Tijn Caspar de Leeuw

• Master of Science
• University of Groningen

Polyesters from furandicarboxylic acid derivatives, i.e., dimethyl 2,5-furandicarboxylate (2,5-DMFDCA) and 2,4-DMFDCA, show interesting properties among bio-based polymers. Another potential heteroaromatic monomer, 3,4-bis(hydroxymethyl)furan (3,4-BHMF), is often overlooked but holds promise for biopolymer synthesis. Cleaning and greening synthetic...

As awareness of the environmental impact of fossil‐based polymers grows, the demand for biobased alternatives rises. In this context, combining eco‐friendly synthesis techniques with renewable resources is important to produce polymers efficiently and sustainably. Furandicarboxylic acid (FDCA) is one of the key building blocks for producing biobase...

The demand for biobased polymers is on the rise, driven by increasing environmental awareness and the imperative for sustainability. Biobased materials, which offer renewability, have emerged as a solution to the depletion of petroleum-based resources. Among biobased raw materials, 2,5-furandicarboxylic acid (2,5-FDCA) has gained prominence as an e...

GtfC-type 4,6-α-glucanotransferase (α-GT) enzymes from Glycoside Hydrolase Family 70 (GH70) are of interest for the modification of starch into low-glycemic index food ingredients. Compared to the related GH70 GtfB-type α-GTs, found exclusively in lactic acid bacteria (LAB), GtfCs occur in non-LAB, share low sequence identity, lack circular permuta...

GtfC-type 4,6-α-glucanotransferase (α-GT) enzymes are of interest for modification of starch into low-glycemic index food ingredients [1]. GtfCs have been classified in Glyco-side Hydrolase family 70 (GH70), together with glucansucrases and GtfB-type α-GTs from lactic acid bacteria (LAB). However, GtfCs have been identified only in non-lactic acid...

Polyphenols exhibit various beneficial biological activities and represent very promising candidates as active compounds for food industry. However, the low solubility, poor stability and low bioavailability of polyphenols have severely limited their industrial applications. Enzymatic glycosylation is an effective way to improve the physicochemical...

For various research questions in metabolism, it is highly desirable to have means available, with which the flux through specific pathways can be perturbed dynamically, in a reversible manner, and at a timescale that is consistent with the fast turnover rates of metabolism. Optogenetics, in principle, offers such possibility. Here, we developed an...