Thomas Horst Loew

Thomas Horst Loew
University Hospital Regensburg | Uni Regensburg · Dept. of Psychosomatic Medicine

MD

About

249
Publications
50,858
Reads
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4,365
Citations
Additional affiliations
October 2006 - March 2011
Universität Regensburg
Position
  • Head of Department (acting)
March 2001 - May 2016
University Hospital Regensburg
Position
  • Head of Department
February 2001 - May 2016
University Hospital Regensburg
Position
  • Head of Department

Publications

Publications (249)
Article
Full-text available
Background: Beyond the degree of adiposity, the pattern of fat distribution has a profound influence on cardiometabolic risk. It is unclear if sex differences in body fat distribution can potentially explain any sex differences in the prevalence of the metabolic syndrome (MetS) and in individual cardiometabolic risk factors among obese men and wom...
Poster
Background: Up to 80% of patients suffering from persistent symptoms more than six months after a COVID-19 infection complain about a variety of psychosomatic symptoms with no organ cause. Most patients suffer from chronic fatigue, pain, depression or difficulty concentrating. Experimental studies showed that these symptoms could be significantly i...
Article
Introduction Endothelial dysfunction is a very common finding in obesity and metabolic syndrome. The aim of our study was to investigate if longterm weight reduction (WR) success may reverse endothelial activation in individuals with severe obesity participating in a multimodal WR program. Methods Participants with obesity (øBMI 40.3 ±7.5 kg/m²) u...
Article
Full-text available
This study compared the effectiveness of a 12-day stress-prevention program (SGS) supplemented by individualized, structured, four-session telephone-coaching to that of an SGS without telephone-coaching in entrepreneurs from the green professions presenting with increased stress levels. All participants went through the SGS before being randomized...
Article
Background Diet induced weight loss represents an intervention for obesity to prevent associated diseases. However there is considerable inter-individual variation. Single nucleotide polymorphisms (SNPs) and plasma miRNA might be contributing factors. We therefore hypothesized that changes in the miRNA pattern during weight loss depend on the SNP g...
Article
Full-text available
Within the Routine Outcome Monitoring System “OQ-Analyst”, the questionnaire “Assessment for Signal Cases” (ASC) supports therapists in detecting potential reasons for not-on-track trajectories. Factor analysis and a machine learning algorithm (LASSO with 10-fold cross-validation) were applied and potential predictors of not-on-track classification...
Article
Full-text available
Background: Recent research shows that placebo mechanisms can be utilized in ethical and legal ways such as in open-label conditions, when patients know that they receive placebos, and through psychological interventions aiming to optimize patients’ expectations. Showing that placebo interventions are also cost-efficient could improve their accepta...
Article
Numerous methods for enhancing consciousness and well-being emphasize the role of breathing. We have for the first time investigated the link between body rhythms and slow cortical brain dynamics during paced breathing. Physiological data from 37 participants are presented, who conducted paced breathing sessions with respiration rates (RR) from 6 t...
Article
Full-text available
Background In present times, we see ourselves confronted by the challenge of engaging increasingly diverse views of the world, god and healing in a constructive dialogue. Consequently, it is important to research into the contrary effects of religiosity on the human psyche. Methods Original- and literary medical historian research Results Gottfri...
Article
Zusammenfassung Die Atmung hat Einfluss auf unseren Körper und dient letztlich dem Zweck, Sauerstoff in benötigter Menge aufzunehmen. Aber die Atmung dient auch zu Regulationszwecken, und wir können sie willentlich beeinflussen. Mittels des langsamen, bewussten Atmens können Organfunktionen reguliert werden. Es fußt auf dem Prinzip, dem Körper vorz...
Data
Table S1. Activin A levels compared in normal and pathologic metabolic syndrome (MetS) parameters in the obese.
Article
Full-text available
Aims Left ventricular diastolic dysfunction (LVDD) is common in obese subjects, and a relationship between epicardial adipose tissue (EAT), increased adipocytokines, and cardiovascular diseases has been reported. This study sought to examine as to whether the adipo‐fibrokine activin A is a link between increased EAT, the metabolic syndrome (MetS),...
Poster
Full-text available
Fragestellung: Innerhalb der kognitiv-behavioralen Therapie bei Insomnie (CBT-I) werden häufig Entspannungsverfahren wie die progressive Muskelrelaxation (PMR) angewandt. Nach den Prinzipien der PMR funktioniert auch das Atemtakter-Gerät des Herstellers taxxos. Bei dem Atemtakter handelt es sich um ein mobiles Gerät zur Therapieunterstützung bei ve...
Poster
Full-text available
On the occasion of the first Indian Traumahelper project 28 voluntary participants were tested. For this study we included 25 Traumahelper which got four consecutive interventions: Functional Relaxation, SURE (Somatic Universal Regulative Exercises), Slow-Paced-Breathing and Bilateral Stimulation. Pre-post-changes in stress levels were documented v...
Article
Full-text available
Zusammenfassung Einleitung Das 500-jährige Reformationsjubiläum bildet den Anlass, die Historie der Pathographie Martin Luthers (1483–1546) zu skizzieren und mögliche Schlussfolgerungen für die psychiatrische Praxis abzuleiten. Methode Relevantes Schrifttum wurde ausgewertet. Ergebnisse Luther wurde als manisch-depressiv diagnostiziert, er wurde pa...
Article
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This study sought to examine the relationships between right ventricular (RV) function and geometry, morbid obesity with and without the metabolic syndrome, and the effect of long-term weight loss. Obese (n = 153, BMI 41.2 ± 8.7 kg/m²) and healthy non-obese control subjects (n = 38, BMI 25.5 ± 3.3 kg/m²) of similar age and gender distribution were...
Article
Full-text available
Research has shown that pain is associated with disability and that depressed mood mediates the relationship between pain and disability. The question of whether duration of pain moderates these effects was addressed in this cross-sectional study with 356 chronic pain patients. A simple mediation model replicated the notion that depressed mood expl...
Chapter
Psychosomatische Beeinträchtigungen sind sehr häufige Phänomene. Jeder Mensch kennt körperliche Phänomene, beginnend beim plötzlichen Ohrgeräusch, das Sekunden bis Minuten anhalten kann, absteigend über Engegefühle im Hals, Herzsensationen, Druckgefühle im Oberbauch, Übelkeit, Schmerzen in verschiedenen Gelenken, bis zum Gefühl der Muskelschwäche o...
Article
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Objectives: Within the clinical support tools (CST) of the OQ-Analyst, the “Assessment for Signal Cases” (ASC) evaluates the therapeutic alliance, social support, motivation, and life events. We investigated whether the ASC covers domains of importance in treatment weeks with extreme deviations from expected recovery curves (ERCs). Methods: Psychos...
Article
The ICD-10 Symptom Rating (ISR) 1 measures the severity of psychiatric disorders with 29 items on 5 subscales as comprehensively as possible. The following syndromes are measured: Depressive syndrome, anxiety syndrome, obsessive-compulsive syndrome, Somatoform syndrome, eating disorder syndrome as well as additional items that cover various mental...
Book
Full-text available
ICD-10-Symptom-Rating (ISR) - Das Handbuch zum Fragebogen Das Handbuch zum lizenzfreien ICD-10-Symptomrating (ISR) für die schnelle syndrom-übergreifende Bewertung psychischer Symptomatik durch den Patienten. Es enthält Angaben zur Entstehung, Durchführung, Normierung und Studien zur Güte des ISR. Das lizenzfreie „ICD-10-Symptomrating“ (ISR) ermö...
Article
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Background: Obesity is a risk factor for left ventricular diastolic function (LVDD), yet the impact of long-term weight reduction (LTWR) on diastolic function remains unclear. We assessed the effect of LTWR on diastolic function in morbidly obese subjects over 1 year. Methods: Eligible participants with a BMI ≥30kg/m2 and stable body weight over th...
Conference Paper
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The Psychosomatic clinic Waldmünchen is Germany's only psychosomatic hospital with a treatment plan for families. Admitted are parents with psychosomatic diseases with their children or vicecersa or both being burdened from age of 3 and older. In addition to the specific patient population the specialized hospital Waldmünchen offers a unique treatm...
Article
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Most dental procedures require a dry working environment. Although many evaporative drying methods are available, an additional reduction of salivary flow would often be helpful. This prospective randomized cross-over study compares salivary production in 31 volunteers during direct, indirect, and non-suggestive (control group) intervention. Overal...
Article
The “ICD-10 Symptom-Rating” (ISR) is a novel 29-item self-rating questionnaire with scales for the assessment of depression, anxiety, OCD, somatisation and eating disorders and additional items. This study aims at the validation of the depression subscale.Methods Based on a sample of 1844 depressed inpatients, the ISR was correlated with the Beck-D...
Article
Objective: Because premature discontinuation of psychotherapy limits the effectiveness of the interventions, in a naturalistic design we examined the prevalence, predictors, and outcome of premature discontinuation. Methods: The sample included N = 584 patients with various mental disorders. Risk factors were identified using regression analysis...
Article
Full-text available
Objective: The evaluation of medical research performance is a key prerequisite for the systematic advancement of medical faculties, research foci, academic departments, and individual scientists’ careers. However, it is often based on vaguely defined aims and questionable methods and can thereby lead to unwanted regulatory effects. The current pap...
Article
Background In previous studies of on-track patients (OT) involving therapists receiving only patient progress feedback without clinical support tools (CST) inconsistent results were found. Possible effects of combining patient progress feedback with CST on OT patients remain unclear. Methods At intake (t1), 252 patients of two in-patient psychosom...
Article
Full-text available
Objectives: This study aimed to examine the association of adipocyte fatty acid-binding protein (FABP4) levels with left ventricular diastolic dysfunction (LVDD) in obese subjects with varying degrees of the metabolic syndrome (MetS). Methods: Fifty morbidly obese subjects with LVDD were selected at random and matched by age (±5 years) and sex wit...
Article
Full-text available
Method: Patients of two psychodynamic-oriented psychosomatic in-patient clinics filled out two questionnaires (Outcome Questionnaire „OQ-45“ and ICD-10 Symptomrating „ISR“) on a weekly basis during their stay. The scores of the questionnaires were used to assess the severity of distress during the intake week (week 0) and to evaluate its change in...
Article
Chronic pain conditions are highly prevalent, with somatoform pain disorder accounting for a large proportion. However, the psychological forms of treatment currently used achieve only small to medium effect sizes. This retrospective study investigated the effectiveness of a 5-week multimodal pain program for patients with somatoform pain disorder....
Poster
Full-text available
Background: Prolongation of the QT interval has been related to various components of the metabolic syndrome (MetS), including type 2 diabetes and obesity. The underlying mechanisms of the QTc prolongation in these subjects are still unknown. We conducted a prospective study to determine ventricular repolarization in parallel to detailed metabolic...
Data
Full-text available
The increase of psychosomatic disorders due to cultural changes requires enhanced therapeutic models. This study investigated a salutogenetic treatment concept for inpatient psychosomatic treatment, based on data from more than 11000 patients of a psychosomatic clinic in Germany. The clinic aims at supporting patients' health improvement by fosteri...
Article
Full-text available
In the past, phenomenological research on subjective body experience was characterised by vaguely defined terminology and methodological shortcomings. The term "body image" has been applied heterogeneously in literature in order to describe a variety of bodily phenomena. In this paper, the German terminology applied to the phenomenology of body exp...
Article
Full-text available
Background. Early retirement of teachers due to burnout is frequent in Germany. In this study short- and medium-term effects of AFA breathing therapy were evaluated. Methods. This study was designed as a longitudinal controlled intervention design with four points of measurements: before assessment (T1), after intervention (T2), three months (follo...
Article
Full-text available
The increase of psychosomatic disorders due to cultural changes requires enhanced therapeutic models. This study investigated a salutogenetic treatment concept for inpatient psychosomatic treatment, based on data from more than 11000 patients of a psychosomatic clinic in Germany. The clinic aims at supporting patients' health improvement by fosteri...
Article
Full-text available
Although gender differences are increasingly the focus of current research, gender aspects in the response to pharmacological and non-pharmacological treatment of depression still remain unclear. The aim of this study was to analyze the impact of gender on the outcome of a CBT-orientated multimodal treatment in depressed outpatients with chronic pa...
Article
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AimsThis study aimed to examine the incremental value of growth-differentiation factor-15 (GDF-15) to N-terminal pro brain natriuretic hormone (NT-proBNP) levels for the diagnosis of left ventricular diastolic dysfunction (LVDD) and possible heart failure (HF) in morbidly obese patients.Method and resultsWe analysed data from 207 obese subjects [bo...
Article
In subjects with metabolic syndrome (MetS) endothelial dysfunction is a very consistent finding. Processes leading to endothelial dysfunction and atherosclerosis involve the altered control of subclinical inflammation by innate immune defenses that possibly include mannose-binding lectin (MBL). We investigated the associations of MBL with traits of...
Article
Full-text available
Although gender differences in pain and analgesia are well known, it still remains unclear whether men and women vary in response to multimodal pain treatment. This study was conducted to investigate whether men and women exhibited different outcomes after an intensive multimodal pain treatment program. The daily outpatient program consisted of ind...
Article
Full-text available
This prospective study investigated personality traits as predictors of the outcome in a 52-week weight-loss program for obesity. Personality traits were rated with the Inventory of Interpersonal Problems (IIP) in 54 consecutive obese outpatients when entering a multimodal weight-reduction program. The value of these variables to predict success wa...
Article
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Zusammenfassung Fragestellung: Ziel dieser epidemiologischen Multicenter Studie ist die Erhebung von Pravalenz und Komorbiditat somatoformer Storungen bei stationaren psychosomatischen Patienten. Methode: 20 psychosomatische Kliniken erfassten von 1998 bis 2007 die Diagnosen aller behandelten Patienten standardisiert mit der "Psychische[n] Basisdok...