Thomas Pfeffer

Thomas Pfeffer
University Pompeu Fabra | UPF · Center of Brain and Cognition (CBC)

PhD

About

18
Publications
3,812
Reads
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415
Citations
Introduction
Postdoc in the Computational Neuroscience group of Gustavo Deco at UPF Barcelona.
Additional affiliations
November 2019 - present
University Pompeu Fabra
Position
  • PostDoc Position
November 2017 - present
University Medical Center Hamburg - Eppendorf
Position
  • PostDoc Position
January 2013 - November 2017
University Medical Center Hamburg - Eppendorf
Position
  • PhD Student
Education
September 2010 - October 2012
University of Amsterdam
Field of study
  • Brain & Cognitive Sciences
October 2008 - September 2010
October 2006 - September 2008
University of Vienna
Field of study
  • Psychology

Publications

Publications (18)
Article
Full-text available
The ascending modulatory systems of the brain stem are powerful regulators of global brain state. Disturbances of these systems are implicated in several major neuropsychiatric disorders. Yet, how these systems interact with specific neural computations in the cerebral cortex to shape perception, cognition, and behavior remains poorly understood. H...
Preprint
Full-text available
Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence cortical population activity in detail has only been characterized for a few selected brain regions so far. Traditional accounts conceptualize arousa...
Article
Full-text available
Influential theories postulate distinct roles of catecholamines and acetylcholine in cognition and behavior. However, previous physiological work reported similar effects of these neuromodulators on the response properties (specifically, the gain) of individual cortical neurons. Here, we show a double dissociation between the effects of catecholami...
Article
Full-text available
Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying this process are poorly understood. The developmental transition has important functional consequences, as the latter state is thought to allow for more efficient st...
Article
Full-text available
Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence cortical population activity in detail has so far only been characterized for a few selected brain regions. Traditional accounts conceptualize arousa...
Preprint
Full-text available
Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying this process are unknown. The developmental transition has important functional consequences, as the latter state allows for more efficient storage, retrieval and pr...
Article
Full-text available
Complex cognitive functions such as working memory and decision-making require information maintenance over seconds to years, from transient sensory stimuli to long-term contextual cues. While theoretical accounts predict the emergence of a corresponding hierarchy of neuronal timescales, direct electrophysiological evidence across the human cortex...
Preprint
Full-text available
Influential accounts postulate distinct roles of the catecholamine and acetylcholine neuromodulatory systems in cognition and behavior. But previous work found similar effects of these modulators on the response properties of individual cortical neurons. Here, we report a double dissociation between catecholamine and acetylcholine effects at the le...
Preprint
Full-text available
Complex cognitive functions such as working memory and decision-making require the maintenance of information over many timescales, from transient sensory stimuli to long-term contextual cues ¹ . However, while theoretical accounts predict that a corresponding hierarchy of neuronal timescales likely emerges as a result of graded variations in recur...
Article
Full-text available
Brain activity fluctuates continuously, even in the absence of changes in sensory input or motor output. These intrinsic activity fluctuations are correlated across brain regions and are spatially organized in macroscale networks. Variations in the strength, topography, and topology of correlated activity occur over time, and unfold upon a backbone...
Preprint
Full-text available
Brain activity fluctuates continuously, even in the absence of changes in sensory input or motor output. These intrinsic activity fluctuations are correlated across brain regions and are spatially organized in macroscale networks. Variations in the strength, topography, and topology of correlated activity occur over time, and unfold upon a backbone...
Preprint
Brain activity fluctuates continuously, even in the absence of changes in sensory input or motor output. These intrinsic activity fluctuations are correlated across brain regions and are spatially organized in macroscale networks. Variations in the strength, topography, and topology of correlated activity occur over time, and unfold upon a backbone...
Preprint
Full-text available
The ascending modulatory systems of the brainstem are powerful regulators of global brain state. Disturbances of these systems are implicated in several major neuropsychiatric disorders. Yet, how these systems interact with specific neural computations in the cerebral cortex to shape perception, cognition, and behavior remains poorly understood. He...
Article
Full-text available
Unlabelled: The brain commonly exhibits spontaneous (i.e., in the absence of a task) fluctuations in neural activity that are correlated across brain regions. It has been established that the spatial structure, or topography, of these intrinsic correlations is in part determined by the fixed anatomical connectivity between regions. However, it rem...
Article
Full-text available
Perceptual decisions are based on the temporal integration of sensory evidence for different states of the outside world. The timescale of this integration process varies widely across behavioral contexts and individuals, and it is diagnostic for the underlying neural mechanisms. In many situations, the decision-maker knows the required mapping bet...
Article
Full-text available
Imagine walking on a busy street with a large number of people approaching you. To successfully navigate through such a moving crowd and avoid bumping into other pedestrians, you must continuously collect sensory information to decide whether to swerve left or right. But how exactly does your brain
Article
Full-text available
A key computation underlying perceptual decisions is the temporal integration of "evidence" in favor of different states of the world. Studies from psychology and neuroscience have shown that observers integrate multiple samples of noisy perceptual evidence over time toward a decision [1-11]. An influential model posits perfect evidence integration...

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