Tina Koch

Tina Koch
Flinders University · College of Nursing and Health Sciences

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56
Publications
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905
Citations

Publications

Publications (56)
Chapter
Cebranopadol is a novel first-in-class analgesic with highly potent agonistic activity at nociceptin/orphanin FQ peptide (NOP) and opioid receptors. It is highly potent and efficacious across a broad range of preclinical pain models. Its side effect profile is better compared to typical opioids. Mechanistic studies have shown that cebranopadol’s ac...
Article
Agonists selectively acting at NOP, MOP, DOP and KOP receptors as well as mixed opioid receptor agonists are known to exert anti-hypersensitive efficacy in the rat spinal nerve ligation (SNL) model of neuropathic pain. To investigate the relative contribution of individual opioid receptor activation to the overall efficacy of mixed opioid receptor...
Article
Eight Guyanese expatriate women, who had been living in and around London for decades, came together driven by a participatory inquiry approach. Do we just have ‘a touch of sugar’ or is diabetes a serious affliction were questions asked. The study’s objective was to find answers to these questions. Three nurse academics, one a Guyanese/English woma...
Article
Targeting functionally independent receptors may provide synergistic analgesic effects in neuropathic pain. To examine the interdependency between different opioid receptors (µ-opioid peptide [MOP], δ-opioid peptide [DOP] and κ-opioid peptide [KOP]) and the nociceptin/orphanin FQ peptide (NOP) receptor in streptozotocin (STZ)-induced diabetic polyn...
Article
Full-text available
Cebranopadol (trans-6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine) is a novel analgesic nociceptin/orphanin FQ peptide (NOP) and opioid receptor agonist (Ki [nM]/EC50 [nM]/relative efficacy [%]: human NOP receptor 0.9/13.0/89; human mu opioid peptide [MOP] receptor 0.7/1.2/104; human kappa opi...
Article
The first line of treatment for people diagnosed with type 2 diabetes is a change in diet and an increase in exercise. If the blood glucose level is not stabilized, then hypoglycaemic tablets and or insulin may be prescribed. People receiving a diagnosis of diabetes must absorb complex information and adopt a new lifestyle almost immediately. The p...
Article
We researched alongside older Australian women who were newly diagnosed with type II diabetes. This inquiry was guided by Koch and Kralik's participatory action research (PAR) methodology. We asked women to talk about their self-management and learning post-diagnosis and continued to talk with them for 12 months. Once we had built relationships we...
Article
Intuition usually is defined as the capability to act or decide appropriately without deliberately and consciously balancing alternatives, without following a certain rule or routine, and possibly without awareness (Gigerenzer, 2007; Hogarth, 2001; Klein, 2003; Myers, 2002). It allows action which is quick (e.g. reaction to a challenging situation)...
Article
Aim. In this paper, we present the findings of a recent research project in which we explored self- management with older people who were diagnosed with asthma. Background. Asthma self-management literature has focused on the need for the patient to ‘adhere’ to prescribed therapies, in particular the taking of medications, monitoring of respirator...
Article
Aim.The purpose of this paper is to outline understandings about the construction of sexuality and the impact of a changing body for women living with multiple sclerosis (MS). We suggest that the process of transition towards incorporating the experience of chronic illness into one's life is influenced by the (re)construction of self-identity. Des...
Article
The purpose of this paper is to outline understandings about the construction of sexuality and the impact of a changing body for women living with multiple sclerosis (MS). We suggest that the process of transition towards incorporating the experience of chronic illness into one's life is influenced by the (re)construction of self-identity.|A partic...
Article
The terminally ill person's quality of life (QoL) is the principal focus and intended outcome of palliative care, the raison d'être of palliative care interventions, and always of concern to the client. Palliative care case managers are encouraged to assess and/or measure this QoL to support clinical decision making, but little agreement exists abo...
Article
Full-text available
The cosmic microwave background (CMB) is one of only a few physically observable remnants of the early Universe. Studies of the spectrum, polarization and spatial distribution of the CMB can potentially lead to a detailed understanding of the processes that took place in the early Universe. Many of the outstanding cosmological questions regarding t...
Article
Full-text available
We present results from two observations of the cosmic microwave background (CMB) performed from the South Pole during the 1993-1994 austral summer. Each observation employed a 3 deg peak-to-peak sinusoidal, single-difference chop and consisted of a 20 deg x 1 deg strip on the sky. The first observation used a receiver which operates in three chann...
Article
Full-text available
We present results from 2 observations of the CMB performed from the South Pole during the 93-94 austral summer. Each observation employed a 3$^{\circ}$ peak to peak sinusoidal, single difference chop and consisted of a $20^{\circ}\times 1^{\circ}$ strip on the sky near our SP91 observations. The first observation used a Q-band receiver which opera...
Article
The UC Santa Barbara CMB anisotropy group has made three excursions to the South Pole to obtain data on degree scale anisotropies. The most recent trip occurred from November, 1993 to January, 1994. Data were taken with the UCSB Advanced Cosmic Microwave Explorer (ACME), using two different receivers, operating from 26-36 GHz and from 38- 45 GHz. T...
Article
Zusammenfassung Vorangegangene Studien konnten zeigen, dass während einer Immunantwort des Innenohres vorwiegend sensibilisierte Lymphozyten des Blutstromes zum Labyrinth wandern. Die vorliegende Untersuchung sollte die Fähigkeit von sensibilisierten Lymphozyten aufzeigen, eine Autoimmunerkrankung des Innenohres auch bei Abwesenheit eines Antigens...
Chapter
Bei einem Viertel aller Patienten mit Wegenerscher Granulomatose (WG) kommt es im Verlauf der Erkrankung zu einer Mitbeteiligung des Innen- oder Mittelohres. Als Ursache hierfür wurde bisher eine granulomatöse Entzündung der Schleimhaut oder im Rahmen der generalisierten Vaskulitis ein Mitbefall der Innenohrgefäße angenommen.
Article
The distribution of binding sites for atrial natriuretic peptide (ANP) has been examined in frozen sections of the guinea pig inner ear by means of autoradiography. The highest density was found in the stria vascularis of all cochlear turns. In membrane preparations of stria vascularis in vitro, the production of the second messenger cGMP was stron...
Article
The enzyme adenylate cyclase produces the second messenger cAMP and is located in the mammalian inner ear, predominantly in the stria vascularis and to a lesser extent in the organ of Corti. It is coupled to hormone receptors and regulating G proteins in the outer cell membrane. By means of immunofluorescence in cryostat sections of the guinea pig...
Chapter
Die lokale Verteilung des Rezeptors für das Hormon ANP (Atriales Natriuretisches Peptid) und sein Signaltransduktionsweg im Innenohr wurde histochemisch an Gefrierschnitten aus der Cochlea von Meerschweinchen und biochemisch an isolierten Membranen aus der Stria vascularis untersucht. Nach in vitro Markierung der ANP-Rezeptoren mittels 125J-ANP in...

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