Decoding the catalytic machinery of the chemical world!
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Thomas Hansen (ORCID ID: 0000-0002-6291-1569) obtained his Master's degree (2015, summa cum laude) and Ph.D. (2020, cum laude) in Chemistry from Leiden University. Next, he joined the groups of Prof. Bickelhaupt and Dr. Hamlin at the Vrije Universiteit Amsterdam as a postdoctoral researcher. Currently, he is a postdoctoral researcher in the group of Prof. Rovira at the University of Barcelona. His research interests lie at the intersection between (bio)organic and computational chemistry.
August 2021 - present
August 2019 - July 2021
- PostDoc Position
- Supervision: Prof. Bickelhaupt and Hamlin; Field: Computational Chemistry, Theoretical Chemistry; Subject: Theory-driven organic synthesis.
August 2015 - July 2019
Most glycosylation reactions will feature characteristics of both SN1- and SN2-type pathways in the transition states leading to the product(s). It is now commonly accepted that the exact mechanism through which a glycosidic linkage is formed can be found somewhere in the continuum of reaction mechanisms that spans from a completely dissociative SN1 mechanism on one side to an associative SN2 pathway on the other side. On the SN1-side of the spectrum, glycosyl oxocarbenium ions are found as product-forming intermediates. This project contributes to gain knowledge on these elusive intermediates and their role in shaping the overall found stereoselectivity.