Thiemo Dinger

Thiemo Dinger
University Hospital Essen | UK Essen · Clinic for Neurosurgery

Dr. med.

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30
Publications
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88
Citations

Publications

Publications (30)
Article
Full-text available
Purpose Breast cancer (BC) is the most frequently diagnosed tumor entity in women. Occurring at different time intervals (TI) after BC diagnosis, brain metastases (BM) are associated with poor prognosis. We aimed to identify the risk factors related to and the clinical impact of timing on overall survival (OS) after BM surgery. Methods We included...
Article
Full-text available
Abstract Blood pressure management is crucial in the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). Possible association between the blood pressure increase and the risk of delayed cerebral ischemia (DCI) and different systemic complications after aSAH is still a matter of debate. This study aims to elucidate the influence of...
Article
Full-text available
Background: Brain metastases requiring surgical treatment determine the prognosis of patients with breast cancer. We aimed to develop the scores for the prediction of short (<6 months) and long (≥3 years) survival after BCBM surgery. Methods: Female patients with BCBM surgery between 2008 and 2019 were included. The new scores were constructed u...
Article
Objective: The prevalence of multiple intracranial aneurysms (MIAs) has increased over the last decades. Because MIAs have been identified as an independent risk factor for formation, growth, and rupture of intracranial aneurysms (IAs), a more profound understanding of the underlying pathophysiology of MIAs is needed. Therefore, the authors' exten...
Article
Full-text available
Objective Occurrence of brain metastases BM is associated with poor prognosis in patients with breast cancer (BC). Magnetic resonance imaging (MRI) is the standard of care in the diagnosis of BM and determines further treatment strategy. The aim of the present study was to evaluate the association between the radiographic markers of BCBM on MRI wit...
Article
Full-text available
Purpose Degenerative cervical myelopathy (DCM) is the most common non-traumatic cause of spinal cord dysfunction. Prediction of the neurological outcome after surgery is important. The aim of this study was to analyze the relationship between first symptoms of DCM and the neurological outcome after surgery. Methods A retrospective analysis over a...
Article
Full-text available
Spinal epidural lipomatosis (SEL) is a rare condition caused by hypertrophic growth of epidural fat. The prevalence of SEL in the Western world is approximately 1 in 40 patients and is likely to increase due to current medical and socio-economic developments. Rarely, SEL can lead to rapid severe neurological deterioration. The pathophysiology, opti...
Article
BACKGROUND AND PURPOSE: The purpose of this study was to investigate the natural course of cerebral cavernous malformations (CCM) in the pediatric population, with special emphasis on the risk of first and recurrent bleeding over a 5-year period. METHODS: Our institutional database was screened for patients with CCM treated between 2003 and 2020. P...
Article
Full-text available
The partial pressure of carbon dioxide (PaCO2) in the arterial blood is a strong vasomodulator affecting cerebral blood flow and the risk of cerebral edema and ischemia after acute brain injury. In turn, both complications are related to poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). We aimed to analyze the effect of PaCO2...
Article
Traumatic acute subdural hematoma (aSDH) is associated with a high mortality rate due to postoperative cerebral infarction. Recently, brain natriuretic peptide (BNP) was considered a reliable biomarker in the acute phase of traumatic brain injuries. We therefore aimed in this study to analyze BNP levels on admission, identify the predictors of thei...
Article
Objective: To evaluate the predictive value of intraoperative neuromonitoring (IONM) in brainstem cavernous malformation (BSCM) surgery. Methods: Surgically treated BSCM patients were included. All patients received IONM consisting of motor- and somatosensory-evoked potentials (MEP, SSEP). Neurological examination was conducted preoperatively an...
Article
Full-text available
Introduction: Brain natriuretic peptide (BNP) is a reliable biomarker in the acute phase of traumatic brain injury. However, the relationship between BNP and traumatic acute subdural hematoma (aSDH) has not yet been addressed. This study aimed to analyze BNP levels on admission in surgically treated patients and assess their relationship with earl...
Conference Paper
Introduction The severity of early brain edema after aneurysm rupture was reported to be strongly associated with the risk of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Objective/Aim Using the recently developed SEBES, we analyzed the predictors of early brain edema and its impact on the complications related to intracranial pres...
Article
Objective Microsurgical resection of spinal ependymomas is associated with a considerable risk of postoperative neurological deterioration. We aimed to develop a risk score for outcome prediction after surgery for spinal ependymoma. Materials and Methods All patients who underwent microsurgical resection of spinal ependymoma between 1980 and 2015...
Article
Full-text available
Objective The severity of early brain edema after aneurysm rupture was reported to be strongly associated with the risk of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Using the recently developed SEBES (Subarachnoid Hemorrhage Early Brain Edema Score), we analyzed the predictors of early brain edema and its impact on the complicati...
Conference Paper
Objective: Brain natriuretic peptide (BNP) is known as a reliable biomarker in the acute phase of traumatic brain injury, related to its severity, presence of increased intracranial pressure and unfavorable outcome. The purpose of this study was to analyze the plasma BNP level in patients with traumatic acute subdural hematoma (aSDH) and assess its...
Conference Paper
Objective: The increase of plasma brain natriuretic peptide (BNP) concentrations on admission was demonstrated in patients with traumatic brain injury (TBI), but has been not yet addressed in traumatic acute subdural hematoma (aSDH). The aim of this study was to assess the relationship between plasma BNP levels and radiological findings in patients...
Article
Background Hormone and HER2/neu receptor status is prognostic and predictive in breast cancer (BC) and guides the choice of therapy. Due to receptor conversion, receptor conversion may differ in metastases compared to primary tumor. Objective The aim of the present study is to analyze the prognostic value of receptor status, receptor conversion an...
Article
Full-text available
Introduction Brachial plexus lipomas are extremely rare benign tumors that may cause slow progression of neurological deficits leading to thoracic outlet syndrome. Up to now, surgery remains challenging. The aim of this study is to present our surgical treatment regime and long-term neurological outcome in three cases of giant brachial plexus lipom...
Article
Full-text available
Objective Seizures at the onset (SAO) of aneurysmal subarachnoid hemorrhage (aSAH) occur in up to one of every five cases. To date, there is no consensus on causal background and clinical value of these early bleeding-related seizures. This study aimed to analyze the predictors and the impact of SAO in aSAH.Methods All aSAH patients from the instit...
Article
Full-text available
Theranostic biomarkers for putative cancer stem-like cells (CSC) in colorectal cancer (CRC) are of particular interest in translational research to develop patient-individualized treatment strategies. Surface proteins still under debate are CD44 and CD133. The structural and functional diversity of these antigens, as well as their plasticity, has o...
Article
Full-text available
Objective: Despite recent advances in molecular biology and genetics, the development of intracranial aneurysms (IA) is still poorly understood. Elucidation of the processes occurring in the IA wall is essential for a better understanding of IA pathophysiology. We sought to analyze the current evidence from histological, molecular and genetic stud...
Conference Paper
Introduction: Tuberous sclerosis complex (TSC) is a rare autosomal-dominant inherited disease. Arterial wall developmental disorders, such as aneurysms, in association with TSC have been well described for extracranial vasculature. Whereas, intracranial aneurysms (IAs) have not previously been addressed in the literature. A systematic review was p...
Poster
Full-text available
Objective: Tuberous sclerosis complex (TSC) is a rare multisystem genetic disease. Arterial wall developmental disorders in TSC such as aneurysms have been well described for extracranial vasculature. The characteristics of intracranial aneurysms (IA) in TSC have not been addressed in the literature yet. This study aimed to perform a systematic rev...
Article
OBJECTIVE Tuberous sclerosis complex (TSC) is a rare multisystem genetic disease. Arterial wall developmental disorders, such as aneurysms, in association with TSC have been well described for extracranial vasculature. The characteristics of intracranial aneurysms (IAs) in TSC have not previously been addressed in the literature. This systematic re...
Article
Background: The exact causes of intracranial aneurysms (IAs) are still unknown. However, certain diseases are known to be associated with IAs. Objective: To analyze the differences in IA characteristics in the general population and in individuals with sickle-cell disease (SCD). Methods: We systematically searched PubMed, Scopus, Web of Scienc...
Article
Objectives: Intraoperative aneurysm rupture (IOAR) is a common complication during intracranial aneurysm(s) (IA) surgery. In virtue of paradigm shift regarding IA selected for clipping in the post-ISAT era, we aimed to evaluate the risk factors and impact of IOAR in an institutional series of clipped ruptured (RIA) and unruptured (UIA) IA. Materi...
Article
Background and purpose: Multiple intracranial aneurysms (MIAs) are common findings of cerebral angiographies; however, MIA prevalence varies in different patient cohorts. We sought to elucidate risk factors influencing MIA prevalence and the clinical consequences. Methods: We systematically searched PubMed, Scopus, Embase, and Cochrane Library d...

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