Thomas Munzel

Thomas Munzel
Universitätsmedizin der Johannes Gutenberg-Universität Mainz · II. Medical Clinic

MD

About

1,562
Publications
177,012
Reads
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68,638
Citations
Introduction
Currently we investigate the effects of nighttime aircraft noise on vascular (endothelial) function in patients with established coronary artery disease. The measure endothelial function we use the flow dependent dilation of the brachial artery. We also assess annoyance, sleep quality, measure stress hormones and blood pressure.
Additional affiliations
January 2010 - December 2012
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Position
  • Founding Director
April 2004 - present
Johannes Gutenberg-Universität Mainz
Position
  • Chief in Cardiology
October 1995 - March 2004
University Medical Center Hamburg - Eppendorf
Position
  • Professor (Associate)

Publications

Publications (1,562)
Article
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Jeder vierte Erwachsene in Rheinland-Pfalz weist einen Prädiabetes auf. Die Daten der GHS zeigen, dass das kardiovaskuläre Risiko nicht erst bei manifestem Typ-2-Diabetes steigt, sondern schon viel früher. Die Erkenntnisse erfordern neue Konzepte für Prävention und Früherkennung.
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Healthy soil is foundational to human health. Healthy soil is needed to grow crops, provides food, and sustains populations. It supports diverse ecosystems and critical ecological services such as pollination. It stores water and prevents floods. It captures carbon and slows global climate change. Soil pollution is a great and growing threat to hum...
Article
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Background: Smoking is a well-established risk factor for chronic non-communicable diseases. However, the relationship between cigarette smoking and the risk of developing mental health conditions remains largely elusive. This study examined the relationship between cigarette smoking as well as smoking cessation and prevalent and incident symptoms...
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Das Rauchen von Tabakzigaretten ist eine Hauptursache für chronische, nicht übertragbare kardiovaskuläre Erkrankungen und Risikofaktoren wie Atherosklerose und arterielle Hypertonie. Daneben erhöht der Konsum von Tabakzigaretten das Risiko für eine pulmonale oder metabolische Erkrankung. Seit etwa 20 Jahren ist der weltweite Tabakkonsum rückläufi...
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The importance of noise exposure as a major environmental determinant of public health is being increasingly recognized. While in recent years a large body evidence has emerged linking environmental noise exposure mainly to cardiovascular disease, much less is known concerning the adverse health effects of noise on the brain and associated neuropsy...
Conference Paper
Einleitung Fluglärm ist mittlerweile ein nachgewiesener kardiovaskulärer Risikofaktor. Entscheidend hierbei ist die Fluglärm-induzierte Entzündungs- reaktion und der oxidative Stress im Gefäßsystem mit begleitender Endothel- zelldysfunktion. Ziel ZieldervorliegendenStudiewareszuklären,obAdpatationoderToler- anzmechanismen bei Mäusen wirksam werden....
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Introduction: Atherosclerosis and pulmonary embolism (PE) affect cardiovascular mortality substantially. We aimed to investigate the impact of atherosclerosis on the outcomes of patients with deep venous thrombosis (DVT) and to identify the differences in DVT patients with and without PE. Methods: Patients with DVT with and without symptomatic a...
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Aims To investigate the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio [aldosterone-to-renin (ARR)] for incident hypertension in the general population. Methods and results Concentration of renin and aldosterone were measured by a chemiluminescence immunoassay using the fully automated LIAISON® plat...
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Diagnosis of acute PE in pregnant women with haemodynamic instability is following the general integrated risk-adapted diagnostic algorithm and starts with bedside echocardiography to assess RV function. If RV dysfunction is identified, a prompt and immediate reperfusion without further imaging should be initiated. Although pregnancy is listed as a...
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Die Weltgesundheitsorganisation gibt an, dass die Stadtplanung mittlerweile als kritischer Bestandteil einer umfassenden Lösung zur Bekämpfung umweltbedingter Gesundheitsschäden gesehen wird. Die vorliegende Übersicht befasst sich mit nicht übertragbaren Krankheiten mit dem Schwerpunkt auf Herz-Kreislauf-Erkrankungen und dem Urbanisierungsprozess i...
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Zusammenfassung Umgebungslärm stellt einen bedeutsamen umweltbezogenen Risikofaktor für die öffentliche Gesundheit dar. Die Europäische Umweltagentur gibt an, dass mindestens 20% der europäischen Bevölkerung schädlichen Tag-Abend-Nacht-Lärmpegeln von 55 Dezibel (dB) ausgesetzt sind, wobei die Weltgesundheitsorganisation zum Schutz der Bevölkerung,...
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Zusammenfassung Beeinträchtigungen des Schlafes im Sinne von Insomnien, d. h. Ein- und Durchschlafschwierigkeiten, frühmorgendliches Erwachen und ein chronisch unerholsamer Schlaf, sind weit verbreitet in der Bevölkerung und gehen mit einer Vielzahl von körperlichen und psychischen Gesundheitsstörungen einher. Die umweltbedingten Ursachen für Schla...
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Die chronische Belastung durch Luftschadstoffe, insbesondere Feinstaub, ist ein primärer Risikofaktor für die öffentliche Gesundheit. Während sich die Luftqualität in Deutschland in den letzten 3 Jahrzehnten erheblich verbessert hat und die Standards der Europäischen Union die meiste Zeit eingehalten werden, werden die strengeren Richtlinien der We...
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Aktuelle Befunde der großen globalen epidemiologischen Studien wie dem „Global Burden of Disease“-Projekt legen nahe, dass bereits jetzt nahezu ⅔ der jährlichen globalen Todesfälle ursächlich auf chronische nicht übertragbare Erkrankungen wie Atherosklerose oder Diabetes zurückzuführen sind. Dies liegt vor allem an der Überalterung der Menschen in...
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Die Exposition der Bevölkerung durch hochfrequente elektromagnetische Felder (HF-EMF) wird durch die körpernahe Nutzung von drahtlosen Kommunikationsgeräten dominiert. Die Exposition durch körperferne Sendeanlagen liegt im Durchschnitt mehrere Größenordnungen unterhalb der internationalen Richtwerte. Mit der zunehmenden mobilen Datennutzung und der...
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Aircraft noise induces vascular and cerebral inflammation and oxidative stress causing hypertension and cardiovascular/cerebral dysfunction. With the present studies, we sought to determine the role of myeloid cells in the vascular vs. cerebral consequences of exposure to aircraft noise. Toxin-mediated ablation of lysozyme M+ (LysM+) myeloid cells...
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Environmental exposures represent a significant health hazard, which cumulatively may be responsible for up to 2/3 of all chronic non-communicable disease and associated mortality (Global Burden of Disease Study and The Lancet Commission on Pollution and Health), which has given rise to a new concept of the exposome: the sum of environmental factor...
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Background—Several methods to reduce radiation exposure in the setting of coronary procedures are available on the market, and we previously showed that additional radiation shields reduce operator exposure during radial interventions. We set out to examine the efficacy of real-time personal dosimetry monitoring in a real-world setting of radial ar...
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Purpose Low birth weight (BW) is associated with increased corneal aberrations in childhood and alterations of corneal geometry in adulthood. Increased corneal aberrations may be a factor contributing to decreased visual function in former low BW newborns in later life. Hence, the aim of this study was to analyze the long-term effect of low BW on c...
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Both exposure to higher levels of polluted air and physical inactivity are crucial risk factors for the development and progression of major noncommunicable diseases and, in particular, of cardiovascular disease. In this context, the World Health Organization estimated 4.2 and 3.2 million global deaths per year in response to ambient air pollution...
Article
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Intraprocedural transesophageal echocardiography (TEE) guidance plays an essential role in transcatheter repair therapy of the tricuspid valve (TV). So far, several different imaging concepts are in use. We propose an imaging protocol that fully addresses the morphological complexity of the TV and further offers efficacious workarounds for the freq...
Article
Objectives In patients with acute pulmonary embolism (PE), right atrial pressure is elevated, which increases risk for right-to-left shunt when patent foramen ovale (PFO) is present and thus potentially increases risk for paradoxical embolism. Little is known about the clinical outcome of patients with PE and concomitant PFO. Methods We analysed d...
Article
Background A symptomatic and prognostic benefit by Transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR) has been proven. A variety of individual factors including female sex has been suggested to be associated with adverse outcome in cardio-surgical procedures. Purpose While gender is factored in common risk factor models for adv...
Article
Background Venous thromboembolism (VTE) is common and associated with high morbidity and mortality. Although chronic inflammation was not categorized as a traditional risk factor for VTE, chronic inflammation might increase the risk to develop VTE events. While studies confirmed an increased cardiovascular morbidity and mortality in psoriatic patie...
Article
Introduction Diabetes mellitus (DM) represents a notable risk factor after surgical and interventional procedures but data on the influence of DM on long-term survival after Transcatheter Edge-to-edge Repair (TEER) for Mitral valve Regurgitation (MR) are sparse. Purpose To compare the outcome of patients with and without DM after TEER. Methods Re...
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This article contains supporting information on data collection for the research article entitled “Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice” by Eckrich et al. We found that noise-induced stress triggered microvascular dysfunction via involvement of innate immune-derived reactiv...
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Aim We aim to determine the frequency of stressful life events (SLEs) and investigate the association of single and aggregated SLEs with mental health and general subjective health, which has not been reported for an aging representative sample to date. Subjects and methods A total of 12,947 participants (35–74 years old) of the Gutenberg Health S...
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Background: This study sought to investigate the prevalence and clinical outcome of left ventricular (LV) geometry in prediabetes and type 2 diabetes mellitus (T2DM) and the impact of glucose metabolism on the incidence of left ventricular hypertrophy (LVH). Methods: 15,010 subjects (35-74 years) of the population-based Gutenberg Health Study we...
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BACKGROUND: Regular exercise training represents an important modifier of arterial stiffness (AS). Therefore, sex-specific relations between domains of physical activity (PA; commuting, domestic, and leisure-time PA, including active sport and occupational PA) with AS were investigated. METHODS AND RESULTS: Stiffness index by digital photoplethysmo...
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The aim of this study was to compare patients with transcatheter aortic valve replacement (TAVR) receiving new generation prostheses SAPIEN 3 (S3, Edwards Lifesc.) and Evolut R (ER, Medtronic Inc.) in terms of periprocedural and long-term outcome. Our retrospective, single-center analysis included 359 consecutive patients with severe aortic stenosi...
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Despite extensive efforts to combat cigarette smoking/tobacco use, it still remains a leading cause of global morbidity and mortality, killing more than eight million people each year. While tobacco smoking is a major risk factor for non-communicable diseases related to the four main groups - cardiovascular disease, cancer, chronic lung disease, an...
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The world's population is estimated to reach 10 billion by 2050 and 75% of this population will live in cities. Two-third of the European population already live in urban areas and this proportion continues to grow. Between 60% and 80% of the global energy use is consumed by urban areas, with 70% of the greenhouse gas emissions produced within urba...
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Background Concomitant tricuspid regurgitation (TR) is a common finding in mitral regurgitation (MR). Transcatheter repair (TMVR) is a favorable treatment option in patients at elevated surgical risk. To date, evidence on long-term prognosis and the prognostic impact of TR after TMVR is limited. Methods Long-term survival data of patients undergoi...
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Aims: Cigarette smoking is one of the most complex and least understood cardiovascular risk factors. Importantly, differences in the tobacco-related pathophysiology of endothelial dysfunction, an early event in atherogenesis, between circulatory beds remain elusive. Therefore, this study evaluated how smoking impacts endothelial function of conduit...
Article
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Chronic thromboembolic pulmonary hypertension (CTEPH) is considered as a rare but severe complication after acute pulmonary embolism (PE) and is potentially curable by pulmonary endarterectomy (PEA). We aimed to evaluate, over an 11-year period, time trends of in-hospital outcomes of PEA in CTEPH patients and to investigate predictors of the in-hos...
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The World Health Organization estimates that only approximately 25% of diversity in longevity is explained by genetic factors, while the other 75% is largely determined by interactions with the physical and social environments. Indeed, aging is a multifactorial process that is influenced by a range of environmental, sociodemographic, and biopsychos...
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Aim Recent evidence suggests that arterial hypertension could be alternatively explained as a physiological adaptation response to water shortage, termed aestivation, which relies on complex multi‐organ metabolic adjustments to prevent dehydration. Here we tested the hypothesis that chronic water loss across diseased skin leads to similar adaptive...
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Objectives Following an exploratory approach, we examined cardiovascular disease risk factors at baseline and the 5-year incidence proportion of self-reported doctor-diagnosed cardiovascular diseases (CVD) in teachers and other occupational groups of the Gutenberg Health Study. Methods Study participants lived in the region of Mainz, Germany. Data...
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Several studies have shown that tea consumption is associated with beneficial effects on human health, which is mainly explained by the antioxidant properties of tea. However, evidence on the effect of nutrition interventions on oxidative stress in an occupational setting is limited. Therefore, the present study aimed to investigate the effect of t...
Article
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Air pollution in the environment and in households is responsible worldwide for almost 9 million preventable premature deaths per year and almost 800,000 such deaths within Europe. Air pollution therefore shortens life expectancy worldwide by almost 3 years. Smoking, a proven cardiovascular risk factor, shortens the mean life expectancy by 2.2 year...
Article
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Background Environmental noise exposure has been associated with increased cardiovascular morbidity and mortality. Recently, noise annoyance was shown to induce atrial fibrillation, which was accompanied by significantly increased levels of midregional pro atrial natriuretic peptide (MR-proANP). Therefore, the aim of the present study was to analyz...
Article
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Background: We sought to determine structure and changes in organisation and bed capacities of certified German chest pain units (CPU) in response to the emergency plan set-up as a response to the SARS-CoV-2 pandemic. Methods and results: The study was conducted in the form of a standardised telephone interview survey in certified German CPUs. A...
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Aims The risk of mortality from the coronavirus disease that emerged in 2019 (COVID-19) is increased by comorbidity from cardiovascular and pulmonary diseases. Air pollution also causes excess mortality from these conditions. Analysis of the first severe acute respiratory syndrome coronavirus (SARS-CoV-1) outcomes in 2003, and preliminary investiga...
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Aims Catheter-directed treatment of acute pulmonary embolism (PE) is technically advancing. Recent guidelines acknowledge this treatment option for patients with overt or imminent haemodynamic decompensation, particularly when systemic thrombolysis is contraindicated. We investigated patients with PE who underwent catheter-directed thrombolysis (CD...
Article
Purpose: To investigate the incidence of retinal detachment in the German population and assess potential risk factors. Methods: The Gutenberg Health Study is a population-based cohort study in Mainz, Germany including subjects (n=15.010) with an age range from 35 to 74 years at baseline. Participants underwent a comprehensive ophthalmologic exa...
Article
Environmental pollution is a major cause of global mortality and burden of disease. All chemical pollution forms together may be responsible for up to 12 million annual excess deaths as estimated by the Lancet Commission on pollution and health as well as the World Health Organization. Ambient air pollution by particulate matter (PM) and ozone was...
Article
Since the publication of the last American Heart Association scientific statement on air pollution and cardiovascular disease in 2010, unequivocal evidence of the causal role of fine particulate matter air pollution (PM2.5, or particulate matter ≤2.5 μm in diameter) in cardiovascular disease has emerged. There is a compelling case to provide the pu...
Article
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Background Iron deficiency is now accepted as an independent entity beyond anemia. Recently, a new functional definition of iron deficiency was proposed and proved strong efficacy in randomized cardiovascular clinical trials of intravenous iron supplementation. Here, we characterize the impact of iron deficiency on all-cause mortality in the non-an...
Article
In cases of suspected acute coronary syndrome (ACS), rapid and accurate diagnosis is essential to establish effective evidence-based medical treatment. Patients' history, clinical examination, 12-lead electrocardiogram, and cardiac biomarkers are cornerstones in initial management. Since high-sensitivity cardiac troponins were established, they hav...
Article
Background Transcatheter Aortic Valve Implantation (TAVI) is today the first option for older patients with aortic valve stenosis (AS) at intermediate or high risk for surgery. Constant development of bioprosthetic valves and delivery systems have reduced complications and improved outcomes over the years. The 3rd generation Edwards Sapien 3 Valve...
Article
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Background Guidelines recommend evaluating the risk/benefit ratio of novel therapies individually in women and men, as the pathophysiology and the response to treatment may differ between women and men. Among patients with acute heart failure (AHF), a strategy of intensive vasodilation, compared with usual care, overall did provide comparable outco...
Article
Background Venous thromboembolism (VTE) is a frequent acute cardiovascular disease, leading to significant morbidity and mortality worldwide. Major trauma, surgery, immobilisation and joint replacements are major provoking factors for VTE. In particular, patients undergoing knee and hip joint replacement surgery are at high risk of developing VTE p...
Article
Background Transcatheter tricuspid valve repair (TTVR) using edge-to-edge leaflet therapy (E2E) has evolved as a feasible therapy to treating severe tricuspid regurgitation (TR). The TRILUMINATE trial using the new TriClip NT has shown promising clinical and functional improvements. However, the 3rd generation MitraClip XTr (Abbott Structural Heart...
Article
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Background Prediabetes and type 2 diabetes mellitus (T2DM) have been demonstrated to alter left ventricular geometry and promote left ventricular (LV) hypertrophy (LVH). However, the impact of impaired glucose metabolism on cardiac structure is still not completely understood and controversially discussed. Purpose To investigate the impact of pred...