Thibaud Lebouvier

Thibaud Lebouvier
Centre Hospitalier Régional Universitaire de Lille · Neurologie Générale et Centre Mémoire de Ressources et de Recherche

MD, PhD

About

128
Publications
22,036
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4,062
Citations
Additional affiliations
September 2016 - March 2019
Centre Hospitalier Régional Universitaire de Lille
Position
  • Professor (Assistant)
November 2012 - December 2014
Uppsala University
Position
  • PostDoc Position
November 2010 - November 2014
Centre Hospitalier Universitaire de Nantes
Position
  • Specialist Registrar in Neurology

Publications

Publications (128)
Article
Objectives: We aimed to define brain iron distribution patterns in subtypes of early-onset Alzheimer's disease (EOAD) by the use of quantitative susceptibility mapping (QSM). Methods: EOAD patients prospectively underwent MRI on a 3-T scanner and concomitant clinical and neuropsychological evaluation, between 2016 and 2019. An age-matched contro...
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Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up, and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, international neuropsychological and medical collaborations are burgeoning to tackle the global ch...
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Measures of social cognition have now become central in neuropsychology, being essential for early and differential diagnoses, follow-up and rehabilitation in a wide range of conditions. With the scientific world becoming increasingly interconnected, international neuropsychological and medical collaborations are burgeoning to tackle the global cha...
Article
Objective: To elaborate a new algorithm to establish a standardized method to define cuff-offs for CSF biomarkers of Alzheimer's disease (AD) by validating the algorithm against CSF classification derived from PET imaging. Methods: Low and high levels of CSF phosphorylated tau were first identified to establish optimal cut-offs for CSF amyloid-β...
Preprint
The accumulation of pathological Tau in the brain and cerebrospinal fluid (CSF) and its eventual increase in the blood are hallmarks of Alzheimer’s disease (AD). However, the mechanisms of Tau clearance from the brain to the periphery are not clear. We show here, using animal and cellular models as well as patient blood samples and post mortem brai...
Article
This multicenter study was conducted in French memory clinics during the first COVID-2019 lockdown (March–May 2020). The objective was to evaluate the effect of a telemedicine consultation on treatment modification in dementia care. Among 874 patients who had a telemedicine consultation, 103 (10.7%) had treatment modifications, in particular those...
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Aim: Lower interoceptive abilities are a characteristic of chronic pain conditions. Social support plays an important role in chronic low back pain (cLBP) but social cognitive skills have rarely been investigated. This study aimed to characterize interoceptive and social cognitive abilities in cLBP and to study the relationship between both domains...
Article
Recent evidence suggests an association between benzodiazepines (BZDs) use and lower brain amyloid load, a hallmark of AD pathophysiology. Other AD-related markers include hippocampal atrophy, but the effect of BZDs on hippocampal volume remains unclear. We aimed at 1) replicating findings on BZDs use and brain amyloid load and 2) investigating ass...
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Background Although social cognitive dysfunction is a major feature of frontotemporal dementia (FTD), it has been poorly studied in familial forms. A key goal of studies is to detect early cognitive impairment using validated measures in large patient cohorts. Methods We used the Revised Self-Monitoring Scale (RSMS) as a measure of socioemotional...
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Background: In early 2020, COVID-19 outbreak struck France leading to a national lockdown between March 17th and May 11th . While standard in-person medical consultation was complicated, telemedicine dramatically expanded. In order to evaluate the impact of this unpreceded situation on clinical practice and use of psychoactive drug in dementia car...
Preprint
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Neuroinvasion by SARS-CoV-2 is now accepted. To investigate whether low testosterone levels observed in men with severe COVID-19 could be of central origin, we retrospectively analyzed blood samples from 60 male intensive-care patients and explored SARS-CoV-2 brain entry using animal and cellular models as well as adult COVID-19 patient and fetal h...
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Background Dementia with Lewy bodies remains underdiagnosed in clinical practice mainly because of the low sensitivity of existing diagnostic criteria and a strong overlap with Alzheimer’s pathology that can mask the Lewy phenotype.Objective The objective of this study was therefore to develop and validate a new clinical scale designed to detect si...
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Résumé Le dosage des biomarqueurs du liquide cérébrospinal (LCS) a intégré depuis maintenant plusieurs années la démarche diagnostique en cas de suspicion de maladie d’Alzheimer (MA). En France, où l’imagerie moléculaire n’est pas accessible en soin courant, ils sont le seul outil disponible pour poser un diagnostic biologique de MA selon les critè...
Article
Introduction Les dégénérescences lobaires frontotemporales (DLFT) sont un groupe de pathologies hétérogènes dont les présentations cliniques peuvent être similaires à celles de la maladie d’Alzheimer (MA), ce qui est source d’hésitation diagnostique. Objectifs Le but de cette étude est de déterminer les phénotypes cliniques ayant entraîné une hési...
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Infantile myofibromatosis (IMF) is a benign tumor form characterized by the development of nonmetastatic tumors in skin, bone, muscle and sometimes viscera. Autosomal dominant forms of IMF are caused by mutations in the PDGFRB gene, but a family carrying a L1519P mutation in the NOTCH3 gene has also recently been identified. In this report, we addr...
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Background Due to heterogeneous clinical presentation, difficult differential diagnosis with Alzheimer’s disease (AD) and psychiatric disorders, and evolving clinical criteria, the epidemiology and natural history of frontotemporal lobar degeneration (FTD) remain elusive. In order to better characterize FTD patients, we relied on the database of a...
Article
Alzheimer's disease (AD) is a heterogeneous illness, with a common clinical presentation of progressive amnesia and less common « atypical » presentations which may be misdiagnosed with a pathology of the frontotemporal lobar degeneration (FTLD) spectrum. This study sought to characterize which phenotypes of AD are difficult to distinguish from FTL...
Article
Neuropathological bases of suspected non‐Alzheimer’s disease pathophysiology (SNAP) have recently been identified as frequent causes of progressive isolated amnestic non Alzheimer’s disease (AD) neurodegenerative diseases1,2. Nonetheless, their in‐vivo profiles have so far been only poorly characterized. The goal of this study is to specify their c...
Article
Since the new ATN classification system positing a biological definition of Alzheimer’s disease (AD), cerebrospinal fluid (CSF) biomarkers are the keystone of AD diagnosis in countries where amyloid and tau positron emission tomography (PET) are not available. However, data confronting CSF biomarkers with pathology are still scarce. Among the 242 p...
Article
Decades of researches aiming to unveil truths about human neuropsychology may have instead unveil facts appropriate to only a fraction of the world’s population: those living in western educated rich democratic nations (Muthukrishna et al., 2020 Psych Sci). So far, most studies were conducted as if education and cultural assumptions on which neurop...
Article
Objectives: Mild cognitive impairment (MCI) is associated with an increased risk of further cognitive decline, partly depending on demographics and biomarker status. The aim of the present study was to survey the clinical practices of physicians in terms of biomarker counselling, management, and follow-up in European expert centers diagnosing pati...
Article
Introduction Les critères A/T/N de maladie d’Alzheimer (MA) reconnaissent depuis 2018 le ratio Aβ42/40 dans le liquide cérébrospinal (LCS) comme un marqueur d’amyloïdopathie, au même titre que la protéine Aβ42. Objectifs Comparer le profil biochimique, cognitif et en neuro-imagerie des patients MA fort producteurs d’amyloïde (Aβ42 normale, ratio A...
Article
Introduction Depuis les nouveaux critères diagnostiques des différents syndromes de dégénérescence lobaire fronto temporales (DLFT) peu d’études en population ont été réalisées. Objectifs L’objectif de cette étude est d’identifier les caractéristiques des DLFT ainsi que leur profil d’évolution au sein du réseau des consultations mémoire du Nord Pa...
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Introduction: Memory clinics (MCs) are the main model for dementia diagnosis and care. Following the development of a MC network in Northern France, our objectives were to assess its impact on patient characteristics over 20 years. Methods: The characteristics of new consultants were studied from 1997 to 2016. Results: New consultants increase...
Preprint
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Humans have developed specific abilities to interact efficiently with their conspecifics (social cognition). Despite abundant behavioral and neuroscientific research, the influence of cultural factors on these skills remains poorly understood. This issue is of particular importance as most cognitive tasks are developed in highly specific contexts,...
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Amnesia is a key component of Alzheimer’s disease (AD) and the most important feature of its clinical diagnosis but its specificity has recently been challenged. This study investigated the ability of amnesia to predict AD in a clinicopathological dementia series. Ninety-one patients to which free and cued verbal memory assessment was administered...
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The gut-brain axis is a hot topic in Parkinson's disease. In an attempt to decipher its role in the disease pathogenesis, several animal models have been developed. Most of these models tried to reproduce Braak's hypothesis by showing that the pathological process could spread from the gut to the brain (bottom-up scenario). Interestingly, others gr...
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INTRODUCTION Midlife hypertension has been consistently linked with increased risk of cognitive decline and Alzheimer’s disease (AD). Observational studies and randomized trials show that the use of antihypertensive therapy is associated with a lesser incidence or prevalence of cognitive impairment and dementia. However, whether anti-hypertensive a...
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Primary Familial Brain Calcification (PFBC) is an age‐dependent and rare neurodegenerative disorder characterized by microvascular calcium phosphate deposits in the deep brain regions. Known genetic causes of PFBC include loss‐of‐function mutations in genes involved in either of three processes ‐ platelet‐derived growth factor (PDGF) signalling, ph...
Article
It remains unclear whether benzodiazepines (BZDs) constitute a risk factor for Alzheimer's disease (AD). In this study, we investigated associations between chronic use of BZDs and brain amyloid load, a hallmark of AD, in 268 nondemented older individuals. F18-florbetapir positron emission tomography scans were performed to assess amyloid load as m...
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Background In case of suspected normal pressure hydrocephalus, MRI is performed systematically and can sometimes highlight an obstruction of the flow pathways of the CSF (aqueductal stenosis or other downstream obstruction). It seems legitimate for these patients to ask the question of a treatment with endoscopic third ventriculostomy (ETV), even i...
Article
Background: Amnesia is the most prominent symptom of typical AD. An amnesic syndrome (AS) characterized by a deficit in both free and cued verbal memory recalls has been considered to be highly suggestive of AD and a key component of its clinical diagnosis. In this context, the Free and Cued Selective Reminding Test (FCSRT) was established as a ref...
Article
Primary familial brain calcification (PFBC) is a rare neurogenetic disorder with diverse neuropsychiatric expression. Mutations in four genes cause autosomal dominant PFBC: SLC20A2, XPR1, PDGFB and PDGFRB. Recently, biallelic mutations in the MYORG gene have been reported to cause PFBC with an autosomal recessive pattern of inheritance. We screened...
Article
Background: Idiopathic normal-pressure hydrocephalus (iNPH) is a treatable cause of gait and cognitive impairment. iNPH should be differentiated from ventriculomegaly secondary to brain atrophy to choose the best therapeutic option (ventriculoperitoneal shunt vs medical management). Objective: To determine the diagnostic accuracy of automated su...
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Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical characteristics of “true” and “false” A−T+ patients remain elusi...
Article
Résumé Le diagnostic positif et étiologique de la variante comportementale des dégénérescences lobaires frontotemporales (DLFT), également appelé démence frontotemporale (DFTc), reste une gageure en 2019. Le diagnostic différentiel entre DFTc et troubles psychiatriques peut être aidé par l’utilisation stricte des critères diagnostiques du DSM5 et q...
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The G4C2-repeat expansion in C9orf72 is the most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia. The high phenotypic heterogeneity of C9orf72 patients includes a wide range in age of onset, modifiers of which are largely unknown. Age of onset could be influenced by environmental and genetic factors both of which may...
Article
A (GGGGCC)n repeat expansion in C9orf72 gene is the major cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The relations between the repeats size and the age at disease onset (AO) or the clinical phenotype (FTD vs. ALS) were investigated in 125 FTD, ALS, and presymptomatic carriers. Positive correlations were found be...
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Vascular diseases are major causes of death, yet our understanding of the cellular constituents of blood vessels, including how differences in their gene expression profiles create diversity in vascular structure and function, is limited. In this paper, we describe a single-cell RNA sequencing (scRNA-seq) dataset that defines vascular and vessel-as...
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In Fig. 1b of this Article, 'Csf1r' was misspelt 'Csfr1'. In addition, in Extended Data Fig. 11b, owing to an error during figure formatting, the genes listed in the first column shifted down three rows below the first gene on the list, causing a mismatch between the gene names and their characteristics. These errors have been corrected online, and...
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Background: Studies have shown the frequent coexistence of Lewy pathology (LP) in AD. Objective: The aim of this study was to determine the influence of LP on the clinical and cognitive phenotype in a cohort of patients with a neuropathological diagnosis of AD. Methods: We reviewed neuropathologically proven AD cases, reaching Braak stages V a...
Article
Introduction Les biomarqueurs de maladie d’Alzheimer (MA) dans le liquide cérébrospinal (LCS) sont dissociés lorsque T-Tau et/ou P-Tau sont augmentés malgré Aβ42 normal. Aβ42/Aβ40 pourrait être un meilleur marqueur d’amyloïdopathie qu’Aβ42. Objectifs Déterminer la proportion des patients ayant un profil « faux-dissocié » (FD) (P-Tau augmenté, Aβ42...
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Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain...
Chapter
Frontotemporal lobar degeneration (FTLD) includes the behavioral variant of frontotemporal lobar degeneration (bvFTD), also called frontotemporal dementia (FTD), and two language variants, namely, semantic dementia (SD) and primary progressive agrammatic aphasia (PPA). There is a large degree of overlap between the three FTLD variants, as well as b...
Article
Purpose of review: The purpose of this review is to provide an update on the role of tau beyond the stabilization of microtubules and on the clinical, pathological, diagnostic and therapeutic aspects of tauopathies. Recent findings: Beyond its function as a microtubule-associated tau protein, tau is also involved in gene regulation, signal trans...
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Introduction Le syndrome de Gerstmann-Straussler-Scheinker (GSS) est une forme rare d’encephalopathie spongiforme humaine de transmission genetique caracterisee par une grande diversite clinique et genetique. Nous rapportons le cas d’une famille. Observation Cinq membres de la fratrie presentaient une symptomatologie neurologique apparue entre la q...
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Background—Clinical, pathological and genetic overlap between sporadic frontotemporal dementia (FTD), Alzheimer’s disease (AD) and Parkinson’s disease (PD) has been suggested; however, the relationship between these disorders is still not well understood. Here we evaluated genetic overlap between FTD, AD and PD to assess shared pathobiology and ide...
Article
Lewy bodies and neurites, the pathological hallmarks found in the brain of Parkinson’s disease (PD) patients, are primarily composed of aggregated and hyperphosphorylated alpha-synuclein. The observation that alpha-synuclein inclusions are also found in the gut of the vast majority of parkinsonian patients has led to an increasing number of studies...
Article
Introduction La prise en charge du mélanome métastatique a été récemment révolutionnée par l’arrivée des thérapies ciblées et des immunothérapies (anti-CTLA4 et anti-PD1) permettant une augmentation de la survie des malades. Ces molécules nous confrontent à des toxicités nouvelles. Nous rapportons le premier cas de syndrome cérébelleux sous anti-PD...
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Pericytes, the mural cells of blood microvessels, regulate microvascular development and function and have been implicated in many brain diseases. However, due to a paucity of defining markers, pericyte identification and functional characterization remain ambiguous and data interpretation problematic. In mice carrying two transgenic reporters, Pdg...
Article
Objective: To evaluate the efficacy and safety of zonisamide in patients with myoclonus-dystonia. Methods: We conducted a randomized, double-blind, placebo-controlled crossover trial of zonisamide (300 mg/d) in 24 patients with myoclonus-dystonia. Each treatment period consisted of a 6-week titration phase followed by a 3-week fixed-dose phase....