Thomas Sorz-Nechay

• Doctor of Medicine
• PhD Student at CeMM Research Center for Molecular Medicine

Alcohol-related liver disease (ALD) remains a major global health burden with limited therapeutic options due to an incomplete understanding of its underlying molecular mechanisms and cellular crosstalk. Here, we applied ultra-high resolution (on 2μm spots) spatial transcriptomics to a cirrhotic liver tissue obtained from an end-stage ALD patient,...

Background Portal hypertension (PH) resulting from static and dynamic intrahepatic changes drives liver‐related complications even after removing the underlying aetiological factor. Objective We investigated the impact of inflammation on the dynamic component of PH during disease regression in animal models of toxin‐induced cirrhosis and patients...

Artificial intelligence (AI) methods enable humans to analyse large amounts of data, which would otherwise not be feasibly quantifiable. This is especially true for unstructured visual and textual data, which can contain invaluable insights into disease. The hepatology research landscape is complex and has generated large amounts of data to be mine...

AXL and its corresponding ligand growth arrest–specific 6 (GAS‐6) are critically involved in hepatic immunomodulation and regenerative processes. Pleiotropic inhibitory effects on innate inflammatory responses might essentially involve the shift of macrophage phenotype from a pro‐inflammatory M1 to an anti‐inflammatory M2. We aimed to assess the re...

Aim: Anticoagulation was associated with improved survival of hospitalized COVID-19 patients in large-scale studies. Yet, the development of COVID-19 associated coagulopathy (CAC) and the mechanism responsible for improved survival of anticoagulated patients with COVID-19 remain largely elusive. This investigation aimed to explore the effects of a...