Thomas A Agbaedeng

Thomas A Agbaedeng
University of Oxford | OX · Wellcome Trust Centre for Human Genetics

PhD

About

58
Publications
4,432
Reads
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238
Citations
Introduction
Dr Thomas Agbaedeng is a Novo Nordisk Postdoctoral Research Fellow at the University of Oxford. Dr Agbaedeng's research spans pre-clinical drug discovery through translational research. He investigates mechanisms driving cardiovascular dysfunction, including #Gut-Heart-Axis, #EpicardialFat, #(Epi)Genetics, #Inflammation, #Autophagy, and #Fibrogenesis. At the translational and clinical level, Dr Agbaedeng investigates utility of novel #Biomarkers and #BigData in #RiskPrediction
Additional affiliations
January 2020 - present
Academisch Medisch Centrum Universiteit van Amsterdam
Position
  • Fellow
Description
  • In my Fellowship, I am studying the molecular signature of epicardial fat in atrial fibrillation, using multiomics platforms, bioinformatics, and expression analyses (WB and qPCR).
May 2015 - present
University of Adelaide
Position
  • PostDoc Position
Description
  • My Postdoc investigates the links between gut microbiome and atrial fibrillation, using a combination of animal models of hypertension, ageing, and metabolic syndrome, and in vitro cultures
Education
May 2015 - May 2019
University of Adelaide
Field of study
  • Medicine (Cardiac Electrophysiology)
September 2011 - June 2014
University of Brighton
Field of study
  • Biomedical Science

Publications

Publications (58)
Article
Aims Arrhythmogenic right ventricular cardiomyopathy (ARVC), an inherited heart muscle abnormality, is a major cause of sudden cardiac death (SCD). However, the burden of SCD and risk factors in ARVC are not clearly described. Thus, we estimated the rates and predictors of SCD in ARVC in a meta-analysis. Methods and results PubMed, Embase, and Web...
Article
Aims Although overweight and obesity are associated with increased risk of AF, the underlying mechanisms are not well characterised. Recent data suggest that this link may be partly due to abnormal adipose tissue-derived cytokines or adipokines. However, this relationship is not well clarified. To evaluate the association between adipokines and atr...
Article
Objective To summarize data on the prevalence/incidence, risk factors and prognosis of atrial fibrillation (AF) in patients with acute coronary syndromes (ACS). Methods MEDLINE, Embase, and Web of Science were searched to identify all published studies providing relevant data through August 23, 2020. Random-effects meta-analysis method was used to...
Article
Objective This study aimed to investigate the impact of sex on the clinical profile, utilization of rhythm control therapies, cost of hospitalization, length of stay, and in-hospital mortality in patients admitted for atrial fibrillation (AF) in the United States Methods We used data from the Nationwide Inpatient Sample (NIS) for the year 2018. Re...
Article
Background Chronological aging is one of the major risk factors of cardiovascular disease (CVD); however, the impact of biological aging on CVD and outcomes remain poorly understood. Herein, we evaluated the association between leukocyte telomere length (LTL), a marker of biological age, and cardiovascular (CV) outcomes. Methods We searched PubMed...
Article
Background: To estimate the prevalence of concomitant sleep-disordered breathing (SDB) in patients with atrial fibrillation (AF), and to systematically evaluate how SDB is assessed in this population. Methods: We searched MEDLINE, EMBASE and CINAHL databases through August 2020 for studies reporting on SDB in AF patients, with a minimum number o...
Article
Recent preclinical and observational cohort studies have implicated imbalances in gut microbiota composition as a contributor to atrial fibrillation (AF). The gut microbiota is a complex and dynamic ecosystem containing trillions of microorganisms, which produces bioactive metabolites influencing host health and disease development. In addition to...
Article
Background and aims Coronary artery disease (CAD) is a complex disease with a strong genetic basis. While previous studies have combined common single-nucleotide polymorphisms (SNPs) into a polygenic risk score (PRS) to predict CAD risk, this association is poorly characterised. We performed a meta-analysis to estimate the effect of PRS on the risk...
Article
Full-text available
Objective To summarize data on the rates and predictors of left atrial/left atrial appendage thrombus (LAT/LAAT) detection by transoesophageal echocardiography (TEE) prior to electrical cardioversion (ECV) or catheter ablation (CA) for atrial fibrillation (AF). Methods EMBASE, MEDLINE, and Web of Science were searched to identify all studies provi...
Article
Full-text available
Objective To summarize data on atrial fibrillation (AF) detection rates and predictors across different rhythm monitoring strategies in patients with cryptogenic stroke (CS) or embolic stroke of undetermined source (ESUS). Methods MEDLINE, Embase, and Web of Science were searched to identify all published studies providing relevant data through Ju...
Article
Full-text available
Background While physical activity (PA) is an important component of cardiovascular disease prevention and treatment, its role in atrial fibrillation (AF) risk is less well established. Objective The objective of this study is to systematically summarize the evidence pertaining to the relationship of PA and risk of AF. Methods We searched PubMed...
Article
Full-text available
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has led to 47m infected cases and 1.2m (2.6%) deaths. A hallmark of more severe cases of SARS-CoV-2 in patients with acute respiratory distress syndrome (ARDS) appears to be a virally-induced over-activation or unregul...
Article
Atrial fibrillation (AF) and carotid stenosis (CS) can coexist and this association has been reported to result in a higher risk of stroke than attributed to either condition alone. Here we aimed to summarize the data on the association of CS and AF. MEDLINE and Embase were searched to identify all published studies providing relevant data through...
Article
Full-text available
The coronavirus pandemic has reportedly infected over 22 million individuals and caused over 778,000 deaths worldwide. This novel coronavirus, officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), although primarily causes significant respiratory distress, can have significant deleterious effects on the cardiovascular syste...
Article
Full-text available
Although electrocardiography (ECG) is a cost‐effective and convenient tool for routine screening of left ventricular hypertrophy (LVH), its performance has been shown to be poor. The Peguero‐Lo Presti, a novel voltage criterion, was found to be potentially better than the most commonly used criteria. We conducted a systematic review and meta‐analys...
Article
Background Ablation index (AI) and Lesion Size Index (LSI) are novel parameters that incorporates contact force, time, and power in a weighted formula. Recent studies have shown that such indices predict lesion size and durability of pulmonary vein isolation (PVI). However, the outcomes of ablation guided by indices of force-time-power, such as PV...
Article
Background Obesity-mediated epicardial adipose tissue (EAT) expansion drives fat cell infiltration which forms the unique substrate for atrial fibrillation (AF). The LEGACY study showed the benefits of weight loss but an attenuated response with weight fluctuation. How fluxes in weight impacts the atrial substrate in not known. Objective To invest...
Article
Introduction Obesity and enhanced inflammatory response are two independent risk factors involved in the pathogenesis of atrial fibrillation (AF). Components of the NLRP3 inflammasome have been found to be expressed in cardiomyocytes and cardiac fibroblasts and that increased inflammasome activation contributes to the pathogenesis of AF. The NLRP3...
Article
Background Fibrosis is a hallmark of atrial fibrillation (AF) substrate. Recent data suggests that fibrosis detected by late-gadolinium enhancement (LGE) cardiac MRI (CMR) can predict AF. However, this relationship is not well described. Objective To delineate the association of cardiac fibrosis detected by LGE CMR with AF prevalence, AF recurrenc...
Article
Full-text available
The relationship between atrial fibrillation (AF) and thromboembolism is well established. AF confers a greater risk of stroke and systemic thromboembolism in affected patients, such that a third of all stroke events are due to AF. In addition, a significant proportion of embolic strokes of unexplained source are increasingly attributed to asymptom...
Article
Full-text available
The scientific enterprise benefits from diverse perspectives. We asked young scientists to Describe your unique identity and how it contributes to your scientific work and community. Respondents from across the world shared their unique backgrounds and how those experiences shaped them. These scientists described their drive to help their communiti...
Article
Background Atrial fibrillation (AF) is common after pacemaker implantation. However, the impact of pacemaker algorithms in AF prevention is not well understood. Objective The purpose of this study was to evaluate the role of pacing algorithms in preventing AF progression. Methods A systematic search of articles using the PubMed and Embase databas...
Article
Full-text available
Objectives: The aims of the study were to characterize: 1) electrical and electroanatomical remodeling in patients with atrial fibrillation (AF) with obesity; and 2) the impact of epicardial fat depots on adjacent atrial tissue. Background: Obesity is associated with an increased risk of AF. Methods: A total of 115 patients with AF who underwe...
Article
Atrial fibrillation (AF) is the most common sustained arrhythmia and across the developed nations, it contributes to increasing hospitalizations and healthcare burden. Several comorbidities and risk factors including hypertension, heart failure, obstructive sleep apnoea and obesity are known to play an important role in the initiation and perpetuat...
Article
Full-text available
Introduction: Atrial fibrillation (AF) is a complex and debilitating arrhythmia with increasing prevalence. Recent research has unravelled an increasing list of cardiac conditions and novel risk factors that may be responsible for the abnormal underlying atrial substrate that predisposes one to develop AF. Many studies have demonstrated atrial fibr...

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