Thomas Ruzicka

Thomas Ruzicka
Klinik für Dermatologie und Allergologie · Dermatology

Prof. Dr. med. Dr. h.c. mult.

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1,382
Publications
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Publications

Publications (1,382)
Chapter
Das atopische Ekzem ist eine meist chronische, entzündliche, nicht kontagiöse Hauterkrankung, die mit starkem Juckreiz einhergeht und häufig familiär, allein oder in Verbindung mit Asthma bronchiale oder Rhinoconjunctivitis allergica auftritt. Bei den meisten Patienten lassen sich IgE-vermittelte Sensibilisierungen gegen Aero- oder Nahrungsmittelal...
Chapter
Amyloidosen sind seltene Erkrankungen, die durch eine fehlerhafte Faltung von Proteinen verursacht werden. Die hierbei entstehenden fibrillären Proteine werden unlöslich, lagern sich in verschiedenen Geweben und Organen ab und können schließlich zu schweren Fehlfunktionen führen. Man unterscheidet lokalisierte und systemische Amyloidosen, welche be...
Article
Background Fast and simple microscopic evaluation of basal cell carcinoma (BCC) together with its subtype determination would accelerate diagnostic and therapeutic procedures in dermatology including Mohs surgery. Objectives Assessing whether simplified 3‐criteria‐based ex‐vivo confocal microscopic (CM) examination can reliably predict BCC diagnos...
Article
Full-text available
Background: Nemolizumab, an anti-interleukin-31 receptor A monoclonal antibody, improved pruritus, dermatitis, and sleep in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments in a phase II, 12-week, randomized, double-blind, placebo-controlled study (Part A) (NCT01986933). Objective: To assess long-ter...
Article
Background/aims: Ethnic skin types are known to differ in their morphological and physiological features. Thus, treatment responses may vary among different races. We aimed to assess skin morphology of different ethnicities and to compare the effect of short-term moisturizer application using optical coherence tomography (OCT) and reflectance conf...
Article
Birt-Hogg-Dubé syndrome (BHD, also referred to as Hornstein-Knickenberg syndrome) is an autosomal dominant tumor syndrome caused by mutations in the FLCN gene located on chromosome 17. Depending on their age, patients with BHD may exhibit various clinical signs and symptoms. Disease severity can vary greatly among members of the same family. Early...
Article
Zusammenfassung Das Birt‐Hogg‐Dubé‐Syndrom (BHD‐Syndrom, eigentlich Hornstein‐Knickenberg‐ Syndrom) ist ein autosomal dominant erbliches Tumorsyndrom, welches durch Mutationen im FLCN‐Gen auf Chromosom 17 verursacht wird. Patienten mit BHD‐Syndrom können altersabhängig verschiedene Symptome zeigen, deren Ausprägung auch innerhalb einer Familie unte...
Article
a 59-year-old Caucasian man presented to our department with a three weeks history of erythema and edema of the left hand, and a necrotic ulcer of the left thumb, after a holiday in Greece, associated with extreme pain. No other skin or mucosal lesions were present. Systemic symptoms such as nausea, vomiting, hypotension, seizures, cardiac arrhythm...
Article
Isotretinoin is a first generation retinoid with pleiotropic effects on keratinocyte differentiation, proliferation, and activity of sebaceous glands. For years, there has been intense debate on whether the use of isotretinoin combined with cosmetic or surgical procedures is safe and potentially more efficient than either therapy alone. Due to dela...
Article
IL-31 is a novel cytokine expressed in many human tissues and involved mainly in TH2-weighted inflammation. IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, such as atopic eczema, and represents a novel tar...
Article
Full-text available
Background: Wound healing represents a dynamic process involving directional migration of different cell types. Chemokines, a family of chemoattractive proteins, have been suggested to be key players in cell-to-cell communication and essential for directed migration of structural cells. Today, the role of the chemokine network in cutaneous wound h...
Article
Background: Indirect immunofluorescence (IIF) microscopy on monkey oesophagus is an important assay for the diagnosis of bullous pemphigoid (BP). Its relatively low sensitivity (60-80%) may be partly due to insufficient detection of minor IgG subclasses. Aim: To determine the operating characteristics of an IgG subclass in IIF. Methods: We des...
Book
Das Standardwerk der Dermatologie, Venerologie und Allergologie in neuer Auflage! Der "Braun-Falco" wurde für die 7. Auflage umfassend überarbeitet und bietet in beeindruckender Weise eine Übersicht über das komplette Fachgebiet für den klinisch tätigen Dermatologen in der Klinik und Praxis. Den Herausgebern ist es gelungen, mit einem internation...
Article
Rosacea is a common skin disease with a predilection for the face. Patients suffer from symptoms like flushing, redness of the face, telangiectasia, pustules, or papules. A more acute form is rosacea fulminans that occurs preferentially in women. Hormonal fluctuations as during a pregnancy can aggravate existent rosacea. The case of a female patien...
Article
Frontal fibrosing alopecia (FFA) describes the scarring, band-like recession of the frontotemporal hairline. Treatment is difficult, and currently, no evidence-based therapy exists. The purpose of this study is to report clinical features and treatment responses in a large cohort of patients with FFA. The authors analyzed a series of 72 patients wi...
Article
Background: Rapid microscopic evaluation of cutaneous squamous cell carcinoma (SCC), its grade of differentiation and level of invasiveness would enable better management of patients' therapy. Objectives: Analyzing specific ex-vivo confocal microscopy criteria whether they can predict diagnosis of invasive SCC vs. carcinoma in situ and poorly di...
Article
Background: Intralesional corticosteroid injections combined with cryotherapy are considered a first-line therapy for keloids. However, objective evaluation on its efficacy is widely missing. Objective: In this study, the authors evaluated the therapeutic benefits of cryotherapy directly followed by intralesional crystalline triamcinolone aceton...
Article
Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory aetiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signalling promotes antigen-driven and likely pathogenic T-helper 17...
Article
Full-text available
Objective The objective of this study was to characterize factors associated with closure of venous leg ulcers (VLUs) in a pooled analysis of subjects from three randomized clinical trials. Methods Closure of VLUs after treatment with HP802-247, an allogeneic living cell therapy consisting of growth-arrested human keratinocytes and fibroblasts, vs...
Article
Background: Ex-vivo confocal laser scanning microscopy (ex-vivo CLSM) offers rapid examination of freshly excised tissue. During the conventional examination immunohistochemistry enables to distinguish various cell types. The possibility of immunofluorescent techniques could enhance the accuracy of the diagnosis performed by ex-vivo CLSM. Methods...
Article
Full-text available
Rosacea is a chronic inflammatory skin condition that affects the blood vessels and sebaceous glands. It is characterized by recurrent erythema, telangiectasia, papules, and pustules. More than 50% of patients with rosacea have ocular manifestations. Here we report the efficacy of topical ivermectin for ocular rosacea in a 12-year-old girl. We conc...
Article
Full-text available
Birt-Hogg-Dubé syndrome (BHDS) is a rare genetic disorder caused by mutations in the FLCN gene. Clinically, BHDS is highly heterogeneous even within the same family. The most characteristic features of BHDS are fibrofolliculomas, lung cysts that confer the risk of pneumothorax, and benign or malignant renal tumours. Additionally, several other tumo...
Article
Full-text available
Background Hotspot mutations of the oncogenes BRAF and NRAS are the most common genetic alterations in cutaneous melanoma. Specific inhibitors of BRAF and MEK have shown significant survival benefits in large phase III trials. However, the prognostic significance of BRAF and NRAS mutations outside of clinical trials remains unclear. Methods The mut...
Article
Background: The use of immune checkpoint blockade (ICB) for uveal melanoma (UM) is little established. The aim of this review was to provide a comprehensive overview on the efficacy, safety, and tolerability of ICB in patients with UM. Methods: We performed a systematic literature research covering MEDLINE, Embase and CENTRAL. Abstracts of perti...
Article
Die 20-MHz-Sonografie ermöglicht nicht-invasiv und schnell eine Einschätzung der Eindringtiefe von kutanen Melanomen. Ziel dieser Studie war es, die Korrelation zwischen der sonografischen und der histologischen Tumordicke darzustellen. Zudem sollten Faktoren ermittelt werden, welche die sonografische Tumordickenbestimmung beeinflussen und zu einer...
Article
Fragestellung: Aktinische Keratosen (AK) liegen an lichtexpo- nierter Haut in unterschiedlichen Entwicklungsstadien vor. Beson- ders subklinische Läsionen (sAK) stehen zunehmend im Fokus als potentielles Behandlungsziel von Feldtherapien. Zur genaueren Darstellung der AK und vor allem sAK haben nicht-invasive bild- gebende Verfahren, insbesondere...
Article
Full-text available
In this study, we aimed to quantify the effects of fractional ablative carbon dioxide laser therapy in the treatment of widespread hypertrophic burn scars. While many different pilot studies have described the potential of the technology and expert groups and current guidelines, alike, recommend its use, the level of evidence for the efficacy of fr...
Article
Das Melanom ist eine häufige Form von Hautkrebs mit hoher Tendenz zur Metastasenbildung. Tyrosinkinase-Inhibitoren, die zielgerichtet in den MAPK (mitogen-activated protein kinase)-Signaltransduktionsweg eingreifen, sowie die Immun-Checkpoint-Blockade haben in jüngster Zeit die Behandlung des nicht-resezierbaren und des metastasierten Melanoms revo...
Article
Background: With the advent of smartphone devices, an increasing number of mHealth applications that target melanoma identification have been developed, but none addresses the general context of melanoma and nonmelanoma skin cancer identification. Introduction: In this study a smartphone application using fractal and classical image analysis for...
Article
A 52-year-old male patient presented to the hospital with severe difficulties swallowing, sore eyes and an asymptomatic skin rash. The patient was fully oriented, vital signs were normal. Two days before admission to the hospital, the referring physician had suspected an upper respiratory tract infection and had started treatment with oral cefuroxi...
Article
Full-text available
IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis. Its production is controlled at the transcriptional level and by subsequent posttranslational processing via inflammatory caspases. In this study, we detected inflammatory caspase-5 active in ep...
Data
Th1/Th17 cytokine-dependent inflammasome regulation and NLRP1 knock-down efficacy in epidermal keratinocytes. A, B, NLRP1, caspase-5 and caspase-1 levels in keratinocytes stimulated with IFNγ, IL-17A analyzed by immunoblotting and normalized to β-actin. One of three representative experiments is shown. C, Cell lysates of IFNγ and IL17A-treated kera...
Data
Schematic summarizing the proposed mechanism of DNA mediated NLRP1 inflammasome activation in keratinocytes in psoriasis and the therapeutic interference by vitamin D. The autoinflammatory Th1/Th17 milieu in psoriasis contains IFNγ and IL-17A, which induces psoriasin (S100A7)-dependent inflammatory caspases-5 over caspase-1 in keratinocytes. Free d...
Data
Knock-down efficacy for caspase-1, caspase-5 and psoriasin (S100A7). A-C, Human epidermal keratinocytes were transfected with siRNA targeting caspase-1, caspase-5, psoriasin and non-coding siRNA, and corresponding targets and off-target controls were analyzed by RTqPCR and normalized to β-actin. Data represent mean + SEM, *, p<0.05; **, p < 0.01; *...
Data
dsDNA and IFNγ induced regulation of IL-1β and caspase-5. A,B, Human epidermal keratinocytes were transfected with dsDNA and stimulated with IFNγ, and the expression of IL-1β and caspase-5 were analyzed by RTqPCR and normalized to β-actin. Data represent mean + SEM of three independent experiments performed in triplicates *, p < 0.05; **, p < 0.01;...
Data
Differential regulation of IL-1β, caspase-1 and caspase-5 in chronic inflammatory skin diseases. Expression levels of IL-1β, caspase-1, caspase-5 in healthy skin compared to tissues from patients with atopic dermatitis, lupus erythematosus and lichen planus analyzed by RTqPCR and normalized to PBGD. Data represent mean + SEM, *, p < 0.05 determined...
Article
Background: Immune checkpoint blockade (ICB) has been a breakthrough in the treatment of metastatic melanoma. But with only about 20-40% long-term responders and severe side-effects in about 12-17%, finding predictive markers for treatment response is of great interest. Methods: We prospectively assessed clinical data, haematologic parameters an...
Article
Background Interleukin-31 may play a role in the pathobiologic mechanism of atopic dermatitis and pruritus. We wanted to assess the efficacy and safety of nemolizumab (CIM331), a humanized antibody against interleukin-31 receptor A, in the treatment of atopic dermatitis. Methods In this phase 2, randomized, double-blind, placebo-controlled, 12-wee...
Article
Bullous pemphigoid (BP) is the most common autoimmune bullous disorder which is characterized by autoantibodies against hemidesmosomal proteins of the skin and mucous membranes. Collagen XVII and dystonin-e have been identified as target antigens. BP affects mostly the elderly. The incidence of the disease is increasing gradually and is associated...
Article
Ein 89-jähriger Mann stellt sich mit ausgedehntem Gesichtstumor vor. Er sei über zwei bis vier Jahre langsam gewachsen. In letzter Zeit empfand der allein lebende Patient die Neoplasie als zunehmend unangenehm.
Article
Corresponding author. Luana Niculescu Department of Dermatology and Allergology, Ludwig Maximilian University, Frauenlobstr. 9-11, 80337 Munich, Germany.
Article
Background: Hidradenitis suppurativa (HS) has recently been described as a component of two autoinflammatory syndromes: PASH (pyoderma gangrenosum, acne, and HS) and PAPASH (pyoderma gangrenosum, acne, pyogenic arthritis, and HS). These associations together with others such as inflammatory bowel diseases suggest that defects in autoinflammatory p...
Article
Full-text available
Background In vivo reflectance confocal microscopy (RCM) is a novel non-invasive diagnostic tool, which is used to differentiate skin lesions. Even in lesions with similar dermatoscopic images, RCM may improve diagnostic accuracy. Methods Three sets of false “twin lesions” with similar macroscopic and dermatoscopic images are matched. All lesions...
Article
Linear IgG deposits along the basement membrane of adnexa are useful in the diagnosis of bullous pemphigoid (BP), but no controlled studies have been performed. This study evaluated linear IgG fluorescence of the basement membrane of sweat gland ducts (SGD) and other adnexa in perilesional biopsies from patients with BP (n = 64) and controls (n = 8...
Article
Full-text available
Epidermolytic ichthyosis (EI) is a rare disorder of cornification caused by mutations in KRT1 and KRT10, encoding two suprabasal epidermal keratins. Because of the variable clinical features and severity of the disease, histopathology is often required to correctly direct the molecular analysis. EI is characterized by hyperkeratosis and vacuolar de...
Chapter
Amyloidosen sind seltene Erkrankungen, die durch eine fehlerhafte Faltung von Proteinen verursacht werden. Die hierbei entstehenden fibrillären Proteine werden unlöslich, lagern sich in verschiedenen Geweben und Organen ab und können schließlich zu schweren Fehlfunktionen führen. Man unterscheidet lokalisierte und systemische Amyloidosen, welche be...
Article
A 63-year-old Caucasian man presented with a three weeks history of multiple erythematous, rosacea-like, facial and thoracic papules and pustules. No mucosal lesions were present. The patient received a combined therapy for metastatic colon carcinoma with cetuximab 500 mg/m²/week plus capecitabine 500 mg/week; just after the onset he developed the...
Article
Rosacea is a common inflammatory disease, mainly affecting the face and with significant impact on patients' life quality. Just recently, topical Ivermectin (Soolantra(®) 10mg/g Crème) has been introduced in the treatment of rosacea thanks to its double anti-parasitic and anti-inflammatory activity, resulting in a reduction of papulo-pustular manif...
Article
Obwohl bislang für die Rosazea keine kurative Therapie besteht, können verschiedene Optionen zur Behandlung der Symptome und zur Vorbeugung von Exazerbationen empfohlen werden. Neben Selbsthilfemaßnahme wie der Vermeidung von Triggerfaktoren und einer geeigneten Hautpflege sollte das Rosazea-Management bei Patienten mit erythematöser und leichter b...
Article
Based on numerous trials, oral tetracyclines and most commonly their second-generation derivative doxycycline have become the main pillar in systemic rosacea treatment. However, the only preparation that has been approved so far in this setting is 40 mg doxycycline in an anti-inflammatory dosage and with a modified release formulation. With the int...
Article
Basierend auf den Daten zahlreicher Studien sind orale Tetracycline – und hier insbesondere Doxycyclin als Tetracyclin der zweiten Generation – die Grundpfeiler der systemischen Rosazea-Therapie. Bisher ist dafür jedoch nur Doxycyclin 40 mg in antientzündlicher Dosierung mit veränderter Wirkstofffreisetzung zugelassen. Seit Einführung der Therapie...
Article
Rosacea is a common chronic inflammatory skin disorder that typically occurs in adults and affects the face. Synonyms of rosacea include “acne rosacea”, “couperose” and “facial erythrosis”, in German also “Kupferfinne” and “Rotfinne”. The disorder is characterised by a chronic and flaring course and is caused by a genetically predisposed, multifact...
Article
Rosazea ist eine häufige chronisch-entzündliche Hauterkrankung, die typischerweise bei Erwachsenen vorkommt und das Gesicht betrifft. Synonyme der Rosazea sind Acne rosacea, Kupferfinne, Rotfinne, Couperose und Rosacea. Die Erkrankung ist durch einen chronischen und schubartigen Verlauf gekennzeichnet und wird durch ein genetisch prädisponiertes, m...
Article
Although there is presently no cure for rosacea, there are several recommended treatment options available to control many of the symptoms and to prevent them from getting worse. In addition to self-help measures like avoidance of trigger factors and proper skin care, rosacea management should include topical medications as one of the first-line ch...