guangxi) and then their rice bran was abraded into four equal fractions by weight from outside to inside. The component distributions in these four fractions were then investigated. The contents of total lipid‐soluble antioxidant showed no significant difference between rice bran from...

Scope: Consumption of extra virgin olive oil (EVOO) is beneficial for weight control. Tyrosol is one of the main polyphenolic compounds in EVOO and its role in combating obesity is unknown. Thus, this study was designed to investigate the effect of tyrosol consumption on obesity and its underlying mechanisms in high-fat diet (HFD)-induced mice. M...

Background The health effects of dietary phytochemicals (eg., carotenoids, flavonoids, phenolic acids) and their interactions with each other or nutrients (eg., carbohydrate, proteins, lipids, micronutrients) have widely been used in drug therapy studies. Most research contributions on the interactions among phytochemicals are based on their direct...

Our previous study isolated a novel Issatchenkia terricola WJL-G4, which exhibited a potent capability of reducing citric acid. In the current study, I. terricola WJL-G4 was applied to decrease the content of citric acid in red raspberry juice, followed by the red raspberry wine preparation by Saccharomyces cerevisiae fermentation, aiming to invest...

Novel food and food compounds interventions have attracted a lot of attention nowadays for the prevention and treatment of metabolic diseases. Raspberry ketone (RK) is aromatic compound found within red fruits and berries, has been used as an over-the-counter product for weight loss. However, actually, the effect of RK on weight loss is still contr...

Flavonoids (quercetin, luteolin) and carotenoids (lycopene, lutein) were combined at different molecular ratios in a total concentration of 8 μM to investigate their antioxidant interactions. Cellular uptake of carotenoids, the expression of carotenoid transporters, the ROS scavenging ability, and antioxidant enzymes activities were compared in HUV...

Purpose Previously, we reported the octyl ester derivative of ginsenoside Rh2 (Rh2-O) had better antitumor and immunomodulatory effects than Rh2 in H22 tumor-bearing mice. Therefore, this study further explored the effects of Rh2-O on splenic lymphocytes in H22 tumor-bearing mice and the underlying mechanism. Methods Wild type and Tlr4-/- mice wer...

High content of citric acid in lemon juice leads to poor sensory experience. The study aimed to investigate the dynamics changes in organic acids, phenolic compounds, and antioxidant activities of lemon juice fermented with Issatchenkia terricola WJL-G4. The sensory evaluation of fermented lemon juice was conducted as well. Issatchenkia terricola W...

The microstructure, physicochemical properties and adsorption capacities of deoiled red raspberry pomace (DRP) and its total dietary fiber (DRPF) were investigated in the study, aiming to evaluate their potential to use as functional food ingredients. The chemical composition showed that both DRP and DRPF were mainly made of lignin. Compared to DRP...

Hypercholesterolemia, one of the major risk factors of cardiovascular diseases, is a worldwide public health problem. Nutraceuticals and phytochemicals are attracting attention as a result of their cholesterol-lowering ability and minimal side effects. Among them, selenium (Se) is on the list. The amount of Se in foods varies by region. Se-enriched...

In the present study, a kind of structured lipids, namely 1,3‐di‐oleic‐2‐medium chain (OMO) triacylglycerols, were synthesized through lipase‐catalyzed reactions using coconut oil and rapeseed acid as materials in a trace water‐in‐oil system. Experimental analysis and computational simulations were undertaken to compare the stability of four lipase...

The storage and utilization of rice bran are severely impeded due to the rapid rancidity caused by its lipase. However, little research was carried out to explore other factors for rice bran rancidity. In this study, five Bacilli with lipid hydrolysis abilities were isolated from rice bran and then inoculated into sample to explore the influence of...

This research investigated the effects of different triglycerides on lipid deposition and the underlying mechanism in oleic acid-induced human hepatic LO2 cells. Cells were treated with vehicle, oleic acid (OA), OA + coconut oil (CO), OA + rapeseed oil (RO), OA + physical mixture oil of CO and RO (CROM), OA + interesterified oil of CO and RO (CROI,...

Dairy fat intake has been considered as a risk factor for cardiovascular disease. Rodent models show that trans fatty acids in industrial hydrogenated oil and ruminant milk have different effects on cardiovascular diseases. One of the main reasons is that the distributions of trans fatty acids in triacylglycerols from dairy products and from indust...

Obesity and related metabolic disorders have become epidemic diseases. Intermittent fasting has been shown to promote adipose tissue angiogenesis and have an anti-obesity feature; however, the mechanisms of how intermittent fasting modulates adipose tissues angiogenesis are poorly understood. We investigated the effect of fasting on VEGF levels in...

Antibiotics are the most commonly used clinical drugs for anti-infection, but they can also destroy normal microorganisms and cause intestinal barrier dysfunction. To elucidate the effects and mechanism of a water-soluble polysaccharide from Fagopyrum esculentum Moench bee pollen (WFPP) on intestinal barrier integrity in antibiotic-treated mice, BA...

Background: There has been a significant increase, to epidemic levels, of obese and overweight women of reproductive age, causing impairments to reproductive health. Time-restricted feeding (TRF) including isocaloric intake has shown to be preventive of obesity-related disorders. However, its therapeutic ability to improve the reproductive functio...

Different chain lengths diacylglycerols (DAG) (long‐ and medium‐chain) were synthesized from peanut and coconut oils. The effects of DAG with different chain lengths on body fat, blood lipids, and lipid metabolism‐related enzymes in the liver and adipose tissue of C57BL/6J mice were investigated. Compared to peanut and coconut oils containing triac...

Background: Wine aged in oak barrels will incorporate polyphenols inherent in the staves, suggesting that wine stored in these wooden containers will introduce oak compounds into the human body after consumption. Objective: The purpose of the present study is to test whether consumption of these oak compounds could favorably influence metabolism...

The exocrine pancreas expresses the highest concentrations of fibroblast growth factor 21 (FGF21) in the body, where it maintains acinar cell proteostasis. Here, we showed in both mice and humans that acute and chronic pancreatitis is associated with a loss of FGF21 expression due to activation of the integrated stress response (ISR) pathway. Mecha...

Gastrointestinal tract is the second largest organ in the body that mainly functions in nutrients and minerals intake through the intestinal barrier. Intestinal permeability maintains the circulation of minerals and nutrients from digested foods. Life and all the metabolic processes depend either directly or indirectly on proper functioning of GI t...

The present work is undertaken to characterize a Granny Smith apple procyanidin extract (AE) and investigate the beneficial effect of the AE in the intestine in vitro. Each AE was characterized via LC-ESI-MS. Caco-2 cells were used to study the preventive actions of the AE against the downregulation of tight junction protein expression, oxidative s...

The study is designed to determine whether consumption of the soy isoflavones, genistein and daidzein, differentially influence metabolic syndrome, and to further investigate the involvement of Liver X Receptor (LXR) regulation. C57BL/6J mice were fed diets as follows: low fat diet (LF), western-style diet (WD), and WD containing 0.16% (w/w) of gen...

Liver X receptors (LXRs) are nuclear hormone receptors which are involved in the regulation of cholesterol and lipid metabolism. In mice, soy isoflavone consumption reduces hepatic lipid accumulation, however, it is not clear whether these effects are mediated via LXR along with other regulatory factors. We therefore investigated whether the regula...

Previous work has demonstrated that moderate red wine consumption, and intake of some bioactive compounds in wine including quercetin and resveratrol correlate with a reduced incidence of metabolic disease symptoms. The aging of wine in oak barrels adds to the polyphenolic content of wine by introducing oak tannins to the wine. Tannins have been su...

Iron is one of the most abundant metals on earth and is essential to most life forms. Its level is tightly regulated, since iron does not have an excretion regulation pathway, and a high toxicity of free iron can lead to tissue damage. The purpose of this review is to summarize recent knowledge, allowing a better comprehension of iron homeostasis i...

Using an animal model for diet-induced metabolic disease, we have shown previously that the addition of raspberry juice concentrate (RJC) and raspberry puree concentrate (RPC) at a level of 10% of kcal, equivalent to four servings per day, to an obesogenic high-fat, western-style diet (HF) significantly reduced body weight gain, serum resistin leve...

Researches have demonstrated that trans-fatty acids are related to the progression of atherosclerosis, but the underlying mechanism is not clear till now. In the presented study, two-dimensional electrophoresis based proteomics was used to discover the role of elaidic acid in atherosclerosis. In human umbilical vein endothelial cells (HUVEC), twent...

The proliferating effects of 3 different simple triglycerides (tristearin, triolein, and trilinolein) on the human umbilical vein smooth muscle cells (HUVSMCs) induced by oxidized-LDL (ox-LDL) were investigated in this study. The protein and mRNA gene expressions of proliferating cell nuclear antigen (PCNA), smooth muscle-α-actin (SM-α-actin), and...

Soy isoflavones exert beneficial health effects; however, their potential to ameliorate conditions associated with the metabolic syndrome (MetS) has not been studied in detail. In vitro and in vivo models were used to determine the effect of isoflavones on lipid metabolism, inflammation, and oxidative stress. In nude mice, consumption of Novasoy (N...

Background: Although a reductionist approach has sought to understand the roles of individual nutrients and biochemicals in foods, it has become apparent that there can be differences when studying food components in isolation or within the natural matrix of a whole food. Objective: The objective of this study was to determine the ability of who...

BACKGROUND: A significant body of research demonstrates that intake of berries and berry phytochemicals favorably influence metabolism via a number of different biological mechanisms. However, raspberries and select phytochemicals present in raspberries have been less studied than several other berry fruits. OBJECTIVE: The current study tested the...

Background: Intake of polyphenols and polyphenol-rich fruit extracts has been shown to reduce markers of inflammation, diabetes, and hepatic complications that result from the consumption of a high-fat (HF) diet. Objective: The objective of this study was to determine whether mice fed polyphenol-rich apple peel extract (AE), cherry extract (CE),...

Introduction Genistein and daidzein are isoflavones abundant in soybean. These isoflavones have been shown to have a weak but significant estrogenic effect and other studies have shown isoflavones may impact cancer and metabolic disease. Our prior research (Luo et al. 2014) indicated metabolic improvements in male mice fed a high‐fat (HF) diet supp...

Introduction Non‐Alcoholic Fatty Liver Disease (NAFLD) is a condition characterized by fat accumulation in the liver, and can be a precursor to more severe liver diseases, such as Non‐Alcoholic Steatohepatitis, cirrhosis and liver cancer. Currently, there is no accepted therapy for NAFLD, except for diet and exercise, which is difficult to administ...

We tested the hypothesis that addition of PUFA‐rich walnut to a high‐fat Western diet (HF) would improve metabolism in male C57BL/6J mice. Further, various polyphenol‐rich foods were added to walnut‐containing HF diets to evaluate the potential for additional metabolic improvement. Groups of mice (n=8 each) were provided either a low‐fat diet (LF,...

The commonly‐available red raspberry, Rubus strigosis , is a relatively understudied nutrient‐dense fruit with both high phytochemical and fiber content. We tested the hypothesis that intake of whole raspberry food products and/or raspberry phytochemicals would remediate metabolic problems in C57BL/6J male mice fed a high‐fat, high‐sucrose diet mod...

a name=“OLE_LINK14”> The effect of soy isoflavones on metabolic syndrome and hepatic lipid metabolism was investigated in male C57BL/6J mice fed a high‐fat diet (HF), and HF plus soy isoflavone supplement Novasoy (NS, 0.2%, w/w) diet for 10 weeks. Compared to HF, NS‐fed mice, despite no changes in food intake, had reduced percent weight gain over t...

This study aimed to investigate the profiles change in proanthocyanidins (PAs) catalyzed by polyphenol oxidase (PPO) from lotus seedpod in a model wine system (MWS). Results showed that PAs from lotus seedpod consisted of dimer (74.00 %) and trimer (22.75 %). PPO could tolerate ethanol concentrations below 20 % (v/v). The optimum temperature of PPO...

Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process. The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and trilinolein, upon oxidized low-...

Trans fatty acids (TFA) have been considered as an independent risk factor of coronary heart disease, sudden death and insulin-resistance, and different TFA isomers may have different effects on the progression of cardiovascular diseases such as atherosclerosis. The aim of the study was to investigate the effects of two major TFA, elaidic acid and...

The descriptors linking dietary and fish fatty acids (FA) compositions in four one-year-old wild freshwater fish, Mylopharyngodon piceus, Ctenopharyngodon idella, Hypophthalmichthys molitrix, and Hypophthalmichthys nobilis, from Poyang Lake were studied. M. piceus mainly feeding on crustaceans had the highest relation of polyunsaturated fatty acids...

Ginsenoside compound K (CK) is a bioactive compound with poor oral bioavailability due to its high polarity, while its novel ester prodrugs, the butyl and octyl ester (CK-B and CK-O), are more lipophilic than the original drug and have an excellent bioavailability. The aim of this study was to examine the transport mechanisms of CK, CK-B, and CK-O...

In 2008, CLAs received a no-objection letter from the FDA on its generally recognized as safe (GRAS) status for certain foods. However, aside from the mixture of c9, t11-CLA and t10, c12-CLA, other CLA mixtures are still not used in food production. The effects of different concentrations (25, 50, 100, and 200 µmol/L) of CLA mixture (c9, t11-CLA an...

Endothelial cell injury caused by reactive oxygen species (ROS) plays a critical role in the pathogenesis of atherosclerosis. Therefore, phytochemicals or antioxidants that inhibit the production of ROS have clinical value for the treatment of atherosclerosis. Rhein is one of the most important active components of rhubarb (Rheum officinale), a fam...