Thomas W Kelsey

Thomas W Kelsey
University of St Andrews · School of Computer Science

PhD

About

170
Publications
67,955
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5,926
Citations
Additional affiliations
October 1995 - present
University of St Andrews
Position
  • Professor

Publications

Publications (170)
Article
Full-text available
Background: Ovarian tissue cryopreservation with later reimplantation has been shown to preserve fertility in adult women, but this approach remains unproven and experimental in children and adolescents. We aimed to assess the use of the Edinburgh selection criteria for ovarian tissue cryopreservation in girls and young women with cancer to determi...
Article
Full-text available
Improving survival for women with early breast cancer (eBC) requires greater attention to the consequences of treatment, including risk to ovarian function. We have assessed whether biochemical markers of the ovarian reserve might improve prediction of chemotherapy related amenorrhoea. Women (n=59, mean age 42.6years [(range 23.3-52.5]) with eBC we...
Article
Full-text available
Context: Existing biochemical tests for polycystic ovary syndrome (PCOS) have poor sensitivity and specificity. Many women with PCOS have high anti-Müllerian hormone (AMH) concentrations; thus, this may be a useful addition to the diagnostic criteria. Objective: A systematic literature review was performed to assess the true accuracy of AMH in t...
Article
Background There remains a considerable concern among both patients and oncologists that having a live birth (LB) after breast cancer might adversely impact survival. Methods analysis of survival in a national cohort of women with breast cancer diagnosed at age 20–39 years between 1981 and 2017 (n = 5181), and subsequent LB using Scottish Cancer R...
Article
Full-text available
Purpose Accurate diagnosis and prediction of loss of ovarian function after chemotherapy for premenopausal women with early breast cancer (eBC) is important for future fertility and clinical decisions regarding the need for subsequent adjuvant ovarian suppression. We have investigated the value of anti-mullerian hormone (AMH) as serum biomarker for...
Chapter
Further advances in the treatment of young people with cancer have led to improved survival, with 85.6% 5-year relative survival for ages 0–14 in the USA for the years 2010–2016 [18]. However, successful cancer treatment during childhood can cause infertility and premature ovarian insufficiency (POI) in some patients [20, 33]. The risk of developin...
Article
Full-text available
Objective To assess family size and timescale for achieving pregnancy in women who remain fertile after cancer. Design Population-based analysis. Setting National databases. Patient(s) All women diagnosed with cancer before the age of 40 years in Scotland, 1981–2012 (n = 10,267) with no previous pregnancy; each was matched with 3 population cont...
Preprint
Full-text available
Background: Lung cancer is one of the most common and aggressive forms of cancer, resulting in a low survival and high mortality rate. To improve cancer related outcomes, high-risk subpopulations should be identified to reduce overdiagnosis of lung cancer and aid in the implementation of interventions. Electronic Health Records (EHRs) have been eff...
Article
Full-text available
Context Antenatal complications such as hypertensive disorders of pregnancy (HDP), fetal growth restriction (FGR), gestational diabetes (GDM), and preterm birth (PTB) are associated with placental dysfunction. Kisspeptin has emerged as a putative marker of placental function, but limited data exist describing circulating kisspeptin levels across al...
Article
Study question Do the Edinburgh selection criteria correctly identify females, diagnosed with cancer under 18 years old, at high risk of future premature ovarian insufficiency (POI)? Summary answer Patient assessment using these criteria accurately identifies those at risk of POI. Ovarian tissue cryopreservation with future transplantation can be...
Article
552 Background: It is now well established that AMH can indicate the extent of chemotherapy-induced damage on the ovarian reserve. Very low AMH levels in women after chemotherapy for early breast cancer (eBC) may indicate treatment-induced premature ovarian failure (POI), but the evidence to implement its routine clinical use remains limited. Metho...
Article
Full-text available
Objective To compare the performance of kisspeptin and beta human chorionic gonadotropin (βhCG), both alone and in combination, as biomarkers for miscarriage throughout the first trimester. Design Prospective, nested case-control study. Setting Tertiary Centre, Queen Charlotte Hospital, London, United Kingdom. Patient(s) Adult women who had misc...
Presentation
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Talk given at the EUOS Conference 2021
Article
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Background Secondary oligo/amenorrhoea occurs in 3‐5% of women of reproductive age. The two most common causes are Polycystic Ovary Syndrome (PCOS) (2‐13%) and Functional Hypothalamic Amenorrhoea (FHA) (1‐2%). Whilst both conditions have distinct pathophysiology and their diagnosis is supported by guidelines, in practice, differentiating these two...
Article
TB is one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent. Decreasing the length of time for TB treatment is an important step towards the goal of reducing mortality. Mechanistic in silico modelling can provide us with the tools to explore gaps in our knowledge, with the opportunity to model the...
Article
Full-text available
Objective: The maturation of oocytes to acquire competence for fertilization is critical to the success of in vitro fertilization (IVF) treatment. It requires LH-like exposure, provided by either human chorionic gonadotropin (hCG), or gonadotropin releasing hormone agonist (GnRHa). More recently, the hypothalamic stimulator, kisspeptin, was used t...
Presentation
Full-text available
Harnessing the power of data: Applications of data science in reproductive medicine
Article
Final maturation of follicles has, in connection with ovarian stimulation and infertility treatment, traditionally been achieved by the administration of a human chorionic gonadotropin (hCG) bolus trigger of 5,000 to 10,000 IU. This trigger serves two purposes: induce oocyte maturation; and serve as luteal phase support owing to its long half-life....
Article
Full-text available
Objective: Graves' disease is the commonest cause of hyperthyroidism in populations with sufficient dietary iodine intake. Anti-thyroid drugs (ATD) are often used as the initial treatment for Graves' hyperthyroidism, however there is a paucity of data relating the dose of ATD therapy to the effect on thyroid hormone levels, increasing the risk of b...
Article
Full-text available
Background: Placentation (invasion of the placenta into the maternal endometrium) is hypothesised to be critical for healthy placental function and is abnormal in two thirds of miscarriage. Kisspeptin has emerged as a putative regulator of physiological placentation; it is highly expressed in placental syncitio-trophoblasts, whereas its receptor is...
Article
Full-text available
Background: Fear of cancer recurrence (FCR) is common in people affected by breast cancer. FCR is associated with increased health service and medication use, anxiety, depression and reduced quality of life. Existing interventions for FCR are time and resource intensive, making implementation in a National Health Service (NHS) setting challenging....
Article
Full-text available
Background: Trials often struggle to achieve their target sample size with only half doing so. Some researchers have turned to Electronic Health Records (EHRs), seeking a more efficient way of recruitment. The Scottish Health Research Register (SHARE) obtained patients' consent for their EHRs to be used as a searching base from which researchers c...
Preprint
Full-text available
Background: Trials often struggle to achieve their target sample size with only half doing so. Some researchers have turned to Electronic Health Records (EHRs), seeking a more efficient way of recruitment. The Scottish Health Research Register (SHARE) obtained patients’ consent for their EHRs to be used as a searching base from which researchers ca...
Preprint
Background: Trials often struggle to achieve their target sample size with only half doing so. Some researchers have turned to Electronic Health Records (EHRs), seeking a more efficient way of recruitment. The Scottish Health Research Register (SHARE) obtained patients’ consent for their EHRs to be used as a searching base from which researchers ca...
Preprint
Full-text available
Background: Trials often struggle to achieve their target sample size with only half doing so. Some researchers have turned to Electronic Health Records (EHRs), seeking a more efficient way of recruitment. The Scottish Health Research Register (SHARE) obtained patients’ consent for their EHRs to be used as a searching base from which researchers ca...
Presentation
Full-text available
Clinical Insights from Mathematical Modelling of Biological Systems
Article
Full-text available
Introduction: Polycystic ovarian syndrome (PCOS) is a leading cause of female subfertility worldwide, however due to the heterogeneity of the disorder, the criteria for diagnosis remains subject to conjecture. In the present study, we evaluate the utility of serum Anti-Müllerian hormone (AMH) in the diagnosis of menstrual disturbance due to PCOS. M...
Article
Full-text available
Introduction: Ovarian follicle growth is a key step in the success of assisted reproductive treatment, but limited data exists to directly relate follicle growth to recombinant FSH (rFSH) dose. In this study, we aim to evaluate FSH requirements for follicular growth during controlled ovarian stimulation. Method: Single center retrospective cohort s...
Presentation
Full-text available
APOC 2019 presentation
Article
Background: Observational studies have suggested that perinatal outcomes are worse in offspring of cancer survivors. We conducted a systematic review and meta-analysis to examine the risks of perinatal complications in female cancer survivors diagnosed before the age of 40 years. Methods: All published articles on pregnancy, perinatal or congeni...
Article
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Setting University hospital. Patient(s) Fifteen girls and young women with TS aged 5–22 years at OTC were included, together with 42 control girls and young women aged 1–25 years who underwent OTC because of cancer. Intervention(s) None. Main Outcome Measure(s) Follicle density (follicles/mm3), morphology, and health were assessed in ovarian cor...
Article
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Background Many patients who have been treated for breast cancer experience high levels of fear that the cancer will return. The FORECAST pilot study showed that for a third of the patients, fears of cancer recurrence (FCR) increase during radiotherapy treatment and that conversations with their therapeutic radiographer at the weekly review meeting...
Presentation
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Preconceptions, assumptions and the role of the domain expert from the viewpoint of the Health Data Scientist
Article
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PurposeThe aim was to describe the first experience with fertility preservation by cryopreservation of ovarian tissue (OTC) in pre-pubertal girls with galactosemia and further to characterize ovarian follicular morphology and expression of proteins important for ovarian function. Methods Retrospectively, follicle density was estimated in ovarian co...
Article
Full-text available
Study question: What is the impact of cancer in females aged ≤39 years on subsequent chance of pregnancy? Summary answer: Cancer survivors achieved fewer pregnancies across all cancer types, and the chance of achieving a first pregnancy was also lower. What is known already: The diagnosis and treatment of cancer in young females may be associa...
Article
The cover image, by A. Abbara et al., is based on the Original Article Clinical parameters of ovarian hyperstimulation syndrome following different hormonal triggers of oocyte maturation in IVF treatment, DOI: 10.1111/cen.13569.
Article
Full-text available
Objective To identify follicle sizes on the day of trigger most likely to yield a mature oocyte following hCG, GnRH agonist (GnRHa), or kisspeptin during IVF treatment.DesignRetrospective analysis to determine the size of follicles on day of trigger contributing most to the number of mature oocytes retrieved using generalized linear regression and...
Presentation
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The Role of Computer Science in Medical Imaging
Article
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Objective: Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic condition, predominantly related to the hormone used to induce oocyte maturation during IVF treatment. Kisspeptin is a hypothalamic neuropeptide that has recently been demonstrated to safely trigger final oocyte maturation during IVF treatment even in women at high risk of...
Article
Background: Perfluoroalkyl substances (PFASs) are bio-accumulative pollutants, and prenatal exposure to PFASs is believed to impact human foetal development and may have long-term adverse health effects later in life. Additionally, maternal cigarette smoking may be associated with PFAS levels. Foetal exposure has previously been estimated from umb...
Article
Full-text available
The accuracy of Follicle Stimulating Hormone as a predictor of azoospermia in adult survivors of childhood cancer is unclear, with conflicting results in the published literature. A systematic review and post hoc analysis of combined data (n = 367) were performed on all published studies containing extractable data on both serum Follicle Stimulatin...
Article
Full-text available
Background Approximately 11,000 people die in Scotland each year as a result of smoking-related causes. Quitting smoking is relatively easy; maintaining a quit attempt is a very difficult task with success rates for unaided quit attempts stubbornly remaining in the single digits. Pharmaceutical treatment can improve these rates by lowering the over...
Article
Objective To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse. Design Retrospective case-control study. Setting University hospitals. Patient(s) Sixty-three girls under the age of 18 years who underwent OTC before (group 1:...
Presentation
Full-text available
Since smartphones can log spatial, as well as quantitative and qualitative data related to smoking behaviour, we can support smokers by first understanding their smoking behaviour and then sending dynamic support messages post-quit.
Article
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Study question: Do the chemotherapeutic regimens of ABVD (adriamycin, bleomycin, vinblastine and dacarbazine) or OEPA-COPDAC (combined vincristine, etoposide, prednisone, doxorubicin (OEPA) and cyclophosphamide, vincristine, prednisone, dacarbazine (COPDAC)) used to treat Hodgkin lymphoma (HL), affect the density, morphology and in vitro developme...
Poster
Full-text available
We have built a smartphone app that works on Android and iOS platforms. The deployment of this app within a clinical NHS setting has two distinct phases: 1) a two-week logging phase where pre-quit patients log all of their smoking and craving events; and 2) a post-quit phase where users receive dynamic support messages and can continue to log cravi...
Article
Full-text available
For the last two decades, exogenous progesterone administration has been used as luteal phase support (LPS) in connection with controlled ovarian stimulation combined with use of the human chorionic gonadotropin (hCG) trigger for the final maturation of follicles. The introduction of the GnRHa trigger to induce ovulation showed that exogenous proge...
Article
Objective: To study the impact of first-line antineoplastic treatment on ovarian reserve in young girls returning for ovarian tissue cryopreservation (OTC) in connection with a relapse. Design: Retrospective case-control study. Setting: University hospitals. Patient(s): Sixty-three girls under the age of 18 years who underwent OTC before (gr...
Article
Increased risks of female breast cancer, ovarian cancer, fallopian tube cancer, and primary peritoneal cancer have been attributed to germline mutations in the BRCA1 or BRCA2 genes. These also have an impact on ovarian reserve and fertility in women.
Presentation
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International Summer School lecture
Presentation
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Invited Keynote Presentation
Article
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Transabdominal pelvic ultrasound and/or pelvic Magnetic Resonance Imaging are safe, accurate and non-invasive means of determining the size and configuration of the internal female genitalia. The assessment of uterine size and volume is helpful in the assessment of many conditions including disorders of sex development, precocious or delayed pubert...
Data
Combined uterine volume data and validation subsets. The Data worksheet contains our data and the volumes extracted from the published literature (Table 1). The Combined worksheet has the 1,418 age-uterine volume pairs (Table 1), with fixed zero values at conception. Raw values in cubic centimetres are log adjusted after adding 1 (so that zero volu...