Thomas Gener

Thomas Gener
IMIM Hospital del Mar Medical Research Institute | IMIM · Human Pharmacology and Clinical Neurosciences Group

PhD in neurosciences

About

20
Publications
3,127
Reads
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208
Citations
Introduction
Thomas Gener currently works at the Human Pharmacology and Clinical Neurosciences Group, IMIM Hospital del Mar Medical Research Institute. Thomas does research in Neuroscience. Their current projects are related with schizophrenia and down syndrome.
Additional affiliations
February 2011 - February 2015
Centre for Genomic Regulation
Position
  • PostDoc Position
January 2008 - February 2011
IDIBAPS August Pi i Sunyer Biomedical Research Institute
Position
  • PhD Student

Publications

Publications (20)
Article
Atypical antipsychotic drugs (APDs) used to treat positive and negative symptoms in schizophrenia block serotonin receptors 5-HT2AR and dopamine receptors D2R and stimulate 5-HT1AR directly or indirectly. However, the exact cellular mechanisms mediating their therapeutic actions remain unresolved. We recorded neural activity in the prefrontal corte...
Preprint
Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions and dysregulation of dopaminergic transmission is associated with major neurological disorders. However, the available tools to dissect the endogenous dopaminergic circui...
Preprint
Rich social, physical, and cognitively stimulating lifestyles have powerful effects on cognitive abilities, especially when they are experienced early in life. Cognitive therapies are widely used to attenuate cognitive impairment due to intellectual disability, but also aging and neurodegeneration, however the underlying neural mechanisms are poorl...
Article
Neural synchrony and functional connectivity are disrupted in schizophrenia. We investigated changes in prefrontal-hippocampal neural dynamics during psychosis-like states induced by the NMDAR antagonist phencyclidine and subsequent rescue by two atypical antipsychotic drugs (AAPDs), risperidone and clozapine, and the classical APD haloperidol. The...
Preprint
Full-text available
Neural synchrony and functional connectivity are disrupted in neuropsychiatric disorders such as schizophrenia. However, these alterations and how they are affected by commonly prescribed neuropsychiatric medication have not been characterized in depth. Here, we investigated changes in neural dynamics of circuits involving the prefrontal cortex and...
Article
Down syndrome (DS) is the most common form of intellectual disability. The cognitive alterations in DS are thought to depend on brain regions critical for learning and memory such as the prefrontal cortex (PFC) and the hippocampus (HPC). Neuroimaging studies suggest that increased brain connectivity correlates with lower intelligence quotients (IQ)...
Article
Full-text available
Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting muscle and central nervous system (CNS) function. The cellular mechanisms underlying CNS alterations are poorly understood and no useful treatments exist for the neuropsychological deficits observed in DM1 patients. We investigated the progression of behavioral deficits present in...
Article
The inability to properly extinguish fear memories constitutes the foundation of several anxiety disorders, including panic disorder. Recent findings show that boosting prefrontal cortex synaptic plasticity potentiate fear extinction, suggesting that therapies that augment synaptic plasticity could prove useful in rescue fear extinction impairments...
Article
Full-text available
Unlabelled: The dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation and synaptic plasticity and a major candidate of Down syndrome brain alterations and cognitive deficits. DYRK1A is strongly expressed in the cerebral cortex, and its overexpression leads to defective c...
Article
Fundamental laws governing the wiring of neuronal networks in the brain are still largely unknown. Understanding both the role and importance of the connectivity patterns that can be observed at different scales in the central nervous system are of crucial interest for advancing our knowledge on neuroscience in health and disease. Intellectual disa...
Article
Full-text available
There is mounting evidence that most cognitive functions depend upon the coordinated activity of neuronal networks often located far away in the brain. Ensembles of neurons synchronize their activity generating oscillations at different frequencies that may encode behaviour by allowing an efficient communication between brain areas. The serotonin s...
Article
Full-text available
Addiction involves long-lasting maladaptive changes including development of disruptive drug-stimuli associations. Nicotine-induced neuroplasticity underlies the development of tobacco addiction but also, in regions such as the hippocampus, the ability of this drug to enhance cognitive capabilities. Here, we propose that the genetic locus of suscep...
Article
Full-text available
Whole-cell patch recording is an essential tool for quantitatively establishing the biophysics of brain function, particularly in vivo. This method is of particular interest for studying the functional roles of cortical glial cells in the intact brain, which cannot be assessed with extracellular recordings. Nevertheless, a reasonable success rate r...
Article
Neural correlates of spatial representation can be found in the activity of the hippocampal place cells. These neurons are characterized by firing whenever the animal is located in a particular area of the space, the place field. Place fields are modulated by sensory cues, such as visual, auditory, or olfactory cues, being the influence of visual i...
Article
Full-text available
Brain-computer interfaces (BCI) are using the electroencephalogram, the electrocorticogram and trains of action potentials as inputs to analyze brain activity for communication purposes and/or the control of external devices. Thus far it is not known whether a BCI system can be developed that utilizes the states of brain structures that are situate...
Chapter
Full-text available
Place cells are pyramidal neurons located in the hippocampus of rats which action potential activities are in correlation with the position of the animal. The fact that different place cells are active at different locations (place fields) allows the reconstruction of the animal’s position by the use of its brain waves. In the first step of this pr...
Article
The objective of this study was to explore a paradigm that would allow a temporary deprivation of whisker information lasting for a few hours. An additional requirement was to be non-invasive in order to be usable in awake chronically implanted rats without inducing stress. With that aim, electrophysiological recordings from the barrel cortex of an...
Article
This paper describes a method of extracellular recording and subsequent electroporation with the same electrode in single retinal ganglion cells in vitro. We demonstrate anatomical identification of neurons whose receptive fields were measured quantitatively. We discuss how this simple method should also be applicable for the delivery of a variety...

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