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Theodoros Moysiadis

Theodoros Moysiadis

Ph.D in Statistics

About

114
Publications
21,463
Reads
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646
Citations
Introduction
Theodoros Moysiadis received his B.Sc., M.Sc. and Ph.D degree in Mathematics/Statistics at the School of Mathematics, AUTH, Greece (2003, 2005 and 2010). In 2011-2014 he was a Visiting Lecturer at the Department of Mathematics and Statistics, UoC, Cyprus. During 2015-2020, he worked as Postdoctoral Researcher at Institute of Applied Biosciences/CERTH. In 2016, he was granted a 2-year individual Marie Skłodowska-Curie fellowship, successfully completed at 2018.
Additional affiliations
October 2018 - October 2020
Karolinska Institutet
Position
  • Postdoctoral Researcher in Biostatistics
April 2016 - March 2018
The Centre for Research and Technology, Hellas
Position
  • Fellow
Description
  • Marie Skłodowska-Curie Individual Fellowship under the call H2020-MSCA-IF-2015. Project acronym: CLLassify --- Project title: Innovative risk assessment for individualizing treatment in chronic lymphocytic leukemia.
January 2015 - June 2020
The Centre for Research and Technology, Hellas
Position
  • PostDoc Position
Education
January 2006 - May 2010
Aristotle University of Thessaloniki
Field of study
  • Non-homogeneous Markov Systems of high order
September 2003 - November 2005
Aristotle University of Thessaloniki
Field of study
  • Statistical and Operational Research
September 1999 - July 2003
Aristotle University of Thessaloniki
Field of study
  • Mathematics

Publications

Publications (114)
Article
This study presents an assessment of morpho-physiological diversity for one hundred and forty-six sweet cherry (Prunus avium) cultivars, originating from different countries and maintained in an ex situ GeneBank collection. Data of thirty-five traits, describing phenology, plant morphology, yield and fruit quality were recorded over three years and...
Article
Full-text available
The traditionally edible aerial parts of rock samphire (Crithmum maritimum L.) could be a valuable functional food or feed ingredient due to their high antioxidant capacity, ascorbic acid content, and rich content in secondary metabolites such as phenolics and flavonoids. The first objective of this study was to evaluate eighteen genotypes derived...
Article
Multiple Sclerosis (MS) is highly comorbid with mental disorders in any disease stage, while psychiatric manifestations may precede the onset of neurological symptoms as well as diagnosis. Neuropsychiatric comorbidities are associated with an elevated risk of MS disability progression, and therefore, people with multiple sclerosis (PwMS) with psych...
Article
Full-text available
Genome-wide transcriptome analysis is a method that produces important data on plant biology at a systemic level. The lack of understanding of the relationships between proteins and genes in plants, necessitates a further thorough analysis at a proteogenomic level. Recently, our group generated a quantitative proteogenomic atlas of 15 sweet cherry...
Article
Genome-wide transcriptome analysis provides systems-level insights into plant biology. Due to the limited depth of quantitative proteomics our understanding of gene-protein-complex stoichiometry is largely unknown in plants. Recently, the complexity of the proteome and its cell/tissue specific distribution boost the research community to the integr...
Article
Full-text available
Recent studies of chronic lymphocytic leukemia (CLL) have reported recurrent mutations in the RPS15 gene, which encodes the ribosomal protein S15 (RPS15), a component of the 40S ribosomal subunit. Despite some evidence about the role of mutant RPS15 (mostly obtained from the analysis of cell lines), the precise impact of RPS15 mutations on the tran...
Article
Objective: To identify the optimal strategy for the triage of women who test high-risk (hr) HPV positive on self-collected cervicovaginal samples. Methods: This is a diagnostic accuracy sub-analysis of the GRECOSELF study, which reported on HPV-DNA testing with self-sampling in Greece. More than 13,000 women, 25-60 years old, who resided in rura...
Article
Full-text available
Sweet cherry germplasm contains a high variety of phenotypes, which are associated to fruit size and shape, sugar content etc. High phenotypic variation can be a result of genetic or epigenetic diversity, that may interact through time. Recent studies provide evidence that besides allelic variation, epi-allelic variation can establish new heritable...
Article
Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients with (quasi)identical, stereotyped B cell receptor immunoglobulins (BcR IG). Patients in certain major stereotyped subsets often display remarkably consistent clinicobiological profiles, suggesting that the study of BcR IG stereotypy in CLL has important imp...
Article
Full-text available
Objective: To estimate current prevalence of multiple sclerosis (MS) in Greece using administrative data from the nationwide medicine prescription database. Methods: Prescription records of a 24-month period (June 2017-May 2019) were analyzed in order to identify cases of MS. Sex, age, and place of residence were recorded for each identified case....
Article
Background: Human papillomavirus (HPV)-DNA testing combined with self-sampling could increase cervical cancer screening effectiveness, utilizing a sensitive screening modality and an easy sampling method with minimal pain or discomfort. Self-sampling acceptability, though, is pivotal. Materials and Methods: This study is a nested cross-sectional s...
Article
Full-text available
The inflammatory cytokine stem cell factor (SCF, ligand of c-kit receptor) has been implicated as a pro-oncogenic driver and an adverse prognosticator in several human cancers. Increased SCF levels have recently been reported in a small series of patients with chronic lymphocytic leukemia (CLL), however its precise role in CLL pathophysiology remai...
Article
Full-text available
Complex karyotype (CK) identified by chromosome-banding analysis (CBA) has shown prognostic value in chronic lymphocytic leukemia (CLL). Genomic arrays offer high-resolution genome-wide detection of copy-number alterations (CNAs) and could therefore be well equipped to detect the presence of a CK. Current knowledge on genomic arrays in CLL is based...
Article
Full-text available
Background: In order to gain insight into the contribution of DNA methylation to disease progression of chronic lymphocytic leukemia (CLL), using 450K Illumina arrays, we determined the DNA methylation profiles in paired pre-treatment/relapse samples from 34 CLL patients treated with chemoimmunotherapy, mostly (n = 31) with the fludarabine-cycloph...
Article
Self-sampling for human papillomavirus (HPV) testing is an alternative to physician-sampling particularly for cervical cancer screening non-attenders. The GRECOSELF study is a nationwide observational cross-sectional study aiming to suggest a way to implement HPV-DNA testing in conjunction with self-sampling for cervical cancer screening in Greece,...
Article
Full-text available
Cucurbita pepo contains two cultivated subspecies each of which encompasses four fruit-shape morphotypes (cultivar-groups). The Pumpkin, Vegetable Marrow, Cocozelle, and Zucchini Groups are of subsp. pepo and the Acorn, Crookneck, Scallop, and Straightneck Groups are of subsp. ovifera. Recently, a de novo assembly of the C. pepo subsp. pepo Zucchin...
Article
Full-text available
To further understand the impact of grafting on fruit characteristics and to comprehend the mechanisms involved in graft-induced changes we studied homo- and hetero- grafted Cucurbita pepo cultivars (cv.) that vary in fruit size and shape. C. pepo cv. ‘Munchkin’ and cv. ‘Big Moose’ as well as cv. ‘Round green’ and cv. ‘Princess’ were homo-grafted a...
Article
Full-text available
Background: Across recent health reform research, there is growing advocacy and awareness surrounding the idea that patients should act as more effective managers of their health and healthcare. Knowledge dissemination is frequently named as a preliminary requirement for this shift in attitude and behaviors. In 2017, the Lymphoma Coalition (LC) con...
Article
Recent evidence indicates that TAp63, the prevalent isoform of TP63 in Chronic Lymphocytic Leukemia (CLL), is implicated in disease pathogenesis. In CLL, TAp63 expression, modulated by both immune signaling and epigenetic modifications, promotes leukemic cell survival and homing to the bone marrow. In activated normal B cells, the TAp63 transcripti...
Article
Full-text available
Chronic lymphocytic leukemia (CLL) stereotyped subsets #6 and #8 include cases expressing unmutated B cell receptor immunoglobulin (BcR IG) (U‐CLL). Subset #6 (IGHV1‐69/IGKV3‐20) is less aggressive compared to subset #8 (IGHV4‐39/IGKV1(D)‐39) which has the highest risk for Richter's transformation among all CLL. The underlying reasons for this dive...
Article
Full-text available
Chronic lymphocytic leukemia patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinicobiological differences. Considering this, we assessed prognosis separately within mutated and unmutated chronic lymphocytic leukemia in 3015 patients, hypothesizing...
Article
Full-text available
Persistent cervical infection with high-risk human papillomaviruses (hrHPVs) is a necessary, but not sufficient, condition for the development of cervical cancer. Therefore, there are other co-factors facilitating the hrHPV carcinogenic process, one of which is smoking. To assess the effect of smoking on high-risk (hr) HPV DNA positivity and on the...
Article
The aim of the present cohort study was to assess the long-term (follow-up period up to 22 years) recurrence rate of preinvasive disease and the newly detected invasive disease rate in a cohort of women treated with excisional methods for high-grade cervical intraepithelial neoplasia (CIN). Women treated with large loop excision of the transformati...
Preprint
Persistent cervical infection with high-risk Human papillomaviruses (hrHPVs) is a necessary, but not sufficient, condition for the development of cervical cancer. Therefore, there are other co-factors facilitating the hrHPV carcinogenic process, one of which is smoking. In order to assess the effect of smoking on high-risk (hr) HPV DNA positivity a...
Article
Mounting evidence supports the notion that T cells are crucial for the survival and expansion of the malignant clone in chronic lymphocytic leukemia (CLL). Recently, NGS immunoprofiling of the T cell receptor (TR) gene repertoire in CLL revealed "disease-specific" TR clonotypes shared by different patients that persisted and further expanded over t...
Article
A great challenge for early stage patients with chronic lymphocytic leukemia (CLL) is to determine if and, consequently, when they will require treatment, highlighting the need for robust prognostic assessment. Today, immunogenetic and genomic features are considered essential for accurate risk stratification in CLL. However, when utilizing such bi...
Article
Background: The advent of efficacious but also very expensive novel treatment regimens for high-risk chronic lymphocytic leukemia (CLL), has highlighted the need for accurate riskstratification. Published evidence indicates that classic chromosome banding analysis (CBA) offers valuable complementary information to the routinely performed FISH analy...
Preprint
Full-text available
To further understand the impact of grafting on fruit characteristics and to comprehend the mechanisms involved in graft-induced changes we studied homo- and hetero- grafted Cucurbita pepo cultivars (cv.) that vary in fruit size and shape. C. pepo cv. ‘Munchkin’ (small fruit) and cv. ‘Big Moose’ (large fruit) as well as cv. ‘Round green’ (round fru...
Preprint
Full-text available
To further understand the impact of grafting on fruit characteristics and to comprehend the mechanisms involved in graft-induced changes we studied homo- and hetero- grafted Cucurbita pepo cultivars (cv.) that vary in fruit size and shape. C. pepo cv. ‘Munchkin’ (small fruit) and cv. ‘Big Moose’ (large fruit) as well as cv. ‘Round green’ (round fru...
Article
Full-text available
The objective of the presented cross-sectional-evaluation-screening study is the clinical evaluation of high-risk(hr)HPVE7-protein detection as a triage method to colposcopy for hrHPV-positive women, using a newly developed sandwich-ELISA-assay. Between 2013-2015, 2424 women, 30-60 years old, were recruited at the Hippokratio Hospital, Thessaloniki...
Article
The genetic basis of fruit size and shape was investigated for the first time in Cucurbita species and genetic loci associated with fruit morphology have been identified. Although extensive genomic resources are available at present for tomato (Solanum lycopersicum), cucumber (Cucumis sativum), melon (Cucumis melo) and watermelon (Citrullus lanatus...
Poster
Full-text available
Advances in sequencing techniques have massively increased the publicly accessible -omics data and thus enable further and more extensive research opportunities on genome diversity. The concept of the pangenome refers to the union of gene families shared by a set of genomes. Several studies have implemented specific pangenome analyses for a variety...
Poster
Full-text available
High-risk (hr) HPV detection with HPV16/18 genotyping tends to be considered a better method of primary cervical screening than cytology. The purpose of this study is to assess the performance of the detection of E7HPV protein as a triage method for women either hrHPV (non16/18) or HPV16/18 positive, and, consequently, evaluate alternative triage p...
Poster
Full-text available
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. Most CLL patients will need treatment during the course of the disease and although initially responding to treatment, most patients will eventually relapse. The exact molecular mechanisms underlying disease relapse, are not yet fully understood. Moreover, th...
Presentation
Full-text available
Chronic lymphocytic leukemia (CLL) is a malignancy of B lymphocytes and the most common adult leukemia in the West with remarkable clinical hetero- geneity. To estimate the clinical outcome of CLL patients, the Rai and Binet clinical staging systems were developed, yet both have a limited ability at diagnosis to pre- dict the clinical course for pa...