• Home
  • UNSW Sydney
  • Dementia Collaborative Research Centres (DCRC)
  • Tiffany Holmes
Tiffany Holmes

Tiffany Holmes
UNSW Sydney | UNSW · Dementia Collaborative Research Centres (DCRC)

Doctor of Philosophy

About

15
Publications
527
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
230
Citations
Citations since 2017
0 Research Items
69 Citations
201720182019202020212022202302468101214
201720182019202020212022202302468101214
201720182019202020212022202302468101214
201720182019202020212022202302468101214

Publications

Publications (15)
Article
Umbilical cord blood (UCB) is a source of stem cells used for allogeneic transplantation, in addition to bone marrow and peripheral blood. Limited numbers of stem cells in a single UCB unit is associated with slow haematopoietic recovery and high risk of graft failure, particularly in adult patients. UCB stem cells can be expanded ex vivo; however,...
Article
Cord blood (CB) has been established to be an alternative source of haematopoietic stem/progenitor cells (HPC) for transplantation. The number of HPC per CB unit is limited, which results in engraftment delay. Ex vivo expansion of HPC improvement must overcome this. Flow cytometry was used to extensively phenotype HPC pre- and post-expansion and CF...
Article
Glycogen synthase kinase-3β (GSK-3β) has been identified as an important regulator of stem cell function acting through activation of the wingless (Wnt) pathway. Here, we report that treatment with an inhibitor of GSK-3β, 6-bromoindirubin 3'-oxime (BIO) delayed cell cycle progression by increasing cell cycle time. BIO treatment resulted in the accu...
Article
Wingless (Wnt) signaling appears to play an integral role in expansion and quiescence of stem and progenitor hematopoietic cell populations. To better understand this dichotomous role and aid in the translation of therapeutic goals including cellular therapies, greater understanding of the molecular mechanisms that regulate Wnt/β-catenin in the bon...
Article
Full-text available
Interferon regulatory factor (IRF) 1 and its functional antagonist IRF2 were originally discovered as transcription factors that regulate the interferon-beta gene. Control of cell growth has led to the definition of IRF1 as a tumour suppressor gene and IRF2 as an oncogene. Clinically, approximately 70% of cases of acute myeloid leukaemia demonstrat...
Article
Glycogen synthase kinase 3 beta (GSK-3 beta) was one of the first kinases identified and studied, initially for its role in the regulation of glycogen synthesis. Over the past decade, interest in GSK-3 beta has grown far beyond glycogen metabolism, and this is due in large measure to the critical role that GSK-3 beta plays in the regulation of many...
Article
Full-text available
Ex vivo expansion of cord blood cells generally results in reduced stem cell activity in vivo. Glycogen synthase kinase-3β (GSK-3β) regulates the degradation of β-catenin, a critical regulator of hematopoietic stem cells (HSCs). Here we show that GSK-3β inhibition activates β-catenin in cord blood CD34+ cells and upregulates β-catenin transcription...
Article
Glycogen synthase kinase 3 beta (GSK-3beta) was one of the first kinases identified and studied, initially for its role in the regulation of glycogen synthesis. Over the past decade, interest in GSK-3beta has grown far beyond glycogen metabolism, and this is due in large measure to the critical role that GSK-3beta plays in the regulation of many ot...
Article
Rapid availability of an HLA matched marrow donor for allogeneic hematopoietic stem cell transplantation remains a challenge in the clinical setting and has resulted in increased use of alternate stem cell sources, particularly unrelated umbilical cord blood (UCB). Although UCB transplantation has been used to treat a multiplicity of malignant and...
Article
Clinical trials using ex-vivo expanded umbilical cord blood (UCB) cells have thus far failed to demonstrate significant improvement in speed of hematopoietic recovery suggesting better understanding of self-renewal, proliferation, homing and engraftment capabilities of cord blood is needed. Recent progress has been made in the identification and un...

Network

Cited By

Projects

Projects (3)
Project
Improve understanding and approaches for depression, anxiety, disinhibited behaviours, sleep disturbance, apathy, and other changed behaviours and psychological symptoms associated with dementia. Encourage person-centred approaches that improve care and quality of life for people living with dementia. Encourage collaboration between all stakeholders (people living with dementia, families, care partners, clinicians, care providers, researchers, government and policy makers).
Project
HALT is a single-arm longitudinal intervention study in Sydney, Australia. The aim of HALT is to reduce the use of antipsychotic medication to treat behavioural and psychological symptoms of dementia in residential aged care.
Project
Aiming to limit the use of antipsychotic medications prescribed to people with dementia experiencing BPSD. Deprescribing intervention coupled with training and education for GPs and nursing home staff.