Thomas Kurien

Thomas Kurien
University of Nottingham | Notts · Division of Orthopaedic and Accident Surgery

FRCS (Tr& Orth) PhD, MSc, BMBS, BMedSci, MRCSEd

About

23
Publications
2,214
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675
Citations
Additional affiliations
August 2011 - February 2016
University of Nottingham
Position
  • MRC Fellow

Publications

Publications (23)
Article
To determine the reliability, reproducibility, variability and validity of the Osteoarthritis Cartilage Histopathology (OACH) assessment system and Mankin Histological-Histochemical Grading System (HHGS) when applied to the characterisation of the osteoarthritic human knee. Osteoarthritic knees of 10 patients undergoing unilateral knee arthroplasty...
Article
We reviewed 59 bone graft substitutes marketed by 17 companies currently available for implantation in the United Kingdom, with the aim of assessing the peer-reviewed literature to facilitate informed decision-making regarding their use in clinical practice. After critical analysis of the literature, only 22 products (37%) had any clinical data. No...
Article
Preoperative pain characteristics in osteoarthritis (OA) patients may explain persistent pain after total knee replacement (TKR). Fifty patients awaiting TKR and 22 asymptomatic controls were recruited to evaluate the degree of neuropathic pain symptoms and pain sensitisation. OA patients were pain phenotyped into two groups based on the PainDETECT...
Article
Full-text available
Mucins are a large family of glycoproteins expressed by many epithelial cells and their malignant counterparts. Much interest has been focused on expression of its members in breast cancer because of their potential role as prognostic indicators and their involvement in cancer therapy. We have examined 1447 cases of invasive breast carcinoma with a...
Article
Full-text available
Unlabelled: A retrospective study was performed in 100 children aged between two and 16 years, with a dorsally angulated stable fracture of the distal radius or forearm, who were treated with manipulation in the emergency department (ED) using intranasal diamorphine and 50% oxygen and nitrous oxide. Pre- and post-manipulation radiographs, the fina...
Article
Background (including the aim of the study) Young and more active patients with medial compartment osteoarthritis (OA) in conjunction with anterior cruciate ligament (ACL) deficiency are difficult to treat. The aim of this study was to explore the outcomes of combined fixed bearing Physica ZUK medial unicompartmental knee replacement (UKR) (Lima Co...
Article
Full-text available
AIM To investigate a comprehensive range of factors that contribute to long-term patient satisfaction post-total joint replacement (TJR) in people who had undergone knee or hip replacement for osteoarthritis. METHODS Participants (n = 1151) were recruited from Nottinghamshire post-total hip or knee replacement. Questionnaire assessment included me...
Article
Full-text available
We present our case report using a novel metal artefact reduction magnetic resonance imaging (MRI) sequence to observe resolution of subchondral bone marrow lesions (BMLs), which are strongly associated with pain, in a patient after total knee replacement surgery. Large BMLs were seen preoperatively on the 3-Tesla MRI scans in a patient with severe...
Article
Full-text available
Immunosuppressants have been the mainstay of treatment for certain inflammatory joint conditions for many years. Developments in this field, namely biological treatments, have led to a change in the classical presentation of acute bone, joint and soft tissue infections. The normal findings of severe pain and tenderness on examination may be absent...
Article
Dear Sir, We would like to draw the attention of your readers to ‘INSPIRE’, a new five-year UK-wide initiative set up by the Academy of Medical Sciences and funded by the Welcome Trust, with the principal aim of engaging medical students with research. Each medical school was invited to apply for a £10 000 grant in November 2012 and set up new eve...
Article
Issues relating to changes in the working practice for doctors have generated discussion in recent years, particularly in relation to the implementation of the European Working Time Regulations (EWTR). The EWTR's implications concerning medical care have revolved around a perception of improved patient safety via a reduction in hours worked, with t...
Article
Delayed presentation of axillary artery injuries after displaced proximal humeral fractures are rare. We present a report on an 88 year old female who developed a pseudoanersym of the axillary artery 3 weeks after a proximal humeral fracture and a novel approach to the management of this potentially limb and life threatening complication.
Article
Books:Oxford Specialist Handbook of Perioperative Medicine (2nd edn) Essential Orthopaedics and Trauma (5th edn) Principles and Practice of Psychiatric Rehabilitation: An Empirical Approach.
Article
Full-text available
To establish a three dimensional reconstruction of an invasive breast carcinoma using basic laboratory equipment to evaluate and characterise the spatial arrangement of the parenchymal cells of the breast. One hundred and twenty eight sequential 4 microm sections (20 microm apart) of the tumour were stained immunohistochemically with an epithelial...
Conference Paper
Visualisation and data exploration is of interest in many areas of medicine. 3D reconstruction can lead to better understanding of structures and disease growth patterns. 3D serial section alignment and reconstruction techniques can be used for visualisation of complex histological data samples. Presented are the method and results using a system o...

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