Thomas Rose

Thomas Rose
Queen Astrid Military Hospital · Burn Unit

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100
Publications
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Introduction
Skills and Expertise

Publications

Publications (100)
Article
Background: Flavonifractor plautii is a strictly anaerobic rod shaped bacterium belonging to the family of Clostridiales. It is a commensal of the human intestinal microbiota which was seldom isolated from clinical samples, therefore clinical data are scarce. To date, only four cases of F. plautii infections were described, all occurring in immuno...
Article
Full-text available
Advanced Therapy Medicinal Products (ATMPs) embody innovative therapies that have created great hope for patients suffering from previously untreatable diseases. Unfortunately, the pharaonic cost to produce and authorise ATMPs is a challenge for both patients and public health care systems, ultimately reducing patients' access to treatment. Over th...
Article
Full-text available
Phage therapy is increasingly put forward as a “new” potential tool in the fight against antibiotic resistant infections. During the “Centennial Celebration of Bacteriophage Research” conference in Tbilisi, Georgia on 26–29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage the...
Article
Full-text available
Bacteriophages could be used along with burn wound care products to enhance antimicrobial pressure during treatment. However, some of the components of the topical antimicrobials that are traditionally used for the prevention and treatment of burn wound infection might affect the activity of phages. Therefore, it is imperative to determine the coun...
Data
Stability of bacteriophages in burn wound care products and a selection of their active ingredients (in alphabetical order). A) Burn wound care products; B) Active ingredients. The results are the mean values of three titrations. Standard deviations are indicated. Detection thresholds for each product and each bacterial species are indicated by col...
Article
Objective: To describe a case of partial nephrogenic diabetes insipidus in a burned patient after prolonged delivery of low inspired concentrations of sevoflurane via an Anesthetic Conserving Device. Data sources: Clinical observation. Study selection: Case report. Data extraction: Relevant clinical information. Data synthesis: A 34-year-o...
Article
Full-text available
Multidrug resistant Acinetobacter baumannii and its closely related species A. pittii and A. nosocomialis, all members of the Acinetobacter calcoaceticus-baumannii (Acb) complex, are a major cause of hospital acquired infection. In the burn wound center of the Queen Astrid military hospital in Brussels, 48 patients were colonized or infected with A...
Article
Full-text available
18 H uman organs and tissues differ in regard to their clinical and research uses and the regulatory legislation controlling their use. Organs such as livers and hearts are usually taken from donors who are brain-dead; in addition, kidneys can also come from live volunteers. Organs decay rapidly and need to be transplanted quickly. Surgeons and coo...
Article
High-definition optical coherence tomography (HD-OCT) permits real-time 3-D imaging of the impact of selected agents on human skin allografts. The real-time 3-D HD-OCT assessment of i) the impact on morphological and cellular characteristics of the processing of human acellular dermal matrices (HADMs) and ii) repopulation of HADMs in vitro by human...
Article
The knowledge on PK behavior of steroid drugs such as prednisolone or prednisone has indeed been expanding but at a rather slow pace. First, convenient, rapid, and specific determination of plasma levels of these steroids was largely indebted to the breakthrough of high performance liquid chromatography (HPLC). Second, prednisolone is non-linearly...
Article
Full-text available
Antibiotic resistance has become a major public health problem and the antibiotics pipeline is running dry. Bacteriophages (phages) may offer an 'innovative' means of infection treatment, which can be combined or alternated with antibiotic therapy and may enhance our abilities to treat bacterial infections successfully. Today, in the Queen Astrid M...
Article
While real-time 3-D evaluation of human skin constructs is needed, only 2-D non-invasive imaging techniques are available.
Article
Full-text available
The transplantation of conventional human cell and tissue grafts, such as heart valve replacements and skin for severely burnt patients, has saved many lives over the last decades. The late eighties saw the emergence of tissue engineering with the focus on the development of biological substitutes that restore or improve tissue function. In the nin...
Conference Paper
Concepts and tools for process management have often been transferred to emergency management projects. The driving objective has been to bring assistance to planning procedures and quality assurance. This seems rather natural, since idea and concept of business processes and standard operating procedures appear like siblings. In this paper we disc...
Article
Full-text available
Adequate feeding of critically ill patients under continuous renal replacement therapy (CRRT) remains a challenging issue. We performed a systematic search of the literature published between 1992 and 2012 using the quorum guidelines regarding nutrition in intensive care unit patients treated with CRRT. Daily recommended energy requirements during...
Article
Full-text available
With this analysis we would like to raise some issues that emerge as a result of recent evolutions in the burgeoning field of human cells, tissues, and cellular and tissue-based product (HCT/P) transplantation, and this in the light of the current EU regulatory framework. This paper is intended as an open letter addressed to the EU policy makers, w...
Article
Full-text available
Multidrug resistant Acinetobacter baumannii and its closely related species A. pittii and A. nosocomialis, all members of the Acinetobacter calcoaceticus-baumannii (Acb) complex, are a major cause of hospital acquired infection. In the burn wound center of the Queen Astrid military hospital in Brussels, 48 patients were colonized or infected with A...
Conference Paper
Over the last two decades a significant number of projects tried to convey the concept of business process man-agement to the domain of emergency management. Most of these approaches sought a partial automation for the execution of standard operating procedures in the sense of workflow support, while others strived for the sup-port and integration...
Article
Assault chemical burns are uncommon in northern Europe. Besides local toxicity, systemic manifestations are possible after strong acid exposure. A 40-year-old woman was admitted 1 h after a criminal assault with sulfuric acid. The total burned surface area was 35%, third degree. Injury was due to sulfuric acid (measured pH 0.9) obtained from a car...
Article
Full-text available
The worldwide emergence of 'superbugs' and a dry antibiotic pipeline threaten modern society with a return to the preantibiotic era. Phages - the viruses of bacteria - could help fight antibiotic-resistant bacteria. Phage therapy was first attempted in 1919 by Felix d'Herelle and was commercially developed in the 1930s before being replaced by anti...
Article
Process management for rescue organizations and relief services is a vital asset in the context of disaster preparation and response. Major disasters require services provided by an ample range of organizations by nature. Hence, effective networking of these organizations for communication and collaboration is decisive. This networking requires pro...
Article
Full-text available
Viable donor skin is still considered the gold standard for the temporary covering of burns. Since 1985, the Brussels military skin bank supplies cryopreserved viable cadaveric skin for therapeutic use. Unfortunately, viable skin can not be sterilised, which increases the risk of disease transmission. On the other hand, every effort should be made...
Article
Full-text available
Human donor skin allografts are suitable and much used temporary biological (burn) wound dressings. They prepare the excised wound bed for final autografting and form an excellent substrate for revascularisation and for the formation of granulation tissue. Two preservation methods, glycerol preservation and cryopreservation, are commonly used by ti...
Article
Full-text available
Since 1987, keratinocytes have been cultured at the Queen Astrid Military Hospital. These keratinocytes have been used routinely as auto and allografts on more than 1,000 patients, primarily to accelerate the healing of burns and chronic wounds. Initially the method of Rheinwald and Green was used to prepare cultured epithelial autografts, starting...
Article
Full-text available
There is a distinct difference between tissue and organ donation, although it is usually not well perceived by the public. Solid organs (e.g. kidney, liver and heart) can be taken only from donors who are brain-dead and on life support or immediately after irreversible cardio-respiratory arrest. Organs have to be transported quickly from donor to r...
Conference Paper
In this paper we revisit our earlier proposed domain model based approach to requirements management from a situational method engineering perspective. The approach has originally been developed dedicatedly for a small- and medium-sized enterprise (SME) in the field of control system development. Broadening the perspective by considering situationa...
Article
Small and medium-sized enterprises (SMEs) are important drivers for innovation. In particular, project-driven SMEs that closely cooperate with their customers have specific needs in regard to information engineering of their development process. They need a fast requirements capture since this is most often included in the (unpaid) offer developmen...
Article
Full-text available
Since 1991, the skin bank of the Queen Astrid Military Hospital uses food-grade aluminum foil as a primary support for storing cryo preserved human donor skin (511 donors). The possible release of heavy metals into the cryo preservation media (30% (v/v) glycerol in physiological water) and the possible impact this release could have on the quality...
Article
Public sector information furnishes a valuable information resource for many businesses. Thus, the design of value chains across different stakeholders and corresponding business models capitalising on public sector information is a challenge. Business models have been investigated mostly in the realms of eCommerce and rarely for public private par...
Conference Paper
Full-text available
In this paper, we report on the application of i* to the combined capture of control system and software requirements in the context of software-intensive controllers for engines in the automotive domain. Our work has revealed the need to explicitly represent concrete domain knowledge. Revolving around the notion of "domain models", several contrib...
Chapter
Despite major recent therapeutic improvements, septic shock remains a leading cause of mortality in intensive care patients [1]. In addition, it is important to realize that the mortality rate of patients with septic acute kidney injury (AKI) is much higher than that of patients with non-septic AKI [2]. For more than a decade, it has been suggested...
Conference Paper
A domain model based requirements engineering approach has proven to be helpful when developing software-intensive, embedded control systems. A typical characteristic of this domain is the high volatility of ideas resulting in frequent innovations. Aside from evolution from external research, the innovative projects at small and medium-sized enterp...
Article
Since 1991, the skin bank of the Queen Astrid Military Hospital uses food-grade aluminum foil as a primary support for storing cryo preserved human donor skin (511 donors). The possible release of heavy metals into the cryo preservation media (30% (v/v) glycerol in physiological water) and the possible impact this release could have on the quality...
Article
Human donor skin allografts are suitable and much used temporary biological (burn) wound dressings. They prepare the excised wound bed for final autografting and form an excellent substrate for revascularisation and for the formation of granulation tissue. Two preservation methods, glycerol preservation and cryopreservation, are commonly used by ti...
Conference Paper
When developing software-based control systems, knowledge and experiences in the relevant domain are of great importance. Small- and medium-sized enterprises (SMEs) that are most active here need to capture requirements under severe time and costs pressures. In previous work we have shown that a domain model based on the requirements formalism i* a...
Conference Paper
Realtime simulation software is required for the rapid and efficient development of complex embedded software systems such as engine controllers, especially to avoid expensive tests with the real hardware. But as any other software, realtime simulation software also needs to be developed and maintained. In this paper, we analyse the special require...
Conference Paper
When developing control systems software, mathematically based modelling tools such as Matlab/Simulink are used for design, simulation, and implementation. Thus, a continuous model-based approach does not need to map requirements to, for example, UML class diagrams but to this mathematical representation. In this paper, we build on previous work th...
Data
Activity of phages against 113 P. aeruginosa and 99 S. aureus strains, isolated from different clinical and environmental habitats across the world. (0.25 MB XLS)
Data
Activity of phages against 23 P. aeruginosa and 17 S. aureus strains, recently isolated from patients at the Burn Centre of the Queen Astrid Military Hospital in Brussels. (0.03 MB XLS)
Article
Full-text available
We describe the small-scale, laboratory-based, production and quality control of a cocktail, consisting of exclusively lytic bacteriophages, designed for the treatment of Pseudomonas aeruginosa and Staphylococcus aureus infections in burn wound patients. Based on successive selection rounds three bacteriophages were retained from an initial pool of...
Conference Paper
Telos is a formal knowledge representation language designed for the development of information systems. It has been successfully applied in many different software development projects. Although the development of control systems also includes software development, it constitutes a completely different application domain. An in-depth analysis of t...
Conference Paper
Since nowadays more and more control systems are realised within software on electronic control units, a conceptual integration of control systems engineering and software engineering must be aimed at. Within this work, we build on a recent proposal to use the software requirements formalism i* to enable a combined investigation of control systems'...
Article
Process management has proven to be instrumental for the engineering and assessment of courses of actions for business operations in many industrial application domains. Processes management means appear therefore as natural vehicle for the definition and analysis of operating procedures also for the emergency management domain. The question arises...
Chapter
This chapter reports on experiences gained in the sustainable implementation of mobile e-government services. Sustainable operations require appropriate business models and partnerships for the implementation and provision of services. The lessons learned are based on experiences gained in major European research projects for the implementation of...
Chapter
This chapter reports on experiences gained in the sustainable implementation of mobile e-government services. Sustainable operations require appropriate business models and partnerships for the implementation and provision of services. The lessons learned are based on experiences gained in major European research projects for the implementation of...
Article
Project ERMA (Electronic Risk Management Architecture) strives to support risk management processes in small to medium-sized communities in case of natural or man-made disaster. The supported life cycle of risk episodes ranges from key indicator-based monitoring services, via process-oriented guidance for prevention and relieve, up-to public alerti...
Conference Paper
Supporting medical processes is among the most difficult endeavors. In contrast to uniform and unvaried workflows, the complexity and dynamics of patient treatment processes prevents the application of standard methodologies and tools, such as workflow systems. Despite long-term research in flexible and adaptive workflows as well as computerized cl...
Article
Managing risks and emergencies caused by natural and technological hazards is a complex task for local authorities, emergency services, and their partners in risk management. When making risk-related decisions, processing available data and information can be arduous. In that context, information and communication technologies (IT) can help. This h...
Article
Rising cost pressure due to the implementation of the DRG-System and quality assurance lead to an increased use of therapy standards and standard operating procedures (SOPs) in intensive care medicine. The intention of the German Scientific Society supported project "OLGA" (Online Guideline Assist) is to develop a prototype of a knowledge based sys...
Chapter
Situated and context-sensitive information logistics surface as decisive requirement for supporting critical care units, because information relevant for patient treatment stems from heterogeneous as well as distributed data sources. Immediate treatment starts with an incomplete and almost empty array of information which fills continuously over ti...
Chapter
Citizens call for timely and high-quality environmental information for reasons of awareness and personal well-being. Only an informed citizen will be in the position to participate in urban environment decision making and planning. This interest recommends an easy-to-understand and easy-to-access presentation of such up-to-date information. Rather...
Article
Full-text available
Project APNEE (Air Pollution Network for Early warning and information Exchange in Europe) has been conducted amid the Fifth Framework Programme of the European Union to design and evaluate e-services to inform the citizen about the current state of air quality at their location of interest, be it at the citizen's loca-tion or any other place like...
Conference Paper
This paper introduces a methodology for the development of multi-agent systems, in particular multi-agent systems that optimize the collaboration of distributed work groups like clinical departments. A major difficulty with such systems is requirements elicitation, because intimate knowledge of the work processes is needed to identify the potential...
Article
This paper presents an agile development methodology for multi-agent systems based on XP and reports on our experiences with it for the implementation of agents that support the clinical information flow. Our case study shows that XP is a very promising approach for agent development, because agents are rather small units that can be implemented, t...
Article
APNEE (Air Pollution Network for Early warning and online information Exchange in Europe) is establishing a uniform information portal on air quality in different European regions. Rather than elaborating sophisticated air quality management and forecasting approaches, APNEE is striving to develop a technical umbrella for the distribution and custo...
Article
sem Beitrag als Prozesse verstanden. Am Beispiel von projekthaften Prozessen in der Automo- bil- und Anlagenentwicklung wird in diesem Beitrag ein Ansatz zum prozessorientierten Wis- sensmanagement vorgestellt, der es Anwendern ermöglicht, mittels eines Modellierungswerk- zeugs ihre Prozesserfahrungen intuitiv zu erfassen und zu bewerten und währen...
Article
Full-text available
Citizens call for timely and high-quality environmental information for reasons of comfort and health care. This interest recommends an easy-to-understand and easy-to-access presenta-tion of such information. Rather than presenting raw data in an extensive fashion, one ought to engineer customisable information services, that can be tailored to ind...
Article
Full-text available
Environmental information represents an attractive business asset once perceived as levels of comfort improving the daily life of citizens. The need for high-quality information services is further supported by several European directives to inform the citizen about environmental conditions as well as ongoing initiatives concerning access, dissemin...
Chapter
Die Bedeutung von Prozessen und Prozessmanagement ist bereits von verschiedenen Standpunkten analysiert worden (Curtis et al. 1992). Prozessmodelle bilden auf der einen Seite ein Steuerungsinstrument für die Kontrolle und Lenkung von Projekten auf verschiedenen Granularitätsebenen. Auf der anderen Seite ist die explizite Erfassung und Nutzung von P...
Article
This paper presents a new brand of portals that elevates the concepts of information portals to a new level of interaction and navigation means. The graphical information portal is built upon the concept of smart maps for information visualization and exploration. Smart maps serve as navigational hub by indicating the existence of information carry...
Conference Paper
Virtual enterprises face serious difficulties in defining and adapting their business processes across the members of the virtual enterprise. The research in our project ProACTIVE aims at developing a methodology and tool box that allows (semi-)automatic (re-)configuration of one-of-a-kind business process models fitting the specific requirements a...