Thusharie Sugandhika Suresh Née Malalavidhane T S Suresh

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• PhD
• Senior Professor in Biochemistry at University of Sri Jayewardenepura

The potential anti-inflammatory effects of the plant family Aponogetonaceae have yet to be widely studied despite the existing ethnomedicinal evidence. This study aimed to investigate the pharmacognostic characteristics and pharmacological activities of Aponogeton crispus Thunb. and Aponogeton rigidifolius H.Bruggen plants. Anti-inflammatory and an...

The study investigates the pharmacognosy and in vitro antacid activity of Evolvulus alsinoides (L.) L. and Evolvulus nummularius (L.) L. plant species, that would be used in the formulation of a stable antacid dosage form. Pharmacognostic analyses, phytochemical screenings, and in vitro gastric acid-neutralising activity assay were performed on bot...

Sudarshana Suspension (SS) is a novel Ayurveda preparation. The main aim of this study was to evaluate the acute and chronic anti-inflammatory and anti-nociceptive potential of Sudarshana suspension in Wistar rats. The acute anti-inflammatory potential of the Sudarshana suspension was evaluated using the carrageenan-induced paw oedema method and th...

Background: Balabilvashunti decoction (BD) is an ayurvedic polyherbal formulation comprised of three plant ingredients: rhizome of Zingiber officinale, whole plant of Sida alnifolia, and root bark of Aegle marmelos. BD is widely utilized within clinical practice, particularly for addressing geriatric diseases. However, despite its prevalence, patie...

Background: Since early nineties investigators in Sri Lanka have noticed an alarmingly high incidence of a new form of chronic kidney disease of uncertain etiology (CKDu) in North Central Region of the country. The purpose of the present study was to assess the treatment response profile of a selected traditional medicine used for Chronic Kidney Di...

Present study was aimed to investigate the antacid potential of Desmodium triflorum Linn whole plant and Pogostemon heyneanus Benth leaves and to establish their diagnostic characteristics. Powder microscopy, detailed anatomical characteristics, analysis of phytochemicals and Ultra-Performance Liquid Chromatography were done. In addition, neutraliz...

Purpose: This study investigated the in vitro antacid activity of aqueous and ethanolic extracts of Evolvulus alsinoides Linn. plant and formulated an antacid dosage form subsequently. Method: Extracts were prepared by refluxing whole plant of E. alsinoides. The activity of the extracts was evaluated by in vitro neutralising of artificial gastric a...

Amurthashtaka kwatha, is an Ayurvedic polyherbal formulation used in the treatment of fever associated with inflammation. It is made up of eight plants including the bark of Azadirachta indica, seeds of Holarrhena antidysenterica, heart wood of Santalum album, stem of Tinospora cordifolia, whole plant of Trichosanthes cucumerina and rhizomes of Zin...

Tuberculosis (TB) is a chronic disease caused by Mycobacterium tuberculosis (Mtb) complex. The global TB epidemic has been aggravated by the emergence of disease outbreaks caused by multi-drug resistant and extensively drug-resistant strains. The aim of the present study was to evaluate the in-vitro, anti-TB activity of leaves of Psychotria sarment...

Microcystins produced by cyanobacteria has been identified as a potent hepato and neuro toxicant to human and livestock. The present study was aimed to determine the possible hepatotoxic effects of MC-LR on mammals using male Wistar rats as an animal model. An ethically accepted experimental protocol was used in the study enrolling thirty-five rats...

Evolvulus alsinoides (family Convolvulaceae) is commonly known as "Nil Vishnukranthi" or "Shankhpushpi" in Sri Lanka and is used in the treatment of gastric ulceration. In our previous studies, we have investigated the in-vitro antacid potential of aqueous extract (aqE), ethanolic extract (EE) and hexane extract (HE) of E. alsinoides by neutralizat...

Abstract Bees’ honey has been used to treat in many diseases in traditional medicine. The usage of bees’ honey as a medicine is referred to in the most ancient Ayurveda medical records. Therefore, this study was design to evaluated the chronic anti-inflammatory effect of bees’ honey using adjuvant-induced arthritis in experimental rat model. Health...

Evaluate the Effect of Prostaglandin E2 Synthesis of Bees’ honey in Animal model

Effect of Prostaglandin E2 Synthesis of Sudarshana powder in Animal model;

Evaluation of the In Vitro and In Vivo Antioxidant Potentials of Sudarshana Powder; Volume

The article reviews recent studies on the anti-inflammatory effects of herbal extracts with emphasis on different assays that are frequently used to test the in-vitro anti-inflammatory activity of herbal constituents. Protein denaturation assays and membrane stabilization assays are frequently used to evaluate in vitro anti-inflammatory activities....

Sudarshana powder (SP) is a very effective antipyreticAyurvedic preparation, extensively used in Sri Lanka as well as India. This contains 53 ingredients with Andrographis paniculata Burm. F. Nees as the main component (50%). The extreme bitterness of this powder reduces the patient compliance and administration to children is difficult. Therefore,...

According to the Ayruveda classic Ashtanga Hridaya, written around 500 AD, honey can be used to treat many diseases. Eight types of honey are mentioned in Ayurvedic authentic texts. Out of these eight types of honey, the variety produced by honey bees is the most commonly referred to and is the type of honey consumed by humans. Honey produced by ot...

Desmodium triflorum is a well-known Sri Lankan medicinal plant which is in folkloric use. Recent pharmacological studies have established its antioxidant, anti-inflammatory, anti-convulsant and analgesic activities. The plant is rich in alkaloids. The review depicts out on the folkloric uses along with pharmacological and biological activities of t...

This study determined the oral hypoglycaemic effect of suspensions of freeze dried and powdered (SFDP) Pleurotus ostreatus (P.o) and Pleurotus cystidiosus (P.c), using healthy human volunteers and Type 2 diabetic patients on diet control at a dose of 50mg/kg/body weight, followed by a glucose load. The possible hypoglycaemic mechanisms were evaluat...

This study determined the oral hypoglycaemic effect of suspensions of freeze dried and powdered (SFDP) Pleurotus ostreatus (P.o) and Pleurotus cystidiosus (P.c), using healthy human volunteers and Type 2 diabetic patients on diet control at a dose of 50 mg/kg/body weight, followed by a glucose load. The possible hypoglycaemic mechanisms were evalua...

Sudarshana powder (SP) is the most effective anti-pyretic Ayurvedic preparation widely used in Sri Lanka as well as in India from the beginning of Ayurveda treatment. It has 53 ingredients. Presently SP contains Andrographis paniculata (Burm. F.) Nees (50%) and 52 other ingredients (50%). Our aim was to evaluate whether Sudarshana powder exerts any...

This study was designed to prove scientifically the medicinal benefits of a traditional drink. In this study the oral hypoglycaemic effect of the water extract of dried flowers of A. marmelos (L.)Correa (WEAM) was evaluated using Wistar rats. Healthy and alloxan-induced diabetic rats were kept on overnight fasting and they received the WEAM, drugs...

This study was designed to prove scientifically the medicinal benefits of a traditional drink. In this study the oral hypoglycaemic effect of the water extract of dried flowers of A. marmelos (L.)Correa (WEAM) was evaluated using Wistar rats. Healthy and alloxan-induced diabetic rats were kept on overnight fasting and they received the WEAM, drugs...

A new flavone glucoside, andrographidine G (1), was isolated from Andrographis paniculata together with 13 known compounds, including flavonoids, diterpenoids, and iridoids. The structure of 1 was established by spectroscopic and spectrometric techniques, including HR-ESI-TOF-MS, 1D and 2D NMR, and chemical methods. The known compounds were identif...

Knowledge of and attitudes towards dysmenorrhea among adolescent school girls were assessed in this study. A descriptive study was conducted among 200 Year 12 girls at a school in the Nugegoda Educational Division in the district of Colombo. Data collection was done by using non-probability convenience sampling. The results indicated that 84% of th...

This study investigates the oral hypoglycemic activity of Pleurotus ostreatus (P.o.) and P. cystidiosus (P.c.) mushrooms on normal and alloxan-induced diabetic Wistar rats. Different doses (250, 500, 750, 1000, and 1250 mg/kg/body weight) of suspensions of freeze-dried and powdered (SFDP) P.o. and P.c. were administered to normal rats, and postpran...

Ipomoea aquatica Forsk is a common green leafy vegetable consumed in many parts of the world. The present study was designed to investigate the oral hypoglycaemic activity of Ipomea aquatica in streptozotocin induced diabetic Wistar rats, and Type II diabetic patients. Experimental diabetes was induced with streptozotocin in Wistar rats. The rats w...

This study was undertaken to compare the oral hypoglycaemic activity of an aqueous extract of the green leafy vegetable Ipomoea aquatica (dose equivalent to 3.3 g starting material /kg body weight) with that of the known oral hypoglycaemic drug tolbutamide (15 mg/kg body weight) in glucose challenged Wistar rats (3 g/kg body weight, administered 30...

Ipomoea aquatica is a commonly consumed green leafy vegetable in Sri Lanka which is supposed to possess an insulin-like activity [Jayaweera, D.M.A., 1982. Medicinal Plants (Indigenous and Exotic) Used in Ceylon. Part 11. National Science Council, Colombo, Sri Lanka, pp. 99]. Only a little attention has been paid to the therapeutic use of this plant...