Tin Aung

• National University of Singapore

Importance Baseline ocular biometrics of the anterior segment forecast progression from primary angle closure suspect (PACS) to primary angle closure (PAC). As ocular biometrics change with aging, it is also important to understand the progression risk associated with these longitudinal anatomical changes. Objective To assess 18-month ocular biome...

Importance Intraocular pressure (IOP) reduction with phacogoniotomy (phacoemulsification plus goniosynechialysis plus goniotomy) was not less than that of phacotrabeculectomy for advanced primary angle-closure glaucoma (PACG) with cataract at 1-year follow-up, but longer-term outcomes are needed. Objective To investigate if phacogoniotomy is nonin...

Importance The safety and effectiveness of combining surgical peripheral iridectomy (SPI) with goniosynechialysis (GSL) and goniotomy (GT) vs trabeculectomy for intraocular pressure (IOP) reduction remains unknown. Objective To investigate the safety and effectiveness at 1 year of SPI + GSL + GT vs trabeculectomy in advanced primary angle-closure...

Purpose: To characterize the 3D structural phenotypes of the optic nerve head (ONH) in patients with glaucoma, high myopia, and concurrent high myopia and glaucoma, and to evaluate their variations across these conditions. Participants: A total of 685 optical coherence tomography (OCT) scans from 754 subjects of Singapore-Chinese ethnicity, includi...

Purpose To report the 2-year effective and safety profile of integrated phacoemulsification with intraocular lens implantation (PEI), goniosynechialysis (GSL) and 120° goniotomy (GT) in advanced primary angle-closure glaucoma (PACG) and cataracts. Design Multicentre prospective study. Methods 201 eyes of 196 patients who received combined PEI+GSL...

Wide-field optical coherence tomography (OCT) imaging can enable monitoring of peripheral changes in the retina, beyond the conventional fields of view used in current clinical OCT imaging systems. However, wide-field scans can present significant challenges for retinal layer segmentation. Deep Convolutional Neural Networks (CNNs) have shown strong...

Précis Approximately 38% of 467 asymptomatic primary angle closure glaucoma subjects had severe visual field loss (<−20 dB) at first presentation. Gender-based differences in prevalence and biometry suggests the need for an integrated approach for assessing risk. Purpose To compare the clinical characteristics of patients with asymptomatic primary...

Precis Inter-ocular comparison of primary angle closure glaucoma subjects with asymmetrical and symmetrical visual field loss, revealed significantly thinner central corneal thickness and higher presenting intraocular pressure in the worse eye of the asymmetrical group. Purpose To compare the inter-ocular clinical and biometric parameters of prima...

Objective: To identify subgroups of angle closure disease by considering age-independent anterior segment parameters. Methods: Anterior-segment optical coherence tomography (ASOCT) was performed in primary angle closure suspect (PACS) and primary angle closure glaucoma (PACG) patients. Clustering analysis using age-independent parameters, anteri...

Background: To evaluate the 6-year physiological rates-of-change in ganglion cell inner plexiform layer (GCIPL) and retinal nerve fibre layer (RNFL) thickness measured with optical coherence tomography. Methods: We included 2202 out of 2661 subjects from the population-based Singapore Chinese Eye Study who returned for follow-up 6 years after ba...

Purpose To compare changes in macular curvature following acute IOP elevation across a range of myopic conditions. Methods We studied 328 eyes from 184 subjects, comprising 32 emmetropic controls (between +2.75 and −2.75 diopters), 50 eyes with high myopia (<−5 diopters; HM), 108 highly myopic with glaucoma (HMG) and 105 pathologic myopia (PM) eye...

Parkinson’s disease (PD) is an incurable, progressive and common movement disorder that is increasing in incidence globally because of population aging. We hypothesized that the landscape of rare, protein-altering variants could provide further insights into disease pathogenesis. Here we performed whole-exome sequencing followed by gene-based tests...

Primary open-angle glaucoma typically presents as two subtypes. This study aimed to elucidate the shared and distinct genetic architectures of normal-tension (NTG) and high-tension glaucoma (HTG), motivated by the need to develop intraocular pressure (IOP)-independent drug targets for the disease. We conducted a comprehensive multi-ethnic meta-anal...

Importance Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations. Objective To evaluate how established POAG PRSs perform in African-ancestry samples from the Genetics in Glaucoma Patients of Af...

Background/ Aims The lack of context for anterior segment optical coherence tomography (ASOCT) measurements impedes its clinical utility. We established the normative distribution of anterior chamber depth (ACD), area (ACA) and width (ACW) and lens vault (LV), and applied percentile cut-offs to detect primary angle closure disease (PACD; ≥180° post...

Purpose To use finite element (FE) analysis to assess what morphologic and biomechanical factors of the iris and anterior chamber are more likely to influence angle narrowing during pupil dilation. Methods The study consisted of 1344 FE models comprising the cornea, sclera, lens, and iris to simulate pupil dilation. For each model, we varied the f...

Aim To evaluate reproducibility and agreement of angle closure assessment by a novel hyperparallel optical coherence tomography (OCT) system (HP-OCT, Cylite Optics, Melbourne, Australia), in comparison with swept-source OCT (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) and gonioscopy. Methods Cross-sectional study. Phakic subjects >40...

Précis The microvasculature of the optic disc and macula in eyes with acute primary angle closure and primary angle closure glaucoma was lower across the disease spectrum, but the significant difference was only observed in primary angle closure glaucoma. Purpose To assess the microvasculature in the optic nerve head (ONH) and macula across primar...

The study aimed to evaluate the impact of compensating retinal nerve fiber layer (RNFL) thickness for demographic and anatomical factors on glaucoma detection in Chinese and Indian adults. A population‐based study included 1995 healthy participants (1076 Chinese and 919 Indians) to construct a multivariable linear regression compensation model. Thi...

Wide-field optical coherence tomography (OCT) imaging can enable monitoring of peripheral changes in the retina, beyond the conventional fields of view used in current clinical OCT imaging systems. However, wide-field scans can present significant challenges for retinal layer segmentation. Deep Convolutional Neural Networks (CNNs) have shown strong...

To evaluate visual field (VF) progression and rate of glaucomatous VF loss in patients with primary angle-closure glaucoma (PACG)

Objective. (1) To assess whether neural tissue structure and biomechanics could predict functional loss in glaucoma; (2) To evaluate the importance of biomechanics in making such predictions. Design, Setting and Participants. We recruited 238 glaucoma subjects. For one eye of each subject, we imaged the optic nerve head (ONH) using spectral-domain...

Purpose: Topical prostaglandin analogues are commonly used to treat patients with glaucoma, but may cause periocular and periorbital complications known as prostaglandin-associated periorbitopathy syndrome (PAPS). Methods: A literature review was conducted on PAPS. Given the lack of consensus on grading PAPS, glaucoma specialists from Asia conve...

Background To compare intraocular pressure (IOP) and anterior segment parameters between eyes with unilateral primary angle closure glaucoma (PACG) and their fellow eyes with primary angle closure (PAC) or primary angle closure suspect (PACS). Methods Subjects underwent anterior segment imaging using 360‐degree swept‐source optical coherence tomog...

Précis The combination of surgical peripheral iridectomy, goniosynechialysis, and goniotomy is a safe and effective surgical approach for advanced primary angle-closure glaucoma without cataract. Purpose To evaluate the efficacy and safety of surgical peripheral iridectomy (SPI), goniosynechialysis (GSL), and goniotomy (GT) in advanced primary ang...

Purpose To evaluate the impact of the extent of peripheral anterior synechiae (PAS) on the effectiveness and safety of combined phacoemulsification (PEI), goniosynechialysis (GSL), and goniotomy (GT) in eyes with primary angle-closure glaucoma (PACG) and cataract. Patients and Methods This study included patients diagnosed with PACG and cataract w...

Purpose: To assess the diagnostic performance and structure-function association of retinal retardance (RR), a customized metric measured by a prototype polarization-sensitive optical coherence tomography (PS-OCT), across various stages of glaucoma. Methods: This cross-sectional pilot study analyzed 170 eyes from 49 healthy individuals and 68 pa...

Background/aims To investigate whether compensating retinal nerve fibre layer (RNFL) thickness measurements for demographic and anatomical ocular factors can strengthen the structure–function relationship in patients with glaucoma. Methods 600 eyes from 412 patients with glaucoma (mean deviation of the visual field (MD VF) −6.53±5.55 dB) were incl...

Purpose To use finite element (FE) analysis to assess what morphological and biomechanical factors of the iris and of the anterior chamber are more likely to influence angle narrowing during pupil dilation. Methods The study consisted of 1,344 FE models comprising of the cornea, sclera, lens and iris (stroma, sphincter and dilator tissues) to simu...

The aim of the study was to compare the anterior segment parameters after cataract surgery in pseudoexfoliation syndrome (PEX) and control eyes. We conducted a prospective comparative study of 36 eyes (PEX group), 16 eyes (PEXG group) and 46 eyes (control group) of 98 patients after phacoemulsification with intraocular lens implantation. Before sur...

Aims To compare the diagnostic performance of 360° anterior segment optical coherence tomography assessment by applying normative percentile cut-offs versus iris trabecular contact (ITC) for detecting gonioscopic angle closure. Methods In this multicentre study, 394 healthy individuals were included in the normative dataset to derive the age-speci...

The carbonic anhydrase 2 (Car2) gene encodes the primary isoenzyme responsible for aqueous humor (AH) production and plays a major role in the regulation of intraocular pressure (IOP). The CRISPR-Cas9 system, based on the ShH10 adenovirus-associated virus, can efficiently disrupt the Car2 gene in the ciliary body. With a single intravitreal injecti...

Purpose To determine the efficiency, precision, and agreement of GlauCAT-Asian and its corresponding validity and reliability. Methods In this cross-sectional study, 219 participants (mean ± standard deviation age, 66.59 ± 8.61 years; 34% female) across the spectrum of glaucoma severity and 50 glaucoma suspects were recruited from glaucoma clinics...

Aims/Purpose: To determine whether subjects with asymmetric primary angle closure glaucoma (PACG) demonstrate greater central corneal thickness (CCT) asymmetry compared to those with symmetrical disease severity. Methods: The following clinical data were retrospectively extracted from the case records of 281 PACG subjects: presenting intraocular pr...

Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP. Colocalization and Mendelian randomization analys...

Aims To evaluate the effectiveness of glaucoma screening using glaucoma suspect (GS) referral criteria assessed on colour fundus photographs in Singapore’s Integrated Diabetic Retinopathy Programme (SiDRP). Methods A case–control study. This study included diabetic subjects who were referred from SiDRP with and without GS between January 2017 and...

Background/aims To identify ocular determinants of iridolenticular contact area (ILCA), a recently introduced swept-source optical coherence tomography (SSOCT) derived parameter, and assess the association between ILCA and angle closure. Methods In this population-based cross-sectional study, right eyes of 464 subjects underwent SSOCT (SS-1000, CA...

Significance Statement Genome-wide association studies have identified nearly 20 IgA nephropathy susceptibility loci. However, most nonsynonymous coding variants, particularly ones that occur rarely or at a low frequency, have not been well investigated. The authors performed a chip-based association study of IgA nephropathy in 8529 patients with t...

Structural variants (SVs) are significant contributors to inter-individual genetic variation associated with traits and diseases. Current SV studies using whole-genome sequencing (WGS) have a largely Eurocentric composition, with little known about SV diversity in other ancestries particularly from Asia. Here, we present a WGS catalogue of 152,655...

[This corrects the article DOI: 10.1371/journal.pdig.0000193.].

The achievable resolution of a conventional imaging system is inevitably limited due to diffraction. Dealing with precise imaging in scattering media, such as in the case of biomedical imaging, is even more difficult owing to the weak signal-to-noise ratios. Recent developments in non-diffractive beams such as Bessel beams, Airy beams, vortex beams...

Importance: The 3-dimensional (3-D) structural phenotype of glaucoma as a function of severity was thoroughly described and analyzed, enhancing understanding of its intricate pathology beyond current clinical knowledge. Objective: To describe the 3-D structural differences in both connective and neural tissues of the optic nerve head (ONH) betwe...

Objective: To determine the incidence and risk factors for primary open angle glaucoma (POAG) and ocular hypertension (OHT) in a multi-ethnic Asian population. Design: Population based, cohort study PARTICIPANTS: The Singapore Epidemiology of Eye Diseases study included 10,033 participants in the baseline examination between 2004 and 2011. Out o...

Parkinson’s disease is an incurable and progressive disease that adversely affects balance, muscle control, and movement. We hypothesized that the landscape of rare, protein-altering genetic variants could provide further mechanistic insights into disease pathogenesis. We performed whole-exome sequencing on 4,298 persons with Parkinson’s disease an...

Purpose: To assess the role of static and dynamic ocular biometric parameters measured in the dark and light for predicting progression of primary angle closure suspect (PACS) to primary angle closure (PAC). Design: Retrospective cohort study using prospective RCT data from untreated, control eyes. Methods: Zhongshan Angle Closure Prevention T...

Purpose: The purpose of this study was to assess optic nerve head (ONH) deformations following acute intraocular pressure (IOP) elevations and horizontal eye movements in control eyes, highly myopic (HM) eyes, HM eyes with glaucoma (HMG), and eyes with pathologic myopia (PM) alone or PM with staphyloma (PM + S). Methods: We studied 282 eyes, com...

Purpose: To compare the efficacy and safety of 120°, 240°, and 360° goniotomy (GT) with or without phacoemulsification with intraocular lens implantation (PEI) for primary open-angle glaucoma (POAG). Design: Multicenter, retrospective, comparative, non-randomized interventional study. Methods: Patients diagnosed with POAG who underwent GT with...

Prcis: Subgrouping of angle-closure mechanisms based on the swept-source optical coherence tomography images may help to identify the predominant underlying anatomical mechanism, evaluate personal treatment, and improve the better outcomes. Purpose: To evaluate changes in anterior segment parameters in Caucasian eyes with different angle-closure...

Background/aims To assess pupillary light responses (PLRs) in eyes with high myopia (HM) and evaluate the ability of handheld chromatic pupillometry (HCP) to identify glaucomatous functional loss in eyes with HM. Methods This prospective, cross-sectional study included 28 emmetropes (EM), 24 high myopes without glaucoma (HM) and 17 high myopes wit...

Background Primary open-angle glaucoma (POAG) is often divided into two subtypes. High-tension glaucoma (HTG) is characterized by elevated intraocular pressure (IOP), while normal-tension glaucoma (NTG) is characterized by IOP consistently in the normal range. However, this notion is still controversial as some studies argue that different tension...

Purpose: To assess the performance and generalizability of a Convolutional Neural Network (CNN) model for automated, objective and high-throughput identification of primary angle closure disease (PACD) as well as PACD stage differentiation on anterior segment swept-source optical coherence tomography (AS-OCT). The spectrum of PACD include primary...

Objective To develop and validate a deep learning algorithm that could automate the annotation of scleral spur (SS) and segmentation of anterior chamber (AC) structures for measurements of AC, iris, and angle width parameters in anterior segment OCT (ASOCT) scans. Design Cross-sectional study. Subjects Data from 2 population-based studies (i.e.,...

Purpose: To develop and validate the performance of a high myopia (HM)-specific normative database of peripapillary retinal nerve fiber layer thickness (pRNFLT) in differentiating HM from highly myopic glaucoma (HMG). Design: Cross-sectional, multicenter study. Participants: A total of 1367 Chinese participants (2325 eyes) with non-pathologic...

Current management of glaucomatous optic neuropathy is limited to intraocular pressure control. Neuroglobin (Ngb) is an endogenous neuroprotectant expressed in neurons and astrocytes. We recently showed that exogenous intravitreal Ngb reduced inflammatory cytokines and microglial activation in a rodent model of hypoxia. We thus hypothesised that IV...

Purpose To assess the psychometric properties of glaucoma-specific health-related quality of life (HRQoL) item banks (IBs), and explore their efficiency using computerized adaptive testing (CAT) simulations. Methods In this cross-sectional, clinical study, 300 Asian glaucoma patients answered 221 items within seven IBs: Ocular Comfort Symptoms (OS...

Importance: Laser peripheral iridotomy (LPI) is the most common primary treatment for primary angle closure disease (PACD). However, there are sparse data guiding the longitudinal care of PAC suspect (PACS) eyes after LPI. Objective: To elucidate the anatomic effects of LPI that are associated with a protective outcome against progression from P...

Purpose: To assess intraocular pressure (IOP)-induced and gaze-induced optic nerve head (ONH) strains in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). Design: Clinic-based cross-sectional study. Methods: The ONH from one eye of 228 subjects (114 subjects with HTG (pre-treatment IOP≥21 mm Hg) and 114 with NTG (pre...

Prcis: Individuals prescribed ibuprofen post-trabeculectomy have a better post-operative intraocular pressure control and higher chance of bleb survival despite being at a higher risk of scarring. Purpose: To investigate the effects of early adjunctive oral ibuprofen treatment on intraocular pressure (IOP) and bleb failure in eyes at high risk o...

Anterior chamber depth (ACD) is a major risk factor of angle closure disease, and has been used in angle closure screening in various populations. However, ACD is measured from ocular biometer or anterior segment optical coherence tomography (AS-OCT), which are costly and may not be readily available in primary care and community settings. Thus, th...

Purpose: (1) To assess the performance of geometric deep learning in diagnosing glaucoma from a single optical coherence tomography (OCT) scan of the optic nerve head and (2) to compare its performance to that obtained with a three-dimensional (3D) convolutional neural network (CNN), and with a gold-standard parameter, namely, the retinal nerve fi...

Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic–phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world’s population, many Asian ancestries are under-represe...

Purpose: To compare the performance of two relatively recent geometric deep learning techniques in diagnosing glaucoma from a single OCT scan of the ONH; and (2) To identify the three-dimensional (3D) structural features of the ONH that are critical for the diagnosis of glaucoma. Design: Comparison and evaluation of deep learning diagnostic algo...

Studies using machine learning (ML) approaches have reported high diagnostic accuracies for glaucoma detection. However, none assessed model performance across ethnicities. The aim of the study is to externally validate ML models for glaucoma detection from optical coherence tomography (OCT) data. We performed a prospective, cross-sectional study,...

Background/aims To use artificial intelligence (AI) to: (1) exploit biomechanical knowledge of the optic nerve head (ONH) from a relatively large population; (2) assess ONH robustness (ie, sensitivity of the ONH to changes in intraocular pressure (IOP)) from a single optical coherence tomography (OCT) volume scan of the ONH without the need for bio...

\bf{Purpose}$: To describe the 3D structural changes in both connective and neural tissues of the optic nerve head (ONH) that occur concurrently at different stages of glaucoma using traditional and AI-driven approaches. $\bf{Methods}$: We included 213 normal, 204 mild glaucoma (mean deviation [MD] $\ge$ -6.00 dB), 118 moderate glaucoma (MD of -6.0...

Purpose: We aimed to assess optic nerve head (ONH) deformations following acute intraocular pressure (IOP) elevations and horizontal eye movements (adduction and abduction) in control eyes, highly myopic (HM) eyes, HM eyes with glaucoma (HMG), and eyes with pathologic myopia alone (PM) or PM with staphyloma (PM+S). Methods: We studied 282 eyes, com...

Purpose: To evaluate the use of synthetically generated OCT images for the development of deep-learning models in glaucoma detection. Methods: Progressively Grown Generative Adversarial Network (PGGAN) models for glaucoma and healthy eyes were developed with data from 862 Asian glaucoma eyes and 990 Asian normal eyes to generate synthetic circumpap...

Purpose To isolate the structural components of the ex vivo porcine iris tissue and to determine their biomechanical properties. Methods The porcine stroma and dilator tissues were separated, and their dimensions were assessed using optical coherence tomography (OCT). The stroma underwent flow test ( n = 32) to evaluate for permeability using Darc...

Purpose: To assess pupillary light responses (PLRs) in eyes with high myopia and evaluate the ability of handheld chromatic pupillometry (HCP) to identify glaucomatous functional loss in eyes with high myopia. Design: Cross-sectional study with prospective data collection. Methods: Participants included 28 emmetropes (EM), 24 high myopes without gl...

Asian populations are under-represented in human genomics research. Here, we characterize clinically significant genetic variation in 9051 genomes representing East Asian, South Asian, and severely under-represented Austronesian-speaking Southeast Asian ancestries. We observe disparate genetic risk burden attributable to ancestry-specific recurrent...

Background A glaucoma-specific health-related quality of life (HRQoL) item bank (IB) and computerized adaptive testing (CAT) system relevant to Asian populations is not currently available. We aimed to develop content for an IB focusing on HRQoL domains important to Asian people with glaucoma; and to compare the content coverage of our new instrume...

Background and Objectives The distinction of papilledema from other optic nerve head (ONH) lesions mimicking papilledema, such as optic disc drusen (ODD), can be difficult in clinical practice. We aimed: (1) To develop a deep learning algorithm to automatically identify major structures of the optic nerve head (ONH) in three dimensional (3D) optica...

Background/Objectives: To evaluate changes in anterior segment parameters in Caucasian eyes with different angle-closure mechanisms before and after laser peripheral iridotomy (LPI) Subjects/Methods: Sixty-six subjects underwent swept-source optical coherence tomography (SSOCT, CASIA, Tomey Corporation, Nagoya, Japan) angle imaging in the dark befo...

Introduction: There has been a growing interest in the role of vascular factors in glaucoma. Studies have looked at the characteristics of macular choriocapillaris in patients with glaucoma but with conflicting results. Our study aims to use swept-source optical coherence tomography angiography (SS-OCTA) to evaluate macular choriocapillaris metric...

Importance: Deep learning (DL) networks require large data sets for training, which can be challenging to collect clinically. Generative models could be used to generate large numbers of synthetic optical coherence tomography (OCT) images to train such DL networks for glaucoma detection. Objective: To assess whether generative models can synthes...

Purpose To study the associations between optic nerve head (ONH) strains under intraocular pressure (IOP) elevation with retinal sensitivity in glaucoma subjects. Design Clinic based cross-sectional study. Participants 229 subjects with primary open angle glaucoma (subdivided into 115 high tension glaucoma (HTG) subjects and 114 normal tension gl...

To evaluate machine learning (ML) approaches for structure–function modeling to estimate visual field (VF) loss in glaucoma, models from different ML approaches were trained on optical coherence tomography thickness measurements to estimate global VF mean deviation (VF MD) and focal VF loss from 24‐2 standard automated perimetry. The models were co...

Prcis: A literature review of SLT energy dose response found no definitive relationship between IOP reduction with respect to total or pulse energy, race, pigmentation, or application pattern. Purpose: Selective laser trabeculoplasty (SLT) is a safe and effective treatment for lowering intraocular pressure (IOP). While evidence is mounting for t...

\mathbf{Purpose}$: To use artificial intelligence (AI) to: (1) exploit biomechanical knowledge of the optic nerve head (ONH) from a relatively large population; (2) assess ONH robustness from a single optical coherence tomography (OCT) scan of the ONH; (3) identify what critical three-dimensional (3D) structural features make a given ONH robust. $\...

Background/Aims Prophylactic laser peripheral iridotomy (LPI) is performed in primary angle-closure suspect (PACS) eyes to prevent acute angle-closure attacks. However, accelerated cataractogenesis is a potential risk of the procedure that may result in decreased visual acuity. We aimed to assess the long-term impact of LPI on cataract formation in...

Purpose Angle-closure glaucoma is a major cause of blindness worldwide that carries an excess risk of severe, bilateral visual impairment. A common concern among clinicians is precipitating acute angle closure (AAC) attacks by mydriasis. We evaluated the risk of AAC after pharmacologic dilation in Chinese individuals classified as bilateral primary...

Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and ancestry, the major risk factor for glaucoma is increased intraocular pressure (IOP). In primary open-angle glaucoma (POAG), the anterior chamber angle is open but there is...

Purpose: The optic nerve head (ONH) undergoes complex and deep 3D morphological changes during the development and progression of glaucoma. Optical coherence tomography (OCT) is the current gold standard to visualize and quantify these changes, however the resulting 3D deep-tissue information has not yet been fully exploited for the diagnosis and p...

Purpose: (1) To assess the performance of geometric deep learning (PointNet) in diagnosing glaucoma from a single optical coherence tomography (OCT) 3D scan of the optic nerve head (ONH); (2) To compare its performance to that obtained with a standard 3D convolutional neural network (CNN), and with a gold-standard glaucoma parameter, i.e. retinal n...

Aim: To investigate the association between the extent of iridotrabecular contact and other quantitative anterior segment dimensions measured by swept-source optical coherence tomography (SS-OCT; CASIA SS-1000, Tomey, Nagoya, Japan) with intraocular pressure (IOP). Methods: Cross-sectional study. All subjects who were ≥50 years with no history o...

Purpose: To assess whether the three-dimensional (3D) structural configuration of the central retinal vessel trunk and its branches (CRVT&B) could be used as a diagnostic marker for glaucoma. Design: Retrospective, deep-learning approach diagnosis study. Method: We trained a deep learning network to automatically segment the CRVT&B from the B-...

Purpose To develop a classification system of visual field (VF) abnormalities in highly myopic eyes with and without glaucoma. Design Secondary analysis of VF data from a longitudinal cohort study. Subjects One thousand eight hundred and ninety-three VF tests from 1302 eyes (825 individuals). Methods All participants underwent VF testing (Humphr...

Objective To determine the incidence and risk factors of primary angle closure disease (PACD) over six years in a multi-ethnic Asian population. Design Population-based, longitudinal study. Subjects The Singapore Epidemiology of Eye Diseases study is a population-based cohort study conducted amongst adults aged 40 years or more. The baseline exam...