Thomas G. Watkinson

Thomas G. Watkinson
University of Bath | UB · Department of Chemistry

PhD Structural Biology, Unviersity of Leeds

About

4
Publications
570
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140
Citations
Citations since 2016
1 Research Item
112 Citations
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201620172018201920202021202205101520253035
201620172018201920202021202205101520253035
Introduction
Thomas G. Watkinson has a background in Biomolecular Mass Spectrometry and Structural Biology. He currently works at the Department of Chemistry, University of Bath, developing methods for proteomic analysis of environmental and wastewater samples.

Publications

Publications (4)
Article
Full-text available
Amphipols are a class of novel surfactants that are capable of stabilizing the native state of membrane proteins. They have been shown to be highly effective, in some cases more so than detergent micelles, at maintaining the structural integrity of membrane proteins in solution, and have shown promise as vehicles for delivering native membrane prot...
Article
Full-text available
Membrane proteins (MPs) are essential for numerous important biological processes. Recently, mass spectrometry (MS), coupled with an array of related techniques, has been used to probe the structural properties of MPs and their complexes. Typically, detergent micelles have been employed for delivering MPs into the gas-phase, but these complexes hav...
Article
Full-text available
Non-covalent mass spectrometry (MS) is emerging as an invaluable technique to probe the structure, interactions and dynamics of membrane proteins (MPs). However, maintaining native-like MP conformations in the gas phase using detergent solubilised proteins is often challenging and may limit structural analysis. Amphipols, such as the well character...
Article
Full-text available
Amphipols are short amphipathic polymers that can substitute for detergents at the hydrophobic surface of membrane proteins (MPs), keeping them soluble in the absence of detergents while stabilizing them. The most widely used amphipol, known as A8-35, is comprised of a polyacrylic acid (PAA) main chain grafted with octylamine and isopropylamine. Am...

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