Tianne Numan

Tianne Numan
University Medical Center Utrecht | UMC Utrecht · Intensive Care Centrum

About

23
Publications
1,409
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685
Citations
Citations since 2016
17 Research Items
652 Citations
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2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120

Publications

Publications (23)
Article
Full-text available
It is unclear why exactly gliomas show preferential occurrence in certain brain areas. Increased spiking activity around gliomas leads to faster tumour growth in animal models, while higher non-invasively measured brain activity is related to shorter survival in patients. However, it is unknown how regional intrinsic brain activity, as measured in...
Preprint
Full-text available
It is unclear why exactly gliomas show preferential occurrence in certain brain areas. Increased spiking activity around gliomas leads to faster tumor growth in animal models, while higher non-invasively measured brain activity is related to shorter survival in patients. However, it is unknown how regional intrinsic brain activity, as measured in h...
Article
Introduction: Glioma patients show increased global brain network clustering relating to poorer cognition and epilepsy. However, it is unclear whether this increase is spatially widespread, localized in the (peri)tumor region only, or decreases with distance from the tumor. Materials and methods: Weighted global and local brain network clusterin...
Preprint
Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoenceph...
Article
Full-text available
IntroductionProgression-free survival (PFS) in glioma patients varies widely, even when stratifying for known predictors (i.e. age, molecular tumor subtype, presence of epilepsy, tumor grade and Karnofsky performance status). Neuronal activity has been shown to accelerate tumor growth in an animal model, suggesting that brain activity may be valuab...
Article
Introduction Functional brain networks in glioma patients are characterized by higher global clustering than healthy controls, indicating stronger connectivity in triads of brain regions when averaging across the entire brain. However, this could be due to either primary increased local clustering of (peri)tumor regions or higher local clustering t...
Article
Full-text available
Background: Despite widespread application, little is known about the neurophysiological effects of light sedation with midazolam or propofol, particularly in older subjects. The aim of this study was to assess the effects of light sedation with midazolam or propofol on a variety of EEG measures in older subjects. Methods: In patients (≥60 years...
Article
Full-text available
Introduction Cognitive deficits occur frequently in diffuse glioma patients, but are limitedly understood. An important marker for survival in these patients is isocitrate dehydrogenase (IDH) mutation (IDH‐mut). Patients with IDH‐mut glioma have a better prognosis but more often suffer from epilepsy than patients with IDH‐wildtype (IDH‐wt) glioma,...
Article
Background: Delirium is frequently unrecognised. EEG shows slower frequencies (i.e. below 4 Hz) during delirium, which might be useful in improving delirium recognition. We studied the discriminative performance of a brief single-channel EEG recording for delirium detection in an independent cohort of patients. Methods: In this prospective, mult...
Article
Full-text available
Background In network neuroscience, patterns of communication between brain regions are investigated. Particularly high connectivity (‘hubness’) may predispose certain regions to pathology and may impact clinical symptoms. For example, Alzheimer’s pathology and cognitive decline are related to hubness. The relation between hubness, glioma location...
Article
Background Isocitrate dehydrogenase (IDH) mutation (IDH-mut) is an important marker for survival in diffuse glioma patients. Patients with an IDH-mut glioma have a better prognosis but more often suffer from epilepsy. Patients with a wildtype glioma (IDH-wt) are generally older and more often have cognitive deficits. Regardless of IDH status, cogni...
Article
Full-text available
Objectives: To evaluate to what extent delirium experts agree on the diagnosis of delirium when independently assessing exactly the same information and to evaluate the sensitivity of delirium screening tools in routine daily practice of clinical nurses. Design: Prospective observational longitudinal study. Setting: Three medical centers in th...
Article
Objective: To gain insight in the underlying mechanism of reduced levels of consciousness due to hypoactive delirium versus recovery from anesthesia, we studied functional connectivity and network topology using electroencephalography (EEG). Methods: EEG recordings were performed in age and sex-matched patients with hypoactive delirium (n=18), p...
Article
Objective: To determine the degree of agreement between delirium experts on the diagnosis of delirium based on exactly the same information, and to assess the sensitivity of delirium screening methods used by clinical nurses. Design: Prospective observational longitudinal study. Method: Older patients (≥ 60 years) who underwent major surgery w...
Article
We examined the impact of progressive hypotension with and without hypocapnia on regional extracranial cerebral blood flow and intra-cranial velocities. Participants underwent progressive lower-body negative pressure until pre-syncope to inflict hypotension. End-tidal carbon dioxide was clamped at baseline levels (isocapnic trial) or uncontrolled (...
Article
Electroencephalogram (EEG) and magnetoencephalogram (MEG) recordings during resting state are increasingly used to study functional connectivity and network topology. Moreover, the number of different analysis approaches is expanding along with the rising interest in this research area. The comparison between studies can therefore be challenging an...
Article
Introduction Cerebral autoregulation (CA) is a theoretical construct characterized by the relationship between mean arterial pressure (MAP) and cerebral blood flow (CBF). We performed a comprehensive literature search to provide an up-to-date review on the static relationship between MAP and CBF. Methods The results are based on 40 studies (49 ind...
Article
Background: In this article, the authors explore functional connectivity and network topology in electroencephalography recordings of patients with delirium after cardiac surgery, aiming to improve the understanding of the pathophysiology and phenomenology of delirium. The authors hypothesize that disturbances in attention and consciousness in del...
Conference Paper
Introduction: In this study, we explore EEG functional connectivity and network topology in delirium after cardiac surgery, aiming to improve our understanding of the pathophysiology and phenomenology of delirium. Methods: EEG recordings were obtained in cardiac surgery patients with delirium (N = 25) and without delirium (N = 24). We analyzed func...

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